G-protein coupled acetylcholine receptor impairing toxin (mAChR regulator)

Receptor Muscarinic acetylcholine receptors (mAChRs) are a subfamily of G protein-coupled receptors that regulate numerous fundamental functions of the central and peripheral nervous system, such as heart rate, smooth muscle contraction and glandular secretion.
The mAChR family consists of five distinct subtypes, denoted M1 to M5 (encoded by the CHRM1 to CHRM5 genes). Three of these receptor subtypes (M1, M3 and M5) couple to G proteins of the G<SUB>q/11 family, whereas the remaining two subtypes (M2 and M4) preferentially signal through the G<SUB>i/0 family of G proteins (Ishii and Kurachi, 2006, Kruse et al., 2014).
Toxin
Receptor Toxins from different taxa that target receptors.
Click on image to retrieve receptors or toxins of interest.
Human Snake Scorpion Cone
snail 		Spider Cnidarian Insect Other All
mAChR M1/CHRM1 image image - - - - - - image
mAChR M2/CHRM2 image image - - - - - - image
mAChR M3/CHRM3 image image - - - - - - image
mAChR M4/CHRM4 image image - - - - - - image
mAChR M5/CHRM5 image - - - - - - - -
mAChR All image image - - - - - - image
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Back to G-protein coupled receptor impairing toxin
Nomenclature No nomenclature has been given to toxins that target this type of receptor (see King et al., 2008).

Venom protein entries in UniProtKB/Swiss-Prot

(all links/actions below point to uniprot.org website)

29 entries grouped by species

1 entry

Bothrops insularis (Golden lancehead) (Lachesis insularis)

BNP_BOTIN Bradykinin-potentiating and C-type natriuretic peptides ... Bradykinin-potentiating peptide ...

1 entry

Bothrops jararaca (Jararaca) (Bothrops jajaraca)

BPP7A_BOTJA Bradykinin-potentiating peptide 7a (BPP-7a) (Proline-rich ... Bradykinin-potentiating peptide ...

5 entries

Bungarus multicinctus (Many-banded krait)

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3NO52_BUNMU Long neurotoxin homolog NTL2 Snake three-finger toxin family, ...
3NO56_BUNMU Long neurotoxin homolog TA-bm16 (Delta-protein) Snake three-finger toxin family, ...
3NO5I_BUNMU Gamma-bungarotoxin (Long neurotoxin homolog NTL2I) Snake three-finger toxin family, ...

pdb 1MR6

3NOHE_BUNMU Muscarinic toxin BM14 Snake three-finger toxin family, ...
3SO8_BUNMU Muscarinic toxin-like protein Snake three-finger toxin family, ...

9 entries

Dendroaspis angusticeps (Eastern green mamba) (Naja angusticeps)

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3SI12_DENAN Muscarinic m1-toxin2 Snake three-finger toxin family, ...
3SI13_DENAN Muscarinic m1-toxin3 Snake three-finger toxin family, ...
3SI14_DENAN Muscarinic m1-toxin4 Snake three-finger toxin family, ...
3SIM1_DENAN Muscarinic toxin 1 (MT1) (MTx1) Snake three-finger toxin family, ...

pdb 3FEV; 3NEQ; 4DO8

3SIM2_DENAN Muscarinic toxin 2 (MT2) (MTx2) Snake three-finger toxin family, ...

pdb 1FF4

3SIM3_DENAN Muscarinic toxin 3 (MT3) Snake three-finger toxin family, ...
3SIM4_DENAN Muscarinic toxin 4 (MT4) Snake three-finger toxin family, ...
3SIM7_DENAN Muscarinic toxin 7 (MT-7) (MT7) (Muscarinic toxin 1) (m1-toxin) Snake three-finger toxin family, ...

pdb 2VLW; 3FEV; 3NEQ; 6WJC

3SUB_DENAN Muscarinic toxin 2 (m2-toxin) Snake three-finger toxin family, ...

1 entry

Dendroaspis polylepis polylepis (Black mamba)

3SX9_DENPO Dendroaspis polylepis MT9 (Three-finger toxin) (3FTx) Snake three-finger toxin family, ...

pdb 6R5M

1 entry

Micrurus lemniscatus (South American coral snake)

3X_MICLE Muscarinic toxin Mlalpha (MT-Mlalpha) Snake three-finger toxin family

2 entries

Naja atra (Chinese cobra)

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3SO8_NAJAT Neurotoxin homolog NL1 Snake three-finger toxin family, ...
PA2A1_NAJAT Acidic phospholipase A2 1 (svPLA2) (EC 3.1.1.4) (Muscarinic ... Phospholipase A2 family, Group I ...

pdb 1POA; 1POB

3 entries

Naja kaouthia (Monocled cobra) (Naja siamensis)

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3NO2_NAJKA Tryptophan-containing weak neurotoxin (WTX) Snake three-finger toxin family, ...

pdb 2MJ0

3SO8_NAJKA Muscarinic toxin-like protein 3 (MTLP-3) Snake three-finger toxin family, ...
3SUC1_NAJKA Muscarinic toxin-like protein 1 (MTLP-1) Snake three-finger toxin family, ...

1 entry

Naja melanoleuca (Forest cobra) (Black-lipped cobra)

3SUC1_NAJME Muscarinic toxin-like protein Tx-NM3-2 Snake three-finger toxin family, ...

1 entry

Naja naja (Indian cobra)

3SO8_NAJNA Muscarinic toxin-like protein 1 (MTLP-1) (Muscarinic toxin-like ... Snake three-finger toxin family, ...

1 entry

Naja sputatrix (Malayan spitting cobra) (Naja naja sputatrix)

PA2NA_NAJSP Neutral phospholipase A2 muscarinic inhibitor (NPLA) (svPLA2) ... Phospholipase A2 family, Group I ...

3 entries

Ophiophagus hannah (King cobra) (Naja hannah)

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3SI35_OPHHA Short neurotoxin OH-35 Snake three-finger toxin family, ...
3SIM6_OPHHA Muscarinic toxin MTX6 Snake three-finger toxin family, ...
3SIM8_OPHHA Muscarinic toxin 38 (MTX38) Snake three-finger toxin family, ...