Tityus serrulatus (Brazilian scorpion) (taxid:6887)

Venom composition image
Figure 1: Composition of T.serrulatus venom, studied at both proteomic (A) (Verano-Braga et al., 2013) and transcriptomic (B) (de Oliveira et al., 2018) levels. The venom contains the following families: sodium channel toxins (NaTx), potassium channel toxins (KTx), diuretic toxins (hypotensins), bradykinin potentiating peptides (BPPs), antimicrobial peptides (AMP), anticoagulant peptides, hyaluronidases, lipases (negligible), metalloproteinases, phospholipase A2 (PA2), phospholipase C (negligible), phospholipase D (negligible), other proteinases, CRISP, insulin-like growth factor proteins (negligible), anionic peptide, proteinase inhibitors, and conserved venom component. In B, families with an asterix (*) are those with peptides identified by proteomic analysis (de Oliveira et al., 2018).
Clinical Effects, Treatment, Antivenoms See the Clinical Toxinology Resources Website.
Lethal dose LD(50) is 0.99 mg/kg by intraperitoneal injection into mice (Santos da Silva et al., 2017).

Venom protein entries in UniProtKB/Swiss-Prot

(all links/actions below point to uniprot.org website)

62 entries grouped by family

1 entry

CRISP family

"CRISP family" VenomZone page
CRVP_TITSE Cysteine-rich venom protein (CRIVP) ... Tityus serrulatus (Brazilian scorpion)

1 entry

CRISP family, Venom allergen 5-like subfamily

"CRISP family" VenomZone page
VA5_TITSE Venom allergen 5 (Antigen 5) (Cysteine-rich ... Tityus serrulatus (Brazilian scorpion)

1 entry

Glycosyl hydrolase 13 family

AMY_TITSE Alpha-amylase (EC 3.2.1.1) (1,4-alpha-D-glucan ... Tityus serrulatus (Brazilian scorpion)

2 entries

Glycosyl hydrolase 56 family

Select_allDeselect_all "Glycosyl hydrolase 56 family" VenomZone page
HYAL1_TITSE Hyaluronidase 1 (TsHyal-1) (EC 3.2.1.35) ... Tityus serrulatus (Brazilian scorpion)
HYAL2_TITSE Hyaluronidase 2 (TsHyal-2) (EC 3.2.1.35) ... Tityus serrulatus (Brazilian scorpion)

2 entries

Long (3 C-C) scorpion toxin superfamily

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LVA28_TITSE Putative sodium channel toxin Ts28 (Putative ... Tityus serrulatus (Brazilian scorpion)
SCX18_TITSE Putative sodium channel toxin Ts18 (Putative ... Tityus serrulatus (Brazilian scorpion)

3 entries

Long (3 C-C) scorpion toxin superfamily, Sodium channel inhibitor family

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SCX36_TITSE Putative sodium channel toxin Ts36 ... Tityus serrulatus (Brazilian scorpion)
SCX38_TITSE Putative sodium channel toxin Ts38 ... Tityus serrulatus (Brazilian scorpion)
SCX39_TITSE Putative sodium channel toxin Ts39 ... Tityus serrulatus (Brazilian scorpion)

1 entry

Long (4 C-C) scorpion toxin superfamily

LVA41_TITSE Putative sodium channel toxin Ts41 (Putative ... Tityus serrulatus (Brazilian scorpion)

