Daboia siamensis (Eastern Russel's viper)


Venom composition
The venom proteome of Daboia siamensis (collected in Myanmar) was analyzed by 2-D electrophoresis, subsequent MS/MS and enzymatic assays (Risch et al., 2009 ). The proteome comprises toxins from six protein families:
Serine proteases, snake venom metalloproteinases, phospholipase A2, L-amino-acid oxidases, vascular endothelial growth factors (PDGF/VEGF growth factor ) and C-type lectin-like proteins (also named snaclec ). Neither cysteine-rich secretory proteins (CRISPs) nor “free” disintegrins were identified. However, the presence of low molecular mass (less than 10 kDa) disintegrins cannot be excluded because only proteins of more than 10 kDa have been identified (Risch et al., 2009 ).
Surprisingly, trypsin inhibitors from the Kunitz-type family, have not been reported in this study. However proteins of this family have been sequenced (see proteins by clicking on the “Proteins by Family” tab) and characterized (Guo et al., 2013 ). In addition, strong trypsin inhibitory activity has been detected in Russel’s viper venom from Eastern India (Mukherje et al., 2000 ).
Clinical Effects, Treatment, Antivenoms See the Clinical Toxinology Resources Website
and the WHO venomous snake database to access snake distribution and antivenom products.
Lethal dose Lethal dose is 0.7 mg/kg by intravenous injection into mice (Mukherje et al., 2000 ).

Venom protein entries in UniProtKB/Swiss-Prot

38 entries grouped by family (browse by taxonomy, browse by keywords)

1 entry

Flavin monoamine oxidase family, FIG1 subfamily

"Flavin monoamine oxidase family" VenomZone page
OXLA_DABSI L-amino-acid oxidase (DRS-LAAO) (LAO) (EC ... Daboia siamensis (Eastern Russel's viper) ...

1 entry

Not in a family

IVBL_DABSI BPTI-like protein (Fragment) Daboia siamensis (Eastern Russel's viper) ...

1 entry

PDGF/VEGF growth factor family, Snake venom VEGF subfamily

"PDGF/VEGF growth factor family" VenomZone page
TXVE_DABSI Snake venom vascular endothelial growth factor ... Daboia siamensis (Eastern Russel's viper) ...

4 entries

Peptidase S1 family, Snake venom subfamily

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VSPAF_DABSI Alpha-fibrinogenase-like (RVAF) (EC 3.4.21.-) ... Daboia siamensis (Eastern Russel's viper) ...
VSPA_DABSI Factor V activator RVV-V alpha (EC 3.4.21.95) ... Daboia siamensis (Eastern Russel's viper) ...
VSPB_DABSI Beta-fibrinogenase-like (RVBF) (EC 3.4.21.-) ... Daboia siamensis (Eastern Russel's viper) ...
VSPG_DABSI Factor V activator RVV-V gamma (EC 3.4.21.95) ... Daboia siamensis (Eastern Russel's viper) ...

2 entries

Phospholipase A2 family, Group II subfamily

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PA2A_DABSI Acidic phospholipase A2 Drs-PLA2 (svPLA2) (EC ... Daboia siamensis (Eastern Russel's viper) ...
PA2_DABSI Phospholipase A2 (svPLA2) (EC 3.1.1.4) ... Daboia siamensis (Eastern Russel's viper) ...

7 entries

Phospholipase A2 family, Group II subfamily, D49 sub-subfamily

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PA2A2_DABSI Acidic phospholipase A2 DsM-a2/DsM-a2' (svPLA2) ... Daboia siamensis (Eastern Russel's viper) ...
PA2A7_DABSI Acidic phospholipase A2 RV-7 (svPLA2) (EC ... Daboia siamensis (Eastern Russel's viper) ...
PA2AA_DABSI Acidic phospholipase A2 daboiatoxin A chain ... Daboia siamensis (Eastern Russel's viper) ...
PA2AB_DABSI Acidic phospholipase A2 daboiatoxin B chain ... Daboia siamensis (Eastern Russel's viper) ...
PA2B1_DABSI Basic phospholipase A2 DsM-b1/DsM-b1' (svPLA2) ... Daboia siamensis (Eastern Russel's viper) ...
PA2B4_DABSI Basic phospholipase A2 RV-4 (svPLA2) (EC ... Daboia siamensis (Eastern Russel's viper) ...
PA2BS_DABSI Basic phospholipase A2 DsM-S1 (svPLA2) (EC ... Daboia siamensis (Eastern Russel's viper) ...

