Pharmacological target of venom proteins

This page gives the list of channel/receptor families that are targeted by venom proteins and an access to these venom proteins. A detailed information on these families is available by clicking on the "channel/receptor family" blue hyperlink, while clicking on the logo image permits to retrieve venom protein(s) of interest in UniProtKB/Swiss-Prot. Dashes indicate that no venom protein has been described yet to target the channel/receptor family.

The column "Channel/Receptor Human" of the table permits an access to human channel/receptor entries of UniProtKB/Swiss-Prot.

Another view of this table is also available in Animal toxin annotation program, Statistics.

See also Venom protein activity
See also Systems targeted by venom proteins
See also Activity Greek symbol descriptors

Channel/receptor families Channel
Receptor
Venom proteins that target channels/receptors
Click on image to retrieve UniProtKB entries
Ion channel (voltage-gated and
ligand-gated)
Human Snake Scorpion Cone
snail
Spider Cnidarian Insect Other All
Voltage-gated sodium (Nav) channel image image image image image image image image image
Voltage-gated potassium (Kv) channel image image image image image image - image image
Calcium-activated potassium (KCa) channel image image image - image - - - image
Inward-rectifier potassium (KIR) channel image - image - - - image - image
Nicotinic acetylcholine receptor (nAChR) image image - image - - - - image
Voltage-gated calcium (Cav) channel image image image image image - image image image
Ryanodine-sensitive calcium-release (RyR) channel image image image - - - - image image
P2X receptor (P2RX) image - - - image - - - image
Voltage-gated chloride (ClC) channel image - image - - - - - image
CFTR channel image image image - - - - - image
Ionotropic GABA receptor image image - - - - - - image
Ionotropic glutamate receptor image - - image image - - - image
HCNa nonspecific cation channel image - - image - - - - image
Cyclic nucleotide-gated channel (CNG) image image - - - - - - image
Transient receptor potential (TRP) channel image - image - image image - image image
Acid-sensing ion channel (ASIC) image image - - image image - - image
5-HT receptor image - - image - - - - image
Ion channel (voltage-gated and
ligand-gated) ALL
image image image image image image image image image
receptor 7TM / G-protein coupled receptor (GPCR) Human Snake Scorpion Cone
snail
Spider Cnidarian Insect Other All
Adrenergic receptor image image image image - - - image image
Bradykinin receptor image image image - image - image image image
Cholecystokinin receptor image - - - - - - image image
Endothelin receptor image image - - - - - - image
Dopamine receptor image image - - - - - - image
GABA-B receptor image - - image - - - - image
Glucagon-like peptide receptor image - - - - - - image image
Melanocortin receptor image - image - image - - - image
Muscarinic acetylcholine receptor image image - - - - - - image
Neurotensin receptor image - - image - - - - image
Opioid receptor image image image - - - - image image
Prokineticin receptor image image - - - - - image image
Pruritogenic receptor MRGPRX1 image - - image - - - - image
Somatostatin receptor image - - image - - - - image
Vasoactive intestinal polypeptide receptor image - - - - - - image image
Vasopressin/oxytocin receptor image image - image - - - - image
receptor 7TM / G-protein coupled receptor (GPCR) ALL image image image image image - image image image
receptor 1TM Human Snake Scorpion Cone
snail
Spider Cnidarian Insect Other All
Epidermal growth factor receptor (EGFR) image - - - - image - - image
Insulin receptor (INSR) image - - image - - - - image
Integrin image image - - - - - - image
Vascular endothelial growth factor receptor (VEGFR) image image - - - - - - image
Transporter Human Snake Scorpion Cone
snail
Spider Cnidarian Insect Other All
Glutamate transporter image - - - image - - - image
Noradrenaline transporter image - - image - - - - image