Tityus serrulatus ~ VenomZone

Venom composition

Figure 1: Composition of T.serrulatus venom, studied at both proteomic (A) (Verano-Braga et al., 2013) and transcriptomic (B) (de Oliveira et al., 2018) levels. The venom contains the following families: sodium channel toxins (NaTx), potassium channel toxins (KTx), diuretic toxins (hypotensins), bradykinin potentiating peptides (BPPs), antimicrobial peptides (AMP), anticoagulant peptides, hyaluronidases, lipases (negligible), metalloproteinases, phospholipase A2 (PA2), phospholipase C (negligible), phospholipase D (negligible), other proteinases, CRISP, insulin-like growth factor proteins (negligible), anionic peptide, proteinase inhibitors, and conserved venom component. In B, families with an asterix (*) are those with peptides identified by proteomic analysis (de Oliveira et al., 2018).

Clinical Effects, Treatment, Antivenoms See the Clinical Toxinology Resources Website.

Lethal dose LD(50) is 0.99 mg/kg by intraperitoneal injection into mice (Santos da Silva et al., 2017).

Order:	Scorpiones

Family:	Buthidae
Genus:	Tityus
Species:	serrulatus

Tityus serrulatus (Brazilian scorpion) (taxid:6887)

Venom protein entries in UniProtKB/Swiss-Prot

CRISP family

CRISP family, Venom allergen 5-like subfamily

Glycosyl hydrolase 13 family

Glycosyl hydrolase 56 family

Long (3 C-C) scorpion toxin superfamily

Long (3 C-C) scorpion toxin superfamily, Sodium channel inhibitor family

Long (4 C-C) scorpion toxin superfamily

Long (4 C-C) scorpion toxin superfamily, Sodium channel inhibitor family

Long (4 C-C) scorpion toxin superfamily, Sodium channel inhibitor family, Alpha subfamily

Long (4 C-C) scorpion toxin superfamily, Sodium channel inhibitor family, Beta subfamily

Long chain scorpion toxin family, Class 1 subfamily

Long chain scorpion toxin family, Class 2 subfamily

Natriuretic peptide family

Non-disulfide-bridged peptide (NDBP) superfamily

Non-disulfide-bridged peptide (NDBP) superfamily, Scorpion BPP (group 1) family

Non-disulfide-bridged peptide (NDBP) superfamily, Short antimicrobial peptide (group 4) family

Not in a family

Scorpion calcin-like family

Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 04 subfamily

Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 11 subfamily

Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 12 subfamily

Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 20 subfamily

Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 21 subfamily

Short scorpion toxin superfamily, Potassium channel inhibitor family, Epsilon-KTx 01 subfamily

Venom metalloproteinase (M12B) family