8 entries

Long (4 C-C) scorpion toxin superfamily, Sodium channel inhibitor family

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SCX1_TITSE Beta-mammal/insect toxin Ts1 (Beta-like toxin ... Tityus serrulatus (Brazilian scorpion)
SCX26_TITSE Putative sodium channel toxin Ts26 (Putative ... Tityus serrulatus (Brazilian scorpion)
SCX27_TITSE Probable sodium channel toxin Ts27 (Putative ... Tityus serrulatus (Brazilian scorpion)
SCX33_TITSE Putative sodium channel toxin Ts33 ... Tityus serrulatus (Brazilian scorpion)
SCX34_TITSE Putative sodium channel toxin Ts34 ... Tityus serrulatus (Brazilian scorpion)
SCX35_TITSE Putative sodium channel toxin Ts35 ... Tityus serrulatus (Brazilian scorpion)
SCX37_TITSE Putative sodium channel toxin Ts37 ... Tityus serrulatus (Brazilian scorpion)
SCX40_TITSE Putative sodium channel toxin Ts40 ... Tityus serrulatus (Brazilian scorpion)

4 entries

Long (4 C-C) scorpion toxin superfamily, Sodium channel inhibitor family, Alpha subfamily

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SCX17_TITSE Putative sodium channel toxin Ts17 (Putative ... Tityus serrulatus (Brazilian scorpion)
SCX3_TITSE Alpha-mammal toxin Ts3 (PT-Mice-alpha NaTx3.1) ... Tityus serrulatus (Brazilian scorpion)
SCX4_TITSE Toxin Ts4 (Non-toxic protein TsNTxP) (NTxP) ... Tityus serrulatus (Brazilian scorpion)
SCX5_TITSE Alpha-toxin Ts5 (P-alpha* NaTx3.2) (Tityustoxin ... Tityus serrulatus (Brazilian scorpion)

1 entry

Long (4 C-C) scorpion toxin superfamily, Sodium channel inhibitor family, Beta subfamily

SCX2_TITSE Alpha-mammal toxin Ts2 (P-Mice-beta* NaTx5.1) ... Tityus serrulatus (Brazilian scorpion)

1 entry

Long chain scorpion toxin family, Class 1 subfamily

KBX1_TITSE Potassium channel toxin TsTXK-beta (TsTXKbeta) ... Tityus serrulatus (Brazilian scorpion)

1 entry

Long chain scorpion toxin family, Class 2 subfamily

KBX2_TITSE Tityustoxin-19 (Ts19) (Potassium channel toxin ... Tityus serrulatus (Brazilian scorpion)

1 entry

Natriuretic peptide family

"Natriuretic peptide family" VenomZone page
TSNP_TITSE Natriuretic peptide TsNP Tityus serrulatus (Brazilian scorpion)

4 entries

Non-disulfide-bridged peptide (NDBP) superfamily

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NDB31_TITSE Hypotensin toxin Ts31 (Anti-hypertensive ... Tityus serrulatus (Brazilian scorpion)
NDBH1_TITSE Hypotensin-1 (Anti-hypertensive peptide) ... Tityus serrulatus (Brazilian scorpion)
NDBH2_TITSE Hypotensin-2 (Hypotensin II) (TsHpt-II) (Toxin ... Tityus serrulatus (Brazilian scorpion)
NDBP8_TITSE Venom peptide 8 Tityus serrulatus (Brazilian scorpion)

1 entry

Non-disulfide-bridged peptide (NDBP) superfamily, Scorpion BPP (group 1) family

NDB11_TITSE Bradykinin-potentiating peptide T (BPP-T) ... Tityus serrulatus (Brazilian scorpion)

6 entries

Non-disulfide-bridged peptide (NDBP) superfamily, Short antimicrobial peptide (group 4) family

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NDB4M_TITSE Antimicrobial peptide TsAP-1 ... Tityus serrulatus (Brazilian scorpion)
NDB4N_TITSE Antimicrobial peptide TsAP-2 ... Tityus serrulatus (Brazilian scorpion)
NDB4S_TITSE Venom peptide 1 [Cleaved into: Venom peptide 2] Tityus serrulatus (Brazilian scorpion)
NDB4T_TITSE Venom peptide 3 [Cleaved into: Venom peptide 4; ... Tityus serrulatus (Brazilian scorpion)
NDB4U_TITSE Venom peptide 6 Tityus serrulatus (Brazilian scorpion)
NDB4V_TITSE Venom peptide 7.1 (Venom peptide 7) [Cleaved ... Tityus serrulatus (Brazilian scorpion)

