Pseudonaja textilis (Eastern brown snake)

Venom composition A proteomic analysis of the venom was done in 2006 (Birrell et al., 2006). This study describes the identification of most of the venom proteins previously known: the prothrombin activator complex, which is composed of factor Va-like (from the multicopper oxidase family) and factor Xa-like (from the peptidase S1 family), serine proteinase inhibitors (from the venom Kunitz-type family), various phospholipases A2 (phospholipase A2 family), and pre- and postsynaptic neurotoxins (from the phospholipase A2 family and the three-finger toxin family, respectively). In addition, glucose-regulated protein 78, a protein not previously reported in venom before this study was identified, which is a member of the heat shock protein 70 (HSP70) family. This protein is supposed to play a role in facilitating the assembly of multimeric protein complexes known to exist in the venom (Birrell et al., 2006).

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Clinical Effects, Treatment, Antivenoms See the Clinical Toxinology Resources Website
and the WHO venomous snake database to access snake distribution and antivenom products.

Venom protein entries in UniProtKB/Swiss-Prot

37 entries grouped by family (browse by taxonomy, browse by keywords)

1 entry

Calmodulin family, Calglandulin subfamily

CALGL_PSETE Calglandulin Pseudonaja textilis (Eastern brown snake)

2 entries

Cathelicidin family

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CAMP1_PSETE Cathelicidin-related peptide Pt_CRAMP1 ... Pseudonaja textilis (Eastern brown snake)
CAMP2_PSETE Cathelicidin-related peptide Pt_CRAMP2 ... Pseudonaja textilis (Eastern brown snake)

1 entry

CRISP family

"CRISP family" VenomZone page
CRVP_PSETE Cysteine-rich venom protein pseudechetoxin-like ... Pseudonaja textilis (Eastern brown snake)

1 entry

Cystatin family

"Cystatin family" VenomZone page
CYT_PSETE Cystatin Pseudonaja textilis (Eastern brown snake)

1 entry

Multicopper oxidase family

"Multicopper oxidase family" VenomZone page
FA5V_PSETE Venom prothrombin activator pseutarin-C ... Pseudonaja textilis (Eastern brown snake)

1 entry

Natriuretic peptide family

"Natriuretic peptide family" VenomZone page
VNPA_PSETE Natriuretic peptide PtNP-a (Fragment) Pseudonaja textilis (Eastern brown snake)

2 entries

NGF-beta family

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NGFV1_PSETE Venom nerve growth factor 1 (v-NGF-1) (vNGF-1) Pseudonaja textilis (Eastern brown snake)
NGFV2_PSETE Venom nerve growth factor 2 (v-NGF-2) (vNGF-2) Pseudonaja textilis (Eastern brown snake)

2 entries

Peptidase S1 family, Snake venom subfamily

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FA102_PSETE Coagulation factor X isoform 2 (PFX2) (EC ... Pseudonaja textilis (Eastern brown snake)
FAXC_PSETE Venom prothrombin activator pseutarin-C ... Pseudonaja textilis (Eastern brown snake)

5 entries

Phospholipase A2 family, Group I subfamily, D49 sub-subfamily

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PA2A1_PSETE Acidic phospholipase A2 1 (svPLA2) (EC 3.1.1.4) ... Pseudonaja textilis (Eastern brown snake)
PA2A2_PSETE Acidic phospholipase A2 2 (svPLA2) (EC 3.1.1.4) ... Pseudonaja textilis (Eastern brown snake)
PA2AC_PSETE Acidic phospholipase A2 homolog textilotoxin C ... Pseudonaja textilis (Eastern brown snake)
PA2AD_PSETE Acidic phospholipase A2 homolog textilotoxin D ... Pseudonaja textilis (Eastern brown snake)
PA2BA_PSETE Basic phospholipase A2 textilotoxin A chain ... Pseudonaja textilis (Eastern brown snake)

1 entry

Phospholipase A2 family, Group I subfamily, N49 sub-subfamily

"Phospholipase A2 family" VenomZone page
PA2BB_PSETE Basic phospholipase A2 homolog textilotoxin B ... Pseudonaja textilis (Eastern brown snake)

3 entries

Snake three-finger toxin family, Long-chain subfamily, Type II alpha-neurotoxin sub-subfamily

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3L21_PSETE Long neurotoxin 1 (LNTX-1) Pseudonaja textilis (Eastern brown snake)
3L2B_PSETE Pseudonajatoxin b (Long neurotoxin B) Pseudonaja textilis (Eastern brown snake)
3L2P_PSETE Pseudonajatoxin b homolog (Pt-bp) Pseudonaja textilis (Eastern brown snake)

9 entries

Snake three-finger toxin family, Short-chain subfamily, Type III alpha-neurotoxin sub-subfamily

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3S31_PSETE Short neurotoxin 1/5 (SNTX1) (SNTX5) ... Pseudonaja textilis (Eastern brown snake)
3S32_PSETE Short neurotoxin 2 (SNTX2) (Alpha-neurotoxin 2) Pseudonaja textilis (Eastern brown snake)
3S331_PSETE Short neurotoxin N1 (Alpha-neurotoxin) ... Pseudonaja textilis (Eastern brown snake)
3S332_PSETE Short neurotoxin N2 (Alpha-neurotoxin) ... Pseudonaja textilis (Eastern brown snake)
3S33_PSETE Short neurotoxin 3 (SNTX3) (Alpha-neurotoxin 3) Pseudonaja textilis (Eastern brown snake)
3S34_PSETE Short neurotoxin 4 (SNTX4) (Alpha-neurotoxin 4) Pseudonaja textilis (Eastern brown snake)
3S36_PSETE Short neurotoxin 6 (SNTX6) (Alpha-neurotoxin 6) Pseudonaja textilis (Eastern brown snake)
3S37_PSETE Short neurotoxin 7 (SNTX7) (Alpha-neurotoxin 7) Pseudonaja textilis (Eastern brown snake)
3S38_PSETE Short neurotoxin 8 (SNTX8) Pseudonaja textilis (Eastern brown snake)

1 entry

Snake waprin family

WAPA_PSETE Textwaprin-a Pseudonaja textilis (Eastern brown snake)

7 entries

Venom Kunitz-type family

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VKT1_PSETT Kunitz-type serine protease inhibitor ... Pseudonaja textilis textilis (Eastern brown ...
VKT2_PSETT Kunitz-type serine protease inhibitor ... Pseudonaja textilis textilis (Eastern brown ...
VKT3_PSETT Kunitz-type serine protease inhibitor ... Pseudonaja textilis textilis (Eastern brown ...
VKT4_PSETT Kunitz-type serine protease inhibitor ... Pseudonaja textilis textilis (Eastern brown ...
VKT5_PSETT Kunitz-type serine protease inhibitor ... Pseudonaja textilis textilis (Eastern brown ...
VKT6_PSETT Kunitz-type serine protease inhibitor ... Pseudonaja textilis textilis (Eastern brown ...
VKT7_PSETT Kunitz-type serine protease inhibitor ... Pseudonaja textilis textilis (Eastern brown ...