Loxosceles intermedia (Brown spider)

Venom composition
Figure 1: Composition of L.intermedia venom, studied at the transcriptomic level (Gremski et al., 2010 ). The venom contains the following families: LiTx3-related, LiTx, peptidase M12A (astacin-like metalloprotease), SicTox (arthropod phospholipase D) , neurotoxin-Magi 3-like,serine protease, TCTP (translationally controlled tumor protein) , allergen, hyaluronidase (glycosyl hydrolase 56) and serine protease inhibitor.
Clinical Effects, Treatment, Antivenoms See the Clinical Toxinology Resources Website.
Lethal dose LD(50) is 0.48 mg/kg when injected into mice (Barbaro et al., 1996 ).
LD(50) is 0.34 mg/kg by subcutaneous injection into mice (Dias-Lopez et al., 2010 ).
LD(50) is 1.80 ± 0.30 μg/g when injected into lepidoperan Agrotis ipsilon larvae (de Castro et al., 2004 ).
LD(50) is 1.39 ± 0.34 μg/g when injected into lepidoperan Diatraea saccharalis larvae (de Castro et al., 2004 ).
LD(50) is 1.92 ± 0.71 μg/g when injected into lepidoperan Spodoptera cosmioides larvae (de Castro et al., 2004 ).
LD(50) is 1.90 ± 0.11 μg/g when injected into lepidoperan Spodoptera frugiperdalarvae larvae
(de Castro et al., 2004 ).
Species diet Ants have been found in the mouth of one specimen of this species (Zobel-Thropp et al., 2012 ).

Venom protein entries in UniProtKB/Swiss-Prot

26 entries grouped by species (browse by taxonomy, browse by keywords)

26 entries

Loxosceles intermedia (Brown spider)

Select_allDeselect_all
A1HA_LOXIN Phospholipase D LiSicTox-alphaIA1a (PLD) (EC 3.1.4.4) ... Arthropod phospholipase D ...
A1HB1_LOXIN Phospholipase D LiSicTox-alphaIA1bi (PLD) (EC 3.1.4.4) ... Arthropod phospholipase D ...
A1HB2_LOXIN Phospholipase D LiSicTox-alphaIA1bii (PLD) (EC 3.1.4.4) ... Arthropod phospholipase D ...
A1IA1_LOXIN Phospholipase D LiSicTox-alphaIA2ai (PLD) (EC 3.1.4.4) ... Arthropod phospholipase D ...
A1IA2_LOXIN Phospholipase D LiSicTox-alphaIA2aii (PLD) (EC 3.1.4.4) ... Arthropod phospholipase D ...
A1IA3_LOXIN Phospholipase D LiSicTox-alphaIA2aiii (PLD) (EC 3.1.4.4) ... Arthropod phospholipase D ...
A1IB1_LOXIN Phospholipase D LiSicTox-alphaIA2bi (PLD) (EC 3.1.4.4) ... Arthropod phospholipase D ...
A1IB2_LOXIN Phospholipase D LiSicTox-alphaIA2bii (PLD) (EC 3.1.4.4) ... Arthropod phospholipase D ...
A1X1_LOXIN Phospholipase D LiSicTox-alphaI-1 (PLD) (EC 3.1.4.4) (35 kDa ... Arthropod phospholipase D ...
A21_LOXIN Phospholipase D LiSicTox-alphaII1 (EC 3.1.4.4) (Dermonecrotic ... Arthropod phospholipase D ...
A22_LOXIN Phospholipase D LiSicTox-alphaII2 (PLD) (EC 3.1.4.4) ... Arthropod phospholipase D ...
A51_LOXIN Phospholipase D LiSicTox-alphaV1 (PLD) (EC 3.1.4.4) ... Arthropod phospholipase D ...
B1H1_LOXIN Phospholipase D LiSicTox-betaIA1i (PLD) (EC 3.1.4.4) ... Arthropod phospholipase D ...
B1H2_LOXIN Phospholipase D LiSicTox-betaIA1ii (PLD) (EC 3.1.4.4) ... Arthropod phospholipase D ...
B1Q_LOXIN Phospholipase D LiSicTox-betaID1 (PLD) (EC 3.1.4.4) ... Arthropod phospholipase D ...
HYAL_LOXIN Hyaluronidase (EC 3.2.1.35) (Chondroitinase) (Dietrich's ... Glycosyl hydrolase 56 family
PLD7_LOXIN Phospholipase D LiRecDT7 (PLD) (EC 3.1.4.4) (Dermonecrotic toxin ... Arthropod phospholipase D ...
TCTP_LOXIN Translationally-controlled tumor protein homolog (LiTCTP) ... TCTP family
TX1_LOXIN U1-sicaritoxin-Li1a (U1-SCRTX-Li1a) (LiTx1) Neurotoxin 28 (Litx) family
TX2_LOXIN U1-sicaritoxin-Li1b (U1-SCRTX-Li1b) (LiTx2) Neurotoxin 28 (Litx) family
TX32_LOXIN U2-sicaritoxin-Li1b (U2-SCRTX-Li1b) Neurotoxin 39 family
TX3_LOXIN U2-sicaritoxin-Li1a (U2-SCRTX-Li1a) (LiTx3) (Toxin 3) Neurotoxin 39 family
TX4_LOXIN U1-sicaritoxin-Li1c (U1-SCRTX-Li1c) (LiTx4) (Fragment) Neurotoxin 28 (Litx) family
VMPA2_LOXIN Astacin-like metalloprotease toxin 2 (EC 3.4.24.-) (Loxosceles ... Not in a family
VMPA3_LOXIN Astacin-like metalloprotease toxin 3 (EC 3.4.24.-) (Loxosceles ... Not in a family
VMPA_LOXIN Astacin-like metalloprotease toxin 1 (EC 3.4.24.-) (Loxosceles ... Not in a family