Tityus obscurus (Amazonian scorpion) (taxid:1221240)

Venom composition image
Figure 1: Composition of T.obscurus venom, studied at the transcriptomic level. This venom contains the following families (classified by activity): sodium channel toxin (NaTx), anionic peptide, anticoagulant peptide (negligible), antimicrobial peptide (AMP), bradykinin potentiating-peptide (BPP), chitinase (negligible), CRISP, hyaluronidase, insulin-like growth factor, lipase, metalloproreinase, phospholipase A2 (PA2), phospholipase C (negligible), potassium channel toxin (KTx), proteinase inhibitor, other proteinase, conserved venom component (de Oliveira et al., 2018). Families with an asterix (*) are those with peptides identified by proteomic analysis.
Clinical Effects, Treatment, Antivenoms See the Clinical Toxinology Resources Website.
Lethal dose LD(50) is 3.13 mg/kg by intraperitoneal injection into mice (Santos da Silva et al., 2017).
Taxonomy

UniProt taxonomy
Wikipedia

Order: Scorpiones


Family: Buthidae
Genus: Tityus
Species:obscurus
Activity see
UniProtKB browsing by keyword
Reference Batista et al., 2004
de Oliveira et al., 2018

Venom protein entries in UniProtKB/Swiss-Prot

(all links/actions below point to uniprot.org website)

39 entries grouped by family

4 entries

Long (4 C-C) scorpion toxin superfamily, Sodium channel inhibitor family

Select_allDeselect_all
SCX13_TITOB Sodium channel toxin To13 (T NaTx8.1) Tityus obscurus (Amazonian scorpion) (Tityus ...
SCX14_TITOB Toxin To14 (T-alpha* NaTx3.10) (Toxin Tc41) ... Tityus obscurus (Amazonian scorpion) (Tityus ...
SCX2_TITOB Alpha-toxin To2 (Alpha-toxin Tc48a) (Alpha-toxin ... Tityus obscurus (Amazonian scorpion) (Tityus ...
SCX7_TITOB Toxin To7 (PT-alpha* NaTx7.6) (Toxin Tc50) ... Tityus obscurus (Amazonian scorpion) (Tityus ...

2 entries

Long (4 C-C) scorpion toxin superfamily, Sodium channel inhibitor family, Alpha subfamily

Select_allDeselect_all
SCX10_TITOB Toxin To10 (T-alpha* NaTx3.9) Tityus obscurus (Amazonian scorpion) (Tityus ...
SCX9_TITOB Toxin To9 (T-alpha* NaTx3.8) Tityus obscurus (Amazonian scorpion) (Tityus ...

9 entries

Long (4 C-C) scorpion toxin superfamily, Sodium channel inhibitor family, Beta subfamily

Select_allDeselect_all
SCX11_TITOB Toxin To11 (T NaTx14.9) Tityus obscurus (Amazonian scorpion) (Tityus ...
SCX12_TITOB Toxin To12 (T-beta* NaTx5.5) Tityus obscurus (Amazonian scorpion) (Tityus ...
SCX15_TITOB Toxin To15 (T-beta* NaTx1.4) Tityus obscurus (Amazonian scorpion) (Tityus ...
SCX1_TITOB Beta-mammal/insect toxin To1 (NaTx12.1) (Toxin ... Tityus obscurus (Amazonian scorpion) (Tityus ...
SCX3_TITOB Toxin To3 (PT-alpha' NaTx14.2) (Toxin ... Tityus obscurus (Amazonian scorpion) (Tityus ...
SCX4_TITOB Beta-toxin To4 (PT-beta* NaTx13.9) (Toxin Tc54) Tityus obscurus (Amazonian scorpion) (Tityus ...
SCX5_TITOB Toxin To5 (PT-Arthr*-beta* NaTx2.7) (Toxin Tc66) ... Tityus obscurus (Amazonian scorpion) (Tityus ...
SCX6_TITOB Toxin To6 (PT-alpha* NaTx7.5) (Toxin Tc43) ... Tityus obscurus (Amazonian scorpion) (Tityus ...
SCX8_TITOB Toxin To8 (PT-beta* NaTx10.1) Tityus obscurus (Amazonian scorpion) (Tityus ...

1 entry

Non-disulfide-bridged peptide (NDBP) superfamily, Medium-length antimicrobial peptide (group 3) family

NDB32_TITOB Antimicrobial peptide ToAP2 Tityus obscurus (Amazonian scorpion) (Tityus ...

3 entries

Non-disulfide-bridged peptide (NDBP) superfamily, Short antimicrobial peptide (group 4) family

Select_allDeselect_all
NDB44_TITOB Peptide ToAP4 Tityus obscurus (Amazonian scorpion) (Tityus ...
TOAP1_TITOB Antimicrobial peptide ToAp1 Tityus obscurus (Amazonian scorpion) (Tityus ...
TOAP3_TITOB Antimicrobial peptide ToAP3 Tityus obscurus (Amazonian scorpion) (Tityus ...

16 entries

Not in a family

Select_allDeselect_all
CYCTI_TITOB Cyclotide trypsin inhibitor TopI1 Tityus obscurus (Amazonian scorpion) (Tityus ...

pdb 6MRQ

SC27_TITOB Toxin To27 (Toxin Tc27) Tityus obscurus (Amazonian scorpion) (Tityus ...
SC29_TITOB Toxin To29 (Toxin Tc29) Tityus obscurus (Amazonian scorpion) (Tityus ...
SC31_TITOB Toxin To31 (Toxin Tc31) Tityus obscurus (Amazonian scorpion) (Tityus ...
SC33_TITOB Toxin To33 (Toxin Tc33) Tityus obscurus (Amazonian scorpion) (Tityus ...
SC35_TITOB Toxin To35 (Toxin Tc35) Tityus obscurus (Amazonian scorpion) (Tityus ...
SC37_TITOB Toxin To37 (Toxin Tc37) Tityus obscurus (Amazonian scorpion) (Tityus ...
SC39_TITOB Toxin To39 (Toxin Tc39) Tityus obscurus (Amazonian scorpion) (Tityus ...
SC40_TITOB Toxin To40 (Toxin Tc40) Tityus obscurus (Amazonian scorpion) (Tityus ...
SC46_TITOB Toxin To46 (Toxin Tc46) Tityus obscurus (Amazonian scorpion) (Tityus ...
SC56_TITOB Toxin To56 (Toxin Tc56) Tityus obscurus (Amazonian scorpion) (Tityus ...
SC58_TITOB Toxin To58 (Toxin Tc58) Tityus obscurus (Amazonian scorpion) (Tityus ...
SC61_TITOB Toxin To61 (Toxin Tc61) Tityus obscurus (Amazonian scorpion) (Tityus ...
SC64_TITOB Toxin To64 (Toxin Tc64) Tityus obscurus (Amazonian scorpion) (Tityus ...
SC83_TITOB Toxin To83 (Toxin Tc83) Tityus obscurus (Amazonian scorpion) (Tityus ...
TOACP_TITOB Peptide ToAcP Tityus obscurus (Amazonian scorpion) (Tityus ...

1 entry

Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 04 subfamily

KAX44_TITOB Potassium channel toxin alpha-KTx 4.4 (Toxin ... Tityus obscurus (Amazonian scorpion) (Tityus ...

1 entry

Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 13 subfamily

KA131_TITOB Potassium channel toxin alpha-KTx 13.1 (Toxin ... Tityus obscurus (Amazonian scorpion) (Tityus ...

pdb 1JLZ

1 entry

Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 18 subfamily

KA181_TITOB Potassium channel toxin alpha-KTx 18.1 (Toxin ... Tityus obscurus (Amazonian scorpion) (Tityus ...

pdb 2JP6

1 entry

Venom metalloproteinase (M12B) family

"Venom metalloproteinase (M12B) family" VenomZone page
VMP_TITOB Metalloproteinase (EC 3.4.24.-) Tityus obscurus (Amazonian scorpion) (Tityus ...