G-protein coupled acetylcholine receptor impairing toxin (mAChR regulator)

Receptor Muscarinic acetylcholine receptors (mAChRs) are a subfamily of G protein-coupled receptors that regulate numerous fundamental functions of the central and peripheral nervous system, such as heart rate, smooth muscle contraction and glandular secretion.
The mAChR family consists of five distinct subtypes, denoted M1 to M5 (encoded by the CHRM1 to CHRM5 genes). Three of these receptor subtypes (M1, M3 and M5) couple to G proteins of the G q/11 family, whereas the remaining two subtypes (M2 and M4) preferentially signal through the G i/0 family of G proteins (Ishii and Kurachi, 2006, Kruse et al., 2014 ).
Toxin
Receptor Toxins from different taxa that target receptors.
Click on to retrieve receptors or toxins of interest.
Human Snake Scorpion Cone
snail
Spider Cnidarian Insect Other All
mAChR M1/CHRM1 - - - - - -
mAChR M2/CHRM2 - - - - - -
mAChR M3/CHRM3 - - - - - -
mAChR M4/CHRM4 - - - - - -
mAChR M5/CHRM5 - - - - - - - -
mAChR All - - - - - -

Venom protein entries in UniProtKB/Swiss-Prot

27 entries grouped by species (browse by taxonomy, browse by keywords)

1 entry

Bothrops insularis (Golden lancehead) (Lachesis insularis)

BNP_BOTIN Bradykinin-potentiating and C-type natriuretic peptides ... Bradykinin-potentiating peptide ...

1 entry

Bothrops jararaca (Jararaca) (Bothrops jajaraca)

BPP7A_BOTJA Bradykinin-potentiating peptide 7a (BPP-7a) (Proline-rich ... Bradykinin-potentiating peptide ...

5 entries

Bungarus multicinctus (Many-banded krait)

Select_allDeselect_all "Bungarus multicinctus" VenomZone page
3NO52_BUNMU Long neurotoxin homolog NTL2 Snake three-finger toxin family, ...
3NO56_BUNMU Long neurotoxin homolog TA-bm16 (Delta-protein) Snake three-finger toxin family, ...
3NO5I_BUNMU Gamma-bungarotoxin (Long neurotoxin homolog NTL2I) Snake three-finger toxin family, ...
3NOHE_BUNMU Muscarinic toxin BM14 Snake three-finger toxin family, ...
3SO8_BUNMU Muscarinic toxin-like protein Snake three-finger toxin family, ...

9 entries

Dendroaspis angusticeps (Eastern green mamba) (Naja angusticeps)

Select_allDeselect_all
3SI12_DENAN Muscarinic m1-toxin2 Snake three-finger toxin family, ...
3SI13_DENAN Muscarinic m1-toxin3 (Fragment) Snake three-finger toxin family, ...
3SI14_DENAN Muscarinic m1-toxin4 (Fragment) Snake three-finger toxin family, ...
3SIM1_DENAN Muscarinic toxin 1 (MT1) (MTx1) Snake three-finger toxin family, ...
3SIM2_DENAN Muscarinic toxin 2 (MT2) (MTx2) Snake three-finger toxin family, ...
3SIM3_DENAN Muscarinic toxin 3 (MT3) Snake three-finger toxin family, ...
3SIM4_DENAN Muscarinic toxin 4 (MT4) Snake three-finger toxin family, ...
3SIM7_DENAN Muscarinic toxin 7 (MT-7) (MT7) (Muscarinic m1-toxin 1) Snake three-finger toxin family, ...
3SUB_DENAN Muscarinic m2-toxin Snake three-finger toxin family, ...

1 entry

Micrurus lemniscatus (South American coral snake)

3X_MICLE Muscarinic toxin Mlalpha (MT-Mlalpha) (Fragment) Snake three-finger toxin family

2 entries

Naja atra (Chinese cobra)

Select_allDeselect_all "Naja atra" VenomZone page
3SO8_NAJAT Neurotoxin homolog NL1 Snake three-finger toxin family, ...
PA2A1_NAJAT Acidic phospholipase A2 1 (svPLA2) (EC 3.1.1.4) (Muscarinic ... Phospholipase A2 family, Group I ...

3 entries

Naja kaouthia (Monocled cobra) (Naja siamensis)

Select_allDeselect_all
3NO2_NAJKA Tryptophan-containing weak neurotoxin (WTX) Snake three-finger toxin family, ...
3SO8_NAJKA Muscarinic toxin-like protein 3 (MTLP-3) Snake three-finger toxin family, ...
3SUC1_NAJKA Muscarinic toxin-like protein 1 (MTLP-1) Snake three-finger toxin family, ...

1 entry

Naja naja (Indian cobra)

3SO8_NAJNA Muscarinic toxin-like protein 1 (MTLP-1) (Muscarinic toxin-like ... Snake three-finger toxin family, ...

1 entry

Naja sputatrix (Malayan spitting cobra) (Naja naja sputatrix)

PA2NA_NAJSP Neutral phospholipase A2 muscarinic inhibitor (NPLA) (svPLA2) ... Phospholipase A2 family, Group I ...

3 entries

Ophiophagus hannah (King cobra) (Naja hannah)

Select_allDeselect_all
3SI35_OPHHA Short neurotoxin OH-35 Snake three-finger toxin family, ...
3SIM6_OPHHA Muscarinic toxin MTX6 Snake three-finger toxin family, ...
3SIM8_OPHHA Muscarinic toxin 38 (MTX38) Snake three-finger toxin family, ...