Voltage-gated calcium channel impairing toxin (Cav channel inhibitor)

Channel Voltage-gated calcium channels (Cav) are the key signal transducers of electrical signaling, converting depolarization of the cell membrane to an influx of calcium ions that initiates contraction, secretion, neurotransmission and other intracellular regulatory events. Skeletal muscle calcium channels first identified by drug labeling, purification, and functional reconstitution have a principal α1 subunit of 212-250 kDa.

The α1 subunit is associated with auxiliary α2, β, γ and δ subunits. The calcium channel α1 subunit is sufficient to form a voltage-gated calcium-selective pore by itself. Ten functional calcium channel α1 subunits are known in vertebrates, and they fall into three subfamilies that differ in function and regulation. The Cav1 subfamily (Cav1.1-Cav1.4) conducts L-type calcium currents that initiate contraction, endocrine secretion, and synaptic transmission at the specialized ribbon synapses involved in sensory input in the eye and ear. L-type calcium currents also are important regulators of gene expression and other intracellular processes. They are blocked by the classical calcium channel antagonists, including dihydropyridines, benzothiazepines, and phenylalkylamines. The Cav2 subfamily of calcium channels (Cav2.1-Cav2.3) conduct N-, P/Q- and R-type calcium currents that initiate fast synaptic transmission at synapses in the central and peripheral nervous systems and are blocked specifically by peptide neurotoxins from spider and cone snail venoms. The Cav3 subfamily of calcium channels (Cav3.1-Cav3.3) conduct T-type calcium currents that are important for repetitive action potential firing of neurons in the brain and in the pacemaker cells of the sino-atrial node in the heart. The protein-protein interactions as well as the functional and regulatory properties of different subfamilies of these ion channels are adapted to their distinct roles in electrical signaling and cellular signal transduction.

Cav1 and Cav2 channels have four distinct auxiliary subunits (Cavα2, Cavβ, Cavγ, and Cavδ), whereas Cav3 channels have none. Each subunits of Cav1 and Cav2 channels comprise a small protein family. The Cavα2 and Cavδ subunits are encoded by the same gene, whose translation product is proteolytically cleaved and disulfide linked to yield the mature extracellular α2 subunit glycoprotein of 140 kDa and transmembrane disulfide-linked δ subunit glycoprotein of 27 kDa. Four Cavα2δ genes are known. The four Cavβ subunits are all intracellular proteins with a common pattern of α helical and unstructured segments. They have important regulatory effects on cell surface expression and they also modulate the gating of calcium channels, causing enhanced activation upon depolarization and altered rate and voltage dependence of inactivation. Recent structural modeling and X-ray crystallography studies have revealed that these subunits contain conserved, interacting SH3 and guanylate kinase domains like the MAGUK family of scaffolding proteins, and therefore may interact with other intracellular proteins. Eight Cavγ subunit genes encode glycoproteins with four transmembrane segments. Although the Cavγ1 subunit is associated specifically with skeletal muscle Cav1.1 channels, other Cavγ subunits interact with other calcium channels, glutamate receptors and possibly with other membrane signaling proteins. Thus, the γ subunits discovered as components of calcium channels apparently have a more widespread role in assembly and cell surface expression of other membrane signaling proteins. Cav3 channels do not have auxiliary subunits.

Toxin
Cav channels Toxins from different taxa that target Cav channels.
Click on to retrieve channels and toxins of interest.
Human Snake Scorpion Cone
snail
Spider Cnidarian Insect Other All
Cav1.1/CACNA1S (L-type) - - - - - - - -
Cav1.2/CACNA1C (L-type) - - - - - -
Cav1.3/CACNA1D (L-type) - - - - - - - -
Cav1.4/CACNA1F (L-type) - - - - - - - -
Cav1 All (L-type) - - - -
Cav2.1/CACNA1A (P/Q-type) - - - - -
Cav2.2/CACNA1B (N-type) - - - -
Cav2.3/CACNA1E (R-type) - - - - - -
Cav2 All - - - -
Cav3.1/CACNA1G (T-type) - - - - -
Cav3.2/CACNA1H (T-type) - - - - - -
Cav3.3/CACNA1I (T-type) - - - - - -
Cav3 All (T-type) - - - - -
Cav All - -

Venom protein entries in UniProtKB/Swiss-Prot

224 entries grouped by family (browse by taxonomy, browse by keywords)

1 entry

Asilidin-1 family

ASI1A_MACAT U-Asilidin(1)-Mar1a Machimus arthriticus (Breck robberfly) (Asilus ...

1 entry

Conotoxin A superfamily

CA13B_CONLT Alpha-conotoxin Lt1.3 b (Fragment) Conus litteratus (Lettered cone)

1 entry

Conotoxin M superfamily

M7E_CONCN Omega-conotoxin-like CnVIIE [Cleaved into: ... Conus consors (Singed cone)

