Voltage-gated calcium channel impairing toxin (Cav channel inhibitor)

Channel Voltage-gated calcium channels (Cav) are the key signal transducers of electrical signaling, converting depolarization of the cell membrane to an influx of calcium ions that initiates contraction, secretion, neurotransmission and other intracellular regulatory events. Skeletal muscle calcium channels first identified by drug labeling, purification, and functional reconstitution have a principal α1 subunit of 212-250 kDa.

The α1 subunit is associated with auxiliary α2, β, γ and δ subunits. The calcium channel α1 subunit is sufficient to form a voltage-gated calcium-selective pore by itself. Ten functional calcium channel α1 subunits are known in vertebrates, and they fall into three subfamilies that differ in function and regulation. The Cav1 subfamily (Cav1.1-Cav1.4) conducts L-type calcium currents that initiate contraction, endocrine secretion, and synaptic transmission at the specialized ribbon synapses involved in sensory input in the eye and ear. L-type calcium currents also are important regulators of gene expression and other intracellular processes. They are blocked by the classical calcium channel antagonists, including dihydropyridines, benzothiazepines, and phenylalkylamines. The Cav2 subfamily of calcium channels (Cav2.1-Cav2.3) conduct N-, P/Q- and R-type calcium currents that initiate fast synaptic transmission at synapses in the central and peripheral nervous systems and are blocked specifically by peptide neurotoxins from spider and cone snail venoms. The Cav3 subfamily of calcium channels (Cav3.1-Cav3.3) conduct T-type calcium currents that are important for repetitive action potential firing of neurons in the brain and in the pacemaker cells of the sino-atrial node in the heart. The protein-protein interactions as well as the functional and regulatory properties of different subfamilies of these ion channels are adapted to their distinct roles in electrical signaling and cellular signal transduction.

Cav1 and Cav2 channels have four distinct auxiliary subunits (Cavα2, Cavβ, Cavγ, and Cavδ), whereas Cav3 channels have none. Each subunits of Cav1 and Cav2 channels comprise a small protein family. The Cavα2 and Cavδ subunits are encoded by the same gene, whose translation product is proteolytically cleaved and disulfide linked to yield the mature extracellular α2 subunit glycoprotein of 140 kDa and transmembrane disulfide-linked δ subunit glycoprotein of 27 kDa. Four Cavα2δ genes are known. The four Cavβ subunits are all intracellular proteins with a common pattern of α helical and unstructured segments. They have important regulatory effects on cell surface expression and they also modulate the gating of calcium channels, causing enhanced activation upon depolarization and altered rate and voltage dependence of inactivation. Recent structural modeling and X-ray crystallography studies have revealed that these subunits contain conserved, interacting SH3 and guanylate kinase domains like the MAGUK family of scaffolding proteins, and therefore may interact with other intracellular proteins. Eight Cavγ subunit genes encode glycoproteins with four transmembrane segments. Although the Cavγ1 subunit is associated specifically with skeletal muscle Cav1.1 channels, other Cavγ subunits interact with other calcium channels, glutamate receptors and possibly with other membrane signaling proteins. Thus, the γ subunits discovered as components of calcium channels apparently have a more widespread role in assembly and cell surface expression of other membrane signaling proteins. Cav3 channels do not have auxiliary subunits.

Toxin
Cav channels Toxins from different taxa that target Cav channels.
Click on to retrieve channels and toxins of interest.
Human Snake Scorpion Cone
snail
Spider Cnidarian Insect Other All
Cav1.1/CACNA1S (L-type) - - - - - - - -
Cav1.2/CACNA1C (L-type) - - - - - -
Cav1.3/CACNA1D (L-type) - - - - - - - -
Cav1.4/CACNA1F (L-type) - - - - - - - -
Cav1 All (L-type) - - - -
Cav2.1/CACNA1A (P-/Q-type) - - - - -
Cav2.2/CACNA1B (N-type) - - - -
Cav2.3/CACNA1E (R-type) - - - - - -
Cav2 All - - - -
Cav3.1/CACNA1G (T-type) - - - - -
Cav3.2/CACNA1H (T-type) - - - - - -
Cav3.3/CACNA1I
(T-type)
- - - - - -
Cav3 All (T-type) - - - - -
Cav All - -

Venom protein entries in UniProtKB/Swiss-Prot

218 entries grouped by species (browse by taxonomy, browse by keywords)

1 entry

Agelena orientalis (Spider)

TXAG1_AGEOR U10-agatoxin-Ao1a (U10-AGTX-Ao1a) (AgorTX_B7b) Omega-agatoxin superfamily, Type ...

