Voltage-gated calcium channel impairing toxin (Cav channel inhibitor)

Channel Voltage-gated calcium channels (Cav) are the key signal transducers of electrical signaling, converting depolarization of the cell membrane to an influx of calcium ions that initiates contraction, secretion, neurotransmission and other intracellular regulatory events. Skeletal muscle calcium channels first identified by drug labeling, purification, and functional reconstitution have a principal α1 subunit of 212-250 kDa.

The α1 subunit is associated with auxiliary α2, β, γ and δ subunits. The calcium channel α1 subunit is sufficient to form a voltage-gated calcium-selective pore by itself. Ten functional calcium channel α1 subunits are known in vertebrates, and they fall into three subfamilies that differ in function and regulation. The Cav1 subfamily (Cav1.1-Cav1.4) conducts L-type calcium currents that initiate contraction, endocrine secretion, and synaptic transmission at the specialized ribbon synapses involved in sensory input in the eye and ear. L-type calcium currents also are important regulators of gene expression and other intracellular processes. They are blocked by the classical calcium channel antagonists, including dihydropyridines, benzothiazepines, and phenylalkylamines. The Cav2 subfamily of calcium channels (Cav2.1-Cav2.3) conduct N-, P/Q- and R-type calcium currents that initiate fast synaptic transmission at synapses in the central and peripheral nervous systems and are blocked specifically by peptide neurotoxins from spider and cone snail venoms. The Cav3 subfamily of calcium channels (Cav3.1-Cav3.3) conduct T-type calcium currents that are important for repetitive action potential firing of neurons in the brain and in the pacemaker cells of the sino-atrial node in the heart. The protein-protein interactions as well as the functional and regulatory properties of different subfamilies of these ion channels are adapted to their distinct roles in electrical signaling and cellular signal transduction.

Cav1 and Cav2 channels have four distinct auxiliary subunits (Cavα2, Cavβ, Cavγ, and Cavδ), whereas Cav3 channels have none. Each subunits of Cav1 and Cav2 channels comprise a small protein family. The Cavα2 and Cavδ subunits are encoded by the same gene, whose translation product is proteolytically cleaved and disulfide linked to yield the mature extracellular α2 subunit glycoprotein of 140 kDa and transmembrane disulfide-linked δ subunit glycoprotein of 27 kDa. Four Cavα2δ genes are known. The four Cavβ subunits are all intracellular proteins with a common pattern of α helical and unstructured segments. They have important regulatory effects on cell surface expression and they also modulate the gating of calcium channels, causing enhanced activation upon depolarization and altered rate and voltage dependence of inactivation. Recent structural modeling and X-ray crystallography studies have revealed that these subunits contain conserved, interacting SH3 and guanylate kinase domains like the MAGUK family of scaffolding proteins, and therefore may interact with other intracellular proteins. Eight Cavγ subunit genes encode glycoproteins with four transmembrane segments. Although the Cavγ1 subunit is associated specifically with skeletal muscle Cav1.1 channels, other Cavγ subunits interact with other calcium channels, glutamate receptors and possibly with other membrane signaling proteins. Thus, the γ subunits discovered as components of calcium channels apparently have a more widespread role in assembly and cell surface expression of other membrane signaling proteins. Cav3 channels do not have auxiliary subunits.

Toxin
Cav channels Toxins from different taxa that target Cav channels.
Click on to retrieve channels and toxins of interest.
Human Snake Scorpion Cone
snail
Spider Cnidarian Insect Other All
Cav1.1/CACNA1S (L-type) - - - - - - - -
Cav1.2/CACNA1C (L-type) - - - - - -
Cav1.3/CACNA1D (L-type) - - - - - - - -
Cav1.4/CACNA1F (L-type) - - - - - - - -
Cav1 All (L-type) - - - -
Cav2.1/CACNA1A (P/Q-type) - - - - -
Cav2.2/CACNA1B (N-type) - - - -
Cav2.3/CACNA1E (R-type) - - - - - -
Cav2 All - - - -
Cav3.1/CACNA1G (T-type) - - - - -
Cav3.2/CACNA1H (T-type) - - - - - -
Cav3.3/CACNA1I (T-type) - - - - - -
Cav3 All (T-type) - - - - -
Cav All - -

Venom protein entries in UniProtKB/Swiss-Prot

223 entries grouped by species (browse by taxonomy, browse by keywords)

1 entry

Agelena orientalis (Funnel-web spider)

TXAG1_AGEOR U10-agatoxin-Ao1a (U10-AGTX-Ao1a) (AgorTX_B7b) Neurotoxin 04 (omega-agtx) ...

10 entries

Agelenopsis aperta (North American funnel-web spider) (Agelenopsis gertschi)

Select_allDeselect_all
TOG1A_AGEAP Omega-agatoxin-1A (Omega-agatoxin IA) (Omega-Aga-IA) [Cleaved ... Neurotoxin 04 (omega-agtx) ...
TOG1B_AGEAP Omega-agatoxin-Aa1b (Omega-AGTX-Aa1b) (Omega-agatoxin IB) ... Neurotoxin 04 (omega-agtx) ...
TOG2A_AGEAP Omega-agatoxin-Aa2a (Omega-AGTX-Aa2a) (Omega-agatoxin IIA) ... Neurotoxin 04 (omega-agtx) ...
TOG3A_AGEAP Omega-agatoxin-Aa3a (Omega-AGTX-Aa3a) (Omega-agatoxin IIIA) ... Neurotoxin 04 (omega-agtx) ...
TOG3B_AGEAP Omega-agatoxin-Aa3b (Omega-AGTX-Aa3b) (Omega-agatoxin IIIB) ... Neurotoxin 04 (omega-agtx) ...
TOG3C_AGEAP Omega-agatoxin-Aa3c (Omega-AGTX-Aa3c) (Omega-agatoxin IIIC) ... Neurotoxin 04 (omega-agtx) ...
TOG3D_AGEAP Omega-agatoxin-Aa3d (Omega-AGTX-Aa3d) (Omega-agatoxin IIID) ... Neurotoxin 04 (omega-agtx) ...
TX20A_AGEAP Omega-agatoxin-Aa5a (Omega-AGTX-Aa5a) (Peptide J2) Neurotoxin 02 (plectoxin) family
TX23A_AGEAP Omega-agatoxin-Aa4a (Omega-AGTX-Aa4a) (Omega-agatoxin IVA) ... Neurotoxin 02 (plectoxin) ...
TX23B_AGEAP Omega-agatoxin-Aa4b (Omega-AGTX-Aa4b) (Omega-agatoxin IVB) ... Neurotoxin 02 (plectoxin) ...