60 entries

Conotoxin O1 superfamily

Select_allDeselect_all
O161A_CONPL Omega-conotoxin-like PuIA Conus pulicarius (Flea-bite cone)
O161_CONCE Omega-conotoxin-like 1 Conus capitaneus (Captain cone)
O161_CONST Omega-conotoxin-like SVIA mutant 1 Conus striatus (Striated cone)
O161_CONTE Omega-conotoxin-like TxMKLT1-0141 Conus textile (Cloth-of-gold cone)
O162A_CONPL Omega-conotoxin-like PuIIA Conus pulicarius (Flea-bite cone)
O162_CONAE Omega-conotoxin-like ArMKLT1-011 (Conotoxin ... Conus arenatus (Sand-dusted cone)
O162_CONAJ Omega-conotoxin-like Ai6.2 Conus ammiralis (Admiral cone)
O162_CONIM Omega-conotoxin-like 2/7 Conus imperialis (Imperial cone)
O162_CONST Omega-conotoxin-like 2 Conus striatus (Striated cone)
O162_CONTE Omega-conotoxin-like TxMKLT1-0142 Conus textile (Cloth-of-gold cone)
O1631_CONTE Omega-conotoxin-like TxMKLT1-031 Conus textile (Cloth-of-gold cone)
O163_CONAE Omega-conotoxin-like ArMKLT1-02 Conus arenatus (Sand-dusted cone)
O163_CONAJ Omega-conotoxin-like Ai6.3 Conus ammiralis (Admiral cone)
O163_CONIM Omega-conotoxin-like 3 Conus imperialis (Imperial cone)
O163_CONTE Omega-conotoxin-like TxO3 Conus textile (Cloth-of-gold cone)
O164_CONAH Omega-conotoxin-like Ac6.4 Conus achatinus (Little frog cone)
O164_CONST Omega-conotoxin-like SO-4 (Omega-conotoxin SO4) Conus striatus (Striated cone)
O164_CONTE Omega-conotoxin-like TxO4 (Conotoxin ... Conus textile (Cloth-of-gold cone)
O165_CONAH Omega-conotoxin-like Ac6.5 Conus achatinus (Little frog cone)
O165_CONST Omega-conotoxin-like SO-5 (Omega-conotoxin SO5) Conus striatus (Striated cone)
O165_CONTE Omega-conotoxin-like TxO5 Conus textile (Cloth-of-gold cone)
O1661_CONTE Omega-conotoxin-like TeA61 Conus textile (Cloth-of-gold cone)
O166_CONST Omega-conotoxin-like S6.6 Conus striatus (Striated cone)
O167_CONMR Omega-conotoxin-like MaIr137 Conus marmoreus (Marble cone)
O167_CONST Omega-conotoxin-like S6.7 (Fragment) Conus striatus (Striated cone)
O168_CONBU Omega-conotoxin-like Bu8 (Fragment) Conus bullatus (Bubble cone)
O168_CONVE Omega-conotoxin-like VnMKLT1-0111 Conus ventricosus (Mediterranean cone)
O16A2_CONST Omega-conotoxin-like SVIA mutant 2 Conus striatus (Striated cone)
O16A_CONCT Omega-conotoxin CVIA Conus catus (Cat cone)
O16A_CONGE Omega-conotoxin GVIA (SNX-124) (Shaker peptide) ... Conus geographus (Geography cone) (Nubecula ...
O16A_CONMB Omega-conotoxin MoVIA [Cleaved into: ... Conus moncuri (Sea snail)
O16A_CONPE Omega-conotoxin PnVIA Conus pennaceus (Feathered cone) (Conus ...
O16A_CONRA Omega-conotoxin RVIA Conus radiatus (Rayed cone)
O16A_CONST Omega-conotoxin SVIA (SNX-157) Conus striatus (Striated cone)
O16A_CONTU Omega-conotoxin TVIA (SNX-185) Conus tulipa (Fish-hunting cone snail) (Tulip ...
O16B_CONCT Omega-conotoxin CVIB Conus catus (Cat cone)
O16B_CONPE Omega-conotoxin PnVIB Conus pennaceus (Feathered cone) (Conus ...
O16B_CONST Omega-conotoxin SVIB (SNX-183) Conus striatus (Striated cone)
O16C_CONCT Omega-conotoxin CVIC Conus catus (Cat cone)
O16C_CONST Omega-conotoxin-like 12 Conus striatus (Striated cone)
O16D_CONCT Omega-conotoxin CVID (AM-336) (AM336) (CNSB004) ... Conus catus (Cat cone)
O16F_CONCT Omega conotoxin-CVIF Conus catus (Cat cone)
O16F_CONST Omega-conotoxin-like 15 Conus striatus (Striated cone)
O16K_CONTE Omega-conotoxin-like TxO5 (Conotoxin ... Conus textile (Cloth-of-gold cone)
O16L6_CONST Omega-conotoxin-like 6 Conus striatus (Striated cone)
O16L_CONTE Omega-conotoxin-like TxMKLT1-0223 Conus textile (Cloth-of-gold cone)
O16M_CONTE Omega-conotoxin-like TxMKLT1-0211 Conus textile (Cloth-of-gold cone)
O16O2_CONTE Omega-conotoxin-like TxO2 Conus textile (Cloth-of-gold cone)
O16O3_CONST Omega-conotoxin SO-3 (SO3) Conus striatus (Striated cone)
O16O6_CONTE Omega-conotoxin-like TxO6 Conus textile (Cloth-of-gold cone)
O171_CONBU Omega-conotoxin-like Bu1 Conus bullatus (Bubble cone)
O17A_CONMA Omega-conotoxin MVIIA (SNX-111) (Ziconotide) Conus magus (Magus cone) (Magician's cone snail)
O17B_CONBU Omega-conotoxin-like Bu11 (Fragment) Conus bullatus (Bubble cone)
O17B_CONMA Omega-conotoxin MVIIB (SNX-159) Conus magus (Magus cone) (Magician's cone snail)
O17C_CONMA Omega-conotoxin MVIIC (Omega-CgTxMVIIC) ... Conus magus (Magus cone) (Magician's cone snail)
O17D_CONMA Omega-conotoxin MVIID (SNX-238) (Fragment) Conus magus (Magus cone) (Magician's cone snail)
O17H_CONCN Omega-conotoxin-like CnVIIH [Cleaved into: ... Conus consors (Singed cone)
O17_CONTE Omega-conotoxin TxVII Conus textile (Cloth-of-gold cone)
O19_CONST Omega-conotoxin-like 9 Conus striatus (Striated cone)
O1X1_CONTE Omega-conotoxin-like TxO1 Conus textile (Cloth-of-gold cone)

