Terebridae (auger shells)

The Terebridae is a family of small to large predatory marine gastropods. These gastropods have extremely high spired shells with numerous whorls, and the common name ""auger":http://en.wikipedia.org/wiki/Auger_%28drill%29 snail" refers to the resemblance of their shells to drill bits.

These snails are sand-dwelling carnivores which live in warmer waters. In most species, a venomous barb similar to that of the cone snails, is used to stun and immobilize prey, which typically consists of various marine worms.


image  image
Terebra subulata (Photo courtesy of Juliette Gorson).                Hastula hectica (Photo courtesy of Yves Terryn).
Use of photos governed by creative commons noncommercial license.




The table below shows the cysteine frameworks (using the Conus nomenclature) that are found in this family of gastropods.
Cysteine framework number of Cys Cys pattern UniProtKB entries or reference
I 4 CC-C-C image
α2/8 (CCxxCxxxxxxxxC image
α4/4 (CCxxCxxxxxxxxC image
α4/5 (CCxxCxxxxxxxxC image
VI/VII 6 C-C-CC-C-C image
VIII 10 C-C-C-C-C-C-C-C-C-C   image
IX 6 C-C-C-C-C-C image
XI 8 C-C-CC-CC-C-C image
XIII 8 C-C-C-CC-C-C-C image
XIV 4 C-C-C-C image
XV 8 C-C-CC-C-C-C-C image
XVI 4 C-C-CC image
XVII 8 C-C-CC-C-CC-C   image
XXII 8 C-C-C-C-C-C-C-C image
Novel-8-cys 8 C-C-C-C-C-CCC image
Novel-10-cys 10 C-CC-C-C-C-C-C-C-C image
Novel-12-cys 12 C-CC-CC-C-C-C-C-C-C-C image


The table below shows the classification of teretoxins based on similarities in precursor signal peptide sequences.
Protein family or
Superfamily in UniProtKB
UniProtKB entries or reference
Teretoxin A (TA) superfamily image
Teretoxin B (TB) superfamily   image
Teretoxin C (TC) superfamily image
Teretoxin D (TD) superfamily   image
Teretoxin E (TE) superfamily   image
Teretoxin F (TF) superfamily   image
Teretoxin G (TG) superfamily   image
Teretoxin H (TH) superfamily image
Teretoxin I (TI) superfamily   image
Teretoxin J (TJ) superfamily image
Teretoxin K (TK) superfamily   image
Teretoxin L (TL) superfamily   image
Teretoxin M (TM ) superfamily image
Teretoxin N (TN) superfamily image
Vasopressin/oxytocin family image
Porin family image

Venom protein entries in UniProtKB/Swiss-Prot

45 entries grouped by family (browse by taxonomy, browse by keywords)

2 entries

Actinoporin family, Conoidea subfamily

Select_allDeselect_all
ACTP1_TERAN Tereporin-Ca1 (Actinoporin-like protein) ... Terebra anilis (Auger snail) (Cinguloterebra ...
ACTP1_TERSU Tereporin-Ts1 (Actinoporin-like protein) ... Terebra subulata (Chocolate spotted auger) ...

25 entries

Not in a family

Select_allDeselect_all
AX6A_TERSU Augerpeptide-s6a (Agx-s6a) Terebra subulata (Chocolate spotted auger) ...
AX7A_TERSU Augerpeptide-s7a (Agx-s7a) (Fragments) Terebra subulata (Chocolate spotted auger) ...
AXBA_TERSU Augerpeptide-s11a (Agx-s11a) Terebra subulata (Chocolate spotted auger) ...
T3A_TERVA Venom peptide Tv1 (Teretoxin v3a) Terebra variegata (Variegate auger snail)
T64_TERSU Teretoxin Tsu6.4 Terebra subulata (Chocolate spotted auger) ...
T68_TERAN Teretoxin Tan6.8 Terebra anilis (Auger snail) (Cinguloterebra ...
T6E_TERAN Teretoxin Tan6.14 Terebra anilis (Auger snail) (Cinguloterebra ...
T96_TERAN Teretoxin Tan9.6 Terebra anilis (Auger snail) (Cinguloterebra ...
TE2_HASHE Augerpeptide hheTx2 Hastula hectica (Sea snail) (Impages hectica)
TE53_HASHE Augerpeptide hhe53 Hastula hectica (Sea snail) (Impages hectica)
TE61_HASHE Augerpeptide hhe6.1 Hastula hectica (Sea snail) (Impages hectica)
TE62_HASHE Augerpeptide hhe6.2 Hastula hectica (Sea snail) (Impages hectica)
TE63_HASHE Augerpeptide hhe6.3 Hastula hectica (Sea snail) (Impages hectica)
TE64_HASHE Augerpeptide hhe6.4 Hastula hectica (Sea snail) (Impages hectica)
TE7A_HASHE Augerpeptide hhe7a Hastula hectica (Sea snail) (Impages hectica)
TE92_HASHE Augerpeptide hhe9.2 Hastula hectica (Sea snail) (Impages hectica)
TE9A_HASHE Augerpeptide Hhe9a (Hhe9.1) Hastula hectica (Sea snail) (Impages hectica)
TE9_HASHE Augerpeptide hhe9 Hastula hectica (Sea snail) (Impages hectica)
TED_HASHE Augerpeptide hheTx3 Hastula hectica (Sea snail) (Impages hectica)
TEF4_HASHE Augerpeptide hheTx4 Hastula hectica (Sea snail) (Impages hectica)
TEF5_HASHE Augerpeptide hheTx5 Hastula hectica (Sea snail) (Impages hectica)
TEG1_HASHE Augerpeptide hheTx1 Hastula hectica (Sea snail) (Impages hectica)
TEIA_HASHE Augerpeptide hhe1a Hastula hectica (Sea snail) (Impages hectica)
TF2_TERAN Teretoxin Tan15.2 Terebra anilis (Auger snail) (Cinguloterebra ...
TF4_TERSU Teretoxin Tsu15.4 Terebra subulata (Chocolate spotted auger) ...

2 entries

Teretoxin A (TA) superfamily

Select_allDeselect_all
T11_TERAN Teretoxin Tan1.1 Terebra anilis (Auger snail) (Cinguloterebra ...
T11_TERSU Teretoxin Tsu1.1 Terebra subulata (Chocolate spotted auger) ...

4 entries

Teretoxin C (TC) superfamily

Select_allDeselect_all
TAC_TERAN Tan_10cys Terebra anilis (Auger snail) (Cinguloterebra ...
TCC_TERAN Tan_12Cys Terebra anilis (Auger snail) (Cinguloterebra ...
TMC_TERAN Teretoxin Tan22.12 Terebra anilis (Auger snail) (Cinguloterebra ...
TMD_TERAN Teretoxin Tan22.13 Terebra anilis (Auger snail) (Cinguloterebra ...

2 entries

Teretoxin H (TH) superfamily

Select_allDeselect_all
TB1_TERAN Teretoxin Tan11.1 Terebra anilis (Auger snail) (Cinguloterebra ...
TB2_TERSU Teretoxin Tsu11.2 Terebra subulata (Chocolate spotted auger) ...

1 entry

Teretoxin J (TJ) superfamily

TM5_TERAN Teretoxin Tan22.5 Terebra anilis (Auger snail) (Cinguloterebra ...

6 entries

Teretoxin M (TM) superfamily

Select_allDeselect_all
T61_TERAN Teretoxin Tan6.1 Terebra anilis (Auger snail) (Cinguloterebra ...
T62_TERAN Teretoxin Tan6.2 Terebra anilis (Auger snail) (Cinguloterebra ...
T65_TERSU Teretoxin Tsu6.5 Terebra subulata (Chocolate spotted auger) ...
T68_TERSU Teretoxin Tsu6.8 Terebra subulata (Chocolate spotted auger) ...
T6F_TERSU Teretoxin Tsu6.15 Terebra subulata (Chocolate spotted auger) ...
T6G_TERSU Teretoxin Tsu6.16 Terebra subulata (Chocolate spotted auger) ...

1 entry

Teretoxin N (TN) superfamily

TE1_TERAN Teretoxin Tan14.1 Terebra anilis (Auger snail) (Cinguloterebra ...

2 entries

Vasopressin/oxytocin family

Select_allDeselect_all
TESS_TERAN Terepressin/terephysin ... Terebra anilis (Auger snail) (Cinguloterebra ...
TESS_TERSU Terepressin/terephysin ... Terebra subulata (Chocolate spotted auger) ...