G-protein coupled receptor impairing toxin (GPCR regulator)

Receptor G-protein coupled receptors (GPCRs) are membrane proteins constituted of seven transmembrane segments linked by three external and three internal loops. GPCRs constitute the largest family of membrane proteins. They transduce external stimuli into the cell and control almost all physiological processes in humans (Jacoby et al., 2006).

Venom protein entries in UniProtKB/Swiss-Prot

(all links/actions below point to uniprot.org website)

148 entries grouped by family

reorder by species

3 entries

AVIT (prokineticin) family

"AVIT (prokineticin) family" VenomZone page

MIT1_DENPO Toxin MIT1 (MIT 1) (Black mamba intestinal toxin ... Dendroaspis polylepis polylepis (Black mamba)

pdb 1IMT

VAR1_VARVA AVIToxin-VAR1 Varanus varius (Lace monitor lizard) (Lacerta ...

VAR2_VARVA AVIToxin-VAR2 Varanus varius (Lace monitor lizard) (Lacerta ...

3 entries

Bradykinin inhibitor peptide family

BKIP_AGKBI Bradykinin inhibitor peptide (BIP) Agkistrodon bilineatus (Cantil) (Tropical ...

BKIP_CROAT Bradykinin inhibitor peptide (BIP) Crotalus atrox (Western diamondback rattlesnake)

BKIP_CROVV Bradykinin inhibitor peptide (BIP) Crotalus viridis viridis (Prairie rattlesnake)

1 entry

Bradykinin-potentiating peptide family

1 entry

Bradykinin-potentiating peptide family; Natriuretic peptide family

2 entries

Bradykinin-potentiating peptide family; PHpG family; Natriuretic peptide family

"Bradykinin-potentiating peptide family" VenomZone page

BNP1_BOTJA Bradykinin-potentiating and C-type natriuretic ... Bothrops jararaca (Jararaca) (Bothrops jajaraca)

BNP2_BOTJA Bradykinin-potentiating and C-type natriuretic ... Bothrops jararaca (Jararaca) (Bothrops jajaraca)

12 entries

Bradykinin-related peptide family

BRK1_PROEX Protopolybiakinin-1 (Bradykinin-related peptide) ... Protopolybia exigua (Neotropical social wasp)

BRK6_CYPDO Bradykinin-related peptide Cd-146 Cyphononyx dorsalis (Spider wasp) (Cyphononyx ...

BRKC_CYPDO Cyphokinin (Bradykinin-related peptide) [Cleaved ... Cyphononyx dorsalis (Spider wasp) (Cyphononyx ...

BRKF_CYPDO Fulvonin (Bradykinin-related peptide) Cyphononyx dorsalis (Spider wasp) (Cyphononyx ...

BRK_MEGFL Megascoliakinin (MBK) (Thr6-bradykinin-Lys-Ala) ... Megascolia flavifrons (Garden dagger wasp) ...

BRK_PARID Waspkinin (Bradykinin-related peptide) Parapolybia indica (Lesser paper wasp)

BRK_POLMJ Wasp kinin PMM1 (Bradykinin-related peptide) Polistes major (Neotropical social wasp)

BRK_POLOC Thr6-bradykinin (Bradykinin-related peptide) Polybia occidentalis (Paper wasp)

BRK_VESMA Vespakinin-M (Bradykinin-related peptide) Vespa mandarinia (Asian giant hornet)

BRK_VESMC Vespulakinin-1 [Cleaved into: Vespulakinin-2 ... Vespula maculifrons (Eastern yellow jacket) ...

BRK_VESXA Vespakinin-X (Bradykinin-related peptide) Vespa xanthoptera (Japanese yellow hornet) ...

KLPS_LYCER Kinin-like peptide-S Lycosa erythrognatha (Wolf spider) (Scaptocosa ...

2 entries

Cationic peptide 01 (latrotoxin) family, 03 (alpha-latrotoxin) subfamily

LATA_LATGE Alpha-latrotoxin-Lg1a (Alpha-LTX-Lg1a) ... Latrodectus geometricus (Brown widow spider)

LATA_LATTR Alpha-latrotoxin-Lt1a (Alpha-LTX-Lt1a) ... Latrodectus tredecimguttatus (Mediterranean ...