1 entry

Allagelena opulenta (Funnel weaving spider) (Agelena opulenta)

TXAG_ALLOP U2-agatoxin-Aop1a (U2-AGTX-Aop1a) (Agelenin) Neurotoxin 01 (U2-agtx) family

7 entries

Alopecosa marikovskyi (Wolf spider) (Lycosa kazakhstanicus)

Select_allDeselect_all
TLCOA_ALOMR Omega-lycotoxin-Gsp2671a (Omega-LCTX-Gsp2671a) (Lsp-1) ... Neurotoxin (omega-lctx) family
TLCOB_ALOMR Omega-lycotoxin-Gsp2671b (Omega-LCTX-Gsp2671b) ... Neurotoxin (omega-lctx) family
TLCOC_ALOMR Omega-lycotoxin-Gsp2671c (Omega-LCTX-Gsp2671c) ... Neurotoxin (omega-lctx) family
TLCOD_ALOMR Omega-lycotoxin-Gsp2671d (Omega-LCTX-Gsp2671d) ... Neurotoxin (omega-lctx) family
TLCOE_ALOMR Omega-lycotoxin-Gsp2671e (Omega-LCTX-Gsp2671e) ... Neurotoxin (omega-lctx) family
TLCOF_ALOMR Omega-lycotoxin-Gsp2671f (Omega-LCTX-Gsp2671f) ... Neurotoxin (omega-lctx) family
TLCOG_ALOMR Omega-lycotoxin-Gsp2671g (Omega-LCTX-Gsp2671g) ... Neurotoxin (omega-lctx) family

1 entry

Ancylometes sp. (South American fishing spider)

32C7_ANCSP U1-ctenitoxin-Asp1a (U1-CNTX-Asp1a) (Neurotoxin ANC32C7) ... Neurotoxin 04 (omega-agtx) ...

1 entry

Anochetus emarginatus (Ant) (Stenomyrmex emarginatus)

PON1A_ANOEM U1-poneritoxin-Ae1a (U1-PONTX-Ae1a) Poneritoxin-Ae1 family

4 entries

Aphonopelma sp. (American tarantula)

Select_allDeselect_all
TX132_APHSP Omega-theraphotoxin-Asp3a (Omega-TRTX-Asp3a) (Peptide 7-13.2) Neurotoxin 14 (magi-1) family, ...
TX1A_APHSP Omega-theraphotoxin-Asp1a (Omega-TRTX-Asp1a) (Peptide 6-6) Neurotoxin 12 (Hwtx-2) family, ...
TX1F_APHSP Omega-theraphotoxin-Asp1f (Omega-TRTX-Asp1f) (Eurypelma spider ... Neurotoxin 12 (Hwtx-2) family, ...
TX1G_APHSP Omega-theraphotoxin-Asp1g (Omega-TRTX-Asp1g) (Eurypelma spider ... Neurotoxin 12 (Hwtx-2) family, ...

1 entry

Apomastus schlingeri (Trap-door spider) (Aptostichus schlingeri)

TXP3_APOSC Mu-cyrtautoxin-As1a (Mu-CUTX-As1a) (Aptotoxin III) (Aps III) ... Neurotoxin 13 (insecticidal ...

6 entries

Atrax robustus (Sydney funnel-web spider)

Select_allDeselect_all "Atrax robustus" VenomZone page
TO1A_ATRRO Omega-hexatoxin-Ar1a (Omega-HXTX-Ar1a) (Omega-atracotoxin-Ar1a) ... Neurotoxin 08 (Shiva) family, 01 ...
TO1B_ATRRO Omega-hexatoxin-Ar1b (Omega-HXTX-Ar1b) (Omega-atracotoxin-Ar1b) ... Neurotoxin 08 (Shiva) family, 01 ...
TO1C_ATRRO Omega-hexatoxin-Ar1c (Omega-HXTX-Ar1c) (Omega-atracotoxin-Ar1c) ... Neurotoxin 08 (Shiva) family, 01 ...
TO1D_ATRRO Omega-hexatoxin-Ar1d (Omega-HXTX-Ar1d) (Omega-atracotoxin-Ar1d) ... Neurotoxin 08 (Shiva) family, 01 ...
TO1E_ATRRO Omega-hexatoxin-Ar1e (Omega-HXTX-Ar1e) (Omega-atracotoxin-Ar1e) ... Neurotoxin 08 (Shiva) family, 01 ...
TO1F_ATRRO Omega-hexatoxin-Ar1f (Omega-HXTX-Ar1f) (Omega-atracotoxin-Ar1f) ... Neurotoxin 08 (Shiva) family, 01 ...

2 entries

Atrax sp. (strain Illawarra) (Funnel-web spider)

Select_allDeselect_all
TOT2A_ATRIL Omega-hexatoxin-Asp2a (Omega-HXTX-Asp2a) ... Neurotoxin 15 family, 02 ...
TOT2B_ATRIL Omega-hexatoxin-Asp2b (Omega-HXTX-Asp2b) ... Neurotoxin 15 family, 02 ...

