Ophiophagus hannah (king cobra) (taxid:8665)

Venom composition

Figure 1: Composition of O. hannah venom, studied at proteomic level (Vonk et al., 2013). This venom contains the following families: 3FTx (snake three-finger toxin), SVMP (snake venom metalloproteinase), CRISP, PA2 (phospholipase A2), CVF (cobra venom factor of the venom complement C3 homolog family), VEGF (PDGF/VEGF growth factor), LAAO (Flavin monoamine oxidase (L-amino-acid oxidase) ), NP (natriuretic peptide), PDE (phosphodiesterase), vespryn (ohanin/vespryn), kallikrein, Kunitz (venom Kunitz-type). Transcriptome of the venom and accessory glands are also available as pie charts in Fig.1 of Vonk et al., 2013.

Clinical Effects, Treatment, Antivenoms See the Clinical Toxinology Resources Website (Postsynaptic neurotoxins).

Venom protein entries in UniProtKB/Swiss-Prot

(all links/actions below point to uniprot.org website)

59 entries grouped by family

reorder by species

1 entry

Cathelicidin family

1 entry

CRISP family

1 entry

Flavin monoamine oxidase family, FIG1 subfamily

1 entry

Natriuretic peptide family

1 entry

Ohanin/vespryn family

1 entry

Peptidase S1 family, Snake venom subfamily

3 entries

Phospholipase A2 family, Group I subfamily, D49 sub-subfamily

"Phospholipase A2 family" VenomZone page

PA2A1_OPHHA Acidic phospholipase A2 1 (svPLA2) (EC 3.1.1.4) ... Ophiophagus hannah (King cobra) (Naja hannah)

pdb 1GP7

PA2A2_OPHHA Acidic phospholipase A2 2 (svPLA2) (EC 3.1.1.4) ... Ophiophagus hannah (King cobra) (Naja hannah)

pdb 1M8T

PA2A_OPHHA Acidic phospholipase A2 (svPLA2) (EC 3.1.1.4) ... Ophiophagus hannah (King cobra) (Naja hannah)

2 entries

Snaclec family

"Snaclec family" VenomZone page

SLA_OPHHA Snaclec ophioluxin subunit alpha Ophiophagus hannah (King cobra) (Naja hannah)

SLB_OPHHA Snaclec ophioluxin subunit beta Ophiophagus hannah (King cobra) (Naja hannah)

2 entries

Snake three-finger toxin family, Ancestral subfamily, Orphan group II sub-subfamily

"Snake three-finger toxin family" VenomZone page

3NO24_OPHHA Weak neurotoxin WNTX34 Ophiophagus hannah (King cobra) (Naja hannah)

3NO2_OPHHA Weak neurotoxin OH-72 Ophiophagus hannah (King cobra) (Naja hannah)

20 entries

Snake three-finger toxin family, Long-chain subfamily, Type II alpha-neurotoxin sub-subfamily

"Snake three-finger toxin family" VenomZone page

3L217_OPHHA Long neurotoxin OH-17 Ophiophagus hannah (King cobra) (Naja hannah)

3L21_OPHHA Long neurotoxin 1 (Neurotoxin A) Ophiophagus hannah (King cobra) (Naja hannah)

3L222_OPHHA Long neurotoxin LNTX22 Ophiophagus hannah (King cobra) (Naja hannah)

3L228_OPHHA Long neurotoxin LNTX28 Ophiophagus hannah (King cobra) (Naja hannah)

3L22A_OPHHA Alpha-elapitoxin-Oh2a (Alpha-EPTX-Oh2a) (Long ... Ophiophagus hannah (King cobra) (Naja hannah)

3L22H_OPHHA Long neurotoxin LNTX-2 homolog Ophiophagus hannah (King cobra) (Naja hannah)

3L22_OPHHA Long neurotoxin 2 (Neurotoxin B) Ophiophagus hannah (King cobra) (Naja hannah)

pdb 1TXA; 1TXB; 8SXP

3L231_OPHHA Long neurotoxin-like OH-31 Ophiophagus hannah (King cobra) (Naja hannah)

3L234_OPHHA Long neurotoxin OH-34 Ophiophagus hannah (King cobra) (Naja hannah)

3L237_OPHHA Long neurotoxin OH-37 Ophiophagus hannah (King cobra) (Naja hannah)

3L23X_OPHHA Long neurotoxin LNTX37 Ophiophagus hannah (King cobra) (Naja hannah)

3L23_OPHHA Long neurotoxin 3 (Neurotoxin CM-9) Ophiophagus hannah (King cobra) (Naja hannah)

3L24_OPHHA Long neurotoxin 4 (Alpha-neurotoxin) Ophiophagus hannah (King cobra) (Naja hannah)

3L255_OPHHA Alpha-elapitoxin-Oh3a (CM-11) (Long neurotoxin ... Ophiophagus hannah (King cobra) (Naja hannah)

pdb 7ULQ

3L256_OPHHA Long neurotoxin OH-56 Ophiophagus hannah (King cobra) (Naja hannah)

3L257_OPHHA Long neurotoxin OH-57 Ophiophagus hannah (King cobra) (Naja hannah)