10 entries

Agelenopsis aperta (North American funnel-web spider) (Agelenopsis gertschi)

Select_allDeselect_all
TOG1A_AGEAP Omega-agatoxin-1A (Omega-agatoxin IA) (Omega-Aga-IA) [Cleaved ... Omega-agatoxin superfamily, Type ...
TOG1B_AGEAP Omega-agatoxin-Aa1b (Omega-AGTX-Aa1b) (Omega-agatoxin IB) ... Omega-agatoxin superfamily, Type ...
TOG2A_AGEAP Omega-agatoxin-Aa2a (Omega-AGTX-Aa2a) (Omega-agatoxin IIA) ... Omega-agatoxin superfamily, Type ...
TOG3A_AGEAP Omega-agatoxin-Aa3a (Omega-AGTX-Aa3a) (Omega-agatoxin IIIA) ... Omega-agatoxin superfamily, Type ...
TOG3B_AGEAP Omega-agatoxin-Aa3b (Omega-AGTX-Aa3b) (Omega-agatoxin IIIB) ... Omega-agatoxin superfamily, Type ...
TOG3C_AGEAP Omega-agatoxin-Aa3c (Omega-AGTX-Aa3c) (Omega-agatoxin IIIC) ... Omega-agatoxin superfamily, Type ...
TOG3D_AGEAP Omega-agatoxin-Aa3d (Omega-AGTX-Aa3d) (Omega-agatoxin IIID) ... Omega-agatoxin superfamily, Type ...
TOG4A_AGEAP Omega-agatoxin-Aa4a (Omega-AGTX-Aa4a) (Omega-agatoxin IVA) ... Plectoxin superfamily, Type IV ...
TOG4B_AGEAP Omega-agatoxin-Aa4b (Omega-AGTX-Aa4b) (Omega-agatoxin IVB) ... Plectoxin superfamily, Type IV ...
TX3_AGEAP Omega-agatoxin-Aa5a (Omega-AGTX-Aa5a) (Peptide J2) Plectoxin superfamily, Tx3 ...

1 entry

Allagelena opulenta (Funnel weaving spider) (Agelena opulenta)

TXAG_ALLOP U2-agatoxin-Aop1a (U2-AGTX-Aop1a) (Agelenin) Not in a family

1 entry

Ancylometes sp. (South American fishing spider)

32C7_ANCSP U1-ctenitoxin-Asp1a (U1-CNTX-Asp1a) (Neurotoxin ANC32C7) ... Omega-agatoxin superfamily, Type ...

1 entry

Anochetus emarginatus (Ant) (Stenomyrmex emarginatus)

PON1A_ANOEM U1-poneritoxin-Ae1a (U1-PONTX-Ae1a) Not in a family

4 entries

Aphonopelma sp. (American tarantula)

Select_allDeselect_all
TX132_APHSP Omega-theraphotoxin-Asp3a (Omega-TRTX-Asp3a) (Peptide 7-13.2) Magi-1 superfamily, Ltx4 family
TX1A_APHSP Omega-theraphotoxin-Asp1a (Omega-TRTX-Asp1a) (Peptide 6-6) Huwentoxin-2 family, TXP1 ...
TX1F_APHSP Omega-theraphotoxin-Asp1f (Omega-TRTX-Asp1f) (Eurypelma spider ... Huwentoxin-2 family, TXP1 ...
TX1G_APHSP Omega-theraphotoxin-Asp1g (Omega-TRTX-Asp1g) (Eurypelma spider ... Huwentoxin-2 family, TXP1 ...

1 entry

Apomastus schlingeri (Trap-door spider) (Aptostichus schlingeri)

TXP3_APOSC Mu-cyrtautoxin-As1a (Mu-CUTX-As1a) (Aptotoxin III) (Aps III) ... Insecticidal toxin ABC family, ...

6 entries

Atrax robustus (Sydney funnel-web spider)

Select_allDeselect_all "Atrax robustus" VenomZone page
TO1A_ATRRO Omega-hexatoxin-Ar1a (Omega-HXTX-Ar1a) (Omega-atracotoxin-Ar1a) ... Shiva superfamily, Omega toxin ...
TO1B_ATRRO Omega-hexatoxin-Ar1b (Omega-HXTX-Ar1b) (Omega-atracotoxin-Ar1b) ... Shiva superfamily, Omega toxin ...
TO1C_ATRRO Omega-hexatoxin-Ar1c (Omega-HXTX-Ar1c) (Omega-atracotoxin-Ar1c) ... Shiva superfamily, Omega toxin ...
TO1D_ATRRO Omega-hexatoxin-Ar1d (Omega-HXTX-Ar1d) (Omega-atracotoxin-Ar1d) ... Shiva superfamily, Omega toxin ...
TO1E_ATRRO Omega-hexatoxin-Ar1e (Omega-HXTX-Ar1e) (Omega-atracotoxin-Ar1e) ... Shiva superfamily, Omega toxin ...
TO1F_ATRRO Omega-hexatoxin-Ar1f (Omega-HXTX-Ar1f) (Omega-atracotoxin-Ar1f) ... Shiva superfamily, Omega toxin ...

2 entries

Atrax sp. (strain Illawarra) (Funnel-web spider)

Select_allDeselect_all
TOT2A_ATRIL Omega-hexatoxin-Asp2a (Omega-HXTX-Asp2a) ... Omega-atracotoxin type 2 family
TOT2B_ATRIL Omega-hexatoxin-Asp2b (Omega-HXTX-Asp2b) ... Omega-atracotoxin type 2 family

3 entries

Brachypelma ruhnaui (Mexican golden redrump tarantula) (Brachypelma albiceps)

Select_allDeselect_all
TXP1_BRARH Omega-theraphotoxin-Ba1a (Omega-TRTX-Ba1a) (Venom peptide 1) Huwentoxin-2 family, TXP1 ...
TXP2_BRARH Omega-theraphotoxin-Ba1b (Omega-TRTX-Ba1b) (Venom peptide 2) Huwentoxin-2 family, TXP1 ...
TXP3_BRARH Omega-theraphotoxin-Ba1c (Omega-TRTX-Ba1c) (Venom peptide Ba3) Huwentoxin-2 family, TXP1 ...

