Glycosyl hydrolase 56 family
(Hyaluronidase) (Venom spreading factor)
Hyaluronidase catalyzes the hydrolysis of hyaluronic acid (HA), an anionic, non-sulfated glycosaminoglycan distributed widely throughout connective, epithelial and neural tissues, forming part of the extracellular matrix.
, glycosaminoglycan hydrolysis by hyaluronidases is thought to participate in the degradation of the extracellular matrix, thus allowing a rapid spreading of other venom components during the envenomation process.
Degradation of the extracellular matrix
This protein family in
Harrison et al, 2007
Bordon et al, 2012
SIB Swiss Institute of Bioinformatics