Bradykinin receptor impairing toxin

Receptor Bradykinin (BK) receptors are a class of G protein-coupled receptors (GPCRs) that are targets of kinins. The B2 receptors are the best characterized kinin receptors. They are largely expressed in a constitutive manner throughout the central and peripheral nervous systems, mediating most of physiological effects of kinins. With only a few exceptions, B1 receptors are not expressed in significant levels in normal tissues, but their expression occurs rapidly in certain pathological conditions or by the action of proinflammatory agents (Calixto et al., 2000).
Toxin
Receptor Toxins from different taxa that target receptors.
Click on image to retrieve receptors or toxins of interest.
Human Snake Scorpion Cone
snail 		Spider Cnidarian Insect Other All
BK receptor B1/BDKRB1 image - - - - - image - image
BK receptor B2/BDKRB2 image image image - - - image image image
BK receptor All image image image - image - image image image
Link Back to Pharmacological targets
Back to G-protein coupled receptor impairing toxin
Other link of interest Bradykinin-related peptide
Nomenclature No nomenclature has been given to toxins that target this type of receptor (see King et al., 2008).

Venom protein entries in UniProtKB/Swiss-Prot

(all links/actions below point to uniprot.org website)

21 entries grouped by family

3 entries

Bradykinin inhibitor peptide family

Select_allDeselect_all
BKIP_AGKBI Bradykinin inhibitor peptide (BIP) Agkistrodon bilineatus (Cantil) (Tropical ...
BKIP_CROAT Bradykinin inhibitor peptide (BIP) Crotalus atrox (Western diamondback rattlesnake)
BKIP_CROVV Bradykinin inhibitor peptide (BIP) Crotalus viridis viridis (Prairie rattlesnake)

11 entries

Bradykinin-related peptide family

Select_allDeselect_all
BRK6_CYPDO Bradykinin-related peptide Cd-146 Cyphononyx dorsalis (Spider wasp) (Cyphononyx ...
BRKC_CYPDO Cyphokinin (Bradykinin-related peptide) [Cleaved ... Cyphononyx dorsalis (Spider wasp) (Cyphononyx ...
BRKF_CYPDO Fulvonin (Bradykinin-related peptide) Cyphononyx dorsalis (Spider wasp) (Cyphononyx ...
BRK_MEGFL Megascoliakinin (MBK) (Thr6-bradykinin-Lys-Ala) ... Megascolia flavifrons (Garden dagger wasp) ...
BRK_PARID Waspkinin (Bradykinin-related peptide) Parapolybia indica (Lesser paper wasp)
BRK_POLMJ Wasp kinin PMM1 (Bradykinin-related peptide) Polistes major (Neotropical social wasp)
BRK_POLOC Thr6-bradykinin (Bradykinin-related peptide) Polybia occidentalis (Paper wasp)
BRK_VESMA Vespakinin-M (Bradykinin-related peptide) Vespa mandarinia (Asian giant hornet)
BRK_VESMC Vespulakinin-1 [Cleaved into: Vespulakinin-2 ... Vespula maculifrons (Eastern yellow jacket) ...
BRK_VESXA Vespakinin-X (Bradykinin-related peptide) Vespa xanthoptera (Japanese yellow hornet) ...
KLPS_LYCER Kinin-like peptide-S Lycosa erythrognatha (Wolf spider) (Scaptocosa ...

1 entry

Natriuretic peptide family

"Natriuretic peptide family" VenomZone page
VNHP_HELSC Natriuretic and helokinestatin peptides [Cleaved ... Heloderma suspectum cinctum (Banded Gila ...

4 entries

Non-disulfide-bridged peptide (NDBP) superfamily

Select_allDeselect_all
NDB31_TITSE Hypotensin toxin Ts31 (Anti-hypertensive ... Tityus serrulatus (Brazilian scorpion)
NDBH1_TITSE Hypotensin-1 (Anti-hypertensive peptide) ... Tityus serrulatus (Brazilian scorpion)
NDBH2_TITSE Hypotensin-2 (Hypotensin II) (TsHpt-II) (Toxin ... Tityus serrulatus (Brazilian scorpion)
NDBH_TITST Hypotensin (TistH) Tityus stigmurus (Brazilian scorpion)

2 entries

Not in a family

Select_allDeselect_all
HKS_HELHO Helokinestatin-1 (Helokinestatin) Heloderma horridum horridum (Mexican beaded ...
HKS_HELSS Helokinestatin-1 Heloderma suspectum suspectum (Reticulate Gila ...