Loxosceles intermedia (Brown spider)

Venom composition image
Figure 1: Composition of L.intermedia venom, studied at the transcriptomic level (Gremski et al., 2010). The venom contains the following families: LiTx3-related, LiTx, peptidase M12A (astacin-like metalloprotease), SicTox (arthropod phospholipase D) , neurotoxin-Magi 3-like,serine protease, TCTP (translationally controlled tumor protein) , allergen, hyaluronidase (glycosyl hydrolase 56) and serine protease inhibitor.
Clinical Effects, Treatment, Antivenoms See the Clinical Toxinology Resources Website.
Lethal dose LD(50) is 0.48 mg/kg when injected into mice (Barbaro et al., 1996).
LD(50) is 0.34 mg/kg by subcutaneous injection into mice (Dias-Lopez et al., 2010).
LD(50) is 1.80 ± 0.30 μg/g when injected into lepidoperan Agrotis ipsilon larvae (de Castro et al., 2004).
LD(50) is 1.39 ± 0.34 μg/g when injected into lepidoperan Diatraea saccharalis larvae (de Castro et al., 2004).
LD(50) is 1.92 ± 0.71 μg/g when injected into lepidoperan Spodoptera cosmioides larvae (de Castro et al., 2004).
LD(50) is 1.90 ± 0.11 μg/g when injected into lepidoperan Spodoptera frugiperdalarvae larvae
(de Castro et al., 2004).
Species diet Ants have been found in the mouth of one specimen of this species (Zobel-Thropp et al., 2012).
Taxonomy

UniProt taxonomy
Wikipedia

Infraorder: Araneae


Suborder: Araneomorphae
Family: Sicariidae
Genus: Loxosceles
Species: intermedia
Activity Complement system impairing toxin
Dermonecrotic toxin
Hemostasis impairing toxin
  Hemorrhagic toxin
Neurotoxin
and also
G-protein coupled receptor impairing toxin
Ion channel impairing toxin
or see
UniProtKB browsing by keyword
Reference Transcriptomic
Gremski et al., 2010
Proteomic
Machado et al., 2005, dos Sandos et al., 2009

Venom protein entries in UniProtKB/Swiss-Prot

(all links/actions below point to uniprot.org website)

26 entries grouped by species (browse by taxonomy, browse by keywords)

26 entries

Loxosceles intermedia (Brown spider)

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A1HA_LOXIN Dermonecrotic toxin LiSicTox-alphaIA1a (EC 4.6.1.-) ... Arthropod phospholipase D ...

pdb 3RLG; 3RLH

A1HB1_LOXIN Dermonecrotic toxin LiSicTox-alphaIA1bi (EC 4.6.1.-) (LiD1) ... Arthropod phospholipase D ...
A1HB2_LOXIN Dermonecrotic toxin LiSicTox-alphaIA1bii (EC 4.6.1.-) (LiRecDT1) ... Arthropod phospholipase D ...

pdb 4RW3; 4RW5

A1IA1_LOXIN Dermonecrotic toxin LiSicTox-alphaIA2ai (EC 4.6.1.-) (LiP2) (P2) ... Arthropod phospholipase D ...
A1IA2_LOXIN Dermonecrotic toxin LiSicTox-alphaIA2aii (EC 4.6.1.-) ... Arthropod phospholipase D ...
A1IA3_LOXIN Dermonecrotic toxin LiSicTox-alphaIA2aiii (EC 4.6.1.-) (Loxtox ... Arthropod phospholipase D ...
A1IB1_LOXIN Dermonecrotic toxin LiSicTox-alphaIA2bi (EC 4.6.1.-) (Loxtox i1) ... Arthropod phospholipase D ...
A1IB2_LOXIN Dermonecrotic toxin LiSicTox-alphaIA2bii (EC 4.6.1.-) (Loxtox ... Arthropod phospholipase D ...
A1X1_LOXIN Dermonecrotic toxin LiSicTox-alphaI-1 (EC 4.6.1.-) ... Arthropod phospholipase D ...
A21_LOXIN Dermonecrotic toxin LiSicTox-alphaII1 (EC 4.6.1.-) ... Arthropod phospholipase D ...
A22_LOXIN Dermonecrotic toxin LiSicTox-alphaII2 (EC 4.6.1.-) (Loxtox i5) ... Arthropod phospholipase D ...
A4A1_LOXIN Dermonecrotic toxin LiSicTox-alphaIVA1 (EC 4.6.1.-) ... Arthropod phospholipase D ...
A51_LOXIN Dermonecrotic toxin LiSicTox-alphaV1 (EC 4.6.1.-) (Dermonecrotic ... Arthropod phospholipase D ...
B1H1_LOXIN Dermonecrotic toxin LiSicTox-betaIA1i (EC 4.6.1.-) ... Arthropod phospholipase D ...
B1H2_LOXIN Dermonecrotic toxin LiSicTox-betaIA1ii (EC 4.6.1.-) ... Arthropod phospholipase D ...
B1Q_LOXIN Dermonecrotic toxin LiSicTox-betaID1 (EC 4.6.1.-) (Dermonecrotic ... Arthropod phospholipase D ...
HYAL_LOXIN Hyaluronidase (EC 3.2.1.35) (Chondroitinase) (Dietrich's ... Glycosyl hydrolase 56 family
TCTP_LOXIN Translationally-controlled tumor protein homolog (LiTCTP) ... TCTP family
TX1_LOXIN U1-sicaritoxin-Li1a (U1-SCRTX-Li1a) (LiTx1) Neurotoxin 28 (Litx) family
TX2_LOXIN U1-sicaritoxin-Li1b (U1-SCRTX-Li1b) (LiTx2) Neurotoxin 28 (Litx) family
TX32_LOXIN U2-sicaritoxin-Li1b (U2-SCRTX-Li1b) Neurotoxin 39 family
TX3_LOXIN U2-sicaritoxin-Li1a (U2-SCRTX-Li1a) (LiTx3) (Toxin 3) Neurotoxin 39 family
TX4_LOXIN U1-sicaritoxin-Li1c (U1-SCRTX-Li1c) (LiTx4) (Fragment) Neurotoxin 28 (Litx) family
VMPA2_LOXIN Astacin-like metalloprotease toxin 2 (EC 3.4.24.-) (Loxosceles ... Not in a family
VMPA3_LOXIN Astacin-like metalloprotease toxin 3 (EC 3.4.24.-) (Loxosceles ... Not in a family
VMPA_LOXIN Astacin-like metalloprotease toxin 1 (EC 3.4.24.-) (Loxosceles ... Not in a family