Agkistrodon contortrix contortrix (southern copperhead)

Venom composition image
Figure 1: Composition of contortrix contortrix venom, studied at proteomic level (Lomonte, et al., 2014).

This venom contains the following families: SVMP (venom metalloproteinase), serine protease (peptidase S1), peptides (include tripeptide SVMP inhibitors and bradykinin-potentiating and bradykinin-inhibitory peptides), LAAO (L-amino-acid oxidase (flavin monoamine oxidase) ), disintegrin, snaclec (also known as C-type lectin-like), NGF (-beta) , CRISP, oha (ohanin/vespryn), DC-fragments (disintegrin/cysteine-rich fragment from P-III