1 entry

Californiconus californicus (California cone) (Conus californicus)

CUG6A_CONCL Omega-conotoxin Cl16a (Conotoxin CalTx) (Omega-conotoxin Cl15a) Not in a family

2 entries

Conus achatinus (Little frog cone)

Select_allDeselect_all
CO164_CONAH Omega-conotoxin-like Ac6.4 Conotoxin O1 superfamily
CO165_CONAH Omega-conotoxin-like Ac6.5 Conotoxin O1 superfamily

1 entry

Conus amadis (Amadis cone)

COW_CONAA Contryphan-Am (Am975) [Cleaved into: Contryphan-Am Am918] Contryphan family

2 entries

Conus ammiralis (Admiral cone)

Select_allDeselect_all
CO162_CONAJ Omega-conotoxin-like Ai6.2 Conotoxin O1 superfamily
CO163_CONAJ Omega-conotoxin-like Ai6.3 Conotoxin O1 superfamily

2 entries

Conus arenatus (Sand-dusted cone)

Select_allDeselect_all
O162_CONAE Omega-conotoxin-like ArMKLT1-011 (Conotoxin ArMKLT1-0131) Conotoxin O1 superfamily
O163_CONAE Omega-conotoxin-like ArMKLT1-02 Conotoxin O1 superfamily

1 entry

Conus betulinus (Beech cone)

COW_CONBE Contryphan-Bt (B1187) Contryphan family

4 entries

Conus bullatus (Bubble cone)

Select_allDeselect_all
CO711_CONBU Omega-conotoxin-like Bu11 (Fragment) Conotoxin O1 superfamily
CO71_CONBU Omega-conotoxin-like Bu1 Conotoxin O1 superfamily
CO8_CONBU Omega-conotoxin-like Bu8 (Fragment) Conotoxin O1 superfamily
COW_CONBU Contryphan-Bu Contryphan family

1 entry

Conus buxeus loroisii (Cone snail) (Conus loroisii)

COW_CONBL Contryphan-Lo (Lo959) [Cleaved into: Contryphan-Lo Lo902] Contryphan family

1 entry

Conus capitaneus (Captain cone)

CO1A_CONCE Omega-conotoxin-like 1 Conotoxin O1 superfamily

1 entry

Conus caracteristicus (Characteristic cone)

COWA_CONCB Contryphan-C Contryphan family

4 entries

Conus catus (Cat cone)

Select_allDeselect_all
CO16A_CONCT Omega-conotoxin CVIA Conotoxin O1 superfamily
CO16D_CONCT Omega-conotoxin CVID (AM-336) (AM336) (CNSB004) (Leconotide) Conotoxin O1 superfamily
CO6B_CONCT Omega-conotoxin CVIB Conotoxin O1 superfamily
CO6C_CONCT Omega-conotoxin CVIC Conotoxin O1 superfamily

2 entries

Conus consors (Singed cone)

Select_allDeselect_all "Conus consors" VenomZone page
CM7E_CONCN Omega-conotoxin-like CnVIIE [Cleaved into: Omega-conotoxin-like ... Conotoxin M superfamily
CO7A_CONCN Omega-conotoxin-like CnVIIH [Cleaved into: Omega-conotoxin ... Conotoxin O1 superfamily

1 entry

Conus delessertii (Sozon's cone) (Conus sozoni)

CO7B_CONDE Conotoxin de7b Not in a family

3 entries

Conus figulinus (Fig cone)

Select_allDeselect_all
COWA_CONFI Contryphan-Fia (Fi1187) Contryphan family
COWB_CONFI Contryphan Fib Contryphan family
COWC_CONFI Contryphan Fic [Cleaved into: Contryphan Fid] Contryphan family

2 entries

Conus geographus (Geography cone) (Nubecula geographus)

Select_allDeselect_all
CO16A_CONGE Omega-conotoxin GVIA (SNX-124) (Shaker peptide) [Cleaved into: ... Conotoxin O1 superfamily
CO7AB_CONGE Omega-conotoxins GVIIA/GVIIB (SNX-178) (Shaker peptides ... Not in a family

2 entries

Conus imperialis (Imperial cone)

Select_allDeselect_all
CO12_CONIM Omega-conotoxin-like 2/7 Conotoxin O1 superfamily
CO13_CONIM Omega-conotoxin-like 3 Conotoxin O1 superfamily

1 entry

Conus inscriptus (Engraved cone)

COW_CONIN Contryphan-In (In936) [Cleaved into: Contryphan-In In880] Contryphan family

1 entry

Conus leopardus (Leopard cone)

COWA_CONLE Contryphan-Le Contryphan family

4 entries

Conus magus (Magus cone) (Magician's cone snail)

Select_allDeselect_all
CO17A_CONMA Omega-conotoxin MVIIA (SNX-111) (Ziconotide) Conotoxin O1 superfamily
CO7B_CONMA Omega-conotoxin MVIIB (SNX-159) Conotoxin O1 superfamily
CO7C_CONMA Omega-conotoxin MVIIC (SNX-230) (Fragment) Conotoxin O1 superfamily
CO7D_CONMA Omega-conotoxin MVIID (SNX-238) (Fragment) Conotoxin O1 superfamily

2 entries

Conus marmoreus (Marble cone)

