Pseudonaja textilis (Eastern brown snake) (taxid:8673)

Venom composition A proteomic analysis of the venom was done in 2006 (Birrell et al., 2006). This study describes the identification of most of the venom proteins previously known: the prothrombin activator complex, which is composed of factor Va-like (from the multicopper oxidase family) and factor Xa-like (from the peptidase S1 family), serine proteinase inhibitors (from the venom Kunitz-type family), various phospholipases A2 (phospholipase A2 family), and pre- and postsynaptic neurotoxins (from the phospholipase A2 family and the three-finger toxin family, respectively). In addition, glucose-regulated protein 78, a protein not previously reported in venom before this study was identified, which is a member of the heat shock protein 70 (HSP70) family. This protein is supposed to play a role in facilitating the assembly of multimeric protein complexes known to exist in the venom (Birrell et al., 2006).

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Clinical Effects, Treatment, Antivenoms See the Clinical Toxinology Resources Website.
Taxonomy

UniProt taxonomy
The Reptile database
Wikipedia

Infraorder: Serpentes


Family: Elapidae
Genus: Pseudonaja
Species: textilis
Activity Antimicrobial
Hemostasis impairing toxin
  Blood coagulation cascade activating toxin
Hypotensive agent
Neurotoxin
  Postsynaptic neurotoxin
  Presynaptic neurotoxin
Vasoactive
  Vasodilator
and also
Ion channel impairing toxin
or see
UniProtKB browsing by keyword

Venom protein entries in UniProtKB/Swiss-Prot

(all links/actions below point to uniprot.org website)

37 entries grouped by family

1 entry

Calmodulin family, Calglandulin subfamily

CALGL_PSETE Calglandulin Pseudonaja textilis (Eastern brown snake)

2 entries

Cathelicidin family

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CAMP1_PSETE Cathelicidin-related peptide Pt_CRAMP1 ... Pseudonaja textilis (Eastern brown snake)
CAMP2_PSETE Cathelicidin-related peptide Pt_CRAMP2 ... Pseudonaja textilis (Eastern brown snake)

1 entry

CRISP family

"CRISP family" VenomZone page
CRVP_PSETE Cysteine-rich venom protein pseudechetoxin-like ... Pseudonaja textilis (Eastern brown snake)

1 entry

Cystatin family

"Cystatin family" VenomZone page
CYT_PSETE Cystatin Pseudonaja textilis (Eastern brown snake)

1 entry

Multicopper oxidase family

"Multicopper oxidase family" VenomZone page
FA5V_PSETE Venom prothrombin activator pseutarin-C ... Pseudonaja textilis (Eastern brown snake)

pdb 4BXS

1 entry

Natriuretic peptide family

"Natriuretic peptide family" VenomZone page
VNPA_PSETE Natriuretic peptide PtNP-a Pseudonaja textilis (Eastern brown snake)

2 entries

NGF-beta family

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NGFV1_PSETE Venom nerve growth factor 1 (v-NGF-1) (vNGF-1) Pseudonaja textilis (Eastern brown snake)
NGFV2_PSETE Venom nerve growth factor 2 (v-NGF-2) (vNGF-2) Pseudonaja textilis (Eastern brown snake)

2 entries

Peptidase S1 family, Snake venom subfamily

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FA102_PSETE Coagulation factor X isoform 2 (PFX2) (EC ... Pseudonaja textilis (Eastern brown snake)
FAXC_PSETE Venom prothrombin activator pseutarin-C ... Pseudonaja textilis (Eastern brown snake)

pdb 4BXS; 4BXW

5 entries

Phospholipase A2 family, Group I subfamily, D49 sub-subfamily

Select_allDeselect_all "Phospholipase A2 family" VenomZone page
PA2A1_PSETE Acidic phospholipase A2 1 (svPLA2) (EC 3.1.1.4) ... Pseudonaja textilis (Eastern brown snake)
PA2A2_PSETE Acidic phospholipase A2 2 (svPLA2) (EC 3.1.1.4) ... Pseudonaja textilis (Eastern brown snake)
PA2BA_PSETE Basic phospholipase A2 textilotoxin A chain ... Pseudonaja textilis (Eastern brown snake)
PA2HC_PSETE Acidic phospholipase A2 homolog textilotoxin C ... Pseudonaja textilis (Eastern brown snake)
PA2HD_PSETE Acidic phospholipase A2 homolog textilotoxin D ... Pseudonaja textilis (Eastern brown snake)

