G-protein coupled acetylcholine receptor impairing toxin (mAChR regulator)

Receptor Muscarinic acetylcholine receptors (mAChRs) are a subfamily of G protein-coupled receptors that regulate numerous fundamental functions of the central and peripheral nervous system, such as heart rate, smooth muscle contraction and glandular secretion.
The mAChR family consists of five distinct subtypes, denoted M1 to M5 (encoded by the CHRM1 to CHRM5 genes). Three of these receptor subtypes (M1, M3 and M5) couple to G proteins of the G<SUB>q/11 family, whereas the remaining two subtypes (M2 and M4) preferentially signal through the G<SUB>i/0 family of G proteins (Ishii and Kurachi, 2006, Kruse et al., 2014).
Toxin
Receptor Toxins from different taxa that target receptors.
Click on image to retrieve receptors or toxins of interest.
Human Snake Scorpion Cone
snail 		Spider Cnidarian Insect Other All
mAChR M1/CHRM1 image image - - - - - - image
mAChR M2/CHRM2 image image - - - - - - image
mAChR M3/CHRM3 image image - - - - - - image
mAChR M4/CHRM4 image image - - - - - - image
mAChR M5/CHRM5 image - - - - - - - -
mAChR All image image - - - - - - image
Link Back to Pharmacological targets
Back to G-protein coupled receptor impairing toxin
Nomenclature No nomenclature has been given to toxins that target this type of receptor (see King et al., 2008).

Venom protein entries in UniProtKB/Swiss-Prot

(all links/actions below point to uniprot.org website)

31 entries grouped by family

1 entry

Bradykinin-potentiating peptide family

"Bradykinin-potentiating peptide family" VenomZone page
BPP7A_BOTJA Bradykinin-potentiating peptide 7a (BPP-7a) ... Bothrops jararaca (Jararaca) (Bothrops jajaraca)

1 entry

Bradykinin-potentiating peptide family; Natriuretic peptide family

"Bradykinin-potentiating peptide family" VenomZone page
BNP_BOTIN Bradykinin-potentiating and C-type natriuretic ... Bothrops insularis (Golden lancehead) (Lachesis ...

1 entry

Long (4 C-C) scorpion toxin superfamily, Sodium channel inhibitor family, Alpha subfamily

SCX3_TITSE Alpha-mammal toxin Ts3 (PT-Mice-alpha NaTx3.1) ... Tityus serrulatus (Brazilian scorpion)

pdb 5CY0

1 entry

Non-disulfide-bridged peptide (NDBP) superfamily, Scorpion BPP (group 1) family

NDB11_TITSE Bradykinin-potentiating peptide T (BPP-T) ... Tityus serrulatus (Brazilian scorpion)

2 entries

Phospholipase A2 family, Group I subfamily, D49 sub-subfamily

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PA2A1_NAJAT Acidic phospholipase A2 1 (svPLA2) (EC 3.1.1.4) ... Naja atra (Chinese cobra)

pdb 1POA; 1POB

PA2NA_NAJSP Neutral phospholipase A2 muscarinic inhibitor ... Naja sputatrix (Malayan spitting cobra) (Naja ...

1 entry

Snake three-finger toxin family

"Snake three-finger toxin family" VenomZone page
3X_MICLE Muscarinic toxin Mlalpha (MT-Mlalpha) Micrurus lemniscatus (South American coral ...