6 entries

CRISP family

Select_allDeselect_all "CRISP family" VenomZone page
CRVP1_NAJNA Cysteine-rich venom protein (CRVP) ... Naja naja (Indian cobra)
CRVP2_HYDHA Cysteine-rich venom protein 2 (CRVP) Hydrophis hardwickii (Hardwick's spine-bellied ...
CRVP_GLOBL Cysteine-rich venom protein ablomin Gloydius blomhoffii (Mamushi) (Agkistrodon halys ...
CRVP_HELHO Cysteine-rich venom protein helothermine (CRVP ... Heloderma horridum horridum (Mexican beaded ...
CRVP_LATSE Cysteine-rich venom protein latisemin (CRVP) Laticauda semifasciata (Black-banded sea krait) ...
CRVP_PROFL Cysteine-rich venom protein triflin (CRVP) Protobothrops flavoviridis (Habu) (Trimeresurus ...

2 entries

CRISP family, Venom allergen 5-like subfamily

Select_allDeselect_all "CRISP family" VenomZone page
VA546_SCODE Scoloptoxin SSD346 (Cysteine-rich venom protein) ... Scolopendra dehaani (Thai centipede) ...
VA576_SCODE Scoloptoxin SSD976 (Cysteine-rich venom protein) ... Scolopendra dehaani (Thai centipede) ...

2 entries

Ectatomin family, Ectatomin-Et subfamily

Select_allDeselect_all
TX1AA_ECTTU Omega/M-ectatotoxin-Et1a subunit A ... Ectatomma tuberculatum (Selva ant)
TX1AB_ECTTU Omega/M-ectatotoxin-Et1a subunit B ... Ectatomma tuberculatum (Selva ant)

3 entries

Long (4 C-C) scorpion toxin superfamily, Sodium channel inhibitor family, Alpha subfamily

Select_allDeselect_all
KURT1_PARGR Alpha-toxin PgKL1 (Kurtoxin-like 1) ... Parabuthus granulatus (Granulated thick-tailed ...
KURT2_PARGR Toxin PgKL2 (Kurtoxin-like 2) (Kurtoxin-like II) ... Parabuthus granulatus (Granulated thick-tailed ...
KURT_PARTR Kurtoxin (Ktx) Parabuthus transvaalicus (South African fattail ...

7 entries

Neurotoxin (omega-lctx) family

Select_allDeselect_all
TLCOA_ALOMR Omega-lycotoxin-Gsp2671a (Omega-LCTX-Gsp2671a) ... Alopecosa marikovskyi (Wolf spider) (Lycosa ...
TLCOB_ALOMR Omega-lycotoxin-Gsp2671b (Omega-LCTX-Gsp2671b) ... Alopecosa marikovskyi (Wolf spider) (Lycosa ...
TLCOC_ALOMR Omega-lycotoxin-Gsp2671c (Omega-LCTX-Gsp2671c) ... Alopecosa marikovskyi (Wolf spider) (Lycosa ...
TLCOD_ALOMR Omega-lycotoxin-Gsp2671d (Omega-LCTX-Gsp2671d) ... Alopecosa marikovskyi (Wolf spider) (Lycosa ...
TLCOE_ALOMR Omega-lycotoxin-Gsp2671e (Omega-LCTX-Gsp2671e) ... Alopecosa marikovskyi (Wolf spider) (Lycosa ...
TLCOF_ALOMR Omega-lycotoxin-Gsp2671f (Omega-LCTX-Gsp2671f) ... Alopecosa marikovskyi (Wolf spider) (Lycosa ...
TLCOG_ALOMR Omega-lycotoxin-Gsp2671g (Omega-LCTX-Gsp2671g) ... Alopecosa marikovskyi (Wolf spider) (Lycosa ...

1 entry

Neurotoxin 01 (U2-agtx) family

TXAG_ALLOP U2-agatoxin-Aop1a (U2-AGTX-Aop1a) (Agelenin) Allagelena opulenta (Funnel weaving spider) ...

