Tityus serrulatus (Brazilian scorpion) (taxid:6887)

Venom composition image
Figure 1: Composition of T.serrulatus venom, studied at both proteomic (A) (Verano-Braga et al., 2013) and transcriptomic (B) (de Oliveira et al., 2018) levels. The venom contains the following families: sodium channel toxins (NaTx), potassium channel toxins (KTx), diuretic toxins (hypotensins), bradykinin potentiating peptides (BPPs), antimicrobial peptides (AMP), anticoagulant peptides, hyaluronidases, lipases (negligible), metalloproteinases, phospholipase A2 (PA2), phospholipase C (negligible), phospholipase D (negligible), other proteinases, CRISP, insulin-like growth factor proteins (negligible), anionic peptide, proteinase inhibitors, and conserved venom component. In B, families with an asterix (*) are those with peptides identified by proteomic analysis (de Oliveira et al., 2018).
Clinical Effects, Treatment, Antivenoms See the Clinical Toxinology Resources Website.
Lethal dose LD(50) is 0.99 mg/kg by intraperitoneal injection into mice (Santos da Silva et al., 2017).
Taxonomy

UniProt taxonomy
Wikipedia

Order: Scorpiones


Family: Buthidae
Genus: Tityus
Species:serrulatus
Activity Antimicrobial
Hypotensive agent
Neurotoxin
Vasodilator
and also
G-protein coupled receptor impairing toxin
Ion channel impairing toxin
or see
UniProtKB browsing by keyword
Reference Cologna et al., 2009
Alvarenga et al., 2012
Verano-Braga et al., 2013
de Oliveira et al., 2018

Venom protein entries in UniProtKB/Swiss-Prot

(all links/actions below point to uniprot.org website)

62 entries grouped by species

62 entries

Tityus serrulatus (Brazilian scorpion)

Select_allDeselect_all
AMY_TITSE Alpha-amylase (EC 3.2.1.1) (1,4-alpha-D-glucan glucanohydrolase) Glycosyl hydrolase 13 family
CLCPP_TITSE Intracellular calcium channel modulator CCP-Ts (CaTx) (Calcium ... Scorpion calcin-like family
CRVP_TITSE Cysteine-rich venom protein (CRIVP) (Cysteine-rich protein) CRISP family
HYAL1_TITSE Hyaluronidase 1 (TsHyal-1) (EC 3.2.1.35) ... Glycosyl hydrolase 56 family
HYAL2_TITSE Hyaluronidase 2 (TsHyal-2) (EC 3.2.1.35) ... Glycosyl hydrolase 56 family
HYTL_TITSE Hypotensin-like peptide Not in a family
KA121_TITSE Potassium channel toxin alpha-KTx 12.1 (Butantoxin) (BuTX) ... Short scorpion toxin ...

pdb 1C55; 1C56; 1WT7

KA20_TITSE Potassium channel toxin Ts16 (Tityustoxin-16) Short scorpion toxin ...

pdb 2LO7

KA211_TITSE Potassium channel toxin alpha-KTx 21.1 (Tityustoxin-15) (Ts15) Short scorpion toxin ...
KAX41_TITSE Potassium channel toxin alpha-KTx 4.1 (TSK4) (Tityustoxin ... Short scorpion toxin ...

pdb 1HP2

KAX42_TITSE Potassium channel toxin alpha-KTx 4.2 (Neurotoxin Ts-kappa) ... Short scorpion toxin ...

pdb 1TSK; 6ATL

KBX1_TITSE Potassium channel toxin TsTXK-beta (TsTXKbeta) (Potassium ... Long chain scorpion toxin ...
KBX2_TITSE Tityustoxin-19 (Ts19) (Potassium channel toxin beta-Ktx 2) ... Long chain scorpion toxin ...
KEX11_TITSE Potassium channel toxin epsilon-KTx 1.1 (Tityustoxin-11) (Ts11) ... Short scorpion toxin ...