1 entry

Phospholipase A2 family, Group I subfamily, N49 sub-subfamily

"Phospholipase A2 family" VenomZone page
PA2HB_PSETE Basic phospholipase A2 homolog textilotoxin B ... Pseudonaja textilis (Eastern brown snake)

3 entries

Snake three-finger toxin family, Long-chain subfamily, Type II alpha-neurotoxin sub-subfamily

Select_allDeselect_all "Snake three-finger toxin family" VenomZone page
3L21_PSETE Long neurotoxin 1 (LNTX-1) Pseudonaja textilis (Eastern brown snake)
3L2B_PSETE Pseudonajatoxin b (Long neurotoxin B) Pseudonaja textilis (Eastern brown snake)
3L2P_PSETE Pseudonajatoxin b homolog (Pt-bp) Pseudonaja textilis (Eastern brown snake)

9 entries

Snake three-finger toxin family, Short-chain subfamily, Type III alpha-neurotoxin sub-subfamily

Select_allDeselect_all "Snake three-finger toxin family" VenomZone page
3S31_PSETE Short neurotoxin 1/5 (SNTX1) (SNTX5) ... Pseudonaja textilis (Eastern brown snake)
3S32_PSETE Short neurotoxin 2 (SNTX2) (Alpha-neurotoxin 2) Pseudonaja textilis (Eastern brown snake)
3S331_PSETE Short neurotoxin N1 (Alpha-neurotoxin) Pseudonaja textilis (Eastern brown snake)
3S332_PSETE Short neurotoxin N2 (Alpha-neurotoxin) Pseudonaja textilis (Eastern brown snake)
3S33_PSETE Short neurotoxin 3 (SNTX3) (Alpha-neurotoxin 3) Pseudonaja textilis (Eastern brown snake)
3S34_PSETE Short neurotoxin 4 (SNTX4) (Alpha-neurotoxin 4) Pseudonaja textilis (Eastern brown snake)
3S36_PSETE Short neurotoxin 6 (SNTX6) (Alpha-neurotoxin 6) Pseudonaja textilis (Eastern brown snake)
3S37_PSETE Short neurotoxin 7 (SNTX7) (Alpha-neurotoxin 7) Pseudonaja textilis (Eastern brown snake)
3S38_PSETE Short neurotoxin 8 (SNTX8) Pseudonaja textilis (Eastern brown snake)

7 entries

Venom Kunitz-type family

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VKT1_PSETT Kunitz-type serine protease inhibitor ... Pseudonaja textilis textilis (Eastern brown ...

pdb 3BYB; 3D65; 3UIR; 5ZJ3

VKT2_PSETT Kunitz-type serine protease inhibitor ... Pseudonaja textilis textilis (Eastern brown ...
VKT3_PSETT Kunitz-type serine protease inhibitor ... Pseudonaja textilis textilis (Eastern brown ...
VKT4_PSETT Kunitz-type serine protease inhibitor ... Pseudonaja textilis textilis (Eastern brown ...
VKT5_PSETT Kunitz-type serine protease inhibitor ... Pseudonaja textilis textilis (Eastern brown ...
VKT6_PSETT Kunitz-type serine protease inhibitor ... Pseudonaja textilis textilis (Eastern brown ...
VKT7_PSETT Kunitz-type serine protease inhibitor ... Pseudonaja textilis textilis (Eastern brown ...

1 entry

Venom waprin family

WAPA_PSETE Textwaprin-a Pseudonaja textilis (Eastern brown snake)