Pharmacological target of venom proteins
This page gives the list of channel/receptor families that are targeted by venom proteins and an access to these venom proteins. A detailed information on these families is available by clicking on the "channel/receptor family" blue hyperlink, while clicking on the logo 
permits to retrieve venom protein(s) of interest in UniProtKB/Swiss-Prot. Dashes indicate that no venom protein has been described yet to target the channel/receptor family.
The column "Channel/Receptor Human" of the table permits an access to human channel/receptor entries of UniProtKB/Swiss-Prot.
permits to retrieve venom protein(s) of interest in UniProtKB/Swiss-Prot. Dashes indicate that no venom protein has been described yet to target the channel/receptor family.The column "Channel/Receptor Human" of the table permits an access to human channel/receptor entries of UniProtKB/Swiss-Prot.
| See also Venom protein activity | |
| See also Systems targeted by venom proteins | |
| See also Activity Greek symbol descriptors |
| Channel/receptor families | Channel Receptor |
Venom proteins that target channels/receptors Click on to retrieve UniProtKB entries
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|---|---|---|---|---|---|---|---|---|---|
| Ion channel (voltage-gated and ligand-gated) |
Human | Snake | Scorpion | Cone snail |
Spider | Cnidarian | Insect | Other | All |
| Voltage-gated sodium (Nav) channel | |
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|
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| Voltage-gated potassium (Kv) channel | |
|
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| Calcium-activated potassium (KCa) channel | |
|
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|
- | |
|
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| Inward-rectifier potassium (KIR) channel | |
- | |
- | - | - | |
- | |
| Nicotinic acetylcholine receptor (nAChR) | |
|
|
|
- | |
- | - | |
| Voltage-gated calcium (Cav) channel | |
|
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|
- | |
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|
| Ryanodine-sensitive calcium-release (RyR) channel | |
|
|
- | - | - | - | |
|
| P2X receptor (P2RX) | |
- | - | - | |
- | - | - | |
| Voltage-gated chloride (ClC) channel | |
- | |
- | - | - | - | - | |
| CFTR channel | |
|
|
- | - | - | - | - | |
| Ionotropic GABA receptor | |
|
- | - | - | - | - | - | |
| Ionotropic glutamate receptor | |
- | - | |
|
- | - | - | |
| HCNa nonspecific cation channel | |
- | - | |
- | - | - | - | |
| Cyclic nucleotide-gated channel (CNG) | |
|
- | - | - | - | - | - | |
| Transient receptor potential (TRP) channel | |
- | |
- | |
|
- | |
|
| Acid-sensing ion channel (ASIC) | |
|
- | |
|
|
|
- | |
| 5-HT receptor | |
- | |
|
- | - | - | - | |
| Ion channel: ALL | |
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| receptor 7TM / G-protein coupled receptor (GPCR) | Human/Insect | Snake | Scorpion | Cone snail |
Spider | Cnidarian | Insect | Other | All |
| Adipokinetic hormone/corazonin-related peptide (ACP) receptor | |
- | - | - | - | - | |
- | |
| Adrenergic receptor | |
|
|
|
- | - | - | |
|
| Angiotensin II receptor | |
- | - | |
- | - | - | - |
|
| Bradykinin receptor | |
|
|
- | |
- | |
|
|
| Cholecystokinin receptor | |
- | - | - | - | - | - | |
|
| Endothelin receptor | |
|
- | - | - | - | - | - | |
| Dopamine receptor | |
|
- | - | - | - | - | - | |
| GABA-B receptor | |
- | - | |
- | - | - | - | |
| Glucagon-like peptide receptor | |
- | - | - | - | - | - | |
|
| Melanocortin receptor | |
- | |
- | |
- | - | - | |
| Muscarinic acetylcholine receptor | |
|
- | - | - | - | - | - | |
| Neurotensin receptor | |
- | - | |
- | - | - | - | |
| Opioid receptor | |
|
|
- | - | - | - | |
|
| Prokineticin receptor | |
|
- | - | - | - | - | |
|
| Mas-related receptor (MRGPRX1 and MRGPRX2) | |
- | - | |
- | - | |
- |
|
| Somatostatin receptor | |
- | - | |
- | - | - | - | |
| Vasoactive intestinal polypeptide receptor | |
- | - | - | - | - | - | |
|
| Vasopressin/oxytocin receptor | |
|
- | |
- | - | - | - | |
| receptor 7TM / GPCR: ALL | |
|
|
|
|
- | |
|
|
| receptor 1TM | Human | Snake | Scorpion | Cone snail |
Spider | Cnidarian | Insect | Other | All |
| Epidermal growth factor receptor (EGFR) | |
- | - | - | - | |
|
- | |
| Insulin receptor (INSR) | |
- | - | |
- | |
- | - | |
| Integrin | |
|
- | - | - | - | - | - | |
| Natriuretic peptide receptor | |
|
|
- | - | - | - | |
|
| Vascular endothelial growth factor receptor (VEGFR) | |
|
- | - | - | - | - | - | |
| Transporter | Human | Snake | Scorpion | Cone snail |
Spider | Cnidarian | Insect | Other | All |
| GABA transporter | |
- | - | - | - | - | |
- | |
| Noradrenaline transporter | |
- | - | |
- | - | - | - | |