Complement system impairing toxin

The complement system is an intrinsic part of the immune system, with important functions in both innate and adaptive immunity. The complement system consists of approximately twenty plasma proteins as well as numerous receptors and regulatory proteins on the membranes of host cells.

Activation of the complement system occurs through three pathways, the classical pathway , the alternative pathway (Fig.1) and the lectin pathway . All of these pathways share a similar molecular
architecture in that an initial recognition event is amplified by a succession of proteolytic enzymes in a cascade-like fashion, resulting in the generation of numerous biologically active complement activation products.
One activation product of the complement system is the macromolecular membrane attack complex (MAC) , which inserts itself into target membranes, leading to the impairment of membrane function and physical destruction of targets including viruses, bacteria, parasites and tumor cells. Another activation product is C3b which attaches itself covalently to cells, immune complexes and other particles, a process called opsonization. Opsonization tags cells and particles for removal by phagocytes. Further products of proteolytic degradation of C3b (iC3b, C3dg, C3d) are recognized by specific receptors on various immune cells, and have important functions in the regulation of the adaptive immune response. Last but not least, the anaphylatoxins C3a and C5a exhibit important pro-inflammatory activities, such as degranulation of mast cells, increased vascular permeability, and chemotaxis and activation of neutrophils. Both anaphylatoxins are rapidly inactivated by the removal of a C-terminal arginine residue through the action of carboxypeptidase N. However the inactivated form of C5a, C5a-des-Arg, still exhibits its activity for neutrophils, making C5a a particularly powerful pro-inflammatory peptide (reviewed in Vogel et al., 2010, and references therein).


Figure 1: The classical and alternative complement pathways. (Image from Wikimedia / licensed under Creative Commons ).

Complement system impairing toxins target or mimic several complement system proteins. Only a few of them have had their activity specifically described. For example, snake venom complement C3 homologs are structural and functional analogs of complement component C3b. The snake venom serine proteinase flavoxobin independently cleaves endogenous C3 and kick-starts the complement cascade, the cobra metalloproteinase oxiagin prevents interaction of component C2 with C4b, while the cobra metalloproteinase atrase-B cleaves complement factors B, C6, C7, and C8. Most complement system impairing toxins have just been investigated for their effects on hemolytic complement activity, without having a more specific function described.

See also UniProt-keyword.

Venom protein entries in UniProtKB/Swiss-Prot

160 entries grouped by species (browse by taxonomy, browse by keywords)

2 entries

Austrelaps superbus (Lowland copperhead snake) (Hoplocephalus superbus)

Select_allDeselect_all
VCO31_AUSSU A.superbus venom factor 1 (AVF-1) (CVF-like) (Complement C3 ... Venom complement C3 homolog ...
VCO32_AUSSU A.superbus venom factor 2 (AVF-2) (CVF-like) (Complement C3 ... Venom complement C3 homolog ...

1 entry

Bothrops asper (Terciopelo)

"Bothrops asper" VenomZone page
VM1B1_BOTAS Snake venom metalloproteinase BaP1 (SVMP) (EC 3.4.24.-) ... Venom metalloproteinase (M12B) ...

2 entries

Bothrops pirajai (Piraja's lance0 head)

Select_allDeselect_all "Bothrops pirajai" VenomZone page
VSP27_BOTPI Thrombin-like enzyme BpirSP27 (SVTLE) (EC 3.4.21.-) ... Peptidase S1 family, Snake venom ...
VSP41_BOTPI Thrombin-like enzyme BpirSP41 (SVTLE) (EC 3.4.21.-) ... Peptidase S1 family, Snake venom ...

4 entries

Cerberus rynchops (Dog-faced water snake)

Select_allDeselect_all
FCNV1_CERRY Ryncolin-1 Ficolin lectin family, Veficolin ...
FCNV2_CERRY Ryncolin-2 Ficolin lectin family, Veficolin ...
FCNV3_CERRY Ryncolin-3 Ficolin lectin family, Veficolin ...
FCNV4_CERRY Ryncolin-4 Ficolin lectin family, Veficolin ...

1 entry

Crotalus adamanteus (Eastern diamondback rattlesnake)

"Crotalus adamanteus" VenomZone page
VCO3_CROAD Venom factor (VF) (CVF-like) (Complement C3 homolog) [Cleaved ... Venom complement C3 homolog ...