Select_allDeselect_all
CO167_CONMR Omega-conotoxin-like MaIr137 Conotoxin O1 superfamily
COW_CONMR Glacontryphan-M Contryphan family

2 entries

Conus pennaceus (Feathered cone) (Conus episcopus)

Select_allDeselect_all
CO6A_CONPE Omega-conotoxin PnVIA Conotoxin O1 superfamily
CO6B_CONPE Omega-conotoxin PnVIB Conotoxin O1 superfamily

2 entries

Conus pulicarius (Flea-bite cone)

Select_allDeselect_all
CO12A_CONPL Omega-conotoxin-like PuIIA Conotoxin O1 superfamily
CO16A_CONPL Omega-conotoxin-like PuIA Conotoxin O1 superfamily

1 entry

Conus radiatus (Rayed cone)

CO6A_CONRA Omega-conotoxin RVIA Conotoxin O1 superfamily

1 entry

Conus regularis (Regular cone)

CXQA_CONRG Omega-conotoxin RsXXVIA (RsXXIVA) Not in a family

15 entries

Conus striatus (Striated cone)

Select_allDeselect_all
CO112_CONST Omega-conotoxin-like 12 Conotoxin O1 superfamily
CO115_CONST Omega-conotoxin-like 15 Conotoxin O1 superfamily
CO12_CONST Omega-conotoxin-like 2 Conotoxin O1 superfamily
CO13_CONST Omega-conotoxin SO-3 (SO3) Conotoxin O1 superfamily
CO14_CONST Omega-conotoxin-like SO-4 (Omega-conotoxin SO4) Conotoxin O1 superfamily
CO15_CONST Omega-conotoxin-like SO-5 (Omega-conotoxin SO5) Conotoxin O1 superfamily
CO161_CONST Omega-conotoxin-like SVIA mutant 1 Conotoxin O1 superfamily
CO162_CONST Omega-conotoxin-like SVIA mutant 2 Conotoxin O1 superfamily
CO166_CONST Omega-conotoxin-like S6.6 Conotoxin O1 superfamily
CO16A_CONST Omega-conotoxin SVIA (SNX-157) Conotoxin O1 superfamily
CO16B_CONST Omega-conotoxin SVIB (SNX-183) Conotoxin O1 superfamily
CO16_CONST Omega-conotoxin-like 6 Conotoxin O1 superfamily
CO19_CONST Omega-conotoxin-like 9 Conotoxin O1 superfamily
CO67_CONST Omega-conotoxin-like S6.7 (Fragment) Conotoxin O1 superfamily
COW_CONST Contryphan-S (St990) [Cleaved into: Contryphan-S St933] Contryphan family

14 entries

Conus textile (Cloth-of-gold cone)

Select_allDeselect_all "Conus textile" VenomZone page
CO111_CONTE Omega-conotoxin-like TxMKLT1-0211 Conotoxin O1 superfamily
CO12_CONTE Omega-conotoxin-like TxO2 Conotoxin O1 superfamily
CO13_CONTE Omega-conotoxin-like TxO3 Conotoxin O1 superfamily
CO141_CONTE Omega-conotoxin-like TxMKLT1-0141 Conotoxin O1 superfamily
CO142_CONTE Omega-conotoxin-like TxMKLT1-0142 Conotoxin O1 superfamily
CO14_CONTE Omega-conotoxin-like TxO4 (Conotoxin TxMKLT1-0221) Conotoxin O1 superfamily
CO15B_CONTE Omega-conotoxin-like TxO5 (Conotoxin TxMKLT1-012) Conotoxin O1 superfamily
CO15_CONTE Omega-conotoxin-like TxO5 Conotoxin O1 superfamily
CO161_CONTE Omega-conotoxin-like TeA61 Conotoxin O1 superfamily
CO16_CONTE Omega-conotoxin-like TxO6 Conotoxin O1 superfamily
CO1X1_CONTE Omega-conotoxin-like TxO1 Conotoxin O1 superfamily
CO7_CONTE Omega-conotoxin TxVII Conotoxin O1 superfamily
O1631_CONTE Omega-conotoxin-like TxMKLT1-031 Conotoxin O1 superfamily
O164_CONTE Omega-conotoxin-like TxMKLT1-0223 Conotoxin O1 superfamily

1 entry

Conus tulipa (Fish-hunting cone snail) (Tulip cone)

CO6A_CONTU Omega-conotoxin TVIA (SNX-185) Conotoxin O1 superfamily

2 entries

Conus ventricosus (Mediterranean cone)

Select_allDeselect_all "Conus ventricosus" VenomZone page
COVN_CONVE Omega-conotoxin-like Vn2 (Conotoxin Vn2) (Conotoxin-Vn) (Vn6A) Not in a family
O168_CONVE Omega-conotoxin-like VnMKLT1-0111 Conotoxin O1 superfamily

1 entry

Conus zeylanicus (Obese cone) (Puncticulis zeylanicus)

COW_CONZE Contryphan-Ze (Z1187) Contryphan family

1 entry

Coremiocnemis tropix (Australian tarantula spider)

CT1B_CORTR U1-theraphotoxin-Ct1b (U1-TRTX-Ct1b) Huwentoxin-2 family, Juruin ...

