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Loxosceles intermedia
(Brown spider)
Venom composition
Figure 1: Composition of L.intermedia venom, studied at the transcriptomic level (
Gremski et al., 2010
). The venom contains the following families: LiTx3-related, LiTx, peptidase M12A (astacin-like metalloprotease),
SicTox (arthropod phospholipase D)
, neurotoxin-Magi 3-like,
serine protease
,
TCTP (translationally controlled tumor protein)
, allergen,
hyaluronidase (glycosyl hydrolase 56)
and serine protease inhibitor.
Clinical Effects, Treatment, Antivenoms
See the
Clinical Toxinology Resources Website
.
Lethal dose
LD(50) is
0.48 mg/kg
when injected into mice (
Barbaro et al., 1996
).
LD(50) is
0.34 mg/kg
by subcutaneous injection into mice (
Dias-Lopez et al., 2010
).
LD(50) is 1.80 ± 0.30 μg/g when injected into lepidoperan Agrotis ipsilon larvae (
de Castro et al., 2004
).
LD(50) is 1.39 ± 0.34 μg/g when injected into lepidoperan Diatraea saccharalis larvae (
de Castro et al., 2004
).
LD(50) is 1.92 ± 0.71 μg/g when injected into lepidoperan Spodoptera cosmioides larvae (
de Castro et al., 2004
).
LD(50) is 1.90 ± 0.11 μg/g when injected into lepidoperan Spodoptera frugiperdalarvae larvae
(
de Castro et al., 2004
).
Species diet
Ants have been found in the mouth of one specimen of this species (
Zobel-Thropp et al., 2012
).
Taxonomy
UniProt taxonomy
Wikipedia
Infraorder
:
Araneae
Suborder
:
Araneomorphae
Family
:
Sicariidae
Genus:
Loxosceles
Species
:
intermedia
Activity
Complement system impairing toxin
Dermonecrotic toxin
Hemostasis impairing toxin
Hemorrhagic toxin
Neurotoxin
and also
G-protein coupled receptor impairing toxin
Ion channel impairing toxin
or see
UniProtKB browsing by keyword
Reference
Transcriptomic
Gremski et al., 2010
Proteomic
Machado et al., 2005
,
dos Sandos et al., 2009
Venom protein entries in UniProtKB/Swiss-Prot
(all links/actions below point to
uniprot.org
website)
26 entries
grouped
by species
reorder by family
26 entries
Loxosceles intermedia (Brown spider)
A1HA_LOXIN
Dermonecrotic toxin LiSicTox-alphaIA1a (EC 4.6.1.-)
...
Arthropod phospholipase D
...
3RLG
;
3RLH
A1HB1_LOXIN
Dermonecrotic toxin LiSicTox-alphaIA1bi (EC 4.6.1.-) (LiD1)
...
Arthropod phospholipase D
...
A1HB2_LOXIN
Dermonecrotic toxin LiSicTox-alphaIA1bii (EC 4.6.1.-) (LiRecDT1)
...
Arthropod phospholipase D
...
4RW3
;
4RW5
A1IA1_LOXIN
Dermonecrotic toxin LiSicTox-alphaIA2ai (EC 4.6.1.-) (LiP2) (P2)
...
Arthropod phospholipase D
...
A1IA2_LOXIN
Dermonecrotic toxin LiSicTox-alphaIA2aii (EC 4.6.1.-)
...
Arthropod phospholipase D
...
A1IA3_LOXIN
Dermonecrotic toxin LiSicTox-alphaIA2aiii (EC 4.6.1.-) (Loxtox
...
Arthropod phospholipase D
...
A1IB1_LOXIN
Dermonecrotic toxin LiSicTox-alphaIA2bi (EC 4.6.1.-) (Loxtox i1)
...
Arthropod phospholipase D
...
A1IB2_LOXIN
Dermonecrotic toxin LiSicTox-alphaIA2bii (EC 4.6.1.-) (Loxtox
...
Arthropod phospholipase D
...
A1X1_LOXIN
Dermonecrotic toxin LiSicTox-alphaI-1 (EC 4.6.1.-)
...
Arthropod phospholipase D
...
A21_LOXIN
Dermonecrotic toxin LiSicTox-alphaII1 (EC 4.6.1.-)
...
Arthropod phospholipase D
...
A22_LOXIN
Dermonecrotic toxin LiSicTox-alphaII2 (EC 4.6.1.-) (Loxtox i5)
...
Arthropod phospholipase D
...
A4A1_LOXIN
Dermonecrotic toxin LiSicTox-alphaIVA1 (EC 4.6.1.-)
...
Arthropod phospholipase D
...
A51_LOXIN
Dermonecrotic toxin LiSicTox-alphaV1 (EC 4.6.1.-) (Dermonecrotic
...
Arthropod phospholipase D
...
B1H1_LOXIN
Dermonecrotic toxin LiSicTox-betaIA1i (EC 4.6.1.-)
...
Arthropod phospholipase D
...
B1H2_LOXIN
Dermonecrotic toxin LiSicTox-betaIA1ii (EC 4.6.1.-)
...
Arthropod phospholipase D
...
B1Q_LOXIN
Dermonecrotic toxin LiSicTox-betaID1 (EC 4.6.1.-) (Dermonecrotic
...
Arthropod phospholipase D
...
HYAL_LOXIN
Hyaluronidase (EC 3.2.1.35) (Chondroitinase) (Dietrich's
...
Glycosyl hydrolase 56 family
TCTP_LOXIN
Translationally-controlled tumor protein homolog (LiTCTP)
...
TCTP family
TX1_LOXIN
U1-sicaritoxin-Li1a (U1-SCRTX-Li1a) (LiTx1)
Neurotoxin 28 (Litx) family
TX2_LOXIN
U1-sicaritoxin-Li1b (U1-SCRTX-Li1b) (LiTx2)
Neurotoxin 28 (Litx) family
TX32_LOXIN
U2-sicaritoxin-Li1b (U2-SCRTX-Li1b)
Neurotoxin 39 family
TX3_LOXIN
U2-sicaritoxin-Li1a (U2-SCRTX-Li1a) (LiTx3) (Toxin 3)
Neurotoxin 39 family
TX4_LOXIN
U1-sicaritoxin-Li1c (U1-SCRTX-Li1c) (LiTx4)
Neurotoxin 28 (Litx) family
VMPA2_LOXIN
Astacin-like metalloprotease toxin 2 (EC 3.4.24.-) (Loxosceles
...
Not in a family
VMPA3_LOXIN
Astacin-like metalloprotease toxin 3 (EC 3.4.24.-) (Loxosceles
...
Not in a family
VMPA_LOXIN
Astacin-like metalloprotease toxin 1 (EC 3.4.24.-) (Loxosceles
...
Not in a family