2 entries

Conotoxin A superfamily

CA1A_CONRE Alpha-conotoxin RgIA Conus regius (Crown cone)

pdb 2JUQ; 2JUR; 2JUS; 2JUT; 2MTO; 2MTT; 6HY7; 7EGR

CA1A_CONTU Rho-conotoxin TIA (Rho-TIA) Conus tulipa (Fish-hunting cone snail) (Tulip ...

pdb 1IEN; 2LR9

3 entries

Conotoxin C superfamily

CON1_CONLT Contulakin-Lt1 Conus litteratus (Lettered cone)

CON2_CONLT Contulakin-Lt2 Conus litteratus (Lettered cone)

CONG_CONGE Contulakin-G (CGX-1160) Conus geographus (Geography cone) (Nubecula ...

15 entries

Conotoxin C superfamily, Consomatin family

CSST1_CONAE Consomatin Ar1 (ConSST Ar1) ... Conus arenatus (Sand-dusted cone)

CSST1_CONBE Consomatin Be1 (ConSST Be1) ... Conus betulinus (Beech cone)

CSST1_CONGE Consomatin G1 (ConSST G1) (Somatostatin-related ... Conus geographus (Geography cone) (Nubecula ...

CSST1_CONGH Consomatin Gh1 (ConSST Gh1) ... Conus grahami (Cone snail) (Africonus grahami)

CSST1_CONLV Consomatin Le1 (ConSST Le1) ... Conus lenavati (Cone snail)

CSST1_CONMA Consomatin Ma1 (ConSST Ma1) ... Conus magus (Magical cone)

CSST1_CONMH Consomatin Mao1 (ConSST Mao1) (Consomatin Ma1) ... Conus maioensis (Sea snail) (Africonus ...

CSST1_CONMK Consomatin Mrc1 (ConSST Mrc1) ... Conus mercator (Trader cone) (Varioconus ...

CSST1_CONNO Consomatin Nc1 (ConSST Nc1) ... Conus neocostatus (Cone snail) (Asprella ...

CSST1_CONRL Consomatin Rs1 (ConSST Rs1) ... Conus raulsilvai (Sea snail) (Africonus ...

CSST1_CONRO Consomatin Ro1 (ConSST Ro1) ... Conus rolani (Cone snail)

CSST1_CONTC Consomatin Te1 (ConSST Te1) ... Conus terebra (Sea snail) (Virgiconus terebra)

CSST2_CONGE Consomatin G2 (ConSST G2) (Somatostatin-related ... Conus geographus (Geography cone) (Nubecula ...

CSST2_CONRO Consomatin Ro2 (ConSST Ro2) ... Conus rolani (Cone snail)

CSST3_CONMK Consomatin Mrc3 (ConSST Mrc3) ... Conus mercator (Trader cone) (Varioconus ...

2 entries

Conotoxin T superfamily

CT32_CONLI Conotoxin LiC32 Conus lividus (Livid cone)

CT5A_CONCN Tau-conotoxin CnVA (Tau-CnVA) Conus consors (Singed cone)

6 entries

Endothelin/sarafotoxin family

"Endothelin/sarafotoxin family" VenomZone page

SRTX1_ATRIR Sarafotoxin-i1 (SRTX-i1) (Sarafotoxin-i3) ... Atractaspis irregularis (Variable burrowing asp) ...

pdb 2LDE

SRTX2_ATRIR Sarafotoxin-i2 (SRTX-i2) Atractaspis irregularis (Variable burrowing asp) ...

SRTXB_ATRBI Bibrotoxin (BTX) Atractaspis bibronii (Bibron's mole viper) ...

SRTXD_ATREN Sarafotoxin-D (SRTX-D) (S6D) Atractaspis engaddensis (Israeli burrowing asp) ...

SRTXL_ATRMM Long-sarafotoxin (L-SRTX) [Cleaved into: ... Atractaspis microlepidota microlepidota

pdb 2LDF

SRTX_ATREN Sarafotoxin [Cleaved into: Sarafotoxin-A, ... Atractaspis engaddensis (Israeli burrowing asp) ...

pdb 1SRB; 6LRY

3 entries

FARP (FMRFamide related peptide) family

CRFA1_CONSP Conorfamide-Sr1 (CNF-Sr1) (Cono-RFamide-Sr1) Conus spurius (Alphabet cone)

CRFA2_CONTE Conorfamide-Tx2 (CNF-Tx2) (Cono-RFamide-Tx2) Conus textile (Cloth-of-gold cone)

CRFA_CONVC Conorfamide-Vc1 (CNF-Vc1) (Cono-RFamide-Vc1) Conus victoriae (Queen Victoria cone)

1 entry

Gastrin/cholecystokinin family

7 entries

Glucagon family

EXE1_HELHO Exendin-1 (Helospectin-1) (VIP-like 1) [Cleaved ... Heloderma horridum horridum (Mexican beaded ...