3 entries

Brachypelma albiceps (Mexican golden redrump tarantula) (Brachypelma ruhnaui)

Select_allDeselect_all
TXP1_BRAAI Omega-theraphotoxin-Ba1a (Omega-TRTX-Ba1a) (Venom peptide 1) Neurotoxin 12 (Hwtx-2) family, ...
TXP2_BRAAI Omega-theraphotoxin-Ba1b (Omega-TRTX-Ba1b) (Venom peptide 2) Neurotoxin 12 (Hwtx-2) family, ...
TXP3_BRAAI Omega-theraphotoxin-Ba1c (Omega-TRTX-Ba1c) (Venom peptide Ba3) Neurotoxin 12 (Hwtx-2) family, ...

1 entry

Californiconus californicus (California cone) (Conus californicus)

CUG6A_CONCL Omega-conotoxin Cl16a (Conotoxin CalTx) (Omega-conotoxin Cl15a) Not in a family

1 entry

Ceratogyrus darlingi (Rear horned baboon tarantula)

TX1_CERDA Beta-theraphotoxin-Cd1a (Beta-TRTX-Cd1a) Neurotoxin 10 (Hwtx-1) family, ...

2 entries

Ceratogyrus marshalli (Straighthorned baboon tarantula) (Ceratogyrus cornuatus)

Select_allDeselect_all
TX1_CERMR Beta-theraphotoxin-Cm1a (Beta-TRTX-Cm1a) (Ceratotoxin-1) ... Neurotoxin 10 (Hwtx-1) family, ...
TX2_CERMR Beta-theraphotoxin-Cm1b (Beta-TRTX-Cm1b) (Ceratotoxin-2) ... Neurotoxin 10 (Hwtx-1) family, ...

2 entries

Conus achatinus (Little frog cone)

Select_allDeselect_all
O164_CONAH Omega-conotoxin-like Ac6.4 Conotoxin O1 superfamily
O165_CONAH Omega-conotoxin-like Ac6.5 Conotoxin O1 superfamily

1 entry

Conus amadis (Amadis cone)

COW_CONAA Contryphan-Am (Am975) [Cleaved into: Contryphan-Am Am918] O2 superfamily, Contryphan ...

2 entries

Conus ammiralis (Admiral cone)

Select_allDeselect_all
O162_CONAJ Omega-conotoxin-like Ai6.2 Conotoxin O1 superfamily
O163_CONAJ Omega-conotoxin-like Ai6.3 Conotoxin O1 superfamily

2 entries

Conus arenatus (Sand-dusted cone)

Select_allDeselect_all
O162_CONAE Omega-conotoxin-like ArMKLT1-011 (Conotoxin ArMKLT1-0131) Conotoxin O1 superfamily
O163_CONAE Omega-conotoxin-like ArMKLT1-02 Conotoxin O1 superfamily

3 entries

Conus bullatus (Bubble cone)

Select_allDeselect_all
O168_CONBU Omega-conotoxin-like Bu8 (Fragment) Conotoxin O1 superfamily
O171_CONBU Omega-conotoxin-like Bu1 Conotoxin O1 superfamily
O17B_CONBU Omega-conotoxin-like Bu11 (Fragment) Conotoxin O1 superfamily

1 entry

Conus buxeus loroisii (Cone snail) (Conus loroisii)

COW1_CONBL Contryphan-Lo (Contryphan-Lo1) (Lo959) [Cleaved into: ... O2 superfamily, Contryphan ...

1 entry

Conus capitaneus (Captain cone)

O161_CONCE Omega-conotoxin-like 1 Conotoxin O1 superfamily

5 entries

Conus catus (Cat cone)

Select_allDeselect_all
O16A_CONCT Omega-conotoxin CVIA Conotoxin O1 superfamily
O16B_CONCT Omega-conotoxin CVIB Conotoxin O1 superfamily
O16C_CONCT Omega-conotoxin CVIC Conotoxin O1 superfamily
O16D_CONCT Omega-conotoxin CVID (AM-336) (AM336) (CNSB004) (Leconotide) Conotoxin O1 superfamily
O16F_CONCT Omega conotoxin-CVIF Conotoxin O1 superfamily

2 entries

Conus consors (Singed cone)

Select_allDeselect_all "Conus consors" VenomZone page
M7E_CONCN Omega-conotoxin-like CnVIIE [Cleaved into: Omega-conotoxin-like ... Conotoxin M superfamily
O17H_CONCN Omega-conotoxin-like CnVIIH [Cleaved into: Omega-conotoxin ... Conotoxin O1 superfamily

1 entry

Conus delessertii (Sozon's cone) (Conus sozoni)

U7B_CONDE Conotoxin de7b Not in a family

2 entries

Conus geographus (Geography cone) (Nubecula geographus)

Select_allDeselect_all
O16A_CONGE Omega-conotoxin GVIA (SNX-124) (Shaker peptide) [Cleaved into: ... Conotoxin O1 superfamily
U7AB_CONGE Omega-conotoxins GVIIA/GVIIB (SNX-178) (Shaker peptides ... Not in a family

2 entries

Conus imperialis (Imperial cone)

Select_allDeselect_all
O162_CONIM Omega-conotoxin-like 2/7 Conotoxin O1 superfamily
O163_CONIM Omega-conotoxin-like 3 Conotoxin O1 superfamily

1 entry

Conus litteratus (Lettered cone)

"Conus litteratus" VenomZone page
CA13B_CONLT Alpha-conotoxin Lt1.3 b (Fragment) Conotoxin A superfamily

4 entries

Conus magus (Magus cone) (Magician's cone snail)