7 entries

Neurotoxin 02 (plectoxin) family

Select_allDeselect_all
TX20A_AGEAP Omega-agatoxin-Aa5a (Omega-AGTX-Aa5a) (Peptide ... Agelenopsis aperta (North American funnel-web ...
TX20A_CTEON U10-ctenitoxin-Co1b (U10-CNTX-Co1b) (Neurotoxin ... Ctenus ornatus (Brazilian spider) (Oligoctenus ...
TX20A_PHONI Kappa-ctenitoxin-Pn1a (Kappa-CNTX-Pn1a) ... Phoneutria nigriventer (Brazilian armed spider) ...
TX20A_PHORI Omega-ctenitoxin-Pr1a (Omega-CNTX-Pr1a) ... Phoneutria reidyi (Brazilian Amazonian armed ...
TX20B_CTEON U10-ctenitoxin-Co1a (U10-CNTX-Co1a) (Neurotoxin ... Ctenus ornatus (Brazilian spider) (Oligoctenus ...
TX20B_PHONI Omega-ctenitoxin-Pn1a (Omega-CNTX-Pn1a) ... Phoneutria nigriventer (Brazilian armed spider) ...
TX20C_PHONI U7-ctenitoxin-Pn1a (U7-CNTX-Pn1a) (Neurotoxin ... Phoneutria nigriventer (Brazilian armed spider) ...

4 entries

Neurotoxin 02 (plectoxin) family, 01 (Tx3) subfamily

Select_allDeselect_all
TX21A_CTEON U3-ctenitoxin-Co1a (U3-CNTX-Co1a) (Neurotoxin Oc ... Ctenus ornatus (Brazilian spider) (Oligoctenus ...
TX21A_PHONI Omega-ctenitoxin-Pn2a (Omega-CNTX-Pn2a) ... Phoneutria nigriventer (Brazilian armed spider) ...
TX21B_PHONI U6-ctenitoxin-Pn1a (U6-CNTX-Pn1a) (Neurotoxin ... Phoneutria nigriventer (Brazilian armed spider) ...
TX21C_PHONI U9-ctenitoxin-Pn1a (U9-CNTX-Pn1a) (Neurotoxin ... Phoneutria nigriventer (Brazilian armed spider) ...

1 entry

Neurotoxin 02 (plectoxin) family, 02 (plectoxin) subfamily

TX22A_PLETR Omega-plectoxin-Pt1a (Omega-PLTX-Pt1a) (PLTX-II) ... Plectreurys tristis (Spider) (Plectreurys ...

2 entries

Neurotoxin 02 (plectoxin) family, 03 (omega-agtx) subfamily

Select_allDeselect_all
TX23A_AGEAP Omega-agatoxin-Aa4a (Omega-AGTX-Aa4a) ... Agelenopsis aperta (North American funnel-web ...
TX23B_AGEAP Omega-agatoxin-Aa4b (Omega-AGTX-Aa4b) ... Agelenopsis aperta (North American funnel-web ...

1 entry

Neurotoxin 02 (plectoxin) family, 09 subfamily

TX29A_CTEON U6-ctenitoxin-Co1a (U6-CNTX-Co1a) (Neurotoxin Oc ... Ctenus ornatus (Brazilian spider) (Oligoctenus ...

7 entries

Neurotoxin 04 (omega-agtx) family, 01 (type I omega-agtx) subfamily

Select_allDeselect_all
TOG1A_AGEAP Omega-agatoxin-1A (Omega-agatoxin IA) ... Agelenopsis aperta (North American funnel-web ...
TOG1B_AGEAP Omega-agatoxin-Aa1b (Omega-AGTX-Aa1b) ... Agelenopsis aperta (North American funnel-web ...
TX2M1_LYCSI U2-lycotoxin-Ls1a (Toxin-like structure LSTX-M1) Lycosa singoriensis (Wolf spider) (Aranea ...
TX2M2_LYCSI U2-lycotoxin-Ls1b (Toxin-like structure LSTX-M2) Lycosa singoriensis (Wolf spider) (Aranea ...
TX2M3_LYCSI U2-lycotoxin-Ls1c (Toxin-like structure LSTX-M3) Lycosa singoriensis (Wolf spider) (Aranea ...
TX2M4_LYCSI U2-lycotoxin-Ls1d (Toxin-like structure LSTX-M4) Lycosa singoriensis (Wolf spider) (Aranea ...
TX2M5_LYCSI U2-lycotoxin-Ls1e (Toxin-like structure LSTX-M5) Lycosa singoriensis (Wolf spider) (Aranea ...