1 entry

Deinagkistrodon acutus (Hundred-pace snake) (Agkistrodon acutus)

VM3A2_DEIAC Zinc metalloproteinase recombinant fibrinogenase II (FIIa) (rF ... Venom metalloproteinase (M12B) ...

4 entries

Loxosceles amazonica (Recluse spider)

Select_allDeselect_all
A1O_LOXAM Phospholipase D LamSicTox-alphaIC1 (PLD) (EC 3.1.4.4) ... Arthropod phospholipase D ...
A411_LOXAM Phospholipase D LamSicTox-alphaIV1i (PLD) (EC 3.1.4.4) ... Arthropod phospholipase D ...
A412_LOXAM Phospholipase D LamSicTox-alphaIV1ii (PLD) (EC 3.1.4.4) ... Arthropod phospholipase D ...
A413_LOXAM Phospholipase D LamSicTox-alphaIV1iii (PLD) (EC 3.1.4.4) ... Arthropod phospholipase D ...

10 entries

Loxosceles apachea (Apache recluse spider)

Select_allDeselect_all
A1KA1_LOXAP Phospholipase D LapSicTox-alphaIB1ai (PLD) (EC 3.1.4.4) ... Arthropod phospholipase D ...
A1KA2_LOXAP Phospholipase D LapSicTox-alphaIB1aii (PLD) (EC 3.1.4.4) ... Arthropod phospholipase D ...
A1KA3_LOXAP Phospholipase D LapSicTox-alphaIB1aiii (PLD) (EC 3.1.4.4) ... Arthropod phospholipase D ...
A1KA4_LOXAP Phospholipase D LapSicTox-alphaIB1aiv (PLD) (EC 3.1.4.4) ... Arthropod phospholipase D ...
A1KB1_LOXAP Phospholipase D LapSicTox-alphaIB1bi (PLD) (EC 3.1.4.4) ... Arthropod phospholipase D ...
A1KB2_LOXAP Phospholipase D LapSicTox-alphaIB1b2 (PLD) (EC 3.1.4.4) ... Arthropod phospholipase D ...
A1KB3_LOXAP Phospholipase D LapSicTox-alphaIB1b3 (PLD) (EC 3.1.4.4) ... Arthropod phospholipase D ...
A1KC_LOXAP Phospholipase D LapSicTox-alphaIB1c (PLD) (EC 3.1.4.4) ... Arthropod phospholipase D ...
A1L_LOXAP Phospholipase D LapSicTox-alphaIB2 (PLD) (EC 3.1.4.4) ... Arthropod phospholipase D ...
A21_LOXAP Phospholipase D LapSicTox-alphaII1 (PLD) (EC 3.1.4.4) ... Arthropod phospholipase D ...

15 entries

Loxosceles arizonica (Arizona brown spider)

Select_allDeselect_all
A1KA1_LOXAR Phospholipase D LarSicTox-alphaIB1ai (PLD) (EC 3.1.4.4) ... Arthropod phospholipase D ...
A1KA2_LOXAR Phospholipase D LarSicTox-alphaIB1aii (PLD) (EC 3.1.4.4) ... Arthropod phospholipase D ...
A1KA3_LOXAR Phospholipase D LarSicTox-alphaIB1aiii (PLD) (EC 3.1.4.4) ... Arthropod phospholipase D ...
A1KA4_LOXAR Phospholipase D LarSicTox-alphaIB1aiv (PLD) (EC 3.1.4.4) ... Arthropod phospholipase D ...
A1KB_LOXAR Phospholipase D LarSicTox-alphaIB1b (PLD) (EC 3.1.4.4) ... Arthropod phospholipase D ...
A1KC_LOXAR Phospholipase D LarSicTox-alphaIB1c (PLD) (EC 3.1.4.4) ... Arthropod phospholipase D ...
A1LA_LOXAR Phospholipase D LarSicTox-alphaIB2a (PLD) (EC 3.1.4.4) ... Arthropod phospholipase D ...
A1LB1_LOXAR Phospholipase D LarSicTox-alphaIB2bi (PLD) (Dermonecrotic toxin) ... Arthropod phospholipase D ...
A1LB2_LOXAR Phospholipase D LarSicTox-alphaIB2bii (PLD) (EC 3.1.4.4) ... Arthropod phospholipase D ...
A1LC_LOXAR Phospholipase D LarSicTox-alphaIB2c (PLD) (EC 3.1.4.4) ... Arthropod phospholipase D ...
A1X1_LOXAR Phospholipase D LarSicTox-alphaI-1 (PLD) (EC 3.1.4.4) ... Arthropod phospholipase D ...
A21_LOXAR Phospholipase D LarSicTox-alphaII1 (PLD) (EC 3.1.4.4) ... Arthropod phospholipase D ...
A31_LOXAR Phospholipase D LarSicTox-alphaIII1 (PLD) (EC 3.1.4.4) ... Arthropod phospholipase D ...
A41_LOXAR Phospholipase D LarSicTox-alphaIV1 (PLD) (EC 3.1.4.4) ... Arthropod phospholipase D ...
A71_LOXAR Phospholipase D LarSicTox-alphaVII1 (PLD) (EC 3.1.4.4) ... Arthropod phospholipase D ...

