Hypotensive agent (Antihypertensive agents)

A hypotensive agent is a molecule which causes hypotension by lowering blood pressure or causing a sudden drop in blood pressure.

Venom proteins from different families act as hypotensive agents, either by direct or indirect mechanisms. For example, natriuretic peptides modulate body fluid volume by provoking vasodilation, natriuresis and diuresis through binding to the membrane-bound receptors NPR1-NPR3, bradykinin-potentiating peptides potentiate the hypotensive cardiovascular response to bradykinin, while some serine proteases release bradykinin from kininogen.

See also UniProtKB-keyword

Venom protein entries in UniProtKB/Swiss-Prot

159 entries grouped by family (browse by taxonomy, browse by keywords)

56 entries

Bradykinin-potentiating peptide family

Select_allDeselect_all "Bradykinin-potentiating peptide family" VenomZone page
BNP_BOTJR Bradykinin-potentiating and C-type natriuretic ... Bothrops jararacussu (Jararacussu)
BP11A_CROAD Bradykinin-potentiating peptide 11a (BPP-11a) Crotalus adamanteus (Eastern diamondback ...
BP11A_CROVV Bradykinin-potentiating peptide 11a (BPP-11a) Crotalus viridis viridis (Prairie rattlesnake)
BP11B_CROAD Bradykinin-potentiating peptide 11b (BPP-11b) Crotalus adamanteus (Eastern diamondback ...
BP11B_CROVV Bradykinin-potentiating peptide 11b (BPP-11b) Crotalus viridis viridis (Prairie rattlesnake)
BP11C_CROVV Bradykinin-potentiating peptide 11c (BPP-11c) Crotalus viridis viridis (Prairie rattlesnake)
BPP11_BOTAL Bradykinin-potentiating peptide 11 (BPP-11) Bothrops alternatus (Urutu) (Rhinocerophis ...
BPP11_BOTJA Bradykinin-potentiating peptide 11 (BPP-11) Bothrops jararaca (Jararaca) (Bothrops jajaraca)
BPP11_BOTNU Bradykinin-potentiating peptide 11 (BPP-11) Bothrops neuwiedi (Neuwied's lancehead)
BPP12_BOTAT Bradykinin-potentiating peptide 12a (BPP-12a) ... Bothrops atrox (Barba amarilla) (Fer-de-lance)
BPP1_GLOHA Bradykinin-potentiating peptide 1 (BPP-1) ... Gloydius halys (Chinese water mocassin) ...
BPP2_BOTNU Bradykinin-potentiating peptide 2 (BPP-2) ... Bothrops neuwiedi (Neuwied's lancehead)
BPP2_GLOHA Bradykinin-potentiating peptide 2 (AHBPP-2) ... Gloydius halys (Chinese water mocassin) ...
BPP36_CROAT Bradykinin-potentiating peptide POL-236 (BPP ... Crotalus atrox (Western diamondback rattlesnake)
BPP4_BOTIN Bradykinin-potentiating peptide S4,1,2 (BPP) ... Bothrops insularis (Golden lancehead) (Lachesis ...
BPP5_BOTNU Bradykinin-potentiating peptide 5 (BPP-5) ... Bothrops neuwiedi (Neuwied's lancehead)
BPP7A_BOTJA Bradykinin-potentiating peptide 7a (BPP-7a) ... Bothrops jararaca (Jararaca) (Bothrops jajaraca)
BPP7B_BOTCO Bradykinin-potentiating peptide 7b (BPP-7b) Bothrops cotiara (Cotiara) (Rhinocerophis ...
BPP7C_BOTFO Bradykinin-potentiating peptide 7c (BPP-7c) Bothrops fonsecai (Fonseca's lancehead) ...
BPP8A_BOTCO Bradykinin-potentiating peptide 8a (BPP-8a) Bothrops cotiara (Cotiara) (Rhinocerophis ...
BPP8_BOTIN Bradykinin-potentiating peptide S5,1 (BPP) ... Bothrops insularis (Golden lancehead) (Lachesis ...
BPP9A_BOTNU Bradykinin-potentiating peptide 9a (BPP-9) ... Bothrops neuwiedi (Neuwied's lancehead)
BPPAB_BOTJA Bradykinin-potentiating peptide 10b (BPP-10b) ... Bothrops jararaca (Jararaca) (Bothrops jajaraca)
BPPAD_BOTCO Bradykinin-potentiating peptide 10d (BPP-10d) Bothrops cotiara (Cotiara) (Rhinocerophis ...
