Ophiophagus hannah (king cobra)


Venom composition image
Figure 1: Composition of O. hannah venom, studied at proteomic level (Vonk et al., 2013). This venom contains the following families: 3FTx (snake three-finger toxin), SVMP (snake venom metalloproteinase), CRISP, PA2 (phospholipase A2), CVF (cobra venom factor of the venom complement C3 homolog family), VEGF (PDGF/VEGF growth factor), LAAO (Flavin monoamine oxidase (L-amino-acid oxidase) ), NP (natriuretic peptide), PDE (phosphodiesterase), vespryn (ohanin/vespryn), kallikrein, Kunitz (venom Kunitz-type). Transcriptome of the venom and accessory glands are also available as pie charts in Fig.1 of Vonk et al., 2013.
Clinical Effects, Treatment, Antivenoms See the Clinical Toxinology Resources Website (Postsynaptic neurotoxins).
Taxonomy

UniProt taxonomy
The Reptile database
Wikipedia

Infraorder: Serpentes


Family: Elapidae
Genus: Ophiophagus
Species: hannah
Activity Antimicrobial
Cell adhesion impairing toxin
Complement system impairing toxin
Hemostasis impairing toxin
Blood coagulation cascade inhibiting toxin
  Fibrinogenolytic toxin
  Hemorrhagic toxin
  Platelet agg. activating toxin
  Platelet agg. inhibiting toxin
Hypotensive agent
Myotoxin
Neurotoxin
  Postsynaptic neurotoxin
Vasodilator
and also
G-protein coupled receptor impairing toxin
Ion channel impairing toxin
or see
UniProtKB browsing by keyword
Reference Genome reference
Vonk et al., 2013

Venom protein entries in UniProtKB/Swiss-Prot

(all links/actions below point to uniprot.org website)

59 entries grouped by species

59 entries

Ophiophagus hannah (King cobra) (Naja hannah)

Select_allDeselect_all
3L217_OPHHA Long neurotoxin OH-17 Snake three-finger toxin family, ...
3L21_OPHHA Long neurotoxin 1 (Neurotoxin A) Snake three-finger toxin family, ...
3L222_OPHHA Long neurotoxin LNTX22 Snake three-finger toxin family, ...
3L228_OPHHA Long neurotoxin LNTX28 Snake three-finger toxin family, ...
3L22A_OPHHA Alpha-elapitoxin-Oh2a (Alpha-EPTX-Oh2a) (Long chain neurotoxin) Snake three-finger toxin family, ...
3L22H_OPHHA Long neurotoxin LNTX-2 homolog Snake three-finger toxin family, ...
3L22_OPHHA Long neurotoxin 2 (Neurotoxin B) Snake three-finger toxin family, ...

pdb 1TXA; 1TXB

3L231_OPHHA Long neurotoxin-like OH-31 Snake three-finger toxin family, ...
3L234_OPHHA Long neurotoxin OH-34 Snake three-finger toxin family, ...
3L237_OPHHA Long neurotoxin OH-37 Snake three-finger toxin family, ...
3L23X_OPHHA Long neurotoxin LNTX37 Snake three-finger toxin family, ...
3L23_OPHHA Long neurotoxin 3 (Neurotoxin CM-9) Snake three-finger toxin family, ...
3L24_OPHHA Long neurotoxin 4 (Alpha-neurotoxin) Snake three-finger toxin family, ...
3L255_OPHHA Alpha-elapitoxin-Oh3a (CM-11) (Long neurotoxin OH-55) Snake three-finger toxin family, ...
3L256_OPHHA Long neurotoxin OH-56 Snake three-finger toxin family, ...
3L257_OPHHA Long neurotoxin OH-57 Snake three-finger toxin family, ...
3L25_OPHHA Long neurotoxin OH-5 (Alpha-neurotoxin) Snake three-finger toxin family, ...
3L26_OPHHA Alpha-elapitoxin-Oh2b (Alpha-EPTX-Oh2b) (Alpha-neurotoxin) ... Snake three-finger toxin family, ...
3L2X1_OPHHA Long neurotoxin LNTX1 Snake three-finger toxin family, ...
3L2X8_OPHHA Long neurotoxin LNTX8 Snake three-finger toxin family, ...
3NO24_OPHHA Weak neurotoxin WNTX34 Snake three-finger toxin family, ...
3NO2_OPHHA Weak neurotoxin OH-72 Snake three-finger toxin family, ...
3S11A_OPHHA Weak toxin DE-1 Snake three-finger toxin family, ...
3S11H_OPHHA Weak toxin DE-1 homolog 1 (WTX DE-1 homolog 1) Snake three-finger toxin family, ...