7 entries

Not in a family

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HYTL_TITSE Hypotensin-like peptide Tityus serrulatus (Brazilian scorpion)
KTX20_TITSE Putative potassium channel toxin Ts20 (Putative ... Tityus serrulatus (Brazilian scorpion)
PAPE_TITSE Pape peptide Tityus serrulatus (Brazilian scorpion)
PRCT_TITSE [des-Arg1]-proctolin (NEP-inhibiting peptide) Tityus serrulatus (Brazilian scorpion)
SCX30_TITSE Putative sodium channel toxin Ts30 (Putative ... Tityus serrulatus (Brazilian scorpion)
T9797_TITSE Peptide 9797 (Peptide Ts20) Tityus serrulatus (Brazilian scorpion)
TS29_TITSE Putative venom toxin Ts29 (Tityustoxin-29) Tityus serrulatus (Brazilian scorpion)

1 entry

Scorpion calcin-like family

CLCPP_TITSE Intracellular calcium channel modulator CCP-Ts ... Tityus serrulatus (Brazilian scorpion)

6 entries

Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 04 subfamily

Select_allDeselect_all
KAX41_TITSE Potassium channel toxin alpha-KTx 4.1 (TSK4) ... Tityus serrulatus (Brazilian scorpion)
KAX42_TITSE Potassium channel toxin alpha-KTx 4.2 ... Tityus serrulatus (Brazilian scorpion)
KTX22_TITSE Putative potassium channel toxin Ts22 (Putative ... Tityus serrulatus (Brazilian scorpion)
KTX23_TITSE Putative potassium channel toxin Ts23 (Putative ... Tityus serrulatus (Brazilian scorpion)
KTX24_TITSE Putative potassium channel toxin Ts24 (Putative ... Tityus serrulatus (Brazilian scorpion)
KTX25_TITSE Putative potassium channel toxin Ts25 (Putative ... Tityus serrulatus (Brazilian scorpion)

1 entry

Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 11 subfamily

KTX21_TITSE Putative potassium channel toxin Ts21 (Putative ... Tityus serrulatus (Brazilian scorpion)

1 entry

Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 12 subfamily

KA121_TITSE Potassium channel toxin alpha-KTx 12.1 ... Tityus serrulatus (Brazilian scorpion)

1 entry

Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 20 subfamily

KA20_TITSE Potassium channel toxin Ts16 (Tityustoxin-16) Tityus serrulatus (Brazilian scorpion)

1 entry

Short scorpion toxin superfamily, Potassium channel inhibitor family, Alpha-KTx 21 subfamily

KA211_TITSE Potassium channel toxin alpha-KTx 21.1 ... Tityus serrulatus (Brazilian scorpion)

3 entries

Short scorpion toxin superfamily, Potassium channel inhibitor family, Epsilon-KTx 01 subfamily

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KEX11_TITSE Potassium channel toxin epsilon-KTx 1.1 ... Tityus serrulatus (Brazilian scorpion)
KEX12_TITSE Potassium channel toxin epsilon-KTx 1.2 ... Tityus serrulatus (Brazilian scorpion)
KEX1S_TITSE Peptide TsPep3 (Tityustoxin-13) (Ts13) Tityus serrulatus (Brazilian scorpion)

3 entries

Venom metalloproteinase (M12B) family

Select_allDeselect_all "Venom metalloproteinase (M12B) family" VenomZone page
VMPA1_TITSE Venom metalloproteinase antarease TserMP_A ... Tityus serrulatus (Brazilian scorpion)
VMPA2_TITSE Venom metalloproteinase antarease-like TserMP_B ... Tityus serrulatus (Brazilian scorpion)
VMXP_TITSE Venom metalloproteinase (VMP) (EC 3.4.24.-) Tityus serrulatus (Brazilian scorpion)