9 entries

Ctenus ornatus (Brazilian spider) (Oligoctenus ornatus)

Select_allDeselect_all
TXF22_CTEON U2-ctenitoxin-Co1a (U2-CNTX-Co1a) (Neurotoxin Oc F22) (Fragment) Omega-agatoxin superfamily, Type ...
TXF27_CTEON U17-ctenitoxin-Co1a (U17-CNTX-Co1a) (Neurotoxin Oct F27-10) ... Omega-agatoxin superfamily, Type ...
TXF28_CTEON U4-ctenitoxin-Co1a (U4-CNTX-Co1a) (Neurotoxin Oc M27-11) ... Omega-agatoxin superfamily, Type ...
TXF29_CTEON U3-ctenitoxin-Co1a (U3-CNTX-Co1a) (Neurotoxin Oc F29-9) ... Plectoxin superfamily, Tx3 ...
TXF35_CTEON U6-ctenitoxin-Co1a (U6-CNTX-Co1a) (Neurotoxin Oc F35-5) ... Not in a family
TXF91_CTEON U4-ctenitoxin-Co1b (U4-CNTX-Co1b) (Neurotoxin Oc F29-9-1) ... Omega-agatoxin superfamily, Type ...
TXFU5_CTEON U10-ctenitoxin-Co1a (U10-CNTX-Co1a) (Neurotoxin Oc FU-5) ... Plectoxin superfamily, Tx3 ...
TXM20_CTEON U14-ctenitoxin-Co1a (U14-CNTX-Co1a) (Neurotoxin Oc M20-3) ... Omega-agatoxin superfamily, Type ...
TXM31_CTEON U10-ctenitoxin-Co1b (U10-CNTX-Co1b) (Neurotoxin Oc M31-11) ... Plectoxin superfamily, Tx3 ...

2 entries

Cupiennius salei (American wandering spider)

Select_allDeselect_all
TXC1_CUPSA Omega-ctenitoxin-Cs1a (Omega-CNTX-Cs1a) (Toxin CSTX-1) [Cleaved ... Spider toxin CSTX superfamily
TXC9_CUPSA U1-ctenitoxin-Cs1a (U1-CNTX-Cs1a) (Toxin CSTX-9) [Cleaved into: ... Spider toxin CSTX superfamily

1 entry

Dendroaspis angusticeps (Eastern green mamba) (Naja angusticeps)

3SL2_DENAN Toxin C10S2C2 Snake three-finger toxin family, ...

1 entry

Dendroaspis jamesoni kaimosae (Eastern Jameson's mamba)

3SL8_DENJA Toxin S4C8 Snake three-finger toxin family, ...

2 entries

Dendroaspis polylepis polylepis (Black mamba)

Select_allDeselect_all
3SL2_DENPO Toxin FS-2 (FS2) Snake three-finger toxin family, ...
3SLS_DENPO Calciseptin (Calciseptine) (CaS) (L-type calcium channel ... Snake three-finger toxin family, ...

7 entries

Geolycosa sp. (strain A267TDLS2-KZARNA) (Wolf spider) (Lycosa kazakhstanicus)

Select_allDeselect_all
TLCOA_GEOA2 Omega-lycotoxin-Gsp2671a (Omega-LCTX-Gsp2671a) (Lsp-1) ... Omega-lycotoxin family
TLCOB_GEOA2 Omega-lycotoxin-Gsp2671b (Omega-LCTX-Gsp2671b) ... Omega-lycotoxin family
TLCOC_GEOA2 Omega-lycotoxin-Gsp2671c (Omega-LCTX-Gsp2671c) ... Omega-lycotoxin family
TLCOD_GEOA2 Omega-lycotoxin-Gsp2671d (Omega-LCTX-Gsp2671d) ... Omega-lycotoxin family
TLCOE_GEOA2 Omega-lycotoxin-Gsp2671e (Omega-LCTX-Gsp2671e) ... Omega-lycotoxin family
TLCOF_GEOA2 Omega-lycotoxin-Gsp2671f (Omega-LCTX-Gsp2671f) ... Omega-lycotoxin family
TLCOG_GEOA2 Omega-lycotoxin-Gsp2671g (Omega-LCTX-Gsp2671g) ... Omega-lycotoxin family

1 entry

Gloydius blomhoffii (Mamushi) (Agkistrodon halys blomhoffi)

CRVP_GLOBL Cysteine-rich venom protein ablomin CRISP family

1 entry

Grammostola porteri (Tarantula spider) (Lasiodora porteri)

TX15_GRAPO Toxin GTx1-15 (Beta/omega-theraphotoxin-Gr2a) ... Huwentoxin-1 family, Gtx1-15 ...

4 entries

Grammostola rosea (Chilean rose tarantula) (Grammostola spatulata)

Select_allDeselect_all
AF2_GRARO Kappa-theraphotoxin-Gr2c (Kappa-TRTX-Gr2c) (GsAF II) (GsAFII) ... Phrixotoxin family
TX15_GRARO Toxin GTx1-15 (Beta/omega-theraphotoxin-Gr2a) ... Huwentoxin-1 family, Gtx1-15 ...
TXHN1_GRARO Kappa-theraphotoxin-Gr1a (Kappa-TRTX-Gr1a) (Hanatoxin-1) (HaTx1) Huwentoxin-1 family, HaTx ...
WGRTX_GRARO Omega-theraphotoxin-Gr1a (Omega-TRTX-Gr1a) (Omega-GTX SIA) ... Huwentoxin-1 family, GrTx ...