Select_allDeselect_all
O17A_CONMA Omega-conotoxin MVIIA (SNX-111) (Ziconotide) Conotoxin O1 superfamily
O17B_CONMA Omega-conotoxin MVIIB (SNX-159) Conotoxin O1 superfamily
O17C_CONMA Omega-conotoxin MVIIC (Omega-CgTxMVIIC) (SNX-230) (Fragment) Conotoxin O1 superfamily
O17D_CONMA Omega-conotoxin MVIID (SNX-238) (Fragment) Conotoxin O1 superfamily

2 entries

Conus marmoreus (Marble cone)

Select_allDeselect_all
COW_CONMR Glacontryphan-M O2 superfamily, Contryphan ...
O167_CONMR Omega-conotoxin-like MaIr137 Conotoxin O1 superfamily

1 entry

Conus moncuri (Sea snail)

O16A_CONMB Omega-conotoxin MoVIA [Cleaved into: Omega-conotoxin MoVIB] Conotoxin O1 superfamily

2 entries

Conus pennaceus (Feathered cone) (Conus episcopus)

Select_allDeselect_all
O16A_CONPE Omega-conotoxin PnVIA Conotoxin O1 superfamily
O16B_CONPE Omega-conotoxin PnVIB Conotoxin O1 superfamily

2 entries

Conus pulicarius (Flea-bite cone)

Select_allDeselect_all
O161A_CONPL Omega-conotoxin-like PuIA Conotoxin O1 superfamily
O162A_CONPL Omega-conotoxin-like PuIIA Conotoxin O1 superfamily

1 entry

Conus radiatus (Rayed cone)

O16A_CONRA Omega-conotoxin RVIA Conotoxin O1 superfamily

1 entry

Conus regularis (Regular cone)

CXQA_CONRG Omega-conotoxin RsXXVIA (RsXXIVA) Not in a family

14 entries

Conus striatus (Striated cone)

Select_allDeselect_all
O161_CONST Omega-conotoxin-like SVIA mutant 1 Conotoxin O1 superfamily
O162_CONST Omega-conotoxin-like 2 Conotoxin O1 superfamily
O164_CONST Omega-conotoxin-like SO-4 (Omega-conotoxin SO4) Conotoxin O1 superfamily
O165_CONST Omega-conotoxin-like SO-5 (Omega-conotoxin SO5) Conotoxin O1 superfamily
O166_CONST Omega-conotoxin-like S6.6 Conotoxin O1 superfamily
O167_CONST Omega-conotoxin-like S6.7 (Fragment) Conotoxin O1 superfamily
O16A2_CONST Omega-conotoxin-like SVIA mutant 2 Conotoxin O1 superfamily
O16A_CONST Omega-conotoxin SVIA (SNX-157) Conotoxin O1 superfamily
O16B_CONST Omega-conotoxin SVIB (SNX-183) Conotoxin O1 superfamily
O16C_CONST Omega-conotoxin-like 12 Conotoxin O1 superfamily
O16F_CONST Omega-conotoxin-like 15 Conotoxin O1 superfamily
O16L6_CONST Omega-conotoxin-like 6 Conotoxin O1 superfamily
O16O3_CONST Omega-conotoxin SO-3 (SO3) Conotoxin O1 superfamily
O19_CONST Omega-conotoxin-like 9 Conotoxin O1 superfamily

15 entries

Conus textile (Cloth-of-gold cone)

Select_allDeselect_all "Conus textile" VenomZone page
I166_CONTE Conotoxin Tx6.6 O1 superfamily
O161_CONTE Omega-conotoxin-like TxMKLT1-0141 Conotoxin O1 superfamily
O162_CONTE Omega-conotoxin-like TxMKLT1-0142 Conotoxin O1 superfamily
O1631_CONTE Omega-conotoxin-like TxMKLT1-031 Conotoxin O1 superfamily
O163_CONTE Omega-conotoxin-like TxO3 Conotoxin O1 superfamily
O164_CONTE Omega-conotoxin-like TxO4 (Conotoxin TxMKLT1-0221) [Cleaved ... Conotoxin O1 superfamily
O165_CONTE Omega-conotoxin-like TxO5 Conotoxin O1 superfamily
O1661_CONTE Omega-conotoxin-like TeA61 Conotoxin O1 superfamily
O16K_CONTE Omega-conotoxin-like TxO5 (Conotoxin TxMKLT1-012) Conotoxin O1 superfamily
O16L_CONTE Omega-conotoxin-like TxMKLT1-0223 Conotoxin O1 superfamily
O16M_CONTE Omega-conotoxin-like TxMKLT1-0211 Conotoxin O1 superfamily
O16O2_CONTE Omega-conotoxin-like TxO2 Conotoxin O1 superfamily
O16O6_CONTE Omega-conotoxin-like TxO6 Conotoxin O1 superfamily
O17_CONTE Omega-conotoxin TxVII Conotoxin O1 superfamily
O1X1_CONTE Omega-conotoxin-like TxO1 Conotoxin O1 superfamily

1 entry

Conus tulipa (Fish-hunting cone snail) (Tulip cone)

O16A_CONTU Omega-conotoxin TVIA (SNX-185) Conotoxin O1 superfamily

2 entries

Conus ventricosus (Mediterranean cone)

Select_allDeselect_all "Conus ventricosus" VenomZone page
O168_CONVE Omega-conotoxin-like VnMKLT1-0111 Conotoxin O1 superfamily
U6VN_CONVE Omega-conotoxin-like Vn2 (Conotoxin Vn2) (Conotoxin-Vn) (Vn6A) Not in a family

1 entry

Coremiocnemis tropix (Australian tarantula spider)

CT1B_CORTR U1-theraphotoxin-Ct1b (U1-TRTX-Ct1b) Neurotoxin 12 (Hwtx-2) family, ...

