Crotalus adamanteus (eastern diamondback rattlesnake)

Venom composition
Figure 1: Composition of C. adamanteus venom, studied at the transcriptomic level (Rokyta et al., 2011 ). This venom contains the following families: Serine protease (Peptidase S1 ), lectin (True venom lectin ), SVMP (snake venom metalloproteinase, PA2 (Phospholipase A2 ), LAAO (Flavin monoamine oxidase (L-amino-acid oxidase) ), CRISP
Clinical Effects, Treatment, Antivenoms See the Clinical toxinology resources website
and the WHO venomous snake database to access snake distribution and antivenom products.
Lethal dose
Taxonomy

UniProt taxonomy
The Reptile database
Wikipedia

Infraorder: Serpentes


Family: Viperidae
Genus: Crotalus
Species: adamanteus
Activity Antimicrobial
Complement system impairing toxin
Cell adhesion impairing toxin
Hypotensive agent
Hemostasis impairing toxin
  Platelet agg. inhibiting toxin
  Blood coagulation cascade activating toxin
Myotoxin
Neurotoxin
or see
UniProtKB browsing by keyword
Reference Margres et al., 2014
Rokyta et al., 2012
Rokyta et al., 2011

Venom protein entries in UniProtKB/Swiss-Prot

44 entries grouped by species (browse by taxonomy, browse by keywords)

44 entries

Crotalus adamanteus (Eastern diamondback rattlesnake)

Select_allDeselect_all
BP11A_CROAD Bradykinin-potentiating peptide 11a (BPP-11a) Bradykinin-potentiating peptide ...
BP11B_CROAD Bradykinin-potentiating peptide 11b (BPP-11b) Bradykinin-potentiating peptide ...
CRVP_CROAD Cysteine-rich secretory protein (CRVP) CRISP family
CYT1_CROAD Cystatin-1 Cystatin family
CYT2_CROAD Cystatin-2 Cystatin family
HYAL_CROAD Hyaluronidase (EC 3.2.1.35) (Hyaluronoglucosaminidase) (Venom ... Glycosyl hydrolase 56 family
LICH_CROAD Putative lysosomal acid lipase/cholesteryl ester hydrolase (Acid ... AB hydrolase superfamily, Lipase ...
LIPE_CROAD Putative endothelial lipase (EC 3.1.1.3) AB hydrolase superfamily, Lipase ...
MYX_CROAD Myotoxin (CAM-toxin) Crotamine-myotoxin family
OXLA2_CROAD L-amino-acid oxidase (LAAO) (LAO) (EC 1.4.3.2) Flavin monoamine oxidase family, ...
OXLA_CROAD L-amino-acid oxidase (LAAO) (LAO) (EC 1.4.3.2) (Apoxin I) ... Flavin monoamine oxidase family, ...
PA2A_CROAD Acidic phospholipase A2 beta (svPLA2) (EC 3.1.1.4) ... Phospholipase A2 family, Group ...
PDE1_CROAD Venom phosphodiesterase 1 (Ectonucleotide ... Nucleotide ...
PDE2_CROAD Venom phosphodiesterase 2 (Ectonucleotide ... Nucleotide ...
PLB_CROAD Phospholipase B (PLB) (EC 3.1.1.-) Phospholipase B-like family
RCN2V_CROAD Reticulocalbin-2 (Taipoxin-associated calcium-binding protein 49 ... CREC family
SL6_CROAD C-type lectin 6 Snaclec family
SL9A_CROAD C-type lectin 9a Snaclec family
SLD_CROAD C-type lectin 13 Snaclec family
SLG_CROAD C-type lectin 16 Snaclec family
TCTP_CROAD Translationally-controlled tumor protein homolog (TCTP) TCTP family
V5NTD_CROAD Snake venom 5'-nucleotidase (5'-NT) (EC 3.1.3.5) ... 5'-nucleotidase family
VCO3_CROAD Venom factor (VF) (CVF-like) (Complement C3 homolog) [Cleaved ... Venom complement C3 homolog ...
VESP_CROAD Vespryn Ohanin/vespryn family
VM12_CROAD Snake venom metalloproteinase adamalysin-2 (SVMP) (EC 3.4.24.46) ... Venom metalloproteinase (M12B) ...

pdb 1IAG; 2AIG; 3AIG; 4AIG

VM28_CROAD Zinc metalloproteinase-disintegrin 8 (EC 3.4.24.-) (Snake venom ... Venom metalloproteinase (M12B) ...
VM2_CROAD Zinc metalloproteinase-disintegrin VMP-II (CamVMP-II) (EC ... Venom metalloproteinase (M12B) ...
VM32A_CROAD Zinc metalloproteinase-disintegrin-like 2a (EC 3.4.24.-) (Snake ... Venom metalloproteinase (M12B) ...
VM32D_CROAD Zinc metalloproteinase-disintegrin-like 2d (EC 3.4.24.-) (Snake ... Venom metalloproteinase (M12B) ...
VM33_CROAD Zinc metalloproteinase-disintegrin-like 3a (EC 3.4.24.-) (Snake ... Venom metalloproteinase (M12B) ...
VM34_CROAD Zinc metalloproteinase-disintegrin-like 4a (EC 3.4.24.-) (Snake ... Venom metalloproteinase (M12B) ...
VM38_CROAD Zinc metalloproteinase-disintegrin-like 8 (EC 3.4.24.-) (Snake ... Venom metalloproteinase (M12B) ...
VSP1_CROAD Snake venom serine proteinase 1 (SVSP) (EC 3.4.21.-) Peptidase S1 family, Snake venom ...
VSP2_CROAD Snake venom serine proteinase 2 (SVSP) (EC 3.4.21.-) Peptidase S1 family, Snake venom ...
VSP4_CROAD Snake venom serine proteinase 4a (SVSP) (EC 3.4.21.-) Peptidase S1 family, Snake venom ...
VSP5_CROAD Snake venom serine proteinase 5 (SVSP) (EC 3.4.21.-) (Serine ... Peptidase S1 family, Snake venom ...
VSP8_CROAD Snake venom serine proteinase 8 (SVSP) (EC 3.4.21.-) Peptidase S1 family, Snake venom ...
VSP9_CROAD Snake venom serine proteinase 9 (SVSP) (EC 3.4.21.-) Peptidase S1 family, Snake venom ...
VSPB_CROAD Snake venom serine proteinase 11 (SVSP) (EC 3.4.21.-) Peptidase S1 family, Snake venom ...
VSPCR_CROAD Thrombin-like enzyme crotalase (SVTLE) (EC 3.4.21.74) ... Peptidase S1 family, Snake venom ...
VSPC_CROAD Snake venom serine proteinase 12 (SVSP) (EC 3.4.21.-) Peptidase S1 family, Snake venom ...
VSPD_CROAD Inactive snake venom serine proteinase 13 (SVSP) Peptidase S1 family, Snake venom ...
VSPE_CROAD Snake venom serine proteinase 14 (SVSP) (EC 3.4.21.-) Peptidase S1 family, Snake venom ...
VSPS1_CROAD Snake venom serine proteinase Sp1 (SVSP) (EC 3.4.21.-) Peptidase S1 family, Snake venom ...