Voltage-gated chloride channel impairing toxin ~ VenomZone

Channel

Voltage-gated chloride channels (ClC) are found from bacteria to man, and represent a unique family of ion channel proteins not related in sequence or structure to any of the other known families. Nine isoforms of ClC channels in humans are involved in various physiological functions. They are expressed either in the plasma membrane or in the membranes of intracellular organelles. In the plasma membrane, certain ClC channels control the resting potential in muscle and some neurons. Others are involved in the reabsorption of NaCl from the kidney into the bloodstream.

3D-structure view (2PFI) of the chloride channel protein ClC-Ka.

The ClC channels are homodimeric proteins with an overall rhombus-like shape. Each ClC channel has two pores each contained within a single subunit. The ClC subunit consists of two roughly repeated halves that span the membrane with opposite orientations. This antiparallel architecture defines a chloride selectivity filter within the 15-angstrom neck of an hourglass-shaped pore. Three Cl- binding sites within the selectivity filter stabilize ions by interactions with α-helix dipoles and by chemical interactions with nitrogen atoms and hydroxyl groups of residues in the protein (Dutzler, 2004 and references therein).

Toxin

	Channel Receptor	Toxins from different taxa that target channels/receptors. Click on to retrieve toxins of interest.
	Human	Snake	Scorpion	Cone snail	Spider	Cnidarian	Insect	Other	All
Voltage-gated chloride channel CLCN1		-	-	-	-	-	-	-	-
Voltage-gated chloride channel CLCN2		-		-	-	-	-	-
Voltage-gated chloride channel CLCN3		-		-	-	-	-	-
Voltage-gated chloride channel CLCN4		-	-	-	-	-	-	-	-
Voltage-gated chloride channel CLCN5		-	-	-	-	-	-	-	-
Voltage-gated chloride channel CLCN6		-	-	-	-	-	-	-	-
Voltage-gated chloride channel CLCN7		-	-	-	-	-	-	-	-
Voltage-gated chloride channel CLCNKA		-	-	-	-	-	-	-	-
Voltage-gated chloride channel CLCNKB		-	-	-	-	-	-	-	-
Voltage-gated chloride channel All		-		-	-	-	-	-

Voltage-gated chloride channel impairing toxin

Venom protein entries in UniProtKB/Swiss-Prot

Short scorpion toxin superfamily, Chloride channel inhibitor family

Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 08 subfamily