Agkistrodon piscivorus leucostoma ~ VenomZone

Agkistrodon piscivorus leucostoma (Western cottonmouth)

Venom composition

Figure 1: Composition of A.p.leucostoma venom, studied at proteomic level (Lomonte, et al., 2014). This venom contains the following families: SVMP (venom metalloproteinase), serine protease (peptidase S1), peptides (include tripeptide SVMP inhibitors and bradykinin-potentiating and bradykinin-inhibitory peptides), LAAO (L-amino-acid oxidase (flavin monoamine oxidase) ), disintegrin, snaclec (also known as C-type lectin-like), CRISP, PA2 (phospholipase A2).

Clinical Effects, Treatment, Antivenoms See the Clinical Toxinology Resources Website
and the WHO venomous snake database to access snake distribution and antivenom products.

Lethal dose LD(50) of A.piscivorus is
6.24 mg/kg by intraperitoneal injection and
5.13 mg/kg by intravenous injection (Arce et al., 2003).

Venom protein entries in UniProtKB/Swiss-Prot

(all links/actions below point to uniprot.org website)

9 entries

DIDA_AGKPL Disintegrin subunit alpha Disintegrin family, Dimeric ...

PA21_AGKPL Acidic phospholipase A2 AplTX-I (svPLA2) (EC 3.1.1.4) ... Phospholipase A2 family, Group ...

PA2B1_AGKPL Basic phospholipase A2 APL-D49 (svPLA2) (EC 3.1.1.4) (Apl-D49) ... Phospholipase A2 family, Group ...

PA2HB_AGKPL Basic phospholipase A2 homolog APL-K49 (svPLA2 homolog) (AplP2) Phospholipase A2 family, Group ...

VM1V1_AGKPL Snake venom metalloproteinase VMP1 (AplVMP-I) (AplVMP1) (SVMP) ... Venom metalloproteinase (M12B) ...

VM2V2_AGKPL Zinc metalloproteinase/disintegrin VMP-II (AplVMP2) [Cleaved ... Venom metalloproteinase (M12B) ...

VM3V3_AGKPL Zinc metalloproteinase-disintegrin-like VMP-III (AplVMP-III) (EC ... Venom metalloproteinase (M12B) ...

VSPCA_AGKPL Protein C activator (APL-C) (EC 3.4.21.-) (Snake venom serine ... Peptidase S1 family, Snake venom ...

VSPPA_AGKPL Venom plasminogen activator (APL-PA) (EC 3.4.21.-) (Snake venom ... Peptidase S1 family, Snake venom ...