2 entries

Loxosceles boneti (North American fiddleback spider)

Select_allDeselect_all
A1KA_LOXBO Phospholipase D LbSicTox-alphaIB1a (PLD) (EC 3.1.4.4) ... Arthropod phospholipase D ...
A1KB_LOXBO Phospholipase D LbSicTox-alphaIB1b (PLD) (EC 3.1.4.4) ... Arthropod phospholipase D ...

17 entries

Loxosceles deserta (Desert recluse spider)

Select_allDeselect_all
A1KA1_LOXDE Phospholipase D LdSicTox-alphaIB1ai (PLD) (EC 3.1.4.4) ... Arthropod phospholipase D ...
A1KA2_LOXDE Phospholipase D LdSicTox-alphaIB1aii (PLD) (EC 3.1.4.4) ... Arthropod phospholipase D ...
A1KA3_LOXDE Phospholipase D LdSicTox-alphaIB1aiii (PLD) (EC 3.1.4.4) ... Arthropod phospholipase D ...
A1KA4_LOXDE Phospholipase D LdSicTox-alphaIB1aiv (PLD) (EC 3.1.4.4) ... Arthropod phospholipase D ...
A1KA5_LOXDE Phospholipase D LdSicTox-alphaIB1av (PLD) (EC 3.1.4.4) ... Arthropod phospholipase D ...
A1KA6_LOXDE Phospholipase D LdSicTox-alphaIB1avi (PLD) (EC 3.1.4.4) ... Arthropod phospholipase D ...
A1KB1_LOXDE Phospholipase D LdSicTox-alphaIB1bi (PLD) (EC 3.1.4.4) ... Arthropod phospholipase D ...
A1KB2_LOXDE Phospholipase D LdSicTox-alphaIB1bii (PLD) (EC 3.1.4.4) ... Arthropod phospholipase D ...
A1L_LOXDE Phospholipase D LdSicTox-alphaIB2 (PLD) (EC 3.1.4.4) ... Arthropod phospholipase D ...
A1MA1_LOXDE Phospholipase D LdSicTox-alphaIB3ai (PLD) (EC 3.1.4.4) ... Arthropod phospholipase D ...
A1MA2_LOXDE Phospholipase D LdSicTox-alphaIB3aii (PLD) (EC 3.1.4.4) ... Arthropod phospholipase D ...
A1MA3_LOXDE Phospholipase D LdSicTox-alphaIB3aiii (PLD) (EC 3.1.4.4) ... Arthropod phospholipase D ...
A1MA4_LOXDE Phospholipase D LdSicTox-alphaIB3aiv (PLD) (EC 3.1.4.4) ... Arthropod phospholipase D ...
A1MA5_LOXDE Phospholipase D LdSicTox-alphaIB3av (PLD) (EC 3.1.4.4) ... Arthropod phospholipase D ...
A1MA6_LOXDE Phospholipase D LdSicTox-alphaIB3avi (PLD) (EC 3.1.4.4) ... Arthropod phospholipase D ...
A1MB_LOXDE Phospholipase D LdSicTox-alphaIB3b (PLD) (EC 3.1.4.4) ... Arthropod phospholipase D ...
AX1_LOXDE Phospholipase D LdSicTox-alpha-1 (PLD) (EC 3.1.4.4) ... Arthropod phospholipase D ...

3 entries

Loxosceles gaucho (Spider)

Select_allDeselect_all
A1H_LOXGA Phospholipase D LgSicTox-alphaIA1 (PLD) (EC 3.1.4.4) ... Arthropod phospholipase D ...
A1X1_LOXGA Phospholipase D LgSicTox-alphaI-1 (PLD) (EC 3.1.4.4) (35 kDa ... Arthropod phospholipase D ...
A1XA_LOXGA Phospholipase D LgSicTox-alphaI-Loxn-A (PLD) (EC 3.1.4.4) ... Arthropod phospholipase D ...

