Ionotropic GABA receptor impairing toxin
Ionotropic γ-aminobutyric acid (GABA) receptors (also named GABA type A receptors or GABA (A) receptors)
are ion channels that are activated by GABA, the major inhibitory neurotransmitter in the central nervous system. They selectively conduct chloride ions through their pore, resulting in hyperpolarization of the neuron.
Ionotropic GABA receptors are pentameric receptors that are composed of numerous subunit isoforms (α1-α6, β1-β3, γ1-γ3, δ, ε, π, θ, and ρ1-ρ3); the subunits combine to make up a GABA receptor via multiple arrangements. The most common type in the brain is a pentamer comprising two α's, two β's, and a γ (α2β2γ). In general, each subunit consists of four transmembrane domains, in which transmembrane domain 2 delineates the axially positioned chloride channel (
Hevers and Luddens, 1998
Olsen and Sieghart, 2009
Toxins from different taxa that target receptors.
to retrieve toxins of interest.
Ionotropic GABA receptor
Ion channel impairing toxin
Toxins that target this type of receptor should be named
-toxins (SIGMA in upper case) (see
King et al., 2008
SIB Swiss Institute of Bioinformatics
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