1 entry

Hadronyche formidabilis (Northern tree funnel-web spider) (Atrax formidabilis)

TO1B_HADFO Omega-hexatoxin-Hf1a (Omega-HXTX-Hf1a) (Omega-atracotoxin-Hf1a) ... Shiva superfamily, Omega toxin ...

9 entries

Hadronyche infensa (Fraser island funnel-web spider) (Atrax infensus)

Select_allDeselect_all
TO1A_HADIN Omega-hexatoxin-Hi1a (Omega-HXTX-Hi1a) (Omega-atracotoxin-Hi1a) ... Shiva superfamily, Omega toxin ...
TO1B_HADIN Omega-hexatoxin-Hi1b (Omega-HXTX-Hi1b) (Omega-atracotoxin-Hi1b) ... Shiva superfamily, Omega toxin ...
TO1C_HADIN Omega-hexatoxin-Hi1c (Omega-HXTX-Hi1c) (Omega-atracotoxin-Hi1c) ... Shiva superfamily, Omega toxin ...
TO1D_HADIN Omega-hexatoxin-Hi1d Shiva superfamily, Omega toxin ...
TO1E_HADIN Omega-hexatoxin-Hi1e Shiva superfamily, Omega toxin ...
TO1F_HADIN Omega-hexatoxin-Hi1f Shiva superfamily, Omega toxin ...
TO1G_HADIN Omega-hexatoxin-Hi1g Shiva superfamily, Omega toxin ...
TOT2A_HADIN Omega-hexatoxin-Hi2a (Omega-HXTX-Hi2a) (Omega-atracotoxin-Hi2a) ... Omega-atracotoxin type 2 family
TOT2B_HADIN Omega-hexatoxin-Hi2b (Omega-HXTX-Hi2b) (Omega-atracotoxin-Hi2b) ... Omega-atracotoxin type 2 family

4 entries

Hadronyche modesta (Victorian funnel-web spider)

Select_allDeselect_all
TO1A_HADMO Omega-hexatoxin-Hmo1a Shiva superfamily, Omega toxin ...
TO1B_HADMO Omega-hexatoxin-Hmo1b Shiva superfamily, Omega toxin ...
TO1C_HADMO Omega-hexatoxin-Hmo1c Shiva superfamily, Omega toxin ...
TO1D_HADMO Omega-hexatoxin-Hmo1d Shiva superfamily, Omega toxin ...

2 entries

Hadronyche venenata (Tasmanian funnel-web spider)

Select_allDeselect_all
TO1A_HADVN Omega-hexatoxin-Hvn1a Shiva superfamily, Omega toxin ...
TO1B_HADVN Omega-hexatoxin-Hvn1b Shiva superfamily, Omega toxin ...

7 entries

Hadronyche versuta (Blue mountains funnel-web spider) (Atrax versutus)

Select_allDeselect_all
TO1A_HADVE Omega-hexatoxin-Hv1a (Omega-HXTX-Hv1a) (Omega-atracotoxin-Hv1a) ... Shiva superfamily, Omega toxin ...
TO1B_HADVE Omega-hexatoxin-Hv1b (Omega-HXTX-Hv1b) (Omega-atracotoxin-Hv1b) ... Shiva superfamily, Omega toxin ...
TO1C_HADVE Omega-hexatoxin-Hv1c (Omega-HXTX-Hv1c) (Omega-atracotoxin-Hv1c) ... Shiva superfamily, Omega toxin ...
TO1D_HADVE Omega-hexatoxin-Hv1d (Omega-HXTX-Hv1d) (Omega-atracotoxin-Hv1d) ... Shiva superfamily, Omega toxin ...
TO1E_HADVE Omega-hexatoxin-Hv1e (Omega-HXTX-Hv1e) (Omega-atracotoxin-Hv1e) ... Shiva superfamily, Omega toxin ...
TO1F_HADVE Omega-hexatoxin-Hv1f (Omega-HXTX-Hv1f) (Omega-atracotoxin-Hv1f) ... Shiva superfamily, Omega toxin ...
TOT2A_HADVE Omega-hexatoxin-Hv2a (Omega-HXTX-Hv2a) (Omega-atracotoxin-Hv2a) ... Omega-atracotoxin type 2 family

5 entries

Haplopelma hainanum (Chinese bird spider) (Selenocosmia hainana)

Select_allDeselect_all
H10A1_HAPHA Hainantoxin-X (HNTX-X) Not in a family
H10A2_HAPHA Hainantoxin-X.2 (HNTX-X.2) Not in a family
H10A3_HAPHA Hainantoxin-X.3 (HNTX-X.3) Not in a family
H10B1_HAPHA Hainantoxin-X-2 (HNTX-X-2) Not in a family
H10C1_HAPHA Hainantoxin-X-3 (HNTX-X-3) Not in a family

3 entries

Haplopelma schmidti (Chinese bird spider) (Ornithoctonus huwenum)

Select_allDeselect_all
TXH10_HAPSC Omega-theraphotoxin-Hs1a (Omega-TRTX-Hs1a) (Huwentoxin-10) ... Not in a family
TXH1_HAPSC Mu/omega-theraphotoxin-Hs1a (Mu/omega-TRTX-Hs1a) (Huwentoxin-1) ... Huwentoxin-1 family, HwTx-I ...
TXH5_HAPSC Omega-theraphotoxin-Hs2a (Omega-TRTX-Hs2a) (Huwentoxin-5) ... Huwentoxin-1 family, Hntx-9 ...