24 entries

Loxosceles hirsuta (Recluse spider)

Select_allDeselect_all
A1H1_LOXHI Phospholipase D LhSicTox-alphaIA1i (PLD) (EC 3.1.4.4) ... Arthropod phospholipase D ...
A1H2_LOXHI Phospholipase D LhSicTox-alphaIA1ii (PLD) (EC 3.1.4.4) ... Arthropod phospholipase D ...
A1H3_LOXHI Phospholipase D LhSicTox-alphaIA1iii (PLD) (EC 3.1.4.4) ... Arthropod phospholipase D ...
A1H4_LOXHI Phospholipase D LhSicTox-alphaIA1iv (PLD) (EC 3.1.4.4) ... Arthropod phospholipase D ...
A1IA1_LOXHI Phospholipase D LhSicTox-alphaIA2ai (PLD) (EC 3.1.4.4) ... Arthropod phospholipase D ...
A1IA2_LOXHI Phospholipase D LhSicTox-alphaIA2aii (PLD) (EC 3.1.4.4) ... Arthropod phospholipase D ...
A1IA3_LOXHI Phospholipase D LhSicTox-alphaIA2aiii (PLD) (EC 3.1.4.4) ... Arthropod phospholipase D ...
A1IA4_LOXHI Phospholipase D LhSicTox-alphaIA2aiv (PLD) (EC 3.1.4.4) ... Arthropod phospholipase D ...
A1IA5_LOXHI Phospholipase D LhSicTox-alphaIA2av (PLD) (EC 3.1.4.4) ... Arthropod phospholipase D ...
A1IA6_LOXHI Phospholipase D LhSicTox-alphaIA2avi (PLD) (EC 3.1.4.4) ... Arthropod phospholipase D ...
A1IA7_LOXHI Phospholipase D LhSicTox-alphaIA2avii (PLD) (EC 3.1.4.4) ... Arthropod phospholipase D ...
A1IA8_LOXHI Phospholipase D LhSicTox-alphaIA2aviii (PLD) (EC 3.1.4.4) ... Arthropod phospholipase D ...
A1IB1_LOXHI Phospholipase D LhSicTox-alphaIA2bi (PLD) (EC 3.1.4.4) ... Arthropod phospholipase D ...
A1IB2_LOXHI Phospholipase D LhSicTox-alphaIA2bii (PLD) (EC 3.1.4.4) ... Arthropod phospholipase D ...
A1IB3_LOXHI Phospholipase D LhSicTox-alphaIA2biii (PLD) (EC 3.1.4.4) ... Arthropod phospholipase D ...
A1IB4_LOXHI Phospholipase D LhSicTox-alphaIA2biv (PLD) (EC 3.1.4.4) ... Arthropod phospholipase D ...
A1IB5_LOXHI Phospholipase D LhSicTox-alphaIA2bv (PLD) (EC 3.1.4.4) ... Arthropod phospholipase D ...
A1IB6_LOXHI Phospholipase D LhSicTox-alphaIA2bvi (PLD) (EC 3.1.4.4) ... Arthropod phospholipase D ...
A411_LOXHI Phospholipase D LhSicTox-alphaIV1i (PLD) (EC 3.1.4.4) ... Arthropod phospholipase D ...
A412_LOXHI Phospholipase D LhSicTox-alphaIV1ii (PLD) (EC 3.1.4.4) ... Arthropod phospholipase D ...
A413_LOXHI Phospholipase D LhSicTox-alphaIV1iii (PLD) (EC 3.1.4.4) ... Arthropod phospholipase D ...
A42_LOXHI Phospholipase D LhSicTox-alphaIV2 (PLD) (EC 3.1.4.4) ... Arthropod phospholipase D ...
A611_LOXHI Phospholipase D LhSicTox-alphaVI1i (PLD) (EC 3.1.4.4) ... Arthropod phospholipase D ...
A612_LOXHI Phospholipase D LhSicTox-alphaVI1ii (PLD) (EC 3.1.4.4) ... Arthropod phospholipase D ...

