AB hydrolase superfamily, Lipase family
Lipases are enzymes that catalyze the hydrolysis of lipids. They are a subclass of the esterases.
The AB hydrolase superfamily (lipase family) is found
of both wasps and snakes.
(Elapidae and Viperidae), this enzyme (EC 3.1.1.-) catalyses the hydrolysis of triglycerides and cholesteryl esters delivered to lysosomes. The biological contribution of this family to venom activity is unknown (
Correa-Netto et al., 2011
(Vespidae), this enzyme (also called phospholipase A1, EC 188.8.131.52) catalyses the hydrolysis of acyl-ester bonds at both the sn-1 and the sn-2 positions of phosphatidylcholine (
Sudprasert et al., 2013
). It causes local inflammatory reactions and acts as an allergen. It can also cause severe hemolysis with consequent cardiac dysfunction and death (
Ho et al., 1993
Ho and Ko, 1988
). In addition, this enzyme has been reported to activate platelet aggregation and induce thrombosis
Yang et al., 2008
). Characterization of these venom proteins is still incomplete, and their biological functions remain unclear.
Platelet aggregation activating toxin
This protein family in
SIB Swiss Institute of Bioinformatics