pdb 2MSF

KEX12_TITSE Potassium channel toxin epsilon-KTx 1.2 (Tityustoxin-12) (Ts12) ... Short scorpion toxin ...
KEX1S_TITSE Peptide TsPep3 (Tityustoxin-13) (Ts13) Short scorpion toxin ...
KTX20_TITSE Putative potassium channel toxin Ts20 (Putative KTx) ... Not in a family
KTX21_TITSE Putative potassium channel toxin Ts21 (Putative KTx) ... Short scorpion toxin ...
KTX22_TITSE Putative potassium channel toxin Ts22 (Putative KTx) ... Short scorpion toxin ...
KTX23_TITSE Putative potassium channel toxin Ts23 (Putative KTx) ... Short scorpion toxin ...
KTX24_TITSE Putative potassium channel toxin Ts24 (Putative KTx) ... Short scorpion toxin ...
KTX25_TITSE Putative potassium channel toxin Ts25 (Putative KTx) ... Short scorpion toxin ...
LVA28_TITSE Putative sodium channel toxin Ts28 (Putative NaTx) (Putative ... Long (3 C-C) scorpion toxin ...
LVA41_TITSE Putative sodium channel toxin Ts41 (Putative NaTx) (Putative ... Long (4 C-C) scorpion toxin ...
NDB11_TITSE Bradykinin-potentiating peptide T (BPP-T) (Non-disulfide-bridged ... Non-disulfide-bridged peptide ...
NDB31_TITSE Hypotensin toxin Ts31 (Anti-hypertensive peptide) ... Non-disulfide-bridged peptide ...
NDB4M_TITSE Antimicrobial peptide TsAP-1 (Non-disulfide-bridged peptide ... Non-disulfide-bridged peptide ...
NDB4N_TITSE Antimicrobial peptide TsAP-2 (Non-disulfide-bridged peptide ... Non-disulfide-bridged peptide ...
NDB4S_TITSE Venom peptide 1 [Cleaved into: Venom peptide 2] Non-disulfide-bridged peptide ...
NDB4T_TITSE Venom peptide 3 [Cleaved into: Venom peptide 4; Venom peptide 5] Non-disulfide-bridged peptide ...
NDB4U_TITSE Venom peptide 6 Non-disulfide-bridged peptide ...
NDB4V_TITSE Venom peptide 7.1 (Venom peptide 7) [Cleaved into: Venom peptide ... Non-disulfide-bridged peptide ...
NDBH1_TITSE Hypotensin-1 (Anti-hypertensive peptide) (Hypotensin I) ... Non-disulfide-bridged peptide ...
NDBH2_TITSE Hypotensin-2 (Hypotensin II) (TsHpt-II) (Toxin Ts14 2) [Cleaved ... Non-disulfide-bridged peptide ...
NDBP8_TITSE Venom peptide 8 Non-disulfide-bridged peptide ...
PAPE_TITSE Pape peptide Not in a family
PRCT_TITSE [des-Arg1]-proctolin (NEP-inhibiting peptide) Not in a family
SCX17_TITSE Putative sodium channel toxin Ts17 (Putative alpha-NaTx) ... Long (4 C-C) scorpion toxin ...
SCX18_TITSE Putative sodium channel toxin Ts18 (Putative alpha-NaTx) ... Long (3 C-C) scorpion toxin ...
SCX1_TITSE Beta-mammal/insect toxin Ts1 (Beta-like toxin Ts1) ... Long (4 C-C) scorpion toxin ...

pdb 1B7D; 1NPI

SCX26_TITSE Putative sodium channel toxin Ts26 (Putative NaTx) ... Long (4 C-C) scorpion toxin ...
SCX27_TITSE Probable sodium channel toxin Ts27 (Putative NaTx) ... Long (4 C-C) scorpion toxin ...
SCX2_TITSE Alpha-mammal toxin Ts2 (P-Mice-beta* NaTx5.1) (Tityustoxin II) ... Long (4 C-C) scorpion toxin ...
SCX30_TITSE Putative sodium channel toxin Ts30 (Putative NaTx) ... Not in a family
SCX33_TITSE Putative sodium channel toxin Ts33 (Tityustoxin-33) Long (4 C-C) scorpion toxin ...
SCX34_TITSE Putative sodium channel toxin Ts34 (Tityustoxin-34) Long (4 C-C) scorpion toxin ...
SCX35_TITSE Putative sodium channel toxin Ts35 (Tityustoxin-35) Long (4 C-C) scorpion toxin ...
SCX36_TITSE Putative sodium channel toxin Ts36 (Tityustoxin-36) Long (3 C-C) scorpion toxin ...
SCX37_TITSE Putative sodium channel toxin Ts37 (Tityustoxin-37) Long (4 C-C) scorpion toxin ...
SCX38_TITSE Putative sodium channel toxin Ts38 (Tityustoxin-38) Long (3 C-C) scorpion toxin ...
SCX39_TITSE Putative sodium channel toxin Ts39 (Tityustoxin-39) Long (3 C-C) scorpion toxin ...
SCX3_TITSE Alpha-mammal toxin Ts3 (PT-Mice-alpha NaTx3.1) (Tityustoxin IV) ... Long (4 C-C) scorpion toxin ...

pdb 5CY0

SCX40_TITSE Putative sodium channel toxin Ts40 (Tityustoxin-40) Long (4 C-C) scorpion toxin ...
SCX4_TITSE Toxin Ts4 (Non-toxic protein TsNTxP) (NTxP) (P-Allerg-alpha* ... Long (4 C-C) scorpion toxin ...
SCX5_TITSE Alpha-toxin Ts5 (P-alpha* NaTx3.2) (Tityustoxin V) (Toxin V) (Ts ... Long (4 C-C) scorpion toxin ...
T9797_TITSE Peptide 9797 (Peptide Ts20) Not in a family
TS29_TITSE Putative venom toxin Ts29 (Tityustoxin-29) Not in a family
TSNP_TITSE Natriuretic peptide TsNP Natriuretic peptide family
VA5_TITSE Venom allergen 5 (Antigen 5) (Cysteine-rich venom protein) ... CRISP family, Venom allergen ...
VMPA1_TITSE Venom metalloproteinase antarease TserMP_A (VMPA) (EC 3.4.24.-) ... Venom metalloproteinase (M12B) ...
VMPA2_TITSE Venom metalloproteinase antarease-like TserMP_B (VMPA) (EC ... Venom metalloproteinase (M12B) ...
VMXP_TITSE Venom metalloproteinase (VMP) (EC 3.4.24.-) Venom metalloproteinase (M12B) ...