9 entries

Ctenus ornatus (Brazilian spider) (Oligoctenus ornatus)

Select_allDeselect_all
TX20A_CTEON U10-ctenitoxin-Co1b (U10-CNTX-Co1b) (Neurotoxin Oc M31-11) ... Neurotoxin 02 (plectoxin) family
TX20B_CTEON U10-ctenitoxin-Co1a (U10-CNTX-Co1a) (Neurotoxin Oc FU-5) ... Neurotoxin 02 (plectoxin) family
TX21A_CTEON U3-ctenitoxin-Co1a (U3-CNTX-Co1a) (Neurotoxin Oc F29-9) ... Neurotoxin 02 (plectoxin) ...
TX29A_CTEON U6-ctenitoxin-Co1a (U6-CNTX-Co1a) (Neurotoxin Oc F35-5) ... Neurotoxin 02 (plectoxin) ...
TXF22_CTEON U2-ctenitoxin-Co1a (U2-CNTX-Co1a) (Neurotoxin Oc F22) (Fragment) Neurotoxin 04 (omega-agtx) ...
TXF27_CTEON U17-ctenitoxin-Co1a (U17-CNTX-Co1a) (Neurotoxin Oct F27-10) ... Neurotoxin 04 (omega-agtx) ...
TXF28_CTEON U4-ctenitoxin-Co1a (U4-CNTX-Co1a) (Neurotoxin Oc M27-11) ... Neurotoxin 04 (omega-agtx) ...
TXF91_CTEON U4-ctenitoxin-Co1b (U4-CNTX-Co1b) (Neurotoxin Oc F29-9-1) ... Neurotoxin 04 (omega-agtx) ...
TXM20_CTEON U14-ctenitoxin-Co1a (U14-CNTX-Co1a) (Neurotoxin Oc M20-3) ... Neurotoxin 04 (omega-agtx) ...

2 entries

Cupiennius salei (American wandering spider)

Select_allDeselect_all
TXC1_CUPSA Omega-ctenitoxin-Cs1a (Omega-CNTX-Cs1a) (Toxin CSTX-1) [Cleaved ... Neurotoxin 19 (CSTX) family, 04 ...
TXC9_CUPSA U1-ctenitoxin-Cs1a (U1-CNTX-Cs1a) (Toxin CSTX-9) [Cleaved into: ... Neurotoxin 19 (CSTX) family

5 entries

Cyriopagopus hainanus (Chinese bird spider) (Haplopelma hainanum)

Select_allDeselect_all
H10A1_CYRHA Hainantoxin-X (HNTX-X) Neurotoxin 36 family, 02 ...
H10A2_CYRHA Hainantoxin-X.2 (HNTX-X.2) Neurotoxin 36 family, 02 ...
H10A3_CYRHA Hainantoxin-X.3 (HNTX-X.3) Neurotoxin 36 family, 02 ...
H10B1_CYRHA Hainantoxin-X-2 (HNTX-X-2) Neurotoxin 36 family, 02 ...
H10C1_CYRHA Hainantoxin-X-3 (HNTX-X-3) Neurotoxin 36 family, 02 ...

3 entries

Cyriopagopus schmidti (Chinese bird spider) (Haplopelma schmidti)

Select_allDeselect_all
TXH10_CYRSC Omega-theraphotoxin-Hs1a (Omega-TRTX-Hs1a) (Huwentoxin-10) ... Neurotoxin 36 family, 02 ...
TXH1_CYRSC Mu/omega-theraphotoxin-Hs1a (Mu/omega-TRTX-Hs1a) (Huwentoxin-1) ... Neurotoxin 10 (Hwtx-1) family, ...
TXH5_CYRSC Omega-theraphotoxin-Hs2a (Omega-TRTX-Hs2a) (Huwentoxin-5) ... Neurotoxin 10 (Hwtx-1) family, ...

1 entry

Davus fasciatus (Costa Rican tiger rump) (Cyclosternum fasciatus)

TXDF1_DAFVA Mu-theraphotoxin-Df1a (Mu-TRTX-Df1a) Neurotoxin 10 (Hwtx-1) family, ...

1 entry

Dendroaspis angusticeps (Eastern green mamba) (Naja angusticeps)

3SL2_DENAN Toxin C10S2C2 Snake three-finger toxin family, ...

1 entry

Dendroaspis jamesoni kaimosae (Eastern Jameson's mamba)

3SL8_DENJA Toxin S4C8 Snake three-finger toxin family, ...

2 entries

Dendroaspis polylepis polylepis (Black mamba)

Select_allDeselect_all
3SL2_DENPO Toxin FS-2 (FS2) Snake three-finger toxin family, ...
3SLS_DENPO Calciseptin (Calciseptine) (CaS) (L-type calcium channel ... Snake three-finger toxin family, ...

2 entries

Ectatomma tuberculatum (Selva ant)

Select_allDeselect_all
TX1AA_ECTTU Omega/M-ectatotoxin-Et1a subunit A (Omega/M-ECTX-Et1a subunit A) ... Ectatomin family, Ectatomin-Et ...
TX1AB_ECTTU Omega/M-ectatotoxin-Et1a subunit B (Omega/M-ECTX-Et1a subunit B) ... Ectatomin family, Ectatomin-Et ...

1 entry

Gloydius blomhoffii (Mamushi) (Agkistrodon halys blomhoffi)

CRVP_GLOBL Cysteine-rich venom protein ablomin CRISP family

1 entry

Grammostola porteri (Tarantula spider) (Lasiodora porteri)

TX15_GRAPO Toxin GTx1-15 (Beta/omega-theraphotoxin-Gr2a) ... Neurotoxin 10 (Hwtx-1) family, ...