EXE1_HELSU Exendin-1 (Helospectin I) (Helospectin-1) ... Heloderma suspectum (Gila monster)

EXE2_HELSC Exendin-2-long [Cleaved into: Exendin-2 ... Heloderma suspectum cinctum (Banded Gila ...

EXE2_HELSU Exendin-2-long [Cleaved into: Exendin-2 ... Heloderma suspectum (Gila monster)

EXE3_HELHO Exendin-3 (Glucagon-like 3) Heloderma horridum horridum (Mexican beaded ...

EXE4_HELSC Exendin-4 Heloderma suspectum cinctum (Banded Gila ...

EXE4_HELSU Exendin-4 (Exenatide) Heloderma suspectum (Gila monster)

pdb 1JRJ; 2MJ9; 2NAV; 2NAW; 3C59; 3C5T; 5NIQ; 5OTT; 6GDZ; 6GE2; 7LLL; 7MLL

2 entries

Limacoditoxin-1 (ACP-like) family

Z11_DORVU Z-limacoditoxin(1)-Dv1 (Z-LCTX(1)-Dv1) ... Doratifera vulnerans (Mottled cup moth)

Z14_DORVU Z-limacoditoxin(1)-Dv4 (Z-LCTX(1)-Dv4) ... Doratifera vulnerans (Mottled cup moth)

12 entries

Long (3 C-C) scorpion toxin superfamily

LV1A1_LYCMC Lipolysis-activating peptide 1-alpha chain ... Lychas mucronatus (Chinese swimming scorpion)

LV1A2_LYCMC Lipolysis-activating peptide 1-alpha chain ... Lychas mucronatus (Chinese swimming scorpion)

LV1A_BUTOC Lipolysis-activating peptide 1-alpha chain ... Buthus occitanus tunetanus (Common European ...

LV1A_BUTOS Lipolysis-activating peptide 1-alpha chain ... Buthus occitanus israelis (Common yellow ...

LV1A_MESMA Lipolysis-activating peptide 1-alpha chain ... Mesobuthus martensii (Manchurian scorpion) ...

LV1B1_LYCMC Lipolysis-activating peptide 1-beta chain ... Lychas mucronatus (Chinese swimming scorpion)

LV1B2_LYCMC Lipolysis-activating peptide 1-beta chain ... Lychas mucronatus (Chinese swimming scorpion)

LV1B_BUTOC Lipolysis-activating peptide 1-beta chain ... Buthus occitanus tunetanus (Common European ...

LV1B_BUTOS Lipolysis-activating peptide 1-beta chain ... Buthus occitanus israelis (Common yellow ...

LV1B_MESMA HMG-CoA reductase inhibitor bumarsin (JCH2) ... Mesobuthus martensii (Manchurian scorpion) ...

LVPAH_LYCMC Lipolysis-activating peptide 1-alpha chain ... Lychas mucronatus (Chinese swimming scorpion)

LVPAY_LYCMC Lipolysis-activating peptide 1-alpha chain ... Lychas mucronatus (Chinese swimming scorpion)

1 entry

Natriuretic peptide family

3 entries

Non-disulfide-bridged peptide (NDBP) superfamily

NDB31_TITSE Hypotensin toxin Ts31 (Anti-hypertensive ... Tityus serrulatus (Brazilian scorpion)

NDBH1_TITSE Hypotensin-1 (Anti-hypertensive peptide) ... Tityus serrulatus (Brazilian scorpion)

NDBH2_TITSE Hypotensin-2 (Hypotensin II) (TsHpt-II) (Toxin ... Tityus serrulatus (Brazilian scorpion)

6 entries

Not in a family

AIP9_SCOMU Scolopendrasin-9 (Scolopendrasin IX) Scolopendra mutilans (Chinese red-headed ...

HKS_HELHO Helokinestatin-1 (Helokinestatin) Heloderma horridum horridum (Mexican beaded ...

HKS_HELSS Helokinestatin-1 Heloderma suspectum suspectum (Reticulate Gila ...

TXN1A_PARTR NU-buthitoxin-Ptr1a (N-BUTX-Ptr1a) ... Parabuthus transvaalicus (South African fattail ...

pdb 6SAB

TXN1A_POERG NU-theraphotoxin-Preg1a (N-TRTX-Preg1a) ... Poecilotheria regalis (Indian ornamental tree ...

pdb 6SAA

YA_MESMA BmK-YA precursor [Cleaved into: BmK-YA 1 ... Mesobuthus martensii (Manchurian scorpion) ...