12 entries

Loxosceles intermedia (Brown spider)

Select_allDeselect_all "Loxosceles intermedia" VenomZone page
A1HA_LOXIN Phospholipase D LiSicTox-alphaIA1a (PLD) (EC 3.1.4.4) ... Arthropod phospholipase D ...
A1HB1_LOXIN Phospholipase D LiSicTox-alphaIA1bi (PLD) (EC 3.1.4.4) ... Arthropod phospholipase D ...
A1HB2_LOXIN Phospholipase D LiSicTox-alphaIA1bii (PLD) (EC 3.1.4.4) ... Arthropod phospholipase D ...
A1IA1_LOXIN Phospholipase D LiSicTox-alphaIA2ai (PLD) (EC 3.1.4.4) ... Arthropod phospholipase D ...
A1IA2_LOXIN Phospholipase D LiSicTox-alphaIA2aii (PLD) (EC 3.1.4.4) ... Arthropod phospholipase D ...
A1IA3_LOXIN Phospholipase D LiSicTox-alphaIA2aiii (PLD) (EC 3.1.4.4) ... Arthropod phospholipase D ...
A1IB1_LOXIN Phospholipase D LiSicTox-alphaIA2bi (PLD) (EC 3.1.4.4) ... Arthropod phospholipase D ...
A1IB2_LOXIN Phospholipase D LiSicTox-alphaIA2bii (PLD) (EC 3.1.4.4) ... Arthropod phospholipase D ...
A1X1_LOXIN Phospholipase D LiSicTox-alphaI-1 (PLD) (EC 3.1.4.4) (35 kDa ... Arthropod phospholipase D ...
A21_LOXIN Phospholipase D LiSicTox-alphaII1 (EC 3.1.4.4) (Dermonecrotic ... Arthropod phospholipase D ...
A22_LOXIN Phospholipase D LiSicTox-alphaII2 (PLD) (EC 3.1.4.4) ... Arthropod phospholipase D ...
B1Q_LOXIN Phospholipase D LiSicTox-betaID1 (PLD) (EC 3.1.4.4) ... Arthropod phospholipase D ...

16 entries

Loxosceles laeta (South American recluse spider) (Scytodes laeta)

Select_allDeselect_all
A311_LOXLA Phospholipase D LlSicTox-alphaIII1i (PLD) (EC 3.1.4.4) ... Arthropod phospholipase D ...
A312_LOXLA Phospholipase D LlSicTox-alphaIII1ii (PLD) (EC 3.1.4.4) ... Arthropod phospholipase D ...
A32_LOXLA Phospholipase D LlSicTox-alphaIII2 (PLD) (EC 3.1.4.4) ... Arthropod phospholipase D ...
A331_LOXLA Phospholipase D LlSicTox-alphaIII3i (PLD) (EC 3.1.4.4) ... Arthropod phospholipase D ...
A332_LOXLA Phospholipase D LlSicTox-alphaIII3ii (PLD) (EC 3.1.4.4) ... Arthropod phospholipase D ...
A333_LOXLA Phospholipase D LlSicTox-alphaIII3iii (PLD) (EC 3.1.4.4) ... Arthropod phospholipase D ...
A3X1_LOXLA Phospholipase D LlSicTox-alphaIII-1 (PLD) (EC 3.1.4.4) (35 kDa ... Arthropod phospholipase D ...
A411_LOXLA Phospholipase D LlSicTox-alphaIV1i (PLD) (EC 3.1.4.4) ... Arthropod phospholipase D ...
A412_LOXLA Phospholipase D LlSicTox-alphaIV1ii (PLD) (EC 3.1.4.4) ... Arthropod phospholipase D ...
A421_LOXLA Phospholipase D LlSicTox-alphaIV2i (PLD) (EC 3.1.4.4) ... Arthropod phospholipase D ...
A422_LOXLA Phospholipase D LlSicTox-alphaIV2ii (PLD) (EC 3.1.4.4) ... Arthropod phospholipase D ...
A423_LOXLA Phospholipase D LlSicTox-alphaIV2iii (PLD) (EC 3.1.4.4) ... Arthropod phospholipase D ...
A424_LOXLA Phospholipase D LlSicTox-alphaIV2iv (PLD) (EC 3.1.4.4) ... Arthropod phospholipase D ...
A43_LOXLA Phospholipase D LlSicTox-alphaIV3 (PLD) (EC 3.1.4.4) ... Arthropod phospholipase D ...
PLD1_LOXLA Phospholipase D isoform 1 (LlPLD1) (PLD1) (EC 3.1.4.4) ... Arthropod phospholipase D ...
PLD2_LOXLA Phospholipase D isoform 2 (LlPLD2) (PLD2) (EC 3.1.4.4) ... Arthropod phospholipase D ...