1 entry

Snake three-finger toxin family, Ancestral subfamily, Orphan group II sub-subfamily

"Snake three-finger toxin family" VenomZone page
3NO2_NAJKA Tryptophan-containing weak neurotoxin (WTX) Naja kaouthia (Monocled cobra) (Naja siamensis)

pdb 2MJ0

3 entries

Snake three-finger toxin family, Ancestral subfamily, Orphan group V sub-subfamily

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3NO52_BUNMU Long neurotoxin homolog NTL2 Bungarus multicinctus (Many-banded krait)
3NO56_BUNMU Long neurotoxin homolog TA-bm16 (Delta-protein) Bungarus multicinctus (Many-banded krait)
3NO5I_BUNMU Gamma-bungarotoxin (Long neurotoxin homolog ... Bungarus multicinctus (Many-banded krait)

pdb 1MR6

1 entry

Snake three-finger toxin family, Ancestral subfamily, Orphan group XVII sub-subfamily

"Snake three-finger toxin family" VenomZone page
3NOHE_BUNMU Muscarinic toxin BM14 Bungarus multicinctus (Many-banded krait)

1 entry

Snake three-finger toxin family, Short-chain subfamily

"Snake three-finger toxin family" VenomZone page
3SX9_DENPO Dendroaspis polylepis MT9 (Three-finger toxin) ... Dendroaspis polylepis polylepis (Black mamba)

pdb 6R5M

11 entries

Snake three-finger toxin family, Short-chain subfamily, Aminergic toxin sub-subfamily

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3SI12_DENAN Muscarinic m1-toxin2 Dendroaspis angusticeps (Eastern green mamba) ...
3SI13_DENAN Muscarinic m1-toxin3 Dendroaspis angusticeps (Eastern green mamba) ...
3SI14_DENAN Muscarinic m1-toxin4 Dendroaspis angusticeps (Eastern green mamba) ...
3SI35_OPHHA Short neurotoxin OH-35 Ophiophagus hannah (King cobra) (Naja hannah)
3SIM1_DENAN Muscarinic toxin 1 (MT1) (MTx1) Dendroaspis angusticeps (Eastern green mamba) ...

pdb 3FEV; 3NEQ; 4DO8

3SIM2_DENAN Muscarinic toxin 2 (MT2) (MTx2) Dendroaspis angusticeps (Eastern green mamba) ...

pdb 1FF4

3SIM3_DENAN Muscarinic toxin 3 (MT3) Dendroaspis angusticeps (Eastern green mamba) ...
3SIM4_DENAN Muscarinic toxin 4 (MT4) Dendroaspis angusticeps (Eastern green mamba) ...
3SIM6_OPHHA Muscarinic toxin MTX6 Ophiophagus hannah (King cobra) (Naja hannah)
3SIM7_DENAN Muscarinic toxin 7 (MT-7) (MT7) (Muscarinic ... Dendroaspis angusticeps (Eastern green mamba) ...

pdb 2VLW; 3FEV; 3NEQ; 6WJC

3SIM8_OPHHA Muscarinic toxin 38 (MTX38) Ophiophagus hannah (King cobra) (Naja hannah)

4 entries

Snake three-finger toxin family, Short-chain subfamily, Orphan group VIII (haditoxin) sub-subfamily

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3SO8_BUNMU Muscarinic toxin-like protein Bungarus multicinctus (Many-banded krait)
3SO8_NAJAT Neurotoxin homolog NL1 Naja atra (Chinese cobra)
3SO8_NAJKA Muscarinic toxin-like protein 3 (MTLP-3) Naja kaouthia (Monocled cobra) (Naja siamensis)
3SO8_NAJNA Muscarinic toxin-like protein 1 (MTLP-1) ... Naja naja (Indian cobra)

1 entry

Snake three-finger toxin family, Short-chain subfamily, Type B muscarinic toxin sub-subfamily

"Snake three-finger toxin family" VenomZone page
3SUB_DENAN Muscarinic toxin 2 (m2-toxin) Dendroaspis angusticeps (Eastern green mamba) ...

2 entries

Snake three-finger toxin family, Short-chain subfamily, Type C muscarinic toxin sub-subfamily

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3SUC1_NAJKA Muscarinic toxin-like protein 1 (MTLP-1) Naja kaouthia (Monocled cobra) (Naja siamensis)
3SUC1_NAJME Muscarinic toxin-like protein Tx-NM3-2 Naja melanoleuca (Forest cobra) (Black-lipped ...