Ionotropic glutamate receptor inhibitor

Receptor Ionotropic glutamate receptors are glutamate-gated nonselective cation channels that allow the flow of potassium, sodium and sometimes calcium ions in response to glutamate binding. Upon binding, the agonist stimulates direct action of the central pore of the receptor, an ion channel, allowing ion flow and causing excitatory postsynaptic current (EPSC). This current is depolarizing and, if enough glutamate receptors are activated, may trigger an action potential in the postsynaptic neuron. All the receptors produce excitatory postsynaptic current, but the speed and duration of the current is different for each type.
Based on both molecular and pharmacological criteria ionotropic glutamate receptors have been divided into two major classes, the non-NMDA-class, which includes both AMPA and kainate subtypes of receptors, and the NMDA -class. (Dingledine et al., 1999, Traynelis et al., 2010 ).
Toxin
Receptor Toxins from different taxa that target receptors.
Click on to retrieve toxins of interest.
Human Snake Scorpion Cone
snail
Spider Cnidarian Insect Other All
AMPA receptor
GRIA1 - - - - - -
GRIA2 - - - - - -
GRIA3 - - - - - -
GRIA4 - - - - - -
GRID1 - - - - - - - -
GRID2 - - - - - - - -
kainate receptor
GRIK1 - - - - - - - -
GRIK2 - - - - - - - -
GRIK3 - - - - - - - -
GRIK4 - - - - - - - -
GRIK5 - - - - - - - -
NMDA receptor
GRIN1 - - - - - -
GRIN2A - - - - - -
GRIN2B - - - - - -
GRIN2C - - - - - -
GRIN2D - - - - - -
GRIN3A - - - - - - - -
GRIN3B - - - - - -
Glutamate receptor All - - - - -

Venom protein entries in UniProtKB/Swiss-Prot

30 entries grouped by family (browse by taxonomy, browse by keywords)

13 entries

Conotoxin B superfamily

Select_allDeselect_all
CKBR_CONSL Conantokin-Br (Con-Br) (ConBr) (Conantoxin-S1) ... Conus sulcatus (Sulcate cone)
CKE_CONER Conantokin-E (Con-E) (Fragment) Conus ermineus (Atlantic fish-hunting cone)
CKG_CONGE Conantokin-G (Con-G) (CGX-1007) (Conotoxin GV) ... Conus geographus (Geography cone) (Nubecula ...
CKL_CONLY Conantokin-L (Con-L) Conus lynceus (Lynceus cone)
CKP1_CONPI Conantokin-Pr1 (Con-Pr1) Conus parius (Cone snail)
CKP2_CONPI Conantokin-Pr2 (Con-Pr2) Conus parius (Cone snail)
CKP3_CONPI Conantokin-Pr3 (Con-Pr3) Conus parius (Cone snail)
CKP_CONPU Conantokin-P (Con-P) Conus purpurascens (Purple cone)
CKR1A_CONRO Conantokin R1-A (Con R1-A) (ConRl-A) Conus rolani (Cone snail)
CKR1B_CONRO Conantokin Rl-B (Con Rl-B) (ConRl-B) (Fragment) Conus rolani (Cone snail)
CKR1C_CONRO Conantokin Rl-C (Con Rl-C) (ConRl-C) (Fragment) Conus rolani (Cone snail)
CKR_CONRA Conantokin-R (Con-R) Conus radiatus (Rayed cone)
CKT_CONTU Conantokin-T (Con-T) Conus tulipa (Fish-hunting cone snail) (Tulip ...

1 entry

Conotoxin M superfamily, Conopeptide Y family

CPY1_CONPO Conopeptide Y-Pl1 (CPY-Pl1) Conus planorbis (Planorbis cone)

11 entries

Neurotoxin 03 (Tx2) family, 05 subfamily

Select_allDeselect_all
TX35A_CTEON U13-ctenitoxin-Co1a (U13-CNTX-Co1a) (Neurotoxin ... Ctenus ornatus (Brazilian spider) (Oligoctenus ...
TX35A_PHOKE U2-ctenitoxin-Pk1a (U2-CNTX-Pk1a) (Neurotoxin ... Phoneutria keyserlingi (Brazilian wandering ...
TX35A_PHONI U1-ctenitoxin-Pn1a (U1-CNTX-Pn1a) (Toxin Pn4B) Phoneutria nigriventer (Brazilian armed spider) ...
TX35A_PHORI Beta/delta-ctenitoxin-Pr1a ... Phoneutria reidyi (Brazilian Amazonian armed ...
TX35B_CTEON U9-ctenitoxin-Co1a (U9-CNTX-Co1a) (Neurotoxin Oc ... Ctenus ornatus (Brazilian spider) (Oligoctenus ...
TX35B_PHONI Delta-ctenitoxin-Pn1b (Delta-CNTX-Pn1b) ... Phoneutria nigriventer (Brazilian armed spider) ...
TX35C_CTEON U15-ctenitoxin-Co1a (U15-CNTX-Co1a) (Neurotoxin ... Ctenus ornatus (Brazilian spider) (Oligoctenus ...
TX35C_PHONI GAMMA-ctenitoxin-Pn1a (GAMMA-CNTX-Pn1a) ... Phoneutria nigriventer (Brazilian armed spider) ...
TX35D_CTEON U1-ctenitoxin-Co1a (U1-CNTX-Co1a) (Neurotoxin Oc ... Ctenus ornatus (Brazilian spider) (Oligoctenus ...
TX35D_PHONI Delta-ctenitoxin-Pn1a (Delta-CNTX-Pn1a) ... Phoneutria nigriventer (Brazilian armed spider) ...
TX35E_CTEON U12-ctenitoxin-Co1a (U12-CNTX-Co1a) (Neurotoxin ... Ctenus ornatus (Brazilian spider) (Oligoctenus ...

5 entries

Not in a family

Select_allDeselect_all
CKC_CONCB Conantokin-Ca2 (Con-Ca2) Conus caracteristicus (Characteristic cone)
CKG_CONGL Conantokin-Gm (Con-Gm) Conus gloriamaris (Glory-of-the-Seas cone)
CKO_CONOH Conantokin-Oc (Con-Oc) Conus ochroleucus (Perfect cone) (Graphiconus ...
CKQ_CONQU Conantokin-Qu (Con-Qu) Conus quercinus (Oak cone)
CONII_CONST Con-ikot-ikot Conus striatus (Striated cone)