15 entries

Neurotoxin 04 (omega-agtx) family, 03 (type II/III omega-agtx) subfamily

Select_allDeselect_all
32C7_ANCSP U1-ctenitoxin-Asp1a (U1-CNTX-Asp1a) (Neurotoxin ... Ancylometes sp. (South American fishing spider)
TOG2A_AGEAP Omega-agatoxin-Aa2a (Omega-AGTX-Aa2a) ... Agelenopsis aperta (North American funnel-web ...
TOG3A_AGEAP Omega-agatoxin-Aa3a (Omega-AGTX-Aa3a) ... Agelenopsis aperta (North American funnel-web ...
TOG3B_AGEAP Omega-agatoxin-Aa3b (Omega-AGTX-Aa3b) ... Agelenopsis aperta (North American funnel-web ...
TOG3C_AGEAP Omega-agatoxin-Aa3c (Omega-AGTX-Aa3c) ... Agelenopsis aperta (North American funnel-web ...
TOG3D_AGEAP Omega-agatoxin-Aa3d (Omega-AGTX-Aa3d) ... Agelenopsis aperta (North American funnel-web ...
TOPC5_PHONI U20-ctenitoxin-Pn1a (U20-CNTX-Pn1a) ... Phoneutria nigriventer (Brazilian armed spider) ...
TX18_PHORI U1-ctenitoxin-Pr1a (U1-CNTX-Pr1a) (Neurotoxin ... Phoneutria reidyi (Brazilian Amazonian armed ...
TX34_PHONI Omega-ctenitoxin-Pn3a (Omega-CNTX-Pn3a) ... Phoneutria nigriventer (Brazilian armed spider) ...
TXAG1_AGEOR U10-agatoxin-Ao1a (U10-AGTX-Ao1a) (AgorTX_B7b) Agelena orientalis (Funnel-web spider)
TXF22_CTEON U2-ctenitoxin-Co1a (U2-CNTX-Co1a) (Neurotoxin Oc ... Ctenus ornatus (Brazilian spider) (Oligoctenus ...
TXF27_CTEON U17-ctenitoxin-Co1a (U17-CNTX-Co1a) (Neurotoxin ... Ctenus ornatus (Brazilian spider) (Oligoctenus ...
TXF28_CTEON U4-ctenitoxin-Co1a (U4-CNTX-Co1a) (Neurotoxin Oc ... Ctenus ornatus (Brazilian spider) (Oligoctenus ...
TXF91_CTEON U4-ctenitoxin-Co1b (U4-CNTX-Co1b) (Neurotoxin Oc ... Ctenus ornatus (Brazilian spider) (Oligoctenus ...
TXM20_CTEON U14-ctenitoxin-Co1a (U14-CNTX-Co1a) (Neurotoxin ... Ctenus ornatus (Brazilian spider) (Oligoctenus ...

26 entries

Neurotoxin 08 (Shiva) family, 01 (omega toxin) subfamily

Select_allDeselect_all
TO1A_ATRRO Omega-hexatoxin-Ar1a (Omega-HXTX-Ar1a) ... Atrax robustus (Sydney funnel-web spider)
TO1A_HADIN Omega-hexatoxin-Hi1a (Omega-HXTX-Hi1a) ... Hadronyche infensa (Fraser island funnel-web ...
TO1A_HADMO Omega-hexatoxin-Hmo1a Hadronyche modesta (Victorian funnel-web spider)
TO1A_HADVE Omega-hexatoxin-Hv1a (Omega-HXTX-Hv1a) ... Hadronyche versuta (Blue mountains funnel-web ...
TO1A_HADVN Omega-hexatoxin-Hvn1a Hadronyche venenata (Tasmanian funnel-web ...
TO1B_ATRRO Omega-hexatoxin-Ar1b (Omega-HXTX-Ar1b) ... Atrax robustus (Sydney funnel-web spider)
TO1B_HADFO Omega-hexatoxin-Hf1a (Omega-HXTX-Hf1a) ... Hadronyche formidabilis (Northern tree ...
TO1B_HADIN Omega-hexatoxin-Hi1b (Omega-HXTX-Hi1b) ... Hadronyche infensa (Fraser island funnel-web ...
TO1B_HADMO Omega-hexatoxin-Hmo1b Hadronyche modesta (Victorian funnel-web spider)
TO1B_HADVE Omega-hexatoxin-Hv1b (Omega-HXTX-Hv1b) ... Hadronyche versuta (Blue mountains funnel-web ...
TO1B_HADVN Omega-hexatoxin-Hvn1b Hadronyche venenata (Tasmanian funnel-web ...
TO1C_ATRRO Omega-hexatoxin-Ar1c (Omega-HXTX-Ar1c) ... Atrax robustus (Sydney funnel-web spider)
TO1C_HADIN Omega-hexatoxin-Hi1c (Omega-HXTX-Hi1c) ... Hadronyche infensa (Fraser island funnel-web ...
TO1C_HADMO Omega-hexatoxin-Hmo1c Hadronyche modesta (Victorian funnel-web spider)
TO1C_HADVE Omega-hexatoxin-Hv1c (Omega-HXTX-Hv1c) ... Hadronyche versuta (Blue mountains funnel-web ...
TO1D_ATRRO Omega-hexatoxin-Ar1d (Omega-HXTX-Ar1d) ... Atrax robustus (Sydney funnel-web spider)
TO1D_HADIN Omega-hexatoxin-Hi1d Hadronyche infensa (Fraser island funnel-web ...
TO1D_HADMO Omega-hexatoxin-Hmo1d Hadronyche modesta (Victorian funnel-web spider)
TO1D_HADVE Omega-hexatoxin-Hv1d (Omega-HXTX-Hv1d) ... Hadronyche versuta (Blue mountains funnel-web ...
TO1E_ATRRO Omega-hexatoxin-Ar1e (Omega-HXTX-Ar1e) ... Atrax robustus (Sydney funnel-web spider)
TO1E_HADIN Omega-hexatoxin-Hi1e Hadronyche infensa (Fraser island funnel-web ...
TO1E_HADVE Omega-hexatoxin-Hv1e (Omega-HXTX-Hv1e) ... Hadronyche versuta (Blue mountains funnel-web ...
TO1F_ATRRO Omega-hexatoxin-Ar1f (Omega-HXTX-Ar1f) ... Atrax robustus (Sydney funnel-web spider)
TO1F_HADIN Omega-hexatoxin-Hi1f Hadronyche infensa (Fraser island funnel-web ...
TO1F_HADVE Omega-hexatoxin-Hv1f (Omega-HXTX-Hv1f) ... Hadronyche versuta (Blue mountains funnel-web ...
TO1G_HADIN Omega-hexatoxin-Hi1g Hadronyche infensa (Fraser island funnel-web ...