1 entry

Heloderma horridum horridum (Mexican beaded lizard)

CRVP_HELHO Cysteine-rich venom protein helothermine (CRVP HLTx) CRISP family

4 entries

Heteropoda venatoria (Brown huntsman spider) (Aranea venatoria)

Select_allDeselect_all
TX5A_HETVE Omega-sparatoxin-Hv1a (Omega-SPRTX-Hv1a) (Toxin AU5A) Huwentoxin-1 family, AU5A ...
TX5B_HETVE Omega-sparatoxin-Hv1b (Omega-SPRTX-Hv1b) (Toxin AU5B) Huwentoxin-1 family, AU5B ...
TXJ1_HETVE Kappa-sparatoxin-Hv1e (Kappa-SPRTX-Hv1e) (Toxin KJ1) Huwentoxin-1 family, HpTX2 ...
TXU2_HETVE Kappa-sparatoxin-Hv1d (Kappa-SPRTX-Hv1d) (Toxin AU2) Huwentoxin-1 family, HpTX2 ...

1 entry

Hydrophis hardwickii (Hardwick's spine-bellied seasnake) (Lapemis hardwickii)

CRVP2_HYDHA Cysteine-rich venom protein 2 (CRVP) CRISP family

1 entry

Hysterocrates gigas (African tarantula)

TX482_HYSGI Omega-theraphotoxin-Hg1a (Omega-TRTX-Hg1a) (Toxin SNX-482) ... Huwentoxin-1 family, SNX-482 ...

1 entry

Kukulcania hibernalis (Southern house spider) (Filistata hibernalis)

TX13_KUKHI Omega-filistatoxin-Kh1a (Omega-FLTX-Kh1a) (Toxin DW13.3) Not in a family

1 entry

Laticauda semifasciata (Black-banded sea krait) (Pseudolaticauda semifasciata)

CRVP_LATSE Cysteine-rich venom protein latisemin (CRVP) CRISP family

1 entry

Loxosceles intermedia (Brown spider)

"Loxosceles intermedia" VenomZone page
TX4_LOXIN U1-sicaritoxin-Li1c (U1-SCRTX-Li1c) (LiTx4) (Fragment) Litx family

5 entries

Lycosa singoriensis (Wolf spider) (Aranea singoriensis)

Select_allDeselect_all
TX2M1_LYCSI U2-lycotoxin-Ls1a (Toxin-like structure LSTX-M1) Omega-agatoxin superfamily, Type ...
TX2M2_LYCSI U2-lycotoxin-Ls1b (Toxin-like structure LSTX-M2) Omega-agatoxin superfamily, Type ...
TX2M3_LYCSI U2-lycotoxin-Ls1c (Toxin-like structure LSTX-M3) Omega-agatoxin superfamily, Type ...
TX2M4_LYCSI U2-lycotoxin-Ls1d (Toxin-like structure LSTX-M4) Omega-agatoxin superfamily, Type ...
TX2M5_LYCSI U2-lycotoxin-Ls1e (Toxin-like structure LSTX-M5) Omega-agatoxin superfamily, Type ...

1 entry

Missulena bradleyi (Eastern mouse spider)

TOM1A_MISBR Omega-actinopoditoxin-Mb1a (Omega-AOTX-Mb1a) ... Not in a family

1 entry

Naja naja (Indian cobra)

CRVP1_NAJNA Cysteine-rich venom protein (CRVP) (Cysteine-rich secretory ... CRISP family

2 entries

Oxyopes lineatus (Lynx spider)

Select_allDeselect_all
TOX1_OXYLI Omega-oxotoxin-Ol1a (Omega-OXTX-Ol1a) (Oxytoxin-1) (OxyTx1) Not in a family
TOX2_OXYLI Omega-oxotoxin-Ol1b (Omega-OXTX-Ol1b) (Oxytoxin-2) (OxyTx2) Not in a family

1 entry

Oxyopes takobius (Lynx spider) (Oxyopes foliiformis)

TOX1_OXYTA Omega-oxotoxin-Ot1a (Omega-OXTX-Ot1a) (Oxytoxin-1) (OxyTx1) Not in a family

2 entries

Oxyuranus scutellatus scutellatus (Australian taipan) (Coastal taipan)

Select_allDeselect_all
3L2L_OXYSC Taicatoxin, alpha-neurotoxin-like component (TCX, ... Snake three-finger toxin family, ...
VKT_OXYSC Kunitz-type serine protease inhibitor taicotoxin (Taicatoxin, ... Venom Kunitz-type family

2 entries

Parabuthus granulatus (Granulated thick-tailed scorpion)

Select_allDeselect_all
KURT1_PARGR Alpha-toxin PgKL1 (Kurtoxin-like 1) (Kurtoxin-like I) (KLI) Long (4 C-C) scorpion toxin ...
KURT2_PARGR Toxin PgKL2 (Kurtoxin-like 2) (Kurtoxin-like II) (KLII) Long (4 C-C) scorpion toxin ...

1 entry

Parabuthus transvaalicus (South African fattail scorpion)

KURT_PARTR Kurtoxin (Ktx) Long (4 C-C) scorpion toxin ...