4 entries

Grammostola rosea (Chilean rose tarantula) (Grammostola spatulata)

Select_allDeselect_all
AF2_GRARO Kappa-theraphotoxin-Gr2c (Kappa-TRTX-Gr2c) (GsAF II) (GsAFII) ... Neurotoxin 30 (phrixotoxin) ...
TX15_GRARO Toxin GTx1-15 (Beta/omega-theraphotoxin-Gr2a) ... Neurotoxin 10 (Hwtx-1) family, ...
TXHN1_GRARO Kappa-theraphotoxin-Gr1a (Kappa-TRTX-Gr1a) (Hanatoxin-1) (HaTx1) Neurotoxin 10 (Hwtx-1) family, ...
WGRTX_GRARO Omega-theraphotoxin-Gr1a (Omega-TRTX-Gr1a) (Omega-grammotoxin ... Neurotoxin 10 (Hwtx-1) family, ...

1 entry

Hadronyche formidabilis (Northern tree funnel-web spider) (Atrax formidabilis)

TO1B_HADFO Omega-hexatoxin-Hf1a (Omega-HXTX-Hf1a) (Omega-atracotoxin-Hf1a) ... Neurotoxin 08 (Shiva) family, 01 ...

9 entries

Hadronyche infensa (Fraser island funnel-web spider) (Atrax infensus)

Select_allDeselect_all
TO1A_HADIN Omega-hexatoxin-Hi1a (Omega-HXTX-Hi1a) (Omega-atracotoxin-Hi1a) ... Neurotoxin 08 (Shiva) family, 01 ...
TO1B_HADIN Omega-hexatoxin-Hi1b (Omega-HXTX-Hi1b) (Omega-atracotoxin-Hi1b) ... Neurotoxin 08 (Shiva) family, 01 ...
TO1C_HADIN Omega-hexatoxin-Hi1c (Omega-HXTX-Hi1c) (Omega-atracotoxin-Hi1c) ... Neurotoxin 08 (Shiva) family, 01 ...
TO1D_HADIN Omega-hexatoxin-Hi1d Neurotoxin 08 (Shiva) family, 01 ...
TO1E_HADIN Omega-hexatoxin-Hi1e Neurotoxin 08 (Shiva) family, 01 ...
TO1F_HADIN Omega-hexatoxin-Hi1f Neurotoxin 08 (Shiva) family, 01 ...
TO1G_HADIN Omega-hexatoxin-Hi1g Neurotoxin 08 (Shiva) family, 01 ...
TOT2A_HADIN Omega-hexatoxin-Hi2a (Omega-HXTX-Hi2a) (Omega-atracotoxin-Hi2a) ... Neurotoxin 15 family, 02 ...
TOT2B_HADIN Omega-hexatoxin-Hi2b (Omega-HXTX-Hi2b) (Omega-atracotoxin-Hi2b) ... Neurotoxin 15 family, 02 ...

4 entries

Hadronyche modesta (Victorian funnel-web spider)

Select_allDeselect_all
TO1A_HADMO Omega-hexatoxin-Hmo1a Neurotoxin 08 (Shiva) family, 01 ...
TO1B_HADMO Omega-hexatoxin-Hmo1b Neurotoxin 08 (Shiva) family, 01 ...
TO1C_HADMO Omega-hexatoxin-Hmo1c Neurotoxin 08 (Shiva) family, 01 ...
TO1D_HADMO Omega-hexatoxin-Hmo1d Neurotoxin 08 (Shiva) family, 01 ...

2 entries

Hadronyche venenata (Tasmanian funnel-web spider) (Atrax venenatus)

Select_allDeselect_all
TO1A_HADVN Omega-hexatoxin-Hvn1a Neurotoxin 08 (Shiva) family, 01 ...
TO1B_HADVN Omega-hexatoxin-Hvn1b Neurotoxin 08 (Shiva) family, 01 ...

7 entries

Hadronyche versuta (Blue mountains funnel-web spider) (Atrax versutus)

Select_allDeselect_all
TO1A_HADVE Omega-hexatoxin-Hv1a (Omega-HXTX-Hv1a) (Omega-atracotoxin-Hv1a) ... Neurotoxin 08 (Shiva) family, 01 ...
TO1B_HADVE Omega-hexatoxin-Hv1b (Omega-HXTX-Hv1b) (Omega-atracotoxin-Hv1b) ... Neurotoxin 08 (Shiva) family, 01 ...
TO1C_HADVE Omega-hexatoxin-Hv1c (Omega-HXTX-Hv1c) (Omega-atracotoxin-Hv1c) ... Neurotoxin 08 (Shiva) family, 01 ...
TO1D_HADVE Omega-hexatoxin-Hv1d (Omega-HXTX-Hv1d) (Omega-atracotoxin-Hv1d) ... Neurotoxin 08 (Shiva) family, 01 ...
TO1E_HADVE Omega-hexatoxin-Hv1e (Omega-HXTX-Hv1e) (Omega-atracotoxin-Hv1e) ... Neurotoxin 08 (Shiva) family, 01 ...
TO1F_HADVE Omega-hexatoxin-Hv1f (Omega-HXTX-Hv1f) (Omega-atracotoxin-Hv1f) ... Neurotoxin 08 (Shiva) family, 01 ...
TOT2A_HADVE Omega-hexatoxin-Hv2a (Omega-HXTX-Hv2a) (Omega-atracotoxin-Hv2a) ... Neurotoxin 15 family, 02 ...