1 entry

Neurotoxin 08 (Shiva) family, 02 (omega/kappa toxin) subfamily

TOM1A_MISBR Omega-actinopoditoxin-Mb1a (Omega-AOTX-Mb1a) ... Missulena bradleyi (Eastern mouse spider)

2 entries

Neurotoxin 09 (Tx3-6) family

Select_allDeselect_all
TX90A_PHORI Omega-ctenitoxin-Pr2a (Omega-CNTX-Pr2a) ... Phoneutria reidyi (Brazilian Amazonian armed ...
TX90B_PHONI Omega-ctenitoxin-Pn4a (Omega-CNTX-Pn4a) ... Phoneutria nigriventer (Brazilian armed spider) ...

1 entry

Neurotoxin 10 (Hwtx-1) family, 01 (AU5A) subfamily

TX5A_HETVE Omega-sparatoxin-Hv1a (Omega-SPRTX-Hv1a) (Toxin ... Heteropoda venatoria (Brown huntsman spider) ...

1 entry

Neurotoxin 10 (Hwtx-1) family, 02 (AU5B) subfamily

TX5B_HETVE Omega-sparatoxin-Hv1b (Omega-SPRTX-Hv1b) (Toxin ... Heteropoda venatoria (Brown huntsman spider) ...

3 entries

Neurotoxin 10 (Hwtx-1) family, 04 (CcoTx1) subfamily

Select_allDeselect_all
TX1_CERDA Beta-theraphotoxin-Cd1a (Beta-TRTX-Cd1a) Ceratogyrus darlingi (Rear horned baboon ...
TX1_CERMR Beta-theraphotoxin-Cm1a (Beta-TRTX-Cm1a) ... Ceratogyrus marshalli (Straighthorned baboon ...
TX2_CERMR Beta-theraphotoxin-Cm1b (Beta-TRTX-Cm1b) ... Ceratogyrus marshalli (Straighthorned baboon ...

1 entry

Neurotoxin 10 (Hwtx-1) family, 07 (GrTx) subfamily

WGRTX_GRARO Omega-theraphotoxin-Gr1a (Omega-TRTX-Gr1a) ... Grammostola rosea (Chilean rose tarantula) ...

3 entries

Neurotoxin 10 (Hwtx-1) family, 08 (Gtx1-15) subfamily

Select_allDeselect_all
TX15_GRAPO Toxin GTx1-15 (Beta/omega-theraphotoxin-Gr2a) ... Grammostola porteri (Tarantula spider) ...
TX15_GRARO Toxin GTx1-15 (Beta/omega-theraphotoxin-Gr2a) ... Grammostola rosea (Chilean rose tarantula) ...
TX15_PARSR Toxin GTx1-15 (Beta/omega-theraphotoxin-Gr2a) ... Paraphysa scrofa (Chilean copper tarantula) ...

1 entry

Neurotoxin 10 (Hwtx-1) family, 09 (HaTx) subfamily

TXHN1_GRARO Kappa-theraphotoxin-Gr1a (Kappa-TRTX-Gr1a) ... Grammostola rosea (Chilean rose tarantula) ...

1 entry

Neurotoxin 10 (Hwtx-1) family, 17 (Hntx-9) subfamily

TXH5_CYRSC Omega-theraphotoxin-Hs2a (Omega-TRTX-Hs2a) ... Cyriopagopus schmidti (Chinese bird spider) ...

2 entries

Neurotoxin 10 (Hwtx-1) family, 19 (HpTX2) subfamily

Select_allDeselect_all
TXJ1_HETVE Kappa-sparatoxin-Hv1e (Kappa-SPRTX-Hv1e) (Toxin ... Heteropoda venatoria (Brown huntsman spider) ...
TXU2_HETVE Kappa-sparatoxin-Hv1d (Kappa-SPRTX-Hv1d) (Toxin ... Heteropoda venatoria (Brown huntsman spider) ...

1 entry

Neurotoxin 10 (Hwtx-1) family, 23 (HwTx-I) subfamily

TXH1_CYRSC Mu/omega-theraphotoxin-Hs1a (Mu/omega-TRTX-Hs1a) ... Cyriopagopus schmidti (Chinese bird spider) ...

1 entry

Neurotoxin 10 (Hwtx-1) family, 41 (Jztx-36) subfamily

TXO1A_PELMU Omega-theraphotoxin-Cc1a (Omega-TRTX-Cc1a) ... Pelinobius muticus (King baboon spider) ...

3 entries

Neurotoxin 10 (Hwtx-1) family, 53 (PNTx27C4) subfamily

Select_allDeselect_all
TX26A_PHONI Neurotoxin PRTx26An0C3 Phoneutria nigriventer (Brazilian armed spider) ...
TX27_PHONI U17-ctenitoxin-Pn1a (U17-CNTX-Pn1a) (Neurotoxin ... Phoneutria nigriventer (Brazilian armed spider) ...
TX27_PHORI U4-ctenitoxin-Pr1a (U4-CNTX-Pr1a) (Neurotoxin ... Phoneutria reidyi (Brazilian Amazonian armed ...

