Ionotropic GABA receptor impairing toxin

Receptor Ionotropic γ-aminobutyric acid (GABA) receptors (also named GABA type A receptors or GABA (A) receptors) are ion channels that are activated by GABA, the major inhibitory neurotransmitter in the central nervous system. They selectively conduct chloride ions through their pore, resulting in hyperpolarization of the neuron.

Ionotropic GABA receptors are pentameric receptors that are composed of numerous subunit isoforms (α1-α6, β1-β3, γ1-γ3, δ, ε, π, θ, and ρ1-ρ3); the subunits combine to make up a GABA receptor via multiple arrangements. The most common type in the brain is a pentamer comprising two α's, two β's, and a γ (α2β2γ). In general, each subunit consists of four transmembrane domains, in which transmembrane domain 2 delineates the axially positioned chloride channel (Hevers and Luddens, 1998, Olsen and Sieghart, 2009).
Toxin
Receptor Toxins from different taxa that target receptors.
Click on image to retrieve toxins of interest.
Human Snake Scorpion Cone
snail
Spider Cnidarian Insect Other All
α1β3/GABRA1-GABRB3 image image - - - - - - image
α1β2γ2/
GABRA1-GABRB2-GABRG2
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α1β3γ2/
GABRA1-GABRB3-GABRG2
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α2/GABRA2 image image - - - - - - image
α2β2γ2/
GABRA2-GABRB2-GABRG2
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α2β3γ2/
GABRA2-GABRB3-GABRG2
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α4β2γ2/
GABRA4-GABRB2-GABRG2
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α5β2γ2/
GABRA5-GABRB2-GABRG2
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α5β3γ2/
GABRA5-GABRB3-GABRG2
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β1/GABRB1 image image - - - - - - image
β2/GABRB2 image image - - - - - - image
β3/GABRB3 image image - - - - - - image
γ2/GABRG2 image image - - - - - - image
ρ1/GABRR1 image image - - - - - - image
All ionotropic GABA (A) receptors image image - image - - - - image