| Three-finger toxins (3FTs) are non-enzymatic peptides found in all families of snakes. They are characterized by specific folding of three beta-sheet loops (“fingers”) extending from the central core and by four conserved disulfide bridges. The three loops that project from the core region resemble three outstretched fingers of the hand and hence the name. |
Despite their structural similarity, they differ widely in their targets that are numerous: L-type calcium channels (see entries ), sodium channels (see entries ), integrin receptors (see entries ), cell membrane phospholipids (see entries ), acetylcholinesterase (see entries ), nicotinic acetylcholine (see entries ) or muscarinic, adrenergic and dopaminergic receptors (see entries ).
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3D-structure view (PDB 1IJC ) of the three-finger toxin bucandin.