Ionotropic glutamate receptor inhibitor

Receptor Ionotropic glutamate receptors are glutamate-gated nonselective cation channels that allow the flow of potassium, sodium and sometimes calcium ions in response to glutamate binding. Upon binding, the agonist stimulates direct action of the central pore of the receptor, an ion channel, allowing ion flow and causing excitatory postsynaptic current (EPSC). This current is depolarizing and, if enough glutamate receptors are activated, may trigger an action potential in the postsynaptic neuron. All the receptors produce excitatory postsynaptic current, but the speed and duration of the current is different for each type.
Based on both molecular and pharmacological criteria ionotropic glutamate receptors have been divided into two major classes, the non-NMDA-class, which includes both AMPA and kainate subtypes of receptors, and the NMDA -class. (Dingledine et al., 1999, Traynelis et al., 2010 ).
Toxin
Receptor Toxins from different taxa that target receptors.
Click on to retrieve toxins of interest.
Human Snake Scorpion Cone
snail
Spider Cnidarian Insect Other All
AMPA receptor
GRIA1 - - - - - -
GRIA2 - - - - - -
GRIA3 - - - - - -
GRIA4 - - - - - -
GRID1 - - - - - - - -
GRID2 - - - - - - - -
kainate receptor
GRIK1 - - - - - - - -
GRIK2 - - - - - - - -
GRIK3 - - - - - - - -
GRIK4 - - - - - - - -
GRIK5 - - - - - - - -
NMDA receptor
GRIN1 - - - - - -
GRIN2A - - - - - -
GRIN2B - - - - - -
GRIN2C - - - - - -
GRIN2D - - - - - -
GRIN3A - - - - - - - -
GRIN3B - - - - - -
Glutamate receptor All - - - - -

Venom protein entries in UniProtKB/Swiss-Prot

21 entries grouped by species (browse by taxonomy, browse by keywords)

1 entry

Conus caracteristicus (Characteristic cone)

CKC_CONCB Conantokin-Ca2 (Con-Ca2) Not in a family

1 entry

Conus ermineus (Atlantic fish-hunting cone)

CKE_CONER Conantokin-E (Con-E) (Fragment) Conotoxin B superfamily

1 entry

Conus geographus (Geography cone) (Nubecula geographus)

CKG_CONGE Conantokin-G (Con-G) (CGX-1007) (Conotoxin GV) (Sleeper peptide) Conotoxin B superfamily

1 entry

Conus gloriamaris (Glory-of-the-Seas cone)

CKG_CONGL Conantokin-Gm (Con-Gm) Not in a family

1 entry

Conus lynceus (Lynceus cone)

CKL_CONLY Conantokin-L (Con-L) Conotoxin B superfamily

1 entry

Conus ochroleucus (Perfect cone) (Graphiconus ochroleucus)

CKO_CONOH Conantokin-Oc (Con-Oc) Not in a family

3 entries

Conus parius (Cone snail)

Select_allDeselect_all
CKP1_CONPI Conantokin-Pr1 (Con-Pr1) Conotoxin B superfamily
CKP2_CONPI Conantokin-Pr2 (Con-Pr2) Conotoxin B superfamily
CKP3_CONPI Conantokin-Pr3 (Con-Pr3) Conotoxin B superfamily

1 entry

Conus planorbis (Planorbis cone)

CPY1_CONPO Conopeptide Y-Pl1 (CPY-Pl1) Conotoxin M superfamily, ...

1 entry

Conus purpurascens (Purple cone)

CKP_CONPU Conantokin-P (Con-P) Conotoxin B superfamily

1 entry

Conus quercinus (Oak cone)

CKQ_CONQU Conantokin-Qu (Con-Qu) Not in a family

1 entry

Conus radiatus (Rayed cone)

CKR_CONRA Conantokin-R (Con-R) Conotoxin B superfamily

3 entries

Conus rolani (Cone snail)

Select_allDeselect_all
CKR1A_CONRO Conantokin-R1-A (Con-R1-A) Conotoxin B superfamily
CKR1B_CONRO Conantokin-R1-B (Con-R1-B) (Fragment) Conotoxin B superfamily
CKR1C_CONRO Conantokin-R1-C (Con-R1-C) (Fragment) Conotoxin B superfamily

1 entry

Conus striatus (Striated cone)

CONII_CONST Con-ikot-ikot Not in a family

1 entry

Conus sulcatus (Sulcate cone)

CKBR_CONSL Conantokin-Br (Con-Br) (Conantoxin-S1) (Con-S1) Conotoxin B superfamily

1 entry

Conus tulipa (Fish-hunting cone snail) (Tulip cone)

CKT_CONTU Conantokin-T (Con-T) Conotoxin B superfamily

2 entries

Phoneutria nigriventer (Brazilian armed spider) (Ctenus nigriventer)

Select_allDeselect_all
TX455_PHONI GAMMA-ctenitoxin-Pn1a (GAMMA-CNTX-Pn1a) (Insecticidal neurotoxin ... Spider toxin Tx2 family
TX4B_PHONI U1-ctenitoxin-Pn1a (U1-CNTX-Pn1a) (Toxin Pn4B) Spider toxin Tx2 family