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Bothrops atrox
(barba amarilla)
(taxid:8725)
Venom composition
Figure 1: Composition of B.atrox venom, studied at both proteomic (A) (
Kohlhoffa, et al., 2012
) and transcriptomic levels (B) (
Neiva et al., 2009
).
Disintegrins
have been detected by proteomic analysis but not by transcriptomic analysis, suggesting that they are encoded by the SVMP family. VEGF (
PDGF/VEGF growth factor
), PA2 inhibitor and BPP precursor (
bradykinin-potentiating peptide
) have only been detected by transcriptomic analysis, whereas all other families have been detected by both proteomic and transcriptomic analysis.
CRISP
, PA2 (
phospholipase A2
),
serine protease
, C-type lectin (
true venom lectin
), LAAO (
L-amino-acid oxidase also known as flavin monoamine oxidase
), SVMP (snake
venom metalloproteinase
).
Clinical Effects, Treatment, Antivenoms
See the
Clinical Toxinology Resources Website
.
Lethal dose
LD(50) is 5.89 mg/kg by intraperitoneal injection into mice
(117.8 (103.7-137.3) ug/mice) (
Kohlhoff et al., 2012
).
Taxonomy
UniProt taxonomy
The Reptile database
Wikipedia
Infraorder
:
Serpentes
Family
:
Viperidae
Genus:
Bothrops
Species
:
atrox
Activity
see
UniProtKB browsing by keyword
Reference
Proteomic analysis:
Kohlhoff et al., 2012
Nunez et al., 2009
Calvete et al., 2011
Guercio et al., 2006
Transcriptomic analysis:
Neiva et al., 2009
Venom protein entries in UniProtKB/Swiss-Prot
(all links/actions below point to
uniprot.org
website)
13 entries
grouped
by species
reorder by family
13 entries
Bothrops atrox (Barba amarilla) (Fer-de-lance)
BPP12_BOTAT
Bradykinin-potentiating peptide 12a (BPP-12a)
...
Bradykinin-potentiating peptide
...
CAMP_BOTAT
Batroxicidin (BatxC) (Cathelicidin-related antimicrobial
...
Cathelicidin family
LECG_BOTAT
C-type lectin galatrox (CTL)
True venom lectin family
OXLA_BOTAT
L-amino-acid oxidase (BatroxLAAO) (LAO) (EC 1.4.3.2)
Flavin monoamine oxidase family,
...
5TS5
PA2H1_BOTAT
Phospholipase A2 homolog 1 (svPLA2 homolog) (Myotoxin I)
Phospholipase A2 family, Group
...
VM11_BOTAT
Snake venom metalloproteinase atroxlysin-1 (SVMP) (EC 3.4.24.-)
...
Venom metalloproteinase (M12B)
...
VM1B1_BOTAT
Snake venom metalloproteinase Batx-1 (SVMP) (EC 3.4.24.-)
...
Venom metalloproteinase (M12B)
...
VM2_BOTAT
Disintegrin batroxostatin (Disintegrin colombistatin) (Platelet
...
Venom metalloproteinase (M12B)
...
VM31_BOTAT
Zinc metalloproteinase-disintegrin-like batroxstatin-1 (EC
...
Venom metalloproteinase (M12B)
...
VM32_BOTAT
Zinc metalloproteinase-disintegrin-like batroxstatin-2 (EC
...
Venom metalloproteinase (M12B)
...
VM33_BOTAT
Zinc metalloproteinase-disintegrin-like batroxstatin-3 (EC
...
Venom metalloproteinase (M12B)
...
VPA_BOTAT
Venom prothrombin activator (vPA)
Not in a family
VSPF_BOTAT
Thrombin-like enzyme batroxobin (BX) (SVTLE) (EC 3.4.21.74)
...
Peptidase S1 family, Snake venom
...