2 entries

Neurotoxin 10 (Hwtx-1) family, 54 (ProTx-1) subfamily

Select_allDeselect_all
TXDF1_DAFVA Mu-theraphotoxin-Df1a (Mu-TRTX-Df1a) Davus fasciatus (Costa Rican tiger rump) ...
TXPR1_THRPR Beta/omega-theraphotoxin-Tp1a ... Thrixopelma pruriens (Peruvian green velvet ...

1 entry

Neurotoxin 10 (Hwtx-1) family, 56 (SNX-482) subfamily

TX482_HYSGI Omega-theraphotoxin-Hg1a (Omega-TRTX-Hg1a) ... Hysterocrates gigas (Cameroon red baboon ...

1 entry

Neurotoxin 12 (Hwtx-2) family, 03 (juruin) subfamily

CT1B_CORTR U1-theraphotoxin-Ct1b (U1-TRTX-Ct1b) Coremiocnemis tropix (Australian tarantula ...

6 entries

Neurotoxin 12 (Hwtx-2) family, 06 (TXP1) subfamily

Select_allDeselect_all
TX1A_APHSP Omega-theraphotoxin-Asp1a (Omega-TRTX-Asp1a) ... Aphonopelma sp. (American tarantula)
TX1F_APHSP Omega-theraphotoxin-Asp1f (Omega-TRTX-Asp1f) ... Aphonopelma sp. (American tarantula)
TX1G_APHSP Omega-theraphotoxin-Asp1g (Omega-TRTX-Asp1g) ... Aphonopelma sp. (American tarantula)
TXP1_BRAAI Omega-theraphotoxin-Ba1a (Omega-TRTX-Ba1a) (Ba1) Brachypelma albiceps (Mexican golden redrump ...
TXP2_BRAAI Omega-theraphotoxin-Ba1b (Omega-TRTX-Ba1b) (Ba2) Brachypelma albiceps (Mexican golden redrump ...
TXP3_BRAAI Omega-theraphotoxin-Ba1c (Omega-TRTX-Ba1c) ... Brachypelma albiceps (Mexican golden redrump ...

1 entry

Neurotoxin 13 (insecticidal toxin ABC) family, 01 (Aps III) subfamily

TXP3_APOSC Mu-cyrtautoxin-As1a (Mu-CUTX-As1a) (Aptotoxin ... Apomastus schlingeri (Trap-door spider) ...

1 entry

Neurotoxin 14 (magi-1) family, 08 (Ltx-4) subfamily

TX132_APHSP Omega-theraphotoxin-Asp3a (Omega-TRTX-Asp3a) ... Aphonopelma sp. (American tarantula)

5 entries

Neurotoxin 15 family, 02 (omega-actx) subfamily

Select_allDeselect_all
TOT2A_ATRIL Omega-hexatoxin-Asp2a (Omega-HXTX-Asp2a) ... Atrax sp. (strain Illawarra) (Funnel-web spider)
TOT2A_HADIN Omega-hexatoxin-Hi2a (Omega-HXTX-Hi2a) ... Hadronyche infensa (Fraser island funnel-web ...
TOT2A_HADVE Omega-hexatoxin-Hv2a (Omega-HXTX-Hv2a) ... Hadronyche versuta (Blue mountains funnel-web ...
TOT2B_ATRIL Omega-hexatoxin-Asp2b (Omega-HXTX-Asp2b) ... Atrax sp. (strain Illawarra) (Funnel-web spider)
TOT2B_HADIN Omega-hexatoxin-Hi2b (Omega-HXTX-Hi2b) ... Hadronyche infensa (Fraser island funnel-web ...

1 entry

Neurotoxin 19 (CSTX) family

TXC9_CUPSA U1-ctenitoxin-Cs1a (U1-CNTX-Cs1a) (Toxin CSTX-9) ... Cupiennius salei (American wandering spider)

1 entry

Neurotoxin 19 (CSTX) family, 04 (U1-Lctx) subfamily

TXC1_CUPSA Omega-ctenitoxin-Cs1a (Omega-CNTX-Cs1a) (Toxin ... Cupiennius salei (American wandering spider)

1 entry

Neurotoxin 28 (Litx) family

TX4_LOXIN U1-sicaritoxin-Li1c (U1-SCRTX-Li1c) (LiTx4) ... Loxosceles intermedia (Brown spider)

2 entries

Neurotoxin 30 (phrixotoxin) family

Select_allDeselect_all
AF2_GRARO Kappa-theraphotoxin-Gr2c (Kappa-TRTX-Gr2c) (GsAF ... Grammostola rosea (Chilean rose tarantula) ...
TXPR2_THRPR Beta/omega-theraphotoxin-Tp2a ... Thrixopelma pruriens (Peruvian green velvet ...

6 entries

Neurotoxin 36 family, 02 subfamily

Select_allDeselect_all
H10A1_CYRHA Hainantoxin-X (HNTX-X) Cyriopagopus hainanus (Chinese bird spider) ...
H10A2_CYRHA Hainantoxin-X.2 (HNTX-X.2) Cyriopagopus hainanus (Chinese bird spider) ...
H10A3_CYRHA Hainantoxin-X.3 (HNTX-X.3) Cyriopagopus hainanus (Chinese bird spider) ...
H10B1_CYRHA Hainantoxin-X-2 (HNTX-X-2) Cyriopagopus hainanus (Chinese bird spider) ...
H10C1_CYRHA Hainantoxin-X-3 (HNTX-X-3) Cyriopagopus hainanus (Chinese bird spider) ...
TXH10_CYRSC Omega-theraphotoxin-Hs1a (Omega-TRTX-Hs1a) ... Cyriopagopus schmidti (Chinese bird spider) ...

