Agkistrodon piscivorus leucostoma ~ VenomZone

Agkistrodon piscivorus leucostoma (Western cottonmouth)

Venom composition

Figure 1: Composition of A.p.leucostoma venom, studied at proteomic level (Lomonte, et al., 2014). This venom contains the following families: SVMP (venom metalloproteinase), serine protease (peptidase S1), peptides (include tripeptide SVMP inhibitors and bradykinin-potentiating and bradykinin-inhibitory peptides), LAAO (L-amino-acid oxidase (flavin monoamine oxidase) ), disintegrin, snaclec (also known as C-type lectin-like), CRISP, PA2 (phospholipase A2).

Clinical Effects, Treatment, Antivenoms See the Clinical Toxinology Resources Website.

Lethal dose LD(50) of A.piscivorus is
6.24 mg/kg by intraperitoneal injection and
5.13 mg/kg by intravenous injection (Arce et al., 2003).

Venom protein entries in UniProtKB/Swiss-Prot

(all links/actions below point to uniprot.org website)

9 entries

DIDA_AGKPL Disintegrin subunit alpha Disintegrin family, Dimeric ...

PA21_AGKPL Acidic phospholipase A2 AplTX-I (svPLA2) (EC 3.1.1.4) ... Phospholipase A2 family, Group ...

PA2B1_AGKPL Basic phospholipase A2 APL-D49 (svPLA2) (EC 3.1.1.4) (Apl-D49) ... Phospholipase A2 family, Group ...

PA2HB_AGKPL Basic phospholipase A2 homolog APL-K49 (svPLA2 homolog) (AplP2) Phospholipase A2 family, Group ...

VM1V1_AGKPL Snake venom metalloproteinase VMP1 (AplVMP-I) (AplVMP1) (SVMP) ... Venom metalloproteinase (M12B) ...

VM2V2_AGKPL Zinc metalloproteinase/disintegrin VMP-II (AplVMP2) [Cleaved ... Venom metalloproteinase (M12B) ...

VM3V3_AGKPL Zinc metalloproteinase-disintegrin-like VMP-III (AplVMP-III) (EC ... Venom metalloproteinase (M12B) ...

VSPCA_AGKPL Protein C activator (APL-C) (EC 3.4.21.-) (Snake venom serine ... Peptidase S1 family, Snake venom ...

VSPPA_AGKPL Venom plasminogen activator (APL-PA) (EC 3.4.21.-) (Snake venom ... Peptidase S1 family, Snake venom ...