2 entries

Loxosceles reclusa (Brown recluse spider)

Select_allDeselect_all
A1K_LOXRE Phospholipase D LrSicTox-alphaIB1 (PLD) (EC 3.1.4.4) ... Arthropod phospholipase D ...
A1X1_LOXRE Phospholipase D LrSicTox-alphaI-1 (PLD) (EC 3.1.4.4) ... Arthropod phospholipase D ...

6 entries

Loxosceles rufescens (Recluse spider)

Select_allDeselect_all
A1OA_LOXRU Phospholipase D LruSicTox-alphaIC1a (PLD) (EC 3.1.4.4) ... Arthropod phospholipase D ...
A1OB_LOXRU Phospholipase D LruSicTox-alphaIC1b (PLD) (EC 3.1.4.4) ... Arthropod phospholipase D ...
A1OC_LOXRU Phospholipase D LruSicTox-alphaIC1c (PLD) (EC 3.1.4.4) ... Arthropod phospholipase D ...
A1OD_LOXRU Phospholipase D LruSicTox-alphaIC1d (PLD) (EC 3.1.4.4) ... Arthropod phospholipase D ...
A1P_LOXRU Phospholipase D LruSicTox-alphaIC2 (PLD) (EC 3.1.4.4) ... Arthropod phospholipase D ...
A41_LOXRU Phospholipase D LruSicTox-alphaIV1 (PLD) (EC 3.1.4.4) ... Arthropod phospholipase D ...

11 entries

Loxosceles sabina (Tucson recluse spider)

Select_allDeselect_all
A1KA1_LOXSA Phospholipase D LsaSicTox-alphaIB1ai (PLD) (EC 3.1.4.4) ... Arthropod phospholipase D ...
A1KA2_LOXSA Phospholipase D LsaSicTox-alphaIB1aii (PLD) (EC 3.1.4.4) ... Arthropod phospholipase D ...
A1KA3_LOXSA Phospholipase D LsaSicTox-alphaIB1aiii (PLD) (EC 3.1.4.4) ... Arthropod phospholipase D ...
A1KA4_LOXSA Phospholipase D LsaSicTox-alphaIB1aiv (PLD) (EC 3.1.4.4) ... Arthropod phospholipase D ...
A1KA5_LOXSA Phospholipase D LsaSicTox-alphaIB1av (PLD) (EC 3.1.4.4) ... Arthropod phospholipase D ...
A1KA6_LOXSA Phospholipase D LsaSicTox-alphaIB1avi (PLD) (EC 3.1.4.4) ... Arthropod phospholipase D ...
A1KB1_LOXSA Phospholipase D LsaSicTox-alphaIB1bi (PLD) (EC 3.1.4.4) ... Arthropod phospholipase D ...
A1KB2_LOXSA Phospholipase D LsaSicTox-alphaIB1bii (PLD) (EC 3.1.4.4) ... Arthropod phospholipase D ...
A1L1_LOXSA Phospholipase D LsaSicTox-alphaIB2i (PLD) (EC 3.1.4.4) ... Arthropod phospholipase D ...
A1L2_LOXSA Phospholipase D LsaSicTox-alphaIB2ii (PLD) (EC 3.1.4.4) ... Arthropod phospholipase D ...
A1L3_LOXSA Phospholipase D LsaSicTox-alphaIB2iii (PLD) (EC 3.1.4.4) ... Arthropod phospholipase D ...

1 entry

Loxosceles similis (Brazilian brown spider) (Loxosceles surata)

A1H_LOXSM Phospholipase D LsSicTox-alphaIA1 (PLD) (EC 3.1.4.4) ... Arthropod phospholipase D ...

2 entries

Loxosceles sp. (strain 4 GJB-2008) (Recluse spider)

Select_allDeselect_all
A311_LOXS4 Phospholipase D Ls4SicTox-alphaIII1i (PLD) (EC 3.1.4.4) ... Arthropod phospholipase D ...
A312_LOXS4 Phospholipase D Ls4SicTox-alphaIII1ii (PLD) (EC 3.1.4.4) ... Arthropod phospholipase D ...