3L25_OPHHA Long neurotoxin OH-5 (Alpha-neurotoxin) Ophiophagus hannah (King cobra) (Naja hannah)

3L26_OPHHA Alpha-elapitoxin-Oh2b (Alpha-EPTX-Oh2b) ... Ophiophagus hannah (King cobra) (Naja hannah)

3L2X1_OPHHA Long neurotoxin LNTX1 Ophiophagus hannah (King cobra) (Naja hannah)

3L2X8_OPHHA Long neurotoxin LNTX8 Ophiophagus hannah (King cobra) (Naja hannah)

10 entries

Snake three-finger toxin family, Short-chain subfamily

"Snake three-finger toxin family" VenomZone page

3SX1_OPHHA Neurotoxin Oh9-1 (OMEGA-neurotoxin Oh9-1) ... Ophiophagus hannah (King cobra) (Naja hannah)

3SX2_OPHHA Short neurotoxin OH-32 (Three-finger toxin) ... Ophiophagus hannah (King cobra) (Naja hannah)

3SX3_OPHHA Weak neurotoxin WNTX33 (Three-finger toxin) ... Ophiophagus hannah (King cobra) (Naja hannah)

3SX5_OPHHA Short neurotoxin OH-5 (Three-finger toxin) ... Ophiophagus hannah (King cobra) (Naja hannah)

3SX6_OPHHA Short neurotoxin SNTX6 (Three-finger toxin) ... Ophiophagus hannah (King cobra) (Naja hannah)

3SX7_OPHHA Short neurotoxin OH-46 (Three-finger toxin) ... Ophiophagus hannah (King cobra) (Naja hannah)

3SXB_OPHHA Short neurotoxin SNTX11 (Three-finger toxin) ... Ophiophagus hannah (King cobra) (Naja hannah)

3SXE_OPHHA Short neurotoxin SNTX14 (Three-finger toxin) ... Ophiophagus hannah (King cobra) (Naja hannah)

3SXQ_OPHHA Short neurotoxin SNTX26 (Three-finger toxin) ... Ophiophagus hannah (King cobra) (Naja hannah)

3SXZ_OPHHA Short neurotoxin OH-26 (Three-finger toxin) ... Ophiophagus hannah (King cobra) (Naja hannah)

9 entries

Snake three-finger toxin family, Short-chain subfamily, Aminergic toxin sub-subfamily

"Snake three-finger toxin family" VenomZone page

3SDC1_OPHHA Beta-cardiotoxin CTX21 Ophiophagus hannah (King cobra) (Naja hannah)

3SDC3_OPHHA Beta-cardiotoxin CTX23 Ophiophagus hannah (King cobra) (Naja hannah)

3SDC4_OPHHA Beta-cardiotoxin CTX14 Ophiophagus hannah (King cobra) (Naja hannah)

3SDC5_OPHHA Beta-cardiotoxin CTX15 (OH-84) Ophiophagus hannah (King cobra) (Naja hannah)

3SDC7_OPHHA Beta-cardiotoxin CTX27 (OH-27) Ophiophagus hannah (King cobra) (Naja hannah)

pdb 3PLC

3SDC9_OPHHA Beta-cardiotoxin CTX9 Ophiophagus hannah (King cobra) (Naja hannah)

3SI35_OPHHA Short neurotoxin OH-35 Ophiophagus hannah (King cobra) (Naja hannah)

3SIM6_OPHHA Muscarinic toxin MTX6 Ophiophagus hannah (King cobra) (Naja hannah)

3SIM8_OPHHA Muscarinic toxin 38 (MTX38) Ophiophagus hannah (King cobra) (Naja hannah)

1 entry

Snake three-finger toxin family, Short-chain subfamily, Orphan group VIII (haditoxin) sub-subfamily

"Snake three-finger toxin family" VenomZone page

3SO8_OPHHA Haditoxin (Muscarinic toxin-like protein 3 ... Ophiophagus hannah (King cobra) (Naja hannah)

pdb 3HH7

2 entries

Snake three-finger toxin family, Short-chain subfamily, Type I alpha-neurotoxin sub-subfamily

"Snake three-finger toxin family" VenomZone page

3S11A_OPHHA Weak toxin DE-1 Ophiophagus hannah (King cobra) (Naja hannah)

3S11H_OPHHA Weak toxin DE-1 homolog 1 (WTX DE-1 homolog 1) Ophiophagus hannah (King cobra) (Naja hannah)

pdb 5XWE

1 entry

Venom complement C3 homolog family

2 entries

Venom Kunitz-type family

"Venom Kunitz-type family" VenomZone page

VKTCI_OPHHA Kunitz-type serine protease inhibitor (Oh11-1) ... Ophiophagus hannah (King cobra) (Naja hannah)

VKTCT_OPHHA Kunitz-type serine protease inhibitor TCI ... Ophiophagus hannah (King cobra) (Naja hannah)

1 entry

Venom metalloproteinase (M12B) family, P-III subfamily, P-IIIa sub-subfamily

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Infraorder:	Serpentes

Family:	Elapidae
Genus:	Ophiophagus
Species:	hannah