1 entry

Heloderma horridum horridum (Mexican beaded lizard)

CRVP_HELHO Cysteine-rich venom protein helothermine (CRVP HLTx) CRISP family

4 entries

Heteropoda venatoria (Brown huntsman spider) (Aranea venatoria)

Select_allDeselect_all
TX5A_HETVE Omega-sparatoxin-Hv1a (Omega-SPRTX-Hv1a) (Toxin AU5A) Neurotoxin 10 (Hwtx-1) family, ...
TX5B_HETVE Omega-sparatoxin-Hv1b (Omega-SPRTX-Hv1b) (Toxin AU5B) Neurotoxin 10 (Hwtx-1) family, ...
TXJ1_HETVE Kappa-sparatoxin-Hv1e (Kappa-SPRTX-Hv1e) (Toxin KJ1) Neurotoxin 10 (Hwtx-1) family, ...
TXU2_HETVE Kappa-sparatoxin-Hv1d (Kappa-SPRTX-Hv1d) (Toxin AU2) Neurotoxin 10 (Hwtx-1) family, ...

1 entry

Hydrophis hardwickii (Hardwick's spine-bellied seasnake) (Lapemis hardwickii)

CRVP2_HYDHA Cysteine-rich venom protein 2 (CRVP) CRISP family

1 entry

Hysterocrates gigas (Cameroon red baboon tarantula)

TX482_HYSGI Omega-theraphotoxin-Hg1a (Omega-TRTX-Hg1a) (Toxin SNX-482) ... Neurotoxin 10 (Hwtx-1) family, ...

1 entry

Kukulcania hibernalis (Southern house spider) (Filistata hibernalis)

TX13_KUKHI Omega-filistatoxin-Kh1a (Omega-FLTX-Kh1a) (Toxin DW13.3) Not in a family

1 entry

Laticauda semifasciata (Black-banded sea krait) (Pseudolaticauda semifasciata)

CRVP_LATSE Cysteine-rich venom protein latisemin (CRVP) CRISP family

1 entry

Loxosceles intermedia (Brown spider)

"Loxosceles intermedia" VenomZone page
TX4_LOXIN U1-sicaritoxin-Li1c (U1-SCRTX-Li1c) (LiTx4) (Fragment) Neurotoxin 28 (Litx) family

5 entries

Lycosa singoriensis (Wolf spider) (Aranea singoriensis)

Select_allDeselect_all
TX2M1_LYCSI U2-lycotoxin-Ls1a (Toxin-like structure LSTX-M1) Neurotoxin 04 (omega-agtx) ...
TX2M2_LYCSI U2-lycotoxin-Ls1b (Toxin-like structure LSTX-M2) Neurotoxin 04 (omega-agtx) ...
TX2M3_LYCSI U2-lycotoxin-Ls1c (Toxin-like structure LSTX-M3) Neurotoxin 04 (omega-agtx) ...
TX2M4_LYCSI U2-lycotoxin-Ls1d (Toxin-like structure LSTX-M4) Neurotoxin 04 (omega-agtx) ...
TX2M5_LYCSI U2-lycotoxin-Ls1e (Toxin-like structure LSTX-M5) Neurotoxin 04 (omega-agtx) ...

1 entry

Missulena bradleyi (Eastern mouse spider)

TOM1A_MISBR Omega-actinopoditoxin-Mb1a (Omega-AOTX-Mb1a) ... Neurotoxin 08 (Shiva) family, 02 ...

1 entry

Naja naja (Indian cobra)

CRVP1_NAJNA Cysteine-rich venom protein (CRVP) (Cysteine-rich secretory ... CRISP family

2 entries

Oxyopes lineatus (Lynx spider)

Select_allDeselect_all
TOX1_OXYLI Omega-oxotoxin-Ol1a (Omega-OXTX-Ol1a) (Oxytoxin-1) (OxyTx1) Spiderine family, Spiderine ...
TOX2_OXYLI Omega-oxotoxin-Ol1b (Omega-OXTX-Ol1b) (Oxytoxin-2) (OxyTx2) Spiderine family, Spiderine ...

1 entry

Oxyopes takobius (Lynx spider) (Oxyopes foliiformis)

TOX1_OXYTA Omega-oxotoxin-Ot1a (Omega-OXTX-Ot1a) (Oxytoxin-1) (OxyTx1) ... Spiderine family, Spiderine ...

2 entries

Oxyuranus scutellatus scutellatus (Australian taipan) (Coastal taipan)

Select_allDeselect_all
3L2L_OXYSC Taicatoxin, alpha-neurotoxin-like component (TCX, ... Snake three-finger toxin family, ...
VKT_OXYSC Kunitz-type serine protease inhibitor taicotoxin (Taicatoxin, ... Venom Kunitz-type family

2 entries

Parabuthus granulatus (Granulated thick-tailed scorpion)

Select_allDeselect_all
KURT1_PARGR Alpha-toxin PgKL1 (Kurtoxin-like 1) (Kurtoxin-like I) (KLI) Long (4 C-C) scorpion toxin ...
KURT2_PARGR Toxin PgKL2 (Kurtoxin-like 2) (Kurtoxin-like II) (KLII) Long (4 C-C) scorpion toxin ...

1 entry

Parabuthus transvaalicus (South African fattail scorpion)

KURT_PARTR Kurtoxin (Ktx) Long (4 C-C) scorpion toxin ...

1 entry

Paraphysa scrofa (Chilean copper tarantula) (Phrixotrichus auratus)

TX15_PARSR Toxin GTx1-15 (Beta/omega-theraphotoxin-Gr2a) ... Neurotoxin 10 (Hwtx-1) family, ...

1 entry

Pelinobius muticus (King baboon spider) (Citharischius crawshayi)

TXO1A_PELMU Omega-theraphotoxin-Cc1a (Omega-TRTX-Cc1a) (Toxin-like GVDKE) ... Neurotoxin 10 (Hwtx-1) family, ...