1 entry

Opioid neuropeptide precursor family

2 entries

Phospholipase A2 family, Group I subfamily, D49 sub-subfamily

"Phospholipase A2 family" VenomZone page

PA2A1_NAJAT Acidic phospholipase A2 1 (svPLA2) (EC 3.1.1.4) ... Naja atra (Chinese cobra)

pdb 1POA; 1POB

PA2NA_NAJSP Neutral phospholipase A2 muscarinic inhibitor ... Naja sputatrix (Malayan spitting cobra) (Naja ...

1 entry

Phospholipase A2 family, Group II subfamily, D49 sub-subfamily

1 entry

Snake three-finger toxin family

1 entry

Snake three-finger toxin family, Ancestral subfamily, Orphan group II sub-subfamily

3 entries

Snake three-finger toxin family, Ancestral subfamily, Orphan group V sub-subfamily

"Snake three-finger toxin family" VenomZone page

3NO52_BUNMU Long neurotoxin homolog NTL2 Bungarus multicinctus (Many-banded krait)

3NO56_BUNMU Long neurotoxin homolog TA-bm16 (Delta-protein) Bungarus multicinctus (Many-banded krait)

3NO5I_BUNMU Gamma-bungarotoxin (Long neurotoxin homolog ... Bungarus multicinctus (Many-banded krait)

pdb 1MR6

1 entry

Snake three-finger toxin family, Ancestral subfamily, Orphan group XVII sub-subfamily

1 entry

Snake three-finger toxin family, Short-chain subfamily

"Snake three-finger toxin family" VenomZone page

3SX9_DENPO Dendroaspis polylepis MT9 (Three-finger toxin) ... Dendroaspis polylepis polylepis (Black mamba)

pdb 6R5M

22 entries

Snake three-finger toxin family, Short-chain subfamily, Aminergic toxin sub-subfamily

"Snake three-finger toxin family" VenomZone page

3SDC1_OPHHA Beta-cardiotoxin CTX21 Ophiophagus hannah (King cobra) (Naja hannah)

3SDC3_OPHHA Beta-cardiotoxin CTX23 Ophiophagus hannah (King cobra) (Naja hannah)

3SDC4_OPHHA Beta-cardiotoxin CTX14 Ophiophagus hannah (King cobra) (Naja hannah)

3SDC5_OPHHA Beta-cardiotoxin CTX15 (OH-84) Ophiophagus hannah (King cobra) (Naja hannah)

3SDC7_OPHHA Beta-cardiotoxin CTX27 (OH-27) Ophiophagus hannah (King cobra) (Naja hannah)

pdb 3PLC

3SDC9_OPHHA Beta-cardiotoxin CTX9 Ophiophagus hannah (King cobra) (Naja hannah)

3SI12_DENAN Muscarinic m1-toxin2 Dendroaspis angusticeps (Eastern green mamba) ...

3SI13_DENAN Muscarinic m1-toxin3 Dendroaspis angusticeps (Eastern green mamba) ...

3SI14_DENAN Muscarinic m1-toxin4 Dendroaspis angusticeps (Eastern green mamba) ...

3SI1A_DENAN Toxin AdTx1 (Rho-elapitoxin-Da1a) (Rho-Da1a) ... Dendroaspis angusticeps (Eastern green mamba) ...

pdb 4IYE; 5MG9

3SI1B_DENAN Rho-elapitoxin-Da1b (Rho-Da1b) (Rho-EPTX-Da1b) Dendroaspis angusticeps (Eastern green mamba) ...

3SI35_OPHHA Short neurotoxin OH-35 Ophiophagus hannah (King cobra) (Naja hannah)

3SI3_DENPO Adrenergic toxin rho-elapitoxin-Dp1b ... Dendroaspis polylepis polylepis (Black mamba)

3SIM1_DENAN Muscarinic toxin 1 (MT1) (MTx1) Dendroaspis angusticeps (Eastern green mamba) ...

pdb 3FEV; 3NEQ; 4DO8

3SIM2_DENAN Muscarinic toxin 2 (MT2) (MTx2) Dendroaspis angusticeps (Eastern green mamba) ...

pdb 1FF4

3SIM3_DENAN Muscarinic toxin 3 (MT3) Dendroaspis angusticeps (Eastern green mamba) ...

3SIM4_DENAN Muscarinic toxin 4 (MT4) Dendroaspis angusticeps (Eastern green mamba) ...