1 entry

Paraphysa scrofa (Chilean copper tarantula) (Phrixotrichus auratus)

TX15_PARSR Toxin GTx1-15 (Beta/omega-theraphotoxin-Gr2a) ... Huwentoxin-1 family, Gtx1-15 ...

1 entry

Pelinobius muticus (King baboon spider) (Citharischius crawshayi)

TXO1A_PELMU Omega-theraphotoxin-Cc1a (Omega-TRTX-Cc1a) (Toxin-like GVDKE) ... Huwentoxin-1 family

12 entries

Phoneutria nigriventer (Brazilian armed spider) (Ctenus nigriventer)

Select_allDeselect_all
TOPC5_PHONI U20-ctenitoxin-Pn1a (U20-CNTX-Pn1a) (Omega-phonetoxin PNTx22C5) ... Omega-agatoxin superfamily, Type ...
TX26A_PHONI Neurotoxin PRTx26An0C3 Huwentoxin-1 family, PNTx27C4 ...
TX27_PHONI U17-ctenitoxin-Pn1a (U17-CNTX-Pn1a) (Neurotoxin PNTx27C4) Huwentoxin-1 family, PNTx27C4 ...
TX31_PHONI Kappa-ctenitoxin-Pn1a (Kappa-CNTX-Pn1a) (Neurotoxin Tx3-1) ... Plectoxin superfamily, Tx3 ...
TX32_PHONI Omega-ctenitoxin-Pn1a (Omega-CNTX-Pn1a) (Neurotoxin Tx3-2) ... Plectoxin superfamily, Tx3 ...
TX33A_PHONI U9-ctenitoxin-Pn1a (U9-CNTX-Pn1a) (Neurotoxin Pn3-3A) Plectoxin superfamily, Tx3 ...
TX33_PHONI Omega-ctenitoxin-Pn2a (Omega-CNTX-Pn2a) (Neurotoxin Tx3-3) ... Plectoxin superfamily, Tx3 ...
TX34_PHONI Omega-ctenitoxin-Pn3a (Omega-CNTX-Pn3a) (Neurotoxin Tx3-4) ... Omega-agatoxin superfamily, Type ...
TX35_PHONI U7-ctenitoxin-Pn1a (U7-CNTX-Pn1a) (Neurotoxin Tx3-5) (PnTx3-5) Plectoxin superfamily, Tx3 ...
TX36_PHONI Omega-ctenitoxin-Pn4a (Omega-CNTX-Pn4a) (Neurotoxin Tx3-6) ... Spider toxin Tx3-6 family
TX3A_PHONI U6-ctenitoxin-Pn1a (U6-CNTX-Pn1a) (Neurotoxin Pn3A) Plectoxin superfamily, Tx3 ...
TX3_PHONI U7-ctenitoxin-Pn1b (U7-CNTX-Pn1b) (Neurotoxin Tx3) (Fragment) Plectoxin superfamily, Tx3 ...

4 entries

Phoneutria reidyi (Brazilian Amazonian armed spider) (Ctenus reidyi)

Select_allDeselect_all
TX18_PHORI U1-ctenitoxin-Pr1a (U1-CNTX-Pr1a) (Neurotoxin PRTx18C2) ... Omega-agatoxin superfamily, Type ...
TX23_PHORI Omega-ctenitoxin-Pr2a (Omega-CNTX-Pr2a) (Neurotoxin PRTx23C2) Spider toxin Tx3-6 family
TX27_PHORI U4-ctenitoxin-Pr1a (U4-CNTX-Pr1a) (Neurotoxin PRTx27C3) Huwentoxin-1 family, PNTx27C4 ...
TX37_PHORI Omega-ctenitoxin-Pr1a (Omega-CNTX-Pr1a) (Neurotoxin PRTx17C3) ... Plectoxin superfamily, Tx3 ...

1 entry

Plectreurys tristis (Spider) (Plectreurys bispinosus)

TXPL2_PLETR Omega-plectoxin-Pt1a (Omega-PLTX-Pt1a) (PLTX-II) (Toxin PLTX-2) Not in a family

1 entry

Protobothrops flavoviridis (Habu) (Trimeresurus flavoviridis)

CRVP_PROFL Cysteine-rich venom protein triflin (CRVP) CRISP family

3 entries

Scolopendra mutilans (Chinese red-headed centipede) (Scolopendra subspinipes mutilans)

Select_allDeselect_all
TXO1A_SCOMU Omega-scoloptoxin-Ssm1a (Omega-SLPTX-Ssm1a) Not in a family
TXO2A_SCOMU Omega-scoloptoxin-Ssm2a (Omega-SLPTX-Ssm2a) Not in a family
TXO2B_SCOMU Omega-scoloptoxin-Ssm2b (Omega-SLPTX-Ssm2b) Not in a family

1 entry

Segestria florentina (Tube-web spider) (Segestria gracilis)

TX325_SEGFL Omega-segestritoxin-Sf1a (Omega-SGTX-Sf1a) (Toxin SNX-325) Not in a family

2 entries

Thrixopelma pruriens (Peruvian green velvet tarantula)

Select_allDeselect_all
TXPR1_THRPR Beta/omega-theraphotoxin-Tp1a (Beta/omega-TRTX-Tp1a) ... Huwentoxin-1 family, ProTx-1 ...
TXPR2_THRPR Beta/omega-theraphotoxin-Tp2a (Beta/omega-TRTX-Tp2a) (ProTx-II) ... Phrixotoxin family