ionotropic GABA receptor ~ VenomZone

Receptor Ionotropic γ-aminobutyric acid (GABA) receptors (also named GABA type A receptors or GABA (A) receptors) are ion channels that are activated by GABA, the major inhibitory neurotransmitter in the central nervous system. They selectively conduct chloride ions through their pore, resulting in hyperpolarization of the neuron.

Ionotropic GABA receptors are pentameric receptors that are composed of numerous subunit isoforms (α1-α6, β1-β3, γ1-γ3, δ, ε, π, θ, and ρ1-ρ3); the subunits combine to make up a GABA receptor via multiple arrangements. The most common type in the brain is a pentamer comprising two α's, two β's, and a γ (α2β2γ). In general, each subunit consists of four transmembrane domains, in which transmembrane domain 2 delineates the axially positioned chloride channel (Hevers and Luddens, 1998, Olsen and Sieghart, 2009).

Toxin

	Receptor	Toxins from different taxa that target receptors. Click on to retrieve toxins of interest.
	Human	Snake	Scorpion	Cone snail	Spider	Cnidarian	Insect	Other	All
α1β3/GABRA1-GABRB3			-	-	-	-	-	-
α1β2γ2/ GABRA1-GABRB2-GABRG2			-	-	-	-	-	-
α1β3γ2/ GABRA1-GABRB3-GABRG2			-	-	-	-	-	-
α2/GABRA2			-	-	-	-	-	-
α2β2γ2/ GABRA2-GABRB2-GABRG2			-	-	-	-	-	-
α2β3γ2/ GABRA2-GABRB3-GABRG2			-	-	-	-	-	-
α4β2γ2/ GABRA4-GABRB2-GABRG2			-	-	-	-	-	-
α5β2γ2/ GABRA5-GABRB2-GABRG2			-	-	-	-	-	-
α5β3γ2/ GABRA5-GABRB3-GABRG2			-	-	-	-	-	-
β1/GABRB1			-	-	-	-	-	-	-
β2/GABRB2			-	-	-	-	-	-
β3/GABRB3			-	-	-	-	-	-
γ2/GABRG2			-	-	-	-	-	-
ρ1/GABRR1		-	-	-	-	-	-	-	-
All ionotropic GABA (A) receptors			-	-	-	-	-	-

Ionotropic GABA receptor impairing toxin