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Agkistrodon piscivorus leucostoma
(Western cottonmouth)
Venom composition
Figure 1: Composition of A.p.leucostoma venom, studied at proteomic level (
Lomonte, et al., 2014
). This venom contains the following families: SVMP (
venom metalloproteinase
), serine protease (
peptidase S1
), peptides (include tripeptide SVMP inhibitors and bradykinin-potentiating and bradykinin-inhibitory peptides), LAAO (
L-amino-acid oxidase (flavin monoamine oxidase)
),
disintegrin
,
snaclec
(also known as C-type lectin-like),
CRISP
, PA2 (
phospholipase A2
).
Clinical Effects, Treatment, Antivenoms
See the
Clinical Toxinology Resources Website
.
Lethal dose
LD(50) of A.piscivorus is
6.24 mg/kg by intraperitoneal injection and
5.13 mg/kg by intravenous injection (
Arce et al., 2003
).
Taxonomy
UniProt taxonomy
The Reptile database
Wikipedia
Infraorder
:
Serpentes
Family
:
Viperidae
Genus:
Agkistrodon
Activity
Cell adhesion impairing toxin
Hemostasis impairing toxin
Fibrinogenolytic toxin
Fibrinolytic toxin
Hemorrhagic toxin
Platelet agg. inhibiting toxin
Myotoxin
or see
UniProtKB browsing by keyword
Reference
Lomonte, et al., 2014
Venom protein entries in UniProtKB/Swiss-Prot
(all links/actions below point to
uniprot.org
website)
9 entries
grouped
by species
reorder by family
9 entries
Agkistrodon piscivorus leucostoma (Western cottonmouth) (Acontias leucostoma)
DIDA_AGKPL
Disintegrin subunit alpha
Disintegrin family, Dimeric
...
PA21_AGKPL
Acidic phospholipase A2 AplTX-I (svPLA2) (EC 3.1.1.4)
...
Phospholipase A2 family, Group
...
PA2B1_AGKPL
Basic phospholipase A2 APL-D49 (svPLA2) (EC 3.1.1.4) (Apl-D49)
...
Phospholipase A2 family, Group
...
PA2HB_AGKPL
Basic phospholipase A2 homolog APL-K49 (svPLA2 homolog) (AplP2)
Phospholipase A2 family, Group
...
VM1V1_AGKPL
Snake venom metalloproteinase VMP1 (AplVMP-I) (AplVMP1) (SVMP)
...
Venom metalloproteinase (M12B)
...
VM2V2_AGKPL
Zinc metalloproteinase/disintegrin VMP-II (AplVMP2) [Cleaved
...
Venom metalloproteinase (M12B)
...
VM3V3_AGKPL
Zinc metalloproteinase-disintegrin-like VMP-III (AplVMP-III) (EC
...
Venom metalloproteinase (M12B)
...
VSPCA_AGKPL
Protein C activator (APL-C) (EC 3.4.21.-) (Snake venom serine
...
Peptidase S1 family, Snake venom
...
VSPPA_AGKPL
Venom plasminogen activator (APL-PA) (EC 3.4.21.-) (Snake venom
...
Peptidase S1 family, Snake venom
...