3 entries

Snaclec family

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SLA_DABSI Snaclec dabocetin subunit alpha (C-type ... Daboia siamensis (Eastern Russel's viper) ...
SLLC1_DABSI Snaclec coagulation factor X-activating enzyme ... Daboia siamensis (Eastern Russel's viper) ...
SLLC2_DABSI Snaclec coagulation factor X-activating enzyme ... Daboia siamensis (Eastern Russel's viper) ...

17 entries

Venom Kunitz-type family

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VKT10_DABSI Kunitz-type serine protease inhibitor C10 ... Daboia siamensis (Eastern Russel's viper) ...
VKT2_DABSI Kunitz-type serine protease inhibitor 2 (RVV-II) ... Daboia siamensis (Eastern Russel's viper) ...
VKTB1_DABSI Kunitz-type serine protease inhibitor B1 ... Daboia siamensis (Eastern Russel's viper) ...
VKTB2_DABSI Kunitz-type serine protease inhibitor B2 ... Daboia siamensis (Eastern Russel's viper) ...
VKTB3_DABSI Kunitz-type serine protease inhibitor B3 ... Daboia siamensis (Eastern Russel's viper) ...
VKTB4_DABSI Kunitz-type serine protease inhibitor B4 ... Daboia siamensis (Eastern Russel's viper) ...
VKTB5_DABSI Kunitz-type serine protease inhibitor B5 ... Daboia siamensis (Eastern Russel's viper) ...
VKTB6_DABSI Kunitz-type serine protease inhibitor B6 ... Daboia siamensis (Eastern Russel's viper) ...
VKTB7_DABSI Kunitz-type serine protease inhibitor 7 (BPTI-7) ... Daboia siamensis (Eastern Russel's viper) ...
VKTC1_DABSI Kunitz-type serine protease inhibitor C1 ... Daboia siamensis (Eastern Russel's viper) ...
VKTC2_DABSI Kunitz-type serine protease inhibitor C2 ... Daboia siamensis (Eastern Russel's viper) ...
VKTC3_DABSI Kunitz-type serine protease inhibitor C3 ... Daboia siamensis (Eastern Russel's viper) ...
VKTC4_DABSI Kunitz-type serine protease inhibitor C4 ... Daboia siamensis (Eastern Russel's viper) ...
VKTC5_DABSI Kunitz-type serine protease inhibitor C5 ... Daboia siamensis (Eastern Russel's viper) ...
VKTC6_DABSI Kunitz-type serine protease inhibitor C6 ... Daboia siamensis (Eastern Russel's viper) ...
VKTC8_DABSI Kunitz-type serine protease inhibitor C8 ... Daboia siamensis (Eastern Russel's viper) ...
VKTC9_DABSI Kunitz-type serine protease inhibitor C9 ... Daboia siamensis (Eastern Russel's viper) ...

1 entry

Venom metalloproteinase (M12B) family, P-III subfamily, P-IIIa sub-subfamily

"Venom metalloproteinase (M12B) family" VenomZone page
VM3DM_DABSI Zinc metalloproteinase-disintegrin-like ... Daboia siamensis (Eastern Russel's viper) ...

1 entry

Venom metalloproteinase (M12B) family, P-III subfamily, P-IIId sub-subfamily

"Venom metalloproteinase (M12B) family" VenomZone page
VM3CX_DABSI Coagulation factor X-activating enzyme heavy ... Daboia siamensis (Eastern Russel's viper) ...