Agkistrodon contortrix contortrix (southern copperhead)

Venom composition
Figure 1: Composition of contortrix contortrix venom, studied at proteomic level (Lomonte, et al., 2014 ). This venom contains the following families: SVMP (venom metalloproteinase ), serine protease (peptidase S1 ), peptides (include tripeptide SVMP inhibitors and bradykinin-potentiating and bradykinin-inhibitory peptides), LAAO (L-amino-acid oxidase (flavin monoamine oxidase) ), disintegrin, snaclec (also known as C-type lectin-like), NGF (-beta) , CRISP, oha (ohanin/vespryn ), DC-fragments (disintegrin/cysteine-rich fragment from P-III SVMPs) and PA2 (phospholipase A2 ).
Clinical Effects, Treatment, Antivenoms See the Clinical Toxinology Resources Website
and the WHO venomous snake database to access snake distribution and antivenom products.
Lethal dose LD(50) of A.contortrix is
9.17 mg/kg by intraperitoneal injection and
10.17 mg/kg by intravenous injection (Arce et al., 2003 ).

Venom protein entries in UniProtKB/Swiss-Prot

7 entries grouped by family (browse by taxonomy, browse by keywords)

1 entry

Disintegrin family, Dimeric disintegrin subfamily

"Disintegrin family" VenomZone page
DIDA_AGKCO Disintegrin acostatin-alpha [Cleaved into: ... Agkistrodon contortrix contortrix (Southern ...

1 entry

NGF-beta family

"NGF-beta family" VenomZone page
NGFV_AGKCO Venom nerve growth factor (v-NGF) (vNGF) ... Agkistrodon contortrix contortrix (Southern ...

2 entries

Peptidase S1 family, Snake venom subfamily

Select_allDeselect_all "Peptidase S1 family" VenomZone page
VSP2_AGKCO Thrombin-like enzyme contortrixobin (SVTLE) (EC ... Agkistrodon contortrix contortrix (Southern ...
VSPCA_AGKCO Protein C activator (EC 3.4.21.-) (ACC-C) (Snake ... Agkistrodon contortrix contortrix (Southern ...

1 entry

Venom metalloproteinase (M12B) family, P-I subfamily

"Venom metalloproteinase (M12B) family" VenomZone page
VM1F_AGKCO Snake venom metalloproteinase fibrolase (SVMP) ... Agkistrodon contortrix contortrix (Southern ...

1 entry

Venom metalloproteinase (M12B) family, P-II subfamily, P-IId sub-subfamily

"Venom metalloproteinase (M12B) family" VenomZone page
VM2CO_AGKCO Zinc metalloproteinase/disintegrin [Cleaved ... Agkistrodon contortrix contortrix (Southern ...

1 entry

Venom metalloproteinase (M12B) family, P-II subfamily, P-IIe sub-subfamily

"Venom metalloproteinase (M12B) family" VenomZone page
VM2AB_AGKCO Zinc metalloproteinase/disintegrin [Cleaved ... Agkistrodon contortrix contortrix (Southern ...