Loxosceles intermedia (Brown spider) (taxid:58218)

Venom composition image
Figure 1: Composition of L.intermedia venom, studied at the transcriptomic level (Gremski et al., 2010). The venom contains the following families: LiTx3-related, LiTx, peptidase M12A (astacin-like metalloprotease), SicTox (arthropod phospholipase D) , neurotoxin-Magi 3-like,serine protease, TCTP (translationally controlled tumor protein) , allergen, hyaluronidase (glycosyl hydrolase 56) and serine protease inhibitor.
Clinical Effects, Treatment, Antivenoms See the Clinical Toxinology Resources Website.
Lethal dose LD(50) is 0.48 mg/kg when injected into mice (Barbaro et al., 1996).
LD(50) is 0.34 mg/kg by subcutaneous injection into mice (Dias-Lopez et al., 2010).
LD(50) is 1.80 ± 0.30 μg/g when injected into lepidoperan Agrotis ipsilon larvae (de Castro et al., 2004).
LD(50) is 1.39 ± 0.34 μg/g when injected into lepidoperan Diatraea saccharalis larvae (de Castro et al., 2004).
LD(50) is 1.92 ± 0.71 μg/g when injected into lepidoperan Spodoptera cosmioides larvae (de Castro et al., 2004).
LD(50) is 1.90 ± 0.11 μg/g when injected into lepidoperan Spodoptera frugiperdalarvae larvae
(de Castro et al., 2004).
Species diet Ants have been found in the mouth of one specimen of this species (Zobel-Thropp et al., 2012).

Venom protein entries in UniProtKB/Swiss-Prot

(all links/actions below point to uniprot.org website)

26 entries grouped by species

26 entries

Loxosceles intermedia (Brown spider)

Select_allDeselect_all
A1HA_LOXIN Dermonecrotic toxin LiSicTox-alphaIA1a (EC 4.6.1.-) ... Arthropod phospholipase D ...
A1HB1_LOXIN Dermonecrotic toxin LiSicTox-alphaIA1bi (EC 4.6.1.-) (LiD1) ... Arthropod phospholipase D ...
A1HB2_LOXIN Dermonecrotic toxin LiSicTox-alphaIA1bii (EC 4.6.1.-) (LiRecDT1) ... Arthropod phospholipase D ...
A1IA1_LOXIN Dermonecrotic toxin LiSicTox-alphaIA2ai (EC 4.6.1.-) (LiP2) (P2) ... Arthropod phospholipase D ...
A1IA2_LOXIN Dermonecrotic toxin LiSicTox-alphaIA2aii (EC 4.6.1.-) ... Arthropod phospholipase D ...
A1IA3_LOXIN Dermonecrotic toxin LiSicTox-alphaIA2aiii (EC 4.6.1.-) (Loxtox ... Arthropod phospholipase D ...
A1IB1_LOXIN Dermonecrotic toxin LiSicTox-alphaIA2bi (EC 4.6.1.-) (Loxtox i1) ... Arthropod phospholipase D ...
A1IB2_LOXIN Dermonecrotic toxin LiSicTox-alphaIA2bii (EC 4.6.1.-) (Loxtox ... Arthropod phospholipase D ...
A1X1_LOXIN Dermonecrotic toxin LiSicTox-alphaI-1 (EC 4.6.1.-) ... Arthropod phospholipase D ...
A21_LOXIN Dermonecrotic toxin LiSicTox-alphaII1 (EC 4.6.1.-) ... Arthropod phospholipase D ...
A22_LOXIN Dermonecrotic toxin LiSicTox-alphaII2 (EC 4.6.1.-) (Loxtox i5) ... Arthropod phospholipase D ...
A4A1_LOXIN Dermonecrotic toxin LiSicTox-alphaIVA1 (EC 4.6.1.-) ... Arthropod phospholipase D ...
A51_LOXIN Dermonecrotic toxin LiSicTox-alphaV1 (EC 4.6.1.-) (Dermonecrotic ... Arthropod phospholipase D ...
B1H1_LOXIN Dermonecrotic toxin LiSicTox-betaIA1i (EC 4.6.1.-) ... Arthropod phospholipase D ...
B1H2_LOXIN Dermonecrotic toxin LiSicTox-betaIA1ii (EC 4.6.1.-) ... Arthropod phospholipase D ...
B1Q_LOXIN Dermonecrotic toxin LiSicTox-betaID1 (EC 4.6.1.-) (Dermonecrotic ... Arthropod phospholipase D ...
HYAL_LOXIN Hyaluronidase (EC 3.2.1.35) (Chondroitinase) (Dietrich's ... Glycosyl hydrolase 56 family
TCTP_LOXIN Translationally-controlled tumor protein homolog (LiTCTP) ... TCTP family
TX1_LOXIN U1-sicaritoxin-Li1a (U1-SCRTX-Li1a) (LiTx1) Neurotoxin 28 (Litx) family
TX2_LOXIN U1-sicaritoxin-Li1b (U1-SCRTX-Li1b) (LiTx2) Neurotoxin 28 (Litx) family
TX32_LOXIN U2-sicaritoxin-Li1b (U2-SCRTX-Li1b) Neurotoxin 39 family
TX3_LOXIN U2-sicaritoxin-Li1a (U2-SCRTX-Li1a) (LiTx3) (Toxin 3) Neurotoxin 39 family
TX4_LOXIN U1-sicaritoxin-Li1c (U1-SCRTX-Li1c) (LiTx4) Neurotoxin 28 (Litx) family
VMPA2_LOXIN Astacin-like metalloprotease toxin 2 (EC 3.4.24.-) (Loxosceles ... Not in a family
VMPA3_LOXIN Astacin-like metalloprotease toxin 3 (EC 3.4.24.-) (Loxosceles ... Not in a family
VMPA_LOXIN Astacin-like metalloprotease toxin 1 (EC 3.4.24.-) (Loxosceles ... Not in a family