BPPAD_BOTFO Bradykinin-potentiating peptide 10d (BPP-10d) Bothrops fonsecai (Fonseca's lancehead) ...
BPPAE_BOTCO Bradykinin-potentiating peptide 10e (BPP-10e) Bothrops cotiara (Cotiara) (Rhinocerophis ...
BPPAF_BOTFO Bradykinin-potentiating peptide 10f (BPP-10f) Bothrops fonsecai (Fonseca's lancehead) ...
BPPAP_BOTFO Bradykinin-potentiating peptide AP (BPP-AP) ... Bothrops fonsecai (Fonseca's lancehead) ...
BPPBD_BOTJA Bradykinin-potentiating peptide 11d (BPP-11d) Bothrops jararaca (Jararaca) (Bothrops jajaraca)
BPPBF_BOTCO Bradykinin-potentiating peptide 11f (BPP-11f) Bothrops cotiara (Cotiara) (Rhinocerophis ...
BPPBG_BOTFO Bradykinin-potentiating peptide 11g (BPP-11g) Bothrops fonsecai (Fonseca's lancehead) ...
BPPBG_BOTJA Bradykinin-potentiating peptide 11g (BPP-11g) Bothrops jararaca (Jararaca) (Bothrops jajaraca)
BPPBH_BOTJA Bradykinin-potentiating peptide 11h (BPP-11h) Bothrops jararaca (Jararaca) (Bothrops jajaraca)
BPPBI_BOTJA Bradykinin-potentiating peptide 11i (BPP-11i) Bothrops jararaca (Jararaca) (Bothrops jajaraca)
BPPBJ_BOTJA Bradykinin-potentiating peptide 11j (BPP-11j) Bothrops jararaca (Jararaca) (Bothrops jajaraca)
BPPCA_BOTJA Bradykinin-potentiating peptide 12a (BPP-12a) Bothrops jararaca (Jararaca) (Bothrops jajaraca)
BPPCB_BOTJA Bradykinin-potentiating peptide 12b (BPP-12b) Bothrops jararaca (Jararaca) (Bothrops jajaraca)
BPPCC_BOTJA Bradykinin-potentiating peptide 12c (BPP-12c) ... Bothrops jararaca (Jararaca) (Bothrops jajaraca)
BPPCD_BOTCO Bradykinin-potentiating peptide 12d (BPP-12d) Bothrops cotiara (Cotiara) (Rhinocerophis ...
BPPCD_BOTFO Bradykinin-potentiating peptide 12d (BPP-12d) Bothrops fonsecai (Fonseca's lancehead) ...
BPPCE_BOTCO Bradykinin-potentiating peptide 12e (BPP-12e) Bothrops cotiara (Cotiara) (Rhinocerophis ...
BPPCE_BOTJA Bradykinin-potentiating peptide 12e (BPP-12e) Bothrops jararaca (Jararaca) (Bothrops jajaraca)
BPPDA_BOTAL Bradykinin-potentiating peptide 13a (BPP-13a) Bothrops alternatus (Urutu) (Rhinocerophis ...
BPPDA_BOTCO Bradykinin-potentiating peptide 13a (BPP-13a) Bothrops cotiara (Cotiara) (Rhinocerophis ...
BPPDA_BOTER Bradykinin-potentiating peptide 13a (BPP-13a) Bothrops erythromelas (Caatinga lance head)
BPPDA_BOTLC Bradykinin-potentiating peptide 13a (BPP-13a) Bothrops leucurus (Whitetail lancehead)
BPPDA_BOTMO Bradykinin-potentiating peptide 13a (BPP-13a) Bothrops moojeni (Lance-headed viper) (Caissaca)
BPPDA_BOTNU Bradykinin-potentiating peptide 13a (BPP-13a) ... Bothrops neuwiedi (Neuwied's lancehead)
BPPDB_BOTJA Bradykinin-potentiating peptide 13b (BPP-13b) Bothrops jararaca (Jararaca) (Bothrops jajaraca)
BPPDC_BOTJA Bradykinin-potentiating peptide 13c (BPP-13c) Bothrops jararaca (Jararaca) (Bothrops jajaraca)
BPPDD_BOTJA Bradykinin-potentiating peptide 13d (BPP-13d) Bothrops jararaca (Jararaca) (Bothrops jajaraca)
BPPEA_BOTJA Bradykinin-potentiating peptide 14a (BPP-14a) ... Bothrops jararaca (Jararaca) (Bothrops jajaraca)
BPPF_AGKPI Bradykinin-potentiating peptide F (AppF) (BPP-F) Agkistrodon piscivorus piscivorus (Eastern ...
BPPF_PROMU Bradykinin-potentiating peptide TmF (BPP-TmF) Protobothrops mucrosquamatus (Taiwan habu) ...
BPPS_LYCER Bradykinin-potentiating peptide S (BPP-S) Lycosa erythrognatha (Wolf spider) (Scaptocosa ...
BPP_VIPAS Bradykinin-potentiating peptide (BPP) ... Vipera aspis (Aspic viper)