12 entries

Phoneutria nigriventer (Brazilian armed spider) (Ctenus nigriventer)

Select_allDeselect_all
TOPC5_PHONI U20-ctenitoxin-Pn1a (U20-CNTX-Pn1a) (Omega-phonetoxin PNTx22C5) ... Neurotoxin 04 (omega-agtx) ...
TX20A_PHONI Kappa-ctenitoxin-Pn1a (Kappa-CNTX-Pn1a) (Neurotoxin Tx3-1) ... Neurotoxin 02 (plectoxin) family
TX20B_PHONI Omega-ctenitoxin-Pn1a (Omega-CNTX-Pn1a) (Neurotoxin Tx3-2) ... Neurotoxin 02 (plectoxin) family
TX20C_PHONI U7-ctenitoxin-Pn1a (U7-CNTX-Pn1a) (Neurotoxin Tx3-5) (PnTx3-5) Neurotoxin 02 (plectoxin) family
TX21A_PHONI Omega-ctenitoxin-Pn2a (Omega-CNTX-Pn2a) (Neurotoxin Tx3-3) ... Neurotoxin 02 (plectoxin) ...
TX21B_PHONI U6-ctenitoxin-Pn1a (U6-CNTX-Pn1a) (Neurotoxin Pn3A) Neurotoxin 02 (plectoxin) ...
TX21C_PHONI U9-ctenitoxin-Pn1a (U9-CNTX-Pn1a) (Neurotoxin Pn3-3A) Neurotoxin 02 (plectoxin) ...
TX26A_PHONI Neurotoxin PRTx26An0C3 Neurotoxin 10 (Hwtx-1) family, ...
TX27_PHONI U17-ctenitoxin-Pn1a (U17-CNTX-Pn1a) (Neurotoxin PNTx27C4) Neurotoxin 10 (Hwtx-1) family, ...
TX34_PHONI Omega-ctenitoxin-Pn3a (Omega-CNTX-Pn3a) (Neurotoxin Tx3-4) ... Neurotoxin 04 (omega-agtx) ...
TX3_PHONI U7-ctenitoxin-Pn1b (U7-CNTX-Pn1b) (Neurotoxin Tx3) (Fragment) Not in a family
TX90B_PHONI Omega-ctenitoxin-Pn4a (Omega-CNTX-Pn4a) (Neurotoxin Tx3-6) ... Neurotoxin 09 (Tx3-6) family

4 entries

Phoneutria reidyi (Brazilian Amazonian armed spider) (Ctenus reidyi)

Select_allDeselect_all
TX18_PHORI U1-ctenitoxin-Pr1a (U1-CNTX-Pr1a) (Neurotoxin PRTx18C2) ... Neurotoxin 04 (omega-agtx) ...
TX20A_PHORI Omega-ctenitoxin-Pr1a (Omega-CNTX-Pr1a) (Neurotoxin PRTx17C3) ... Neurotoxin 02 (plectoxin) family
TX27_PHORI U4-ctenitoxin-Pr1a (U4-CNTX-Pr1a) (Neurotoxin PRTx27C3) Neurotoxin 10 (Hwtx-1) family, ...
TX90A_PHORI Omega-ctenitoxin-Pr2a (Omega-CNTX-Pr2a) (Neurotoxin PRTx23C2) Neurotoxin 09 (Tx3-6) family

1 entry

Plectreurys tristis (Spider) (Plectreurys bispinosus)

TX22A_PLETR Omega-plectoxin-Pt1a (Omega-PLTX-Pt1a) (PLTX-II) (Toxin PLTX-2) Neurotoxin 02 (plectoxin) ...

1 entry

Protobothrops flavoviridis (Habu) (Trimeresurus flavoviridis)

CRVP_PROFL Cysteine-rich venom protein triflin (CRVP) CRISP family

3 entries

Scolopendra mutilans (Chinese red-headed centipede) (Scolopendra subspinipes mutilans)

Select_allDeselect_all
TX51A_SCOMU Omega-scoloptoxin(05)-Ssm1a (Omega-SLPTX(05)-Ssm1a) ... Scoloptoxin-05 family
TXD2A_SCOMU Omega-scoloptoxin(13)-Ssm2a (Omega-SLPTX(13)-Ssm2a) ... Scoloptoxin-13 family
TXD2B_SCOMU Omega-scoloptoxin(13)-Ssm2b (Omega-SLPTX(13)-Ssm2b) ... Scoloptoxin-13 family

4 entries

Scolopendra subspinipes dehaani (Thai centipede) (Scolopendra dehaani)

Select_allDeselect_all
TXA1B_SCOSD Omega-scoloptoxin(10)-Ssd1b (Omega-SLPTX(10)-Ssd1b) (Toxin ... Scoloptoxin-10 family
TXF3C_SCOSD Omega-scoloptoxin(15)-Ssd3c (Omega-SLPTX(15)-Ssd3c) (Toxin ... Scoloptoxin-15 family
VA546_SCOSD Scoloptoxin SSD346 (Cysteine-rich venom protein) (CRVP) ... CRISP family, Venom allergen ...
VA576_SCOSD Scoloptoxin SSD976 (Cysteine-rich venom protein) (CRVP) CRISP family, Venom allergen ...

1 entry

Segestria florentina (Tube-web spider) (Segestria gracilis)

TX325_SEGFL Omega-segestritoxin-Sf1a (Omega-SGTX-Sf1a) (Toxin SNX-325) Not in a family

2 entries

Thrixopelma pruriens (Peruvian green velvet tarantula)

Select_allDeselect_all
TXPR1_THRPR Beta/omega-theraphotoxin-Tp1a (Beta/omega-TRTX-Tp1a) ... Neurotoxin 10 (Hwtx-1) family, ...
TXPR2_THRPR Beta/omega-theraphotoxin-Tp2a (Beta/omega-TRTX-Tp2a) (ProTx-II) ... Neurotoxin 30 (phrixotoxin) ...

1 entry

Tibellus oblongus (Oblong running crab spider)

TBO_TIBOB Omega-phylotoxin-To1a (Omega-PHTX-To1a) (Omega-Tbo-IT1) Not in a family