8 entries

Loxosceles spadicea (Recluse spider)

Select_allDeselect_all
A1H1_LOXSP Phospholipase D LspaSicTox-alphaIA1i (PLD) (EC 3.1.4.4) ... Arthropod phospholipase D ...
A1H2_LOXSP Phospholipase D LspaSicTox-alphaIA1ii (PLD) (EC 3.1.4.4) ... Arthropod phospholipase D ...
A1H3_LOXSP Phospholipase D LspaSicTox-alphaIA1iii (PLD) (EC 3.1.4.4) ... Arthropod phospholipase D ...
A1I1_LOXSP Phospholipase D LspaSicTox-alphaIA2i (PLD) (EC 3.1.4.4) ... Arthropod phospholipase D ...
A1I2_LOXSP Phospholipase D LspaSicTox-alphaIA2ii (PLD) (EC 3.1.4.4) ... Arthropod phospholipase D ...
A1I3_LOXSP Phospholipase D LspaSicTox-alphaIA2iii (PLD) (EC 3.1.4.4) ... Arthropod phospholipase D ...
A1I4_LOXSP Phospholipase D LspaSicTox-alphaIA2iv (PLD) (EC 3.1.4.4) ... Arthropod phospholipase D ...
A21_LOXSP Phospholipase D LspaSicTox-alphaII1 (PLD) (EC 3.1.4.4) ... Arthropod phospholipase D ...

9 entries

Loxosceles variegata (Recluse spider)

Select_allDeselect_all
A1OA1_LOXVA Phospholipase D LvSicTox-alphaIC1ai (PLD) (EC 3.1.4.4) ... Arthropod phospholipase D ...
A1OA2_LOXVA Phospholipase D LvSicTox-alphaIC1aii (PLD) (EC 3.1.4.4) ... Arthropod phospholipase D ...
A1OA3_LOXVA Phospholipase D LvSicTox-alphaIC1aiii (PLD) (EC 3.1.4.4) ... Arthropod phospholipase D ...
A1OB1_LOXVA Phospholipase D LvSicTox-alphaIC1bi (PLD) (EC 3.1.4.4) ... Arthropod phospholipase D ...
A1OB2_LOXVA Phospholipase D LvSicTox-alphaIC1bii (PLD) (EC 3.1.4.4) ... Arthropod phospholipase D ...
A1OB3_LOXVA Phospholipase D LvSicTox-alphaIC1biii (PLD) (EC 3.1.4.4) ... Arthropod phospholipase D ...
A1OB4_LOXVA Phospholipase D LvSicTox-alphaIC1biv (PLD) (EC 3.1.4.4) ... Arthropod phospholipase D ...
A1OB5_LOXVA Phospholipase D LvSicTox-alphaIC1bv (PLD) (EC 3.1.4.4) ... Arthropod phospholipase D ...
A21_LOXVA Phospholipase D LvSicTox-alphaII1 (PLD) (EC 3.1.4.4) ... Arthropod phospholipase D ...

1 entry

Naja atra (Chinese cobra)

"Naja atra" VenomZone page
VM3B_NAJAT Zinc metalloproteinase-disintegrin-like atrase-B (EC 3.4.24.-) ... Venom metalloproteinase (M12B) ...

2 entries

Naja kaouthia (Monocled cobra) (Naja siamensis)

Select_allDeselect_all
VCO3_NAJKA Cobra venom factor (CVF) (CVFk) (Complement C3 homolog) [Cleaved ... Venom complement C3 homolog ...
VM3_NAJKA Zinc metalloproteinase-disintegrin-like cobrin (EC 3.4.24.-) ... Venom metalloproteinase (M12B) ...

1 entry

Naja oxiana (Central Asian cobra) (Oxus cobra)

VM3_NAJOX Zinc metalloproteinase oxiagin (EC 3.4.24.-) (Snake venom ... Venom metalloproteinase (M12B) ...

1 entry

Ophiophagus hannah (King cobra) (Naja hannah)

VCO3_OPHHA Ophiophagus venom factor (OVF) (CVF-like) (Complement C3 ... Venom complement C3 homolog ...

1 entry

Protobothrops flavoviridis (Habu) (Trimeresurus flavoviridis)

VSP1_PROFL Thrombin-like enzyme flavoxobin (SVTLE) (EC 3.4.21.74) ... Peptidase S1 family, Snake venom ...

1 entry

Varanus komodoensis (Komodo dragon)

FCNV1_VARKO Veficolin-1 (Fragment) Ficolin lectin family, Veficolin ...