2 entries

Bradykinin-potentiating peptide family; Bradykinin inhibitor peptide family; Natriuretic peptide family

Select_allDeselect_all "Bradykinin-potentiating peptide family" VenomZone page
BNP_LACMU Bradykinin-potentiating and C-type natriuretic ... Lachesis muta muta (Bushmaster)
BNP_SISCA Bradykinin potentiating and C-type natriuretic ... Sistrurus catenatus edwardsii (Desert ...

6 entries

Bradykinin-potentiating peptide family; Natriuretic peptide family

Select_allDeselect_all "Bradykinin-potentiating peptide family" VenomZone page
BNP_BOTIN Bradykinin-potentiating and C-type natriuretic ... Bothrops insularis (Golden lancehead) (Lachesis ...
BNP_CRODO Bradykinin-potentiating and C-type natriuretic ... Crotalus durissus collilineatus (Brazilian ...
BNP_CRODU Bradykinin potentiating and C-type natriuretic ... Crotalus durissus terrificus (South American ...
BNP_GLOBL Bradykinin-potentiating and C-type natriuretic ... Gloydius blomhoffii (Mamushi) (Agkistrodon halys ...
BNP_PROFL Bradykinin-potentiating and C-type natriuretic ... Protobothrops flavoviridis (Habu) (Trimeresurus ...
BNP_TRIGA Bradykinin-potentiating and C-type natriuretic ... Trimeresurus gramineus (Bamboo pit viper) ...

2 entries

Bradykinin-potentiating peptide family; PHpG family; Natriuretic peptide family

Select_allDeselect_all "Bradykinin-potentiating peptide family" VenomZone page
BNP1_BOTJA Bradykinin-potentiating and C-type natriuretic ... Bothrops jararaca (Jararaca) (Bothrops jajaraca)
BNP2_BOTJA Bradykinin-potentiating and C-type natriuretic ... Bothrops jararaca (Jararaca) (Bothrops jajaraca)

5 entries

Bradykinin-related peptide family

Select_allDeselect_all
BRK_PARID Waspkinin Parapolybia indica (Lesser paper wasp)
BRK_POLMJ Wasp kinin PMM1 Polistes major (Neotropical social wasp)
BRK_VESMA Vespakinin-M Vespa mandarinia (Asian giant hornet)
BRK_VESMC Vespulakinin-1 [Cleaved into: Vespulakinin-2] Vespula maculifrons (Eastern yellow jacket) ...
BRK_VESXA Vespakinin-X Vespa xanthoptera (Japanese yellow hornet) ...

1 entry

Gastrin/cholecystokinin family

CCT1_VARVA Cholecystoxin (Cholecystoxin-Vvar1) [Cleaved ... Varanus varius (Lace monitor)

7 entries

Glucagon family

Select_allDeselect_all
EXE1_HELHO Exendin-1 (Helospectin-1) (VIP-like 1) [Cleaved ... Heloderma horridum horridum (Mexican beaded ...
EXE1_HELSU Exendin-1 (Helospectin I) (Helospectin-1) ... Heloderma suspectum (Gila monster)
EXE2_HELSC Exendin-2-long [Cleaved into: Exendin-2 ... Heloderma suspectum cinctum (Banded Gila ...
EXE2_HELSU Exendin-2-long [Cleaved into: Exendin-2 ... Heloderma suspectum (Gila monster)
EXE3_HELHO Exendin-3 (Glucagon-like 3) Heloderma horridum horridum (Mexican beaded ...
EXE4_HELSC Exendin-4 Heloderma suspectum cinctum (Banded Gila ...
EXE4_HELSU Exendin-4 (Exenatide) Heloderma suspectum (Gila monster)

46 entries

Natriuretic peptide family

Select_allDeselect_all "Natriuretic peptide family" VenomZone page
ANF39_ORNAN C-type natriuretic peptide (CNP) [Cleaved into: ... Ornithorhynchus anatinus (Duckbill platypus)
ANF_CRODC Natriuretic peptide NP2 (NP2_Casca) Crotalus durissus cascavella (Northeastern ...
BNP_CROAT C-type natriuretic peptide (CNP) Crotalus atrox (Western diamondback rattlesnake)
LEB_MACLB Lebetin-2-alpha (L2alpha) [Cleaved into: ... Macrovipera lebetina (Levantine viper) (Vipera ...
SVMI1_CERCE Snake venom metalloprotease inhibitor 02A10 ... Cerastes cerastes (Horned desert viper)
TSNP_TITSE Natriuretic peptide TsNP Tityus serrulatus (Brazilian scorpion)
VNHP_HELSC Natriuretic and helokinestatin peptides [Cleaved ... Heloderma suspectum cinctum (Banded Gila ...
VNP2_DENAN Natriuretic peptide DNP-2 Dendroaspis angusticeps (Eastern green mamba) ...
VNP31_BUNFL Natriuretic peptide BF131 Bungarus flaviceps flaviceps (Red-headed krait)
VNP32_MICCO Natriuretic peptide Mc-NP (Micrurus natriuretic ... Micrurus corallinus (Brazilian coral snake)
VNPA_AUSSU Natriuretic peptide AsNP-a (Fragment) Austrelaps superbus (Lowland copperhead snake) ...
VNPA_CRYNI Natriuretic peptide CnNP-a (Fragment) Cryptophis nigrescens (Eastern small-eyed snake) ...
VNPA_HOPST Natriuretic peptide HsNP-a (Fragment) Hoplocephalus stephensii (Stephens' banded ...
VNPA_NOTSC Natriuretic peptide NsNP-a (Fragment) Notechis scutatus scutatus (Mainland tiger ...
VNPA_OXYMI Natriuretic peptide TNP-a (Taipan natriuretic ... Oxyuranus microlepidotus (Inland taipan) ...
VNPA_OXYSA Natriuretic peptide TNP-a (Taipan natriuretic ... Oxyuranus scutellatus canni (Papuan taipan)
VNPA_OXYSC Natriuretic peptide TNP-a (Taipan natriuretic ... Oxyuranus scutellatus scutellatus (Australian ...
VNPA_PSEAU Natriuretic peptide PaNP-a (Fragment) Pseudechis australis (Mulga snake) (King brown ...
VNPA_PSEPO Natriuretic peptide PpNP-a (Fragment) Pseudechis porphyriacus (Red-bellied black ...
VNPA_PSETE Natriuretic peptide PtNP-a (Fragment) Pseudonaja textilis (Eastern brown snake)
VNPA_TROCA Natriuretic peptide TcNP-a (Fragment) Tropidechis carinatus (Australian rough-scaled ...
VNPB_CRYNI Natriuretic peptide CnNP-b (Fragment) Cryptophis nigrescens (Eastern small-eyed snake) ...
VNPB_HOPST Natriuretic peptide HsNP-b (Fragment) Hoplocephalus stephensii (Stephens' banded ...
VNPB_NOTSC Natriuretic peptide NsNP-b (Fragment) Notechis scutatus scutatus (Mainland tiger ...
VNPB_OXYMI Natriuretic peptide TNP-b (Taipan natriuretic ... Oxyuranus microlepidotus (Inland taipan) ...
VNPB_OXYSA Natriuretic peptide TNP-b (Taipan natriuretic ... Oxyuranus scutellatus canni (Papuan taipan)
VNPB_OXYSC Natriuretic peptide TNP-b (Taipan natriuretic ... Oxyuranus scutellatus scutellatus (Australian ...
VNPB_PSEAU Natriuretic peptide PaNP-b (Fragment) Pseudechis australis (Mulga snake) (King brown ...
VNPB_PSEPO Natriuretic peptide PpNP-b (Fragment) Pseudechis porphyriacus (Red-bellied black ...
VNPC_OXYMI Peptide TNP-c (Taipan natriuretic peptide) ... Oxyuranus microlepidotus (Inland taipan) ...
VNPC_OXYSA Natriuretic peptide TNP-c (Taipan natriuretic ... Oxyuranus scutellatus canni (Papuan taipan)
VNPC_PSEAU Natriuretic peptide PaNP-c (Fragment) Pseudechis australis (Mulga snake) (King brown ...
VNPD_OXYMI Natriuretic peptide OmNP-d (Fragment) Oxyuranus microlepidotus (Inland taipan) ...
VNPD_OXYSC Natriuretic peptide OsNP-d (Fragment) Oxyuranus scutellatus scutellatus (Australian ...
VNPD_PSEAU Natriuretic peptide PaNP-d (Fragment) Pseudechis australis (Mulga snake) (King brown ...
VNPE_OXYMI Natriuretic peptide OmNP-e (Fragment) Oxyuranus microlepidotus (Inland taipan) ...
VNP_BUNMU Natriuretic peptide BM026 (NP) Bungarus multicinctus (Many-banded krait)
VNP_DENAN Natriuretic peptide DNP Dendroaspis angusticeps (Eastern green mamba) ...
VNP_MICAT Natriuretic peptide (NP) Micrurus altirostris (Uruguayan coral snake) ...
VNP_MICFL Natriuretic peptide Mf-NP Micrurus fulvius (Eastern coral snake) (Coluber ...
VNP_NAJAT Natriuretic peptide Na-NP Naja atra (Chinese cobra)
VNP_OPHHA Natriuretic peptide Oh-NP Ophiophagus hannah (King cobra) (Naja hannah)
VNP_PHIOL C-type natriuretic peptide (CNP) Philodryas olfersii (Green snake)
VNP_PSEPC Natriuretic peptide PNP Pseudocerastes persicus (Persian horned viper) ...
VNP_RHATT Natriuretic peptide Rhabdophis tigrinus tigrinus (Tiger keelback ...
VNP_VARVA Natriuretic peptide GNP1 Varanus varius (Lace monitor)

2 entries

Natriuretic peptide family, Snake NP subfamily

Select_allDeselect_all "Natriuretic peptide family" VenomZone page
BNPL1_CROOA Natriuretic peptide Coa_NP1 Crotalus oreganus abyssus (Grand Canyon ...
BNPL2_CROOA Natriuretic peptide Coa_NP2 Crotalus oreganus abyssus (Grand Canyon ...

1 entry

Natriuretic peptide family; PHpG family

"Natriuretic peptide family" VenomZone page
SVMI_ECHOC Snake venom metalloprotease inhibitor 02D01 ... Echis ocellatus (Ocellated saw-scaled viper)

2 entries

Non-disulfide-bridged peptide (NDBP) superfamily

Select_allDeselect_all
NDBH1_TITSE Hypotensin-1 (Hypotensin I) (TsHpt-I) (Toxin ... Tityus serrulatus (Brazilian scorpion)
NDBH2_TITSE Hypotensin-2 (Hypotensin II) (TsHpt-II) (Toxin ... Tityus serrulatus (Brazilian scorpion)

5 entries

Non-disulfide-bridged peptide (NDBP) superfamily, Long chain multifunctional peptide (group 2) family

Select_allDeselect_all
NDB22_MESMA Bradykinin-potentiating peptide BmKbpp (Bpp ... Mesobuthus martensii (Manchurian scorpion) ...
NDB2_TITDI Bradykinin-potentiating peptide (BPP) (TdBPP) Tityus discrepans (Venezuelan scorpion)
NDBM_LYCMC Bradykinin-potentiating peptide NDBP6 (BPP-6) Lychas mucronatus (Chinese swimming scorpion)
NDBP_LYCMC Bradykinin-potentiating peptide NDBP12 (BPP-12) Lychas mucronatus (Chinese swimming scorpion)
NDBS_LYCMC Bradykinin-potentiating peptide 25.12 ... Lychas mucronatus (Chinese swimming scorpion)

2 entries

Non-disulfide-bridged peptide (NDBP) superfamily, Scorpion BPP (group 1) family

Select_allDeselect_all
NDB11_TITSE Bradykinin-potentiating peptide T (BPP-T) ... Tityus serrulatus (Brazilian scorpion)
NDB12_BUTOI Bradykinin-potentiating peptide K12 (BPP-K12) ... Buthus occitanus (Common European scorpion)

2 entries

Not in a family

Select_allDeselect_all
CLTX_CELWA Celestoxin Celestus warreni (Giant Hispaniolan galliwasp) ...
HYTL_TITSE Hypotensin-like peptide (Fragment) Tityus serrulatus (Brazilian scorpion)

2 entries

NPY family

Select_allDeselect_all
NPYV_MEIAT Pro-neuropeptide Y [Cleaved into: Neuropeptide Y ... Meiacanthus atrodorsalis (Forktail blenny) ...
PYYV_VARER Goannatyrotoxin-Vere1 (Venom peptide YY-like) Varanus eremius (Pygmy desert monitor)

10 entries

Peptidase S1 family, Snake venom subfamily

Select_allDeselect_all "Peptidase S1 family" VenomZone page
VSP1_GLOBL Thrombin-like enzyme halystase (SVTLE) (EC ... Gloydius blomhoffii (Mamushi) (Agkistrodon halys ...
VSP1_PROMU Beta-fibrinogenase mucrofibrase-1 (EC 3.4.21.-) ... Protobothrops mucrosquamatus (Taiwan habu) ...
VSP2_BOTJA Thrombin-like enzyme KN-BJ 2 (SVTLE) (EC ... Bothrops jararaca (Jararaca) (Bothrops jajaraca)
VSP2_PROEL Thrombin-like enzyme elegaxobin-2 (SVTLE) (EC ... Protobothrops elegans (Elegant pitviper) ...
VSP5_PROMU Beta-fibrinogenase mucrofibrase-5 (EC 3.4.21.-) ... Protobothrops mucrosquamatus (Taiwan habu) ...
VSPCR_CROAD Thrombin-like enzyme crotalase (SVTLE) (EC ... Crotalus adamanteus (Eastern diamondback ...
VSPHA_HYDHA Serine protease harobin (EC 3.4.21.-) ... Hydrophis hardwickii (Hardwick's spine-bellied ...
VSPPA_LACMU Venom plasminogen activator LV-PA (EC 3.4.21.-) ... Lachesis muta muta (Bushmaster)
VSPR_BITRH Snake venom serine protease rhinocerase (SVSP) ... Bitis rhinoceros (West African gaboon viper) ...
VSP_CROVV Snake venom serine protease (SVSP) (EC 3.4.21.-) ... Crotalus viridis viridis (Prairie rattlesnake)

4 entries

Phospholipase A2 family, Group II subfamily, D49 sub-subfamily

Select_allDeselect_all "Phospholipase A2 family" VenomZone page
PA2A1_BOTPI Acidic phospholipase A2 BpirPLA2-I (svPLA2) (EC ... Bothrops pirajai (Piraja's lancehead)
PA2A_BOTJR Acidic phospholipase A2 BthA-1 (svPLA2) (EC ... Bothrops jararacussu (Jararacussu)
PA2A_BOTMO Acidic phospholipase A2 BmooPLA2 (svPLA2) (EC ... Bothrops moojeni (Lance-headed viper) (Caissaca)
PA2A_DABPA Acidic phospholipase A2 VpaPLA2 (svPLA2) (EC ... Daboia palaestinae (Palestine viper) (Vipera ...

4 entries

Snake three-finger toxin family, Short-chain subfamily, Type IB cytotoxin sub-subfamily

Select_allDeselect_all "Snake three-finger toxin family" VenomZone page
3SB1_HEMHA Cytotoxin 1 (Hemolytic protein 12B) Hemachatus haemachatus (Rinkhals) (Sepedon ...
3SB2_HEMHA Cytotoxin 2 (Toxin 12A) Hemachatus haemachatus (Rinkhals) (Sepedon ...
3SB3_HEMHA Cytotoxin 3 (Toxin 11/11A) Hemachatus haemachatus (Rinkhals) (Sepedon ...
3SBH_HEMHA Three-finger hemachatoxin Hemachatus haemachatus (Rinkhals) (Sepedon ...