3SIM6_OPHHA Muscarinic toxin MTX6 Ophiophagus hannah (King cobra) (Naja hannah)

3SIM7_DENAN Muscarinic toxin 7 (MT-7) (MT7) (Muscarinic ... Dendroaspis angusticeps (Eastern green mamba) ...

pdb 2VLW; 3FEV; 3NEQ; 6WJC

3SIM8_OPHHA Muscarinic toxin 38 (MTX38) Ophiophagus hannah (King cobra) (Naja hannah)

3SIMA_DENPO Muscarinic toxin alpha (MT-alpha) Dendroaspis polylepis polylepis (Black mamba)

3SIMB_DENPO Adrenergic toxin rho-elapitoxin-Dp1a ... Dendroaspis polylepis polylepis (Black mamba)

4 entries

Snake three-finger toxin family, Short-chain subfamily, Orphan group VIII (haditoxin) sub-subfamily

"Snake three-finger toxin family" VenomZone page

3SO8_BUNMU Muscarinic toxin-like protein Bungarus multicinctus (Many-banded krait)

3SO8_NAJAT Neurotoxin homolog NL1 Naja atra (Chinese cobra)

3SO8_NAJKA Muscarinic toxin-like protein 3 (MTLP-3) Naja kaouthia (Monocled cobra) (Naja siamensis)

3SO8_NAJNA Muscarinic toxin-like protein 1 (MTLP-1) ... Naja naja (Indian cobra)

1 entry

Snake three-finger toxin family, Short-chain subfamily, Type B muscarinic toxin sub-subfamily

2 entries

Snake three-finger toxin family, Short-chain subfamily, Type C muscarinic toxin sub-subfamily

"Snake three-finger toxin family" VenomZone page

3SUC1_NAJKA Muscarinic toxin-like protein 1 (MTLP-1) Naja kaouthia (Monocled cobra) (Naja siamensis)

3SUC1_NAJME Muscarinic toxin-like protein Tx-NM3-2 Naja melanoleuca (Forest cobra) (Black-lipped ...

1 entry

SNTX/VTX toxin family

11 entries

Vasopressin/oxytocin family

CESS1_CONMO Conopressin-conophysin, isoform 1 [Cleaved into: ... Conus monile (Necklace cone)

CESS2_CONMO Conopressin/conophysin, isoform 2 [Cleaved into: ... Conus monile (Necklace cone)

CESS3_CONMO Conopressin/conophysin, isoform 3 [Cleaved into: ... Conus monile (Necklace cone)

CESS_CONGE Conopressin-conophysin [Cleaved into: ... Conus geographus (Geography cone) (Nubecula ...

CONO1_CONML Conopressin-M1 (Con-M1) Conus miliaris (Thousand-spot cone)

CONO2_CONML Conopressin-M2 Conus miliaris (Thousand-spot cone)

CONOT_CONTU Conopressin-T (Con-T) Conus tulipa (Fish-hunting cone snail) (Tulip ...

CONOV_CONVL Gamma-conopressin vil Conus villepinii (Villepin's cone)

CONO_CONST Conopressin-S (Con-S) (Arg-conopressin S) Conus striatus (Striated cone)

CONO_CONTE Conopressin-Tx Conus textile (Cloth-of-gold cone)

CXPH_CONRA Conophysin-R Conus radiatus (Rayed cone)

9 entries

Venom Kunitz-type family

"Venom Kunitz-type family" VenomZone page

MAMB1_DENAN Mambaquaretin-1 (MQ-1) (MQ1) (Upsilon-Da2a) Dendroaspis angusticeps (Eastern green mamba) ...

pdb 5M4V

MAMB2_DENVI Mambaquaretin-2 (MQ2) (Upsilon-Dv2a) Dendroaspis viridis (Western green mamba)

MAMB3_DENPO Mambaquaretin-3 (MQ3) (Upsilon-Dp2a) Dendroaspis polylepis polylepis (Black mamba)

MAMB4_DENVI Mambaquaretin-4 (MQ4) (Upsilon-Dv2c) Dendroaspis viridis (Western green mamba)

MAMB5_DENJA Mambaquaretin-5 (MQ5) (Upsilon-Dj2a) Dendroaspis jamesoni kaimosae (Eastern Jameson's ...

MAMB6_DENVI Mambaquaretin-6 (MQ6) (Upsilon-Dv2d) Dendroaspis viridis (Western green mamba)

MAMB7_DENPO Mambaquaretin-7 (MQ7) (Kunitz-type serine ... Dendroaspis polylepis polylepis (Black mamba)

MAMB9_DENVI Mambaquaretin-9 (MQ9) (Upsilon-Dv2b) Dendroaspis viridis (Western green mamba)

VKT_NAJAT Kunitz-type serine protease inhibitor NACI (Naja ... Naja atra (Chinese cobra)

pdb 2M99

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