Daboia siamensis (Eastern Russel's viper) (taxid:343250)


Venom composition
The venom proteome of Daboia siamensis (collected in Myanmar) was analyzed by 2-D electrophoresis, subsequent MS/MS and enzymatic assays (Risch et al., 2009). The proteome comprises toxins from six protein families: image
Serine proteases, snake venom metalloproteinases, phospholipase A2, L-amino-acid oxidases, vascular endothelial growth factors (PDGF/VEGF growth factor) and C-type lectin-like proteins (also named snaclec). Neither cysteine-rich secretory proteins (CRISPs) nor "free" disintegrins were identified. However, the presence of low molecular mass (less than 10 kDa) disintegrins cannot be excluded because only proteins of more than 10 kDa have been identified (Risch et al., 2009).
Surprisingly, trypsin inhibitors from the Kunitz-type family, have not been reported in this study. However proteins of this family have been sequenced (see proteins by clicking on the "Proteins by Family" tab) and characterized (Guo et al., 2013). In addition, strong trypsin inhibitory activity has been detected in Russel's viper venom from Eastern India (Mukherje et al., 2000).
Clinical Effects, Treatment, Antivenoms See the Clinical Toxinology Resources Website.
Lethal dose Lethal dose is 0.7 mg/kg by intravenous injection into mice (Mukherje et al., 2000).
Taxonomy

UniProt taxonomy
The Reptile database
Wikipedia

Infraorder: Serpentes


Family: Viperidae
Genus: Daboia
Species: siamensis
Activity see
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Reference Risch et al., 2009

Venom protein entries in UniProtKB/Swiss-Prot

(all links/actions below point to uniprot.org website)

38 entries grouped by species

38 entries

Daboia siamensis (Eastern Russel's viper) (Daboia russelii siamensis)

Select_allDeselect_all
IVBL_DABSI BPTI-like protein Not in a family
OXLA_DABSI L-amino-acid oxidase (DRS-LAAO) (LAO) (EC 1.4.3.2) Flavin monoamine oxidase family, ...
PA2A2_DABSI Acidic phospholipase A2 DsM-a2/DsM-a2' (svPLA2) (EC 3.1.1.4) ... Phospholipase A2 family, Group ...
PA2A7_DABSI Acidic phospholipase A2 RV-7 (svPLA2) (EC 3.1.1.4) (F7) ... Phospholipase A2 family, Group ...

pdb 1OQS

PA2AA_DABSI Acidic phospholipase A2 daboiatoxin A chain (DbTx-A) (svPLA2) ... Phospholipase A2 family, Group ...

pdb 2H4C

PA2AB_DABSI Acidic phospholipase A2 daboiatoxin B chain (DbTx-B) (svPLA2) ... Phospholipase A2 family, Group ...

pdb 2H4C

PA2A_DABSI Acidic phospholipase A2 Drs-PLA2 (svPLA2) (EC 3.1.1.4) ... Phospholipase A2 family, Group ...
PA2B1_DABSI Basic phospholipase A2 DsM-b1/DsM-b1' (svPLA2) (EC 3.1.1.4) ... Phospholipase A2 family, Group ...
PA2B4_DABSI Basic phospholipase A2 RV-4 (svPLA2) (EC 3.1.1.4) (F4) ... Phospholipase A2 family, Group ...

pdb 1OQS

PA2BS_DABSI Basic phospholipase A2 DsM-S1 (svPLA2) (EC 3.1.1.4) ... Phospholipase A2 family, Group ...
PA2_DABSI Phospholipase A2 (svPLA2) (EC 3.1.1.4) (Phosphatidylcholine ... Phospholipase A2 family, Group ...
SLA_DABSI Snaclec dabocetin subunit alpha (C-type lectin-like 8) Snaclec family
SLLC1_DABSI Snaclec coagulation factor X-activating enzyme light chain 1 ... Snaclec family

pdb 2E3X

SLLC2_DABSI Snaclec coagulation factor X-activating enzyme light chain 2 ... Snaclec family

pdb 2E3X

TXVE_DABSI Snake venom vascular endothelial growth factor toxin VR-1' ... PDGF/VEGF growth factor family, ...
VKT10_DABSI Kunitz-type serine protease inhibitor C10 (BPTI-10) (Trypsin ... Venom Kunitz-type family
VKT2_DABSI Kunitz-type serine protease inhibitor 2 (RVV-II) (Venom basic ... Venom Kunitz-type family
VKTB1_DABSI Kunitz-type serine protease inhibitor B1 (BBPTI-1) (BPTI-1) ... Venom Kunitz-type family
VKTB2_DABSI Kunitz-type serine protease inhibitor B2 (BPTI-2) (Trypsin ... Venom Kunitz-type family
VKTB3_DABSI Kunitz-type serine protease inhibitor B3 (BPTI-3) (Trypsin ... Venom Kunitz-type family
VKTB4_DABSI Kunitz-type serine protease inhibitor B4 (BPTI-4) (Trypsin ... Venom Kunitz-type family
VKTB5_DABSI Kunitz-type serine protease inhibitor B5 (BBPTI-5) (BPTI-5) ... Venom Kunitz-type family
VKTB6_DABSI Kunitz-type serine protease inhibitor B6 (BPTI-6) (Trypsin ... Venom Kunitz-type family
VKTB7_DABSI Kunitz-type serine protease inhibitor 7 (BPTI-7) (Trypsin ... Venom Kunitz-type family
VKTC1_DABSI Kunitz-type serine protease inhibitor C1 (BPTI-1) (Trypsin ... Venom Kunitz-type family
VKTC2_DABSI Kunitz-type serine protease inhibitor C2 (BPTI-2) (Trypsin ... Venom Kunitz-type family
VKTC3_DABSI Kunitz-type serine protease inhibitor C3 (BPTI-3) (Trypsin ... Venom Kunitz-type family
VKTC4_DABSI Kunitz-type serine protease inhibitor C4 (BPTI-4) (Trypsin ... Venom Kunitz-type family
VKTC5_DABSI Kunitz-type serine protease inhibitor C5 (BPTI-5) (Trypsin ... Venom Kunitz-type family
VKTC6_DABSI Kunitz-type serine protease inhibitor C6 (BPTI-6) (Trypsin ... Venom Kunitz-type family
VKTC8_DABSI Kunitz-type serine protease inhibitor C8 (BPTI-8) (Chymotrypsin ... Venom Kunitz-type family
VKTC9_DABSI Kunitz-type serine protease inhibitor C9 (BPTI-9) (Chymotrypsin ... Venom Kunitz-type family
VM3CX_DABSI Coagulation factor X-activating enzyme heavy chain (EC ... Venom metalloproteinase (M12B) ...

pdb 2E3X

VM3DM_DABSI Zinc metalloproteinase-disintegrin-like daborhagin-M (EC ... Venom metalloproteinase (M12B) ...
VSPAF_DABSI Alpha-fibrinogenase-like (RVAF) (EC 3.4.21.-) (Snake venom ... Peptidase S1 family, Snake venom ...
VSPA_DABSI Factor V activator RVV-V alpha (EC 3.4.21.95) (Russel's viper ... Peptidase S1 family, Snake venom ...
VSPB_DABSI Beta-fibrinogenase-like (RVBF) (EC 3.4.21.-) (Snake venom serine ... Peptidase S1 family, Snake venom ...
VSPG_DABSI Factor V activator RVV-V gamma (EC 3.4.21.95) (Russel's viper ... Peptidase S1 family, Snake venom ...

pdb 3S9A; 3S9B; 3S9C; 3SBK