Voltage-gated chloride channel impairing toxin

Channel
Voltage-gated chloride channels (ClC) are found from bacteria to man, and represent a unique family of ion channel proteins not related in sequence or structure to any of the other known families. Nine isoforms of ClC channels in humans are involved in various physiological functions. They are expressed either in the plasma membrane or in the membranes of intracellular organelles. In the plasma membrane, certain ClC channels control the resting potential in muscle and some neurons. Others are involved in the reabsorption of NaCl from the kidney into the bloodstream.

3D-structure view (2PFI ) of the chloride channel protein ClC-Ka.

The ClC channels are homodimeric proteins with an overall rhombus-like shape. Each ClC channel has two pores each contained within a single subunit. The ClC subunit consists of two roughly repeated halves that span the membrane with opposite orientations. This antiparallel architecture defines a chloride selectivity filter within the 15-angstrom neck of an hourglass-shaped pore. Three Cl- binding sites within the selectivity filter stabilize ions by interactions with α-helix dipoles and by chemical interactions with nitrogen atoms and hydroxyl groups of residues in the protein (Dutzler, 2004 and references therein).
Toxin
Channel
Receptor
Toxins from different taxa that target channels/receptors.
Click on to retrieve toxins of interest.
Human Snake Scorpion Cone
snail
Spider Cnidarian Insect Other All
Voltage-gated chloride channel CLCN1 - - - - - - - -
Voltage-gated chloride channel CLCN2 - - - - - -
Voltage-gated chloride channel CLCN3 - - - - - -
Voltage-gated chloride channel CLCN4 - - - - - - - -
Voltage-gated chloride channel CLCN5 - - - - - - - -
Voltage-gated chloride channel CLCN6 - - - - - - - -
Voltage-gated chloride channel CLCN7 - - - - - - - -
Voltage-gated chloride channel CLCNKA - - - - - - - -
Voltage-gated chloride channel CLCNKB - - - - - - - -
Voltage-gated chloride channel All - - - - - -

Venom protein entries in UniProtKB/Swiss-Prot

18 entries grouped by family (browse by taxonomy, browse by keywords)

17 entries

Short scorpion toxin superfamily, Chloride channel inhibitor family

Select_allDeselect_all
CTX5A_MESEU Insectotoxin-I5A (BeIT5A) Mesobuthus eupeus (Lesser Asian scorpion) ...
CTXI1_MESEU Insectotoxin-I1 Mesobuthus eupeus (Lesser Asian scorpion) ...
CTXI3_MESEU Insectotoxin-I3 (BeI3) Mesobuthus eupeus (Lesser Asian scorpion) ...
CTXI4_MESEU Insectotoxin-I4 (BeI4) Mesobuthus eupeus (Lesser Asian scorpion) ...
CTXI5_MESEU Insectotoxin-I5 (BeI5) Mesobuthus eupeus (Lesser Asian scorpion) ...
CTXL1_HOTTS Small toxin (Chlorotoxin-like peptide Bs 8) ... Hottentotta tamulus sindicus (Scorpion) (Buthus ...
CTXL1_LEIHE Toxin GaTx1 Leiurus hebraeus (Deathstalker scorpion) ...
CTXL1_PARSC Toxin PBITx1 (sITx10) Parabuthus schlechteri (Scorpion)
CTXL3_HOTTA Neurotoxin BtITx3 (Neurotoxin BTChl1) Hottentotta tamulus (Eastern Indian scorpion) ...
CTXL8_LEIHE Probable toxin Lqh 8/6 Leiurus hebraeus (Deathstalker scorpion) ...
CTXLB_MESMA Neurotoxin Bm12-b Mesobuthus martensii (Manchurian scorpion) ...
CTXL_ANDAU Chlorotoxin-like peptide (AaCtx) Androctonus australis (Sahara scorpion)
CTXL_ANDMA Neurotoxin P2 (AmmP2) Androctonus mauritanicus mauritanicus (Scorpion)
CTXL_HOTTA Lepidopteran-selective toxin (BTChl2) (ButaIT) Hottentotta tamulus (Eastern Indian scorpion) ...
CTXL_HOTTS Chlorotoxin-like peptide Bs 14 (Bs14) Hottentotta tamulus sindicus (Scorpion) (Buthus ...
CTXL_LEIQU Chlorotoxin (CTX) (ClTx) (Tozuleristide) Leiurus quinquestriatus quinquestriatus ...
CTXL_MESMA Neurotoxin BmK CT (BmKCT) (Bm-12) (BmKCL1) (CT ... Mesobuthus martensii (Manchurian scorpion) ...

1 entry

Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 08 subfamily

KAX83_LEIHE Potassium channel toxin alpha-KTx 8.3 (Gating ... Leiurus hebraeus (Deathstalker scorpion) ...