9 entries

Not in a family

Select_allDeselect_all
CUG6A_CONCL Omega-conotoxin Cl16a (Conotoxin CalTx) ... Californiconus californicus (California cone) ...
CXQA_CONRG Omega-conotoxin RsXXVIA (RsXXIVA) Conus regularis (Regular cone)
TBO_TIBOB Omega-phylotoxin-To1a (Omega-PHTX-To1a) ... Tibellus oblongus (Oblong running crab spider)
TX13_KUKHI Omega-filistatoxin-Kh1a (Omega-FLTX-Kh1a) (Toxin ... Kukulcania hibernalis (Southern house spider) ...
TX325_SEGFL Omega-segestritoxin-Sf1a (Omega-SGTX-Sf1a) ... Segestria florentina (Tube-web spider) ...
TX3_PHONI U7-ctenitoxin-Pn1b (U7-CNTX-Pn1b) (Neurotoxin ... Phoneutria nigriventer (Brazilian armed spider) ...
U6VN_CONVE Omega-conotoxin-like Vn2 (Conotoxin Vn2) ... Conus ventricosus (Mediterranean cone)
U7AB_CONGE Omega-conotoxins GVIIA/GVIIB (SNX-178) (Shaker ... Conus geographus (Geography cone) (Nubecula ...
U7B_CONDE Conotoxin de7b Conus delessertii (Sozon's cone) (Conus sozoni)

1 entry

O1 superfamily

I166_CONTE Conotoxin Tx6.6 Conus textile (Cloth-of-gold cone)

3 entries

O2 superfamily, Contryphan family

Select_allDeselect_all
COW1_CONBL Contryphan-Lo (Contryphan-Lo1) (Lo959) [Cleaved ... Conus buxeus loroisii (Cone snail) (Conus ...
COW_CONAA Contryphan-Am (Am975) [Cleaved into: ... Conus amadis (Amadis cone)
COW_CONMR Glacontryphan-M Conus marmoreus (Marble cone)

1 entry

Poneritoxin-Ae1 family

PON1A_ANOEM U1-poneritoxin-Ae1a (U1-PONTX-Ae1a) Anochetus emarginatus (Ant) (Stenomyrmex ...

1 entry

Scoloptoxin-05 family

TX51A_SCOSU Omega-scoloptoxin(05)-Ssm1a ... Scolopendra subspinipes (Vietnamese centipede)

1 entry

Scoloptoxin-10 family

TXA1B_SCODE Omega-scoloptoxin(10)-Ssd1b ... Scolopendra dehaani (Thai centipede) ...

2 entries

Scoloptoxin-13 family

Select_allDeselect_all
TXD2A_SCOSU Omega-scoloptoxin(13)-Ssm2a ... Scolopendra subspinipes (Vietnamese centipede)
TXD2B_SCOSU Omega-scoloptoxin(13)-Ssm2b ... Scolopendra subspinipes (Vietnamese centipede)

1 entry

Scoloptoxin-15 family

TXF3C_SCODE Omega-scoloptoxin(15)-Ssd3c ... Scolopendra dehaani (Thai centipede) ...

1 entry

Snake three-finger toxin family, Long-chain subfamily, Type II alpha-neurotoxin sub-subfamily

"Snake three-finger toxin family" VenomZone page
3L2L_OXYSC Taicatoxin, alpha-neurotoxin-like component ... Oxyuranus scutellatus scutellatus (Australian ...

4 entries

Snake three-finger toxin family, Short-chain subfamily, L-type calcium blocker sub-subfamily

Select_allDeselect_all "Snake three-finger toxin family" VenomZone page
3SL2_DENAN Toxin C10S2C2 Dendroaspis angusticeps (Eastern green mamba) ...
3SL2_DENPO Toxin FS-2 (FS2) Dendroaspis polylepis polylepis (Black mamba)
3SL8_DENJA Toxin S4C8 Dendroaspis jamesoni kaimosae (Eastern Jameson's ...
3SLS_DENPO Calciseptin (Calciseptine) (CaS) (L-type calcium ... Dendroaspis polylepis polylepis (Black mamba)

3 entries

Spiderine family, Spiderine subfamily

Select_allDeselect_all
TOX1_OXYLI Omega-oxotoxin-Ol1a (Omega-OXTX-Ol1a) ... Oxyopes lineatus (Lynx spider)
TOX1_OXYTA Omega-oxotoxin-Ot1a (Omega-OXTX-Ot1a) ... Oxyopes takobius (Lynx spider) (Oxyopes ...
TOX2_OXYLI Omega-oxotoxin-Ol1b (Omega-OXTX-Ol1b) ... Oxyopes lineatus (Lynx spider)

1 entry

Venom Kunitz-type family

"Venom Kunitz-type family" VenomZone page
VKT_OXYSC Kunitz-type serine protease inhibitor taicotoxin ... Oxyuranus scutellatus scutellatus (Australian ...