Pharmacological target of venom proteins

This page gives the list of channel/receptor families that are targeted by venom proteins and an access to these venom proteins. A detailed information on these families is available by clicking on the “channel/receptor family” blue hyperlink, while clicking on the logo permits to retrieve venom protein(s) of interest in UniProtKB/Swiss-Prot. Dashes indicate that no venom protein has been described yet to target the channel/receptor family.

The column “Channel/Receptor Human” of the table permits an access to human channel/receptor entries of UniProtKB/Swiss-Prot.

Another view of this table is also available in Animal toxin annotation program, Statistics.

See also Venom protein activity
See also Systems targeted by venom proteins
See also Activity Greek symbol descriptors

Channel/receptor families Channel
Receptor
Venom proteins that target channels/receptors
Click on to retrieve UniProtKB entries
Ion channel (voltage-gated and
ligand-gated)
Human Snake Scorpion Cone
snail
Spider Cnidarian Insect Other All
Voltage-gated sodium (Nav) channel
Voltage-gated potassium (Kv) channel -
Calcium-activated potassium (KCa) channel - - - -
Inward-rectifier potassium (KIR) channel - - - - - -
Nicotinic acetylcholine receptor (nAChR) - - - - -
Voltage-gated calcium (Cav) channel -
Ryanodine-sensitive calcium-release (RyR) channel - - - -
P2X receptor (P2RX) - - - - - -
Voltage-gated chloride (ClC) channel - - - - - -
CFTR channel - - - - -
Ionotropic GABA receptor - - - - - -
Ionotropic glutamate receptor - - - - -
HCNa nonspecific cation channel - - - - - -
Cyclic nucleotide-gated channel (CNG) - - - - - -
Transient receptor potential (TRP) channel - - - -
Acid-sensing ion channel (ASIC) - - - -
5-HT receptor - - - - - -
Ion channel (voltage-gated and
ligand-gated) ALL
receptor 7TM / G-protein coupled receptor (GPCR) Human Snake Scorpion Cone
snail
Spider Cnidarian Insect Other All
Adrenergic receptor - - -
Bradykinin receptor - -
Cholecystokinin receptor - - - - - -
Endothelin receptor - - - - - -
Dopamine receptor - - - - - -
GABA-B receptor - - - - - -
Glucagon-like peptide receptor - - - - - -
Muscarinic acetylcholine receptor - - - - - -
Neurotensin receptor - - - - - -
Opioid receptor - - - -
Prokineticin receptor - - - - -
Somatostatin receptor - - - - - -
Vasoactive intestinal polypeptide receptor - - - - - -
Vasopressin/oxytocin receptor - - - - -
receptor 7TM / G-protein coupled receptor (GPCR) ALL -
receptor 1TM Human Snake Scorpion Cone
snail
Spider Cnidarian Insect Other All
Epidermal growth factor receptor (EGFR) - - - - - -
Insulin receptor (INSR) - - - - - -
Integrin - - - - - -
Vascular endothelial growth factor receptor (VEGFR) - - - - - -
Transporter Human Snake Scorpion Cone
snail
Spider Cnidarian Insect Other All
Glutamate transporter - - - - - -
Noradrenaline transporter - - - - - -