pdb 5XWE

3SDC1_OPHHA Beta-cardiotoxin CTX21 Snake three-finger toxin family, ...
3SDC3_OPHHA Beta-cardiotoxin CTX23 Snake three-finger toxin family, ...
3SDC4_OPHHA Beta-cardiotoxin CTX14 Snake three-finger toxin family, ...
3SDC5_OPHHA Beta-cardiotoxin CTX15 (OH-84) Snake three-finger toxin family, ...
3SDC7_OPHHA Beta-cardiotoxin CTX27 (OH-27) Snake three-finger toxin family, ...

pdb 3PLC

3SDC9_OPHHA Beta-cardiotoxin CTX9 Snake three-finger toxin family, ...
3SI35_OPHHA Short neurotoxin OH-35 Snake three-finger toxin family, ...
3SIM6_OPHHA Muscarinic toxin MTX6 Snake three-finger toxin family, ...
3SIM8_OPHHA Muscarinic toxin 38 (MTX38) Snake three-finger toxin family, ...
3SO8_OPHHA Haditoxin (Muscarinic toxin-like protein 3 homolog) (MTLP-3 ... Snake three-finger toxin family, ...

pdb 3HH7

3SX1_OPHHA Neurotoxin Oh9-1 (OMEGA-neurotoxin Oh9-1) (Three-finger toxin) ... Snake three-finger toxin family, ...
3SX2_OPHHA Short neurotoxin OH-32 (Three-finger toxin) (3FTx) Snake three-finger toxin family, ...
3SX3_OPHHA Weak neurotoxin WNTX33 (Three-finger toxin) (3FTx) Snake three-finger toxin family, ...
3SX5_OPHHA Short neurotoxin OH-5 (Three-finger toxin) (3FTx) Snake three-finger toxin family, ...
3SX6_OPHHA Short neurotoxin SNTX6 (Three-finger toxin) (3FTx) Snake three-finger toxin family, ...
3SX7_OPHHA Short neurotoxin OH-46 (Three-finger toxin) (3FTx) Snake three-finger toxin family, ...
3SXB_OPHHA Short neurotoxin SNTX11 (Three-finger toxin) (3FTx) Snake three-finger toxin family, ...
3SXE_OPHHA Short neurotoxin SNTX14 (Three-finger toxin) (3FTx) Snake three-finger toxin family, ...
3SXQ_OPHHA Short neurotoxin SNTX26 (Three-finger toxin) (3FTx) Snake three-finger toxin family, ...
3SXZ_OPHHA Short neurotoxin OH-26 (Three-finger toxin) (3FTx) Snake three-finger toxin family, ...
CAMP_OPHHA Cathelicidin-related peptide Oh-Cath (Cathelicidin-related ... Cathelicidin family
CRVP_OPHHA Cysteine-rich venom protein ophanin (CRVP) (Opharin) CRISP family
OXLA_OPHHA L-amino-acid oxidase (LAO) (Oh-LAAO) (EC 1.4.3.2) Flavin monoamine oxidase family, ...
PA2A1_OPHHA Acidic phospholipase A2 1 (svPLA2) (EC 3.1.1.4) (APLA2-1) (OHV ... Phospholipase A2 family, Group I ...

pdb 1GP7

PA2A2_OPHHA Acidic phospholipase A2 2 (svPLA2) (EC 3.1.1.4) (APLA2-2) ... Phospholipase A2 family, Group I ...

pdb 1M8T

PA2A_OPHHA Acidic phospholipase A2 (svPLA2) (EC 3.1.1.4) ... Phospholipase A2 family, Group I ...
SLA_OPHHA Snaclec ophioluxin subunit alpha Snaclec family
SLB_OPHHA Snaclec ophioluxin subunit beta Snaclec family
VCO3_OPHHA Ophiophagus venom factor (OVF) (CVF-like) (Complement C3 ... Venom complement C3 homolog ...
VESP_OPHHA Ohanin Ohanin/vespryn family
VKTCI_OPHHA Kunitz-type serine protease inhibitor (Oh11-1) (Venom ... Venom Kunitz-type family
VKTCT_OPHHA Kunitz-type serine protease inhibitor TCI (Trypsin and ... Venom Kunitz-type family
VM3_OPHHA Zinc metalloproteinase-disintegrin-like ohanin (EC 3.4.24.-) ... Venom metalloproteinase (M12B) ...
VNP_OPHHA Natriuretic peptide Oh-NP Natriuretic peptide family
VSP1_OPHHA Alpha- and beta-fibrinogenase OhS1 (EC 3.4.21.-) (Snake venom ... Peptidase S1 family, Snake venom ...