Bothrops jararaca (jararaca)


Venom composition
Figure 1: Composition of toxin transcripts in newborn and adult cDNA libraries from B.jararaca venom glands (Zelanis et al., 2012 ). CRISP, PLA2 (phospholipase A2 ), L-amino-acid oxidase (flavin monoamine oxidase ), C-type lectin (true venom lectin ), SVMP (snake venom metalloproteinase ), serine protease (peptidase S1 ), BPP-natriuretic peptide (bradykinin-potentiating peptide and natriuretic peptide, nerve-growth factor (NGF-beta ), VEGF (vascular endothelium growth factor see PDGF/VEGF growth factor ).

Ontogenic variations are quantitative as shown in Fig.1, but also qualitative when metalloproteinases are considered. Adult and newborn snakes have only a few metalloproteinase transcripts in common, the majority being specific for each transcriptome. In addition, the ratio of subfamilies of metalloproteinases is different, newborn snakes being rich in P-III subfamilies, and adult in P-I. Some other families (i.e. serine proteinases, bradykinin-potentiating peptides, C-type lectins and phospholipases A2) are common to both newborn and adult snakes whereas many families are identified as specific for the adult venom gland transcriptome (Zelanis et al., 2012 ).

Coagulant activity of newborn venom is higher than that of adult venom (Zelanis et al., 2010 ).
Clinical Effects, Treatment, Antivenoms See the Clinical Toxinology Resources Website
and the WHO venomous snake database to access snake distribution and antivenom products.
Lethal dose Newborn venom
LD(50) is 3.33 mg/kg when intraperitoneally injected into mice.
LD(50) is 0.05 mg/kg when intramuscularly injected into chick.

Adult venom
LD(50) is 2.26 mg/kg when intraperitoneally injected into mice.
LD(50) is 1.36 mg/kg when intramuscularly injected into chick.
(Zelanis et al., 2010 )

Venom protein entries in UniProtKB/Swiss-Prot

58 entries grouped by family (browse by taxonomy, browse by keywords)

16 entries

Bradykinin-potentiating peptide family

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BPP11_BOTJA Bradykinin-potentiating peptide 11 (BPP-11) Bothrops jararaca (Jararaca) (Bothrops jajaraca)
BPP7A_BOTJA Bradykinin-potentiating peptide 7a (BPP-7a) ... Bothrops jararaca (Jararaca) (Bothrops jajaraca)
BPPAB_BOTJA Bradykinin-potentiating peptide 10b (BPP-10b) ... Bothrops jararaca (Jararaca) (Bothrops jajaraca)
BPPBD_BOTJA Bradykinin-potentiating peptide 11d (BPP-11d) Bothrops jararaca (Jararaca) (Bothrops jajaraca)
BPPBG_BOTJA Bradykinin-potentiating peptide 11g (BPP-11g) Bothrops jararaca (Jararaca) (Bothrops jajaraca)
BPPBH_BOTJA Bradykinin-potentiating peptide 11h (BPP-11h) Bothrops jararaca (Jararaca) (Bothrops jajaraca)
BPPBI_BOTJA Bradykinin-potentiating peptide 11i (BPP-11i) Bothrops jararaca (Jararaca) (Bothrops jajaraca)
BPPBJ_BOTJA Bradykinin-potentiating peptide 11j (BPP-11j) Bothrops jararaca (Jararaca) (Bothrops jajaraca)
BPPCA_BOTJA Bradykinin-potentiating peptide 12a (BPP-12a) Bothrops jararaca (Jararaca) (Bothrops jajaraca)
BPPCB_BOTJA Bradykinin-potentiating peptide 12b (BPP-12b) Bothrops jararaca (Jararaca) (Bothrops jajaraca)
BPPCC_BOTJA Bradykinin-potentiating peptide 12c (BPP-12c) ... Bothrops jararaca (Jararaca) (Bothrops jajaraca)
BPPCE_BOTJA Bradykinin-potentiating peptide 12e (BPP-12e) Bothrops jararaca (Jararaca) (Bothrops jajaraca)
BPPDB_BOTJA Bradykinin-potentiating peptide 13b (BPP-13b) Bothrops jararaca (Jararaca) (Bothrops jajaraca)
BPPDC_BOTJA Bradykinin-potentiating peptide 13c (BPP-13c) Bothrops jararaca (Jararaca) (Bothrops jajaraca)
BPPDD_BOTJA Bradykinin-potentiating peptide 13d (BPP-13d) Bothrops jararaca (Jararaca) (Bothrops jajaraca)
BPPEA_BOTJA Bradykinin-potentiating peptide 14a (BPP-14a) ... Bothrops jararaca (Jararaca) (Bothrops jajaraca)

2 entries

Bradykinin-potentiating peptide family; PHpG family; Natriuretic peptide family

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BNP1_BOTJA Bradykinin-potentiating and C-type natriuretic ... Bothrops jararaca (Jararaca) (Bothrops jajaraca)
BNP2_BOTJA Bradykinin-potentiating and C-type natriuretic ... Bothrops jararaca (Jararaca) (Bothrops jajaraca)

1 entry

Flavin monoamine oxidase family, FIG1 subfamily

"Flavin monoamine oxidase family" VenomZone page
OXLA_BOTJA L-amino-acid oxidase (BjarLAAO-I) (LAO) (EC ... Bothrops jararaca (Jararaca) (Bothrops jajaraca)

1 entry

Glutaminyl-peptide cyclotransferase family

QPCT_BOTJA Glutaminyl-peptide cyclotransferase (EC 2.3.2.5) ... Bothrops jararaca (Jararaca) (Bothrops jajaraca)

1 entry

PDGF/VEGF growth factor family, Snake venom VEGF subfamily

"PDGF/VEGF growth factor family" VenomZone page
TXVE_BOTJA Snake venom vascular endothelial growth factor ... Bothrops jararaca (Jararaca) (Bothrops jajaraca)

10 entries

Peptidase S1 family, Snake venom subfamily

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VSP12_BOTJA Snake venom serine protease HS112 (SVSP) (EC ... Bothrops jararaca (Jararaca) (Bothrops jajaraca)
VSP14_BOTJA Snake venom serine protease HS114 (SVSP) (EC ... Bothrops jararaca (Jararaca) (Bothrops jajaraca)
VSP1_BOTJA Platelet-aggregating proteinase PA-BJ (EC ... Bothrops jararaca (Jararaca) (Bothrops jajaraca)
VSP20_BOTJA Venom serine proteinase-like HS120 (Snake venom ... Bothrops jararaca (Jararaca) (Bothrops jajaraca)
VSP2_BOTJA Thrombin-like enzyme KN-BJ 2 (SVTLE) (EC ... Bothrops jararaca (Jararaca) (Bothrops jajaraca)
VSP3_BOTJA Snake venom serine protease BPA (SVSP) (EC ... Bothrops jararaca (Jararaca) (Bothrops jajaraca)
VSPA_BOTJA Thrombin-like enzyme bothrombin (SVTLE) (EC ... Bothrops jararaca (Jararaca) (Bothrops jajaraca)
VSPT1_BOTJA Thrombin-like enzyme TL-BJ 1 (SVTLE) (EC ... Bothrops jararaca (Jararaca) (Bothrops jajaraca)
VSPT2_BOTJA Thrombin-like enzyme TL-BJ 2 (SVTLE) (EC ... Bothrops jararaca (Jararaca) (Bothrops jajaraca)
VSPT3_BOTJA Thrombin-like enzyme TL-BJ 3 (SVTLE) (EC ... Bothrops jararaca (Jararaca) (Bothrops jajaraca)

1 entry

Phospholipase A2 family, Group II subfamily

"Phospholipase A2 family" VenomZone page
PA2_BOTJA Phospholipase A2 (svPLA2) (EC 3.1.1.4) ... Bothrops jararaca (Jararaca) (Bothrops jajaraca)

1 entry

Phospholipase A2 family, Group II subfamily, D49 sub-subfamily

"Phospholipase A2 family" VenomZone page
PA2A_BOTJA Acidic phospholipase A2 (svPLA2) (EC 3.1.1.4) ... Bothrops jararaca (Jararaca) (Bothrops jajaraca)

8 entries

Snaclec family

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SL1A_BOTJA Snaclec GPIB-binding protein subunit alpha ... Bothrops jararaca (Jararaca) (Bothrops jajaraca)
SL1B_BOTJA Snaclec GPIB-binding protein subunit beta ... Bothrops jararaca (Jararaca) (Bothrops jajaraca)
SL9A_BOTJA Snaclec coagulation factor IX/factor X-binding ... Bothrops jararaca (Jararaca) (Bothrops jajaraca)
SL9B_BOTJA Snaclec coagulation factor IX/factor X-binding ... Bothrops jararaca (Jararaca) (Bothrops jajaraca)
SLAA_BOTJA Snaclec bothrojaracin subunit alpha (BJC subunit ... Bothrops jararaca (Jararaca) (Bothrops jajaraca)
SLAB_BOTJA Snaclec bothrojaracin subunit beta (BJC subunit ... Bothrops jararaca (Jararaca) (Bothrops jajaraca)
SLEA_BOTJA Snaclec botrocetin subunit alpha (Platelet ... Bothrops jararaca (Jararaca) (Bothrops jajaraca)
SLEB_BOTJA Snaclec botrocetin subunit beta (Platelet ... Bothrops jararaca (Jararaca) (Bothrops jajaraca)

2 entries

True venom lectin family

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LECJ3_BOTJA Jararafibrase-3 (EC 3.4.24.-) (Jararafibrase ... Bothrops jararaca (Jararaca) (Bothrops jajaraca)
LEC_BOTJA C-type lectin BjL (CTL) (Galactoside-binding ... Bothrops jararaca (Jararaca) (Bothrops jajaraca)

2 entries

Venom metalloproteinase (M12B) family

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VMXBN_BOTJA Snake venom metalloproteinase bothrolysin (SVMP) ... Bothrops jararaca (Jararaca) (Bothrops jajaraca)
VMXJ4_BOTJA Snake venom metalloproteinase jararafibrase-4 ... Bothrops jararaca (Jararaca) (Bothrops jajaraca)

1 entry

Venom metalloproteinase (M12B) family, P-I subfamily

"Venom metalloproteinase (M12B) family" VenomZone page
VM1BJ_BOTJA Snake venom metalloproteinase bothrojaractivase ... Bothrops jararaca (Jararaca) (Bothrops jajaraca)

3 entries

Venom metalloproteinase (M12B) family, P-II subfamily, P-IIa sub-subfamily

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VM2J2_BOTJA Zinc metalloproteinase/disintegrin [Cleaved ... Bothrops jararaca (Jararaca) (Bothrops jajaraca)
VM2JA_BOTJA Disintegrin jarastatin (JT) (Platelet ... Bothrops jararaca (Jararaca) (Bothrops jajaraca)
VM2JC_BOTJA Zinc metalloproteinase/disintegrin [Cleaved ... Bothrops jararaca (Jararaca) (Bothrops jajaraca)

1 entry

Venom metalloproteinase (M12B) family, P-II subfamily, P-IIb sub-subfamily

"Venom metalloproteinase (M12B) family" VenomZone page
VM2JR_BOTJA Zinc metalloproteinase-disintegrin jararin (EC ... Bothrops jararaca (Jararaca) (Bothrops jajaraca)

5 entries

Venom metalloproteinase (M12B) family, P-III subfamily, P-IIIa sub-subfamily

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VM3B1_BOTJA Zinc metalloproteinase-disintegrin-like ... Bothrops jararaca (Jararaca) (Bothrops jajaraca)
VM3B2_BOTJA Zinc metalloproteinase-disintegrin-like ... Bothrops jararaca (Jararaca) (Bothrops jajaraca)
VM3B3_BOTJA Zinc metalloproteinase-disintegrin-like ... Bothrops jararaca (Jararaca) (Bothrops jajaraca)
VM3B4_BOTJA Zinc metalloproteinase-disintegrin-like ... Bothrops jararaca (Jararaca) (Bothrops jajaraca)
VM3H3_BOTJA Zinc metalloproteinase-disintegrin-like HF3 (EC ... Bothrops jararaca (Jararaca) (Bothrops jajaraca)

3 entries

Venom metalloproteinase (M12B) family, P-III subfamily, P-IIIb sub-subfamily

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VM3BP_BOTJA Zinc metalloproteinase-disintegrin-like ... Bothrops jararaca (Jararaca) (Bothrops jajaraca)
VM3B_BOTJA Zinc metalloproteinase-disintegrin-like ... Bothrops jararaca (Jararaca) (Bothrops jajaraca)
VM3JA_BOTJA Zinc metalloproteinase-disintegrin-like ... Bothrops jararaca (Jararaca) (Bothrops jajaraca)