Ophiophagus hannah (king cobra)


Venom composition
Figure 1: Composition of O. hannah venom, studied at proteomic level (Vonk et al., 2013 ). This venom contains the following families: 3FTx (snake three-finger toxin ), SVMP (snake venom metalloproteinase ), CRISP, PA2 (phospholipase A2 ), CVF (cobra venom factor of the venom complement C3 homolog family ), VEGF (PDGF/VEGF growth factor ), LAAO (Flavin monoamine oxidase (L-amino-acid oxidase) ), NP (natriuretic peptide ), PDE (phosphodiesterase), vespryn (ohanin/vespryn ), kallikrein, Kunitz (venom Kunitz-type ). Transcriptome of the venom and accessory glands are also available as pie charts in Fig.1 of Vonk et al., 2013
Clinical Effects, Treatment, Antivenoms See the Clinical Toxinology Resources Website (Postsynaptic neurotoxins)
and the WHO venomous snake database to access snake distribution and antivenom products.
Lethal dose

Venom protein entries in UniProtKB/Swiss-Prot

59 entries grouped by family (browse by taxonomy, browse by keywords)

1 entry

Cathelicidin family

"Cathelicidin family" VenomZone page
CAMP_OPHHA Cathelicidin-related peptide Oh-Cath ... Ophiophagus hannah (King cobra) (Naja hannah)

1 entry

CRISP family

"CRISP family" VenomZone page
CRVP_OPHHA Cysteine-rich venom protein ophanin (CRVP) ... Ophiophagus hannah (King cobra) (Naja hannah)

1 entry

Flavin monoamine oxidase family, FIG1 subfamily

"Flavin monoamine oxidase family" VenomZone page
OXLA_OPHHA L-amino-acid oxidase (LAAO) (LAO) (Oh-LAAO) (EC ... Ophiophagus hannah (King cobra) (Naja hannah)

1 entry

Natriuretic peptide family

"Natriuretic peptide family" VenomZone page
VNP_OPHHA Natriuretic peptide Oh-NP Ophiophagus hannah (King cobra) (Naja hannah)

1 entry

Ohanin/vespryn family

"Ohanin/vespryn family" VenomZone page
VESP_OPHHA Ohanin Ophiophagus hannah (King cobra) (Naja hannah)

1 entry

Peptidase S1 family, Snake venom subfamily

"Peptidase S1 family" VenomZone page
VSP1_OPHHA Alpha- and beta-fibrinogenase OhS1 (EC 3.4.21.-) ... Ophiophagus hannah (King cobra) (Naja hannah)

3 entries

Phospholipase A2 family, Group I subfamily, D49 sub-subfamily

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PA2A1_OPHHA Acidic phospholipase A2 1 (svPLA2) (EC 3.1.1.4) ... Ophiophagus hannah (King cobra) (Naja hannah)
PA2A2_OPHHA Acidic phospholipase A2 2 (svPLA2) (EC 3.1.1.4) ... Ophiophagus hannah (King cobra) (Naja hannah)
PA2A_OPHHA Acidic phospholipase A2 (svPLA2) (EC 3.1.1.4) ... Ophiophagus hannah (King cobra) (Naja hannah)

2 entries

Snaclec family

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SLA_OPHHA Snaclec ophioluxin subunit alpha (Fragment) Ophiophagus hannah (King cobra) (Naja hannah)
SLB_OPHHA Snaclec ophioluxin subunit beta (Fragment) Ophiophagus hannah (King cobra) (Naja hannah)

20 entries

Snake three-finger toxin family, Long-chain subfamily, Type II alpha-neurotoxin sub-subfamily

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3L217_OPHHA Long neurotoxin OH-17 Ophiophagus hannah (King cobra) (Naja hannah)
3L21_OPHHA Long neurotoxin 1 (Neurotoxin A) Ophiophagus hannah (King cobra) (Naja hannah)
3L222_OPHHA Long neurotoxin LNTX22 Ophiophagus hannah (King cobra) (Naja hannah)
3L228_OPHHA Long neurotoxin LNTX28 Ophiophagus hannah (King cobra) (Naja hannah)
3L22A_OPHHA Alpha-elapitoxin-Oh2a (Alpha-EPTX-Oh2a) (Long ... Ophiophagus hannah (King cobra) (Naja hannah)
3L22H_OPHHA Long neurotoxin LNTX-2 homolog Ophiophagus hannah (King cobra) (Naja hannah)
3L22_OPHHA Long neurotoxin 2 (Neurotoxin B) Ophiophagus hannah (King cobra) (Naja hannah)
3L231_OPHHA Long neurotoxin-like OH-31 Ophiophagus hannah (King cobra) (Naja hannah)
3L234_OPHHA Long neurotoxin OH-34 (Fragment) Ophiophagus hannah (King cobra) (Naja hannah)
3L237_OPHHA Long neurotoxin OH-37 Ophiophagus hannah (King cobra) (Naja hannah)
3L23X_OPHHA Long neurotoxin LNTX37 Ophiophagus hannah (King cobra) (Naja hannah)
3L23_OPHHA Long neurotoxin 3 (Neurotoxin CM-9) Ophiophagus hannah (King cobra) (Naja hannah)
3L24_OPHHA Long neurotoxin 4 (Alpha-neurotoxin) Ophiophagus hannah (King cobra) (Naja hannah)
3L255_OPHHA Long neurotoxin OH-55 (CM-11) Ophiophagus hannah (King cobra) (Naja hannah)
3L256_OPHHA Long neurotoxin OH-56 Ophiophagus hannah (King cobra) (Naja hannah)
3L257_OPHHA Long neurotoxin OH-57 Ophiophagus hannah (King cobra) (Naja hannah)
3L25_OPHHA Long neurotoxin OH-5 (Alpha-neurotoxin) Ophiophagus hannah (King cobra) (Naja hannah)
3L26_OPHHA Alpha-elapitoxin-Oh2b (Alpha-EPTX-Oh2b) ... Ophiophagus hannah (King cobra) (Naja hannah)
3L2X1_OPHHA Long neurotoxin LNTX1 Ophiophagus hannah (King cobra) (Naja hannah)
3L2X8_OPHHA Long neurotoxin LNTX8 Ophiophagus hannah (King cobra) (Naja hannah)

2 entries

Snake three-finger toxin family, Non-conventional subfamily, Orphan group II sub-subfamily

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3NO24_OPHHA Weak neurotoxin WNTX34 Ophiophagus hannah (King cobra) (Naja hannah)
3NO2_OPHHA Weak neurotoxin OH-72 (Fragment) Ophiophagus hannah (King cobra) (Naja hannah)

10 entries

Snake three-finger toxin family, Short-chain subfamily

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3SX1_OPHHA Neurotoxin Oh9-1 (OMEGA-neurotoxin Oh9-1) Ophiophagus hannah (King cobra) (Naja hannah)
3SX2_OPHHA Short neurotoxin OH-32 Ophiophagus hannah (King cobra) (Naja hannah)
3SX3_OPHHA Weak neurotoxin WNTX33 Ophiophagus hannah (King cobra) (Naja hannah)
3SX5_OPHHA Short neurotoxin OH-5 Ophiophagus hannah (King cobra) (Naja hannah)
3SX6_OPHHA Short neurotoxin SNTX6 Ophiophagus hannah (King cobra) (Naja hannah)
3SX7_OPHHA Short neurotoxin OH-46 Ophiophagus hannah (King cobra) (Naja hannah)
3SXB_OPHHA Short neurotoxin SNTX11 Ophiophagus hannah (King cobra) (Naja hannah)
3SXE_OPHHA Short neurotoxin SNTX14 Ophiophagus hannah (King cobra) (Naja hannah)
3SXQ_OPHHA Short neurotoxin SNTX26 Ophiophagus hannah (King cobra) (Naja hannah)
3SXZ_OPHHA Short neurotoxin OH-26 Ophiophagus hannah (King cobra) (Naja hannah)

3 entries

Snake three-finger toxin family, Short-chain subfamily, Aminergic toxin sub-subfamily

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3SI35_OPHHA Short neurotoxin OH-35 Ophiophagus hannah (King cobra) (Naja hannah)
3SIM6_OPHHA Muscarinic toxin MTX6 Ophiophagus hannah (King cobra) (Naja hannah)
3SIM8_OPHHA Muscarinic toxin 38 (MTX38) Ophiophagus hannah (King cobra) (Naja hannah)

6 entries

Snake three-finger toxin family, Short-chain subfamily, Beta-cardiotoxin sub-subfamily

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3SDC1_OPHHA Beta-cardiotoxin CTX21 Ophiophagus hannah (King cobra) (Naja hannah)
3SDC3_OPHHA Beta-cardiotoxin CTX23 Ophiophagus hannah (King cobra) (Naja hannah)
3SDC4_OPHHA Beta-cardiotoxin CTX14 Ophiophagus hannah (King cobra) (Naja hannah)
3SDC5_OPHHA Beta-cardiotoxin CTX15 (OH-84) Ophiophagus hannah (King cobra) (Naja hannah)
3SDC7_OPHHA Beta-cardiotoxin CTX27 (OH-27) Ophiophagus hannah (King cobra) (Naja hannah)
3SDC9_OPHHA Beta-cardiotoxin CTX9 Ophiophagus hannah (King cobra) (Naja hannah)

1 entry

Snake three-finger toxin family, Short-chain subfamily, Orphan group VIII (haditoxin) sub-subfamily

"Snake three-finger toxin family" VenomZone page
3SO8_OPHHA Haditoxin (Muscarinic toxin-like protein 3 ... Ophiophagus hannah (King cobra) (Naja hannah)

2 entries

Snake three-finger toxin family, Short-chain subfamily, Type I alpha-neurotoxin sub-subfamily

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3S11A_OPHHA Weak toxin DE-1 Ophiophagus hannah (King cobra) (Naja hannah)
3S11H_OPHHA Weak toxin DE-1 homolog 1 (WTX DE-1 homolog 1) Ophiophagus hannah (King cobra) (Naja hannah)

1 entry

Venom complement C3 homolog family

"Venom complement C3 homolog family" VenomZone page
VCO3_OPHHA Ophiophagus venom factor (OVF) (CVF-like) ... Ophiophagus hannah (King cobra) (Naja hannah)

2 entries

Venom Kunitz-type family

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VKTCI_OPHHA Kunitz-type serine protease inhibitor (Oh11-1) ... Ophiophagus hannah (King cobra) (Naja hannah)
VKTCT_OPHHA Kunitz-type serine protease inhibitor TCI ... Ophiophagus hannah (King cobra) (Naja hannah)

1 entry

Venom metalloproteinase (M12B) family, P-III subfamily, P-IIIa sub-subfamily

"Venom metalloproteinase (M12B) family" VenomZone page
VM3_OPHHA Zinc metalloproteinase-disintegrin-like ohanin ... Ophiophagus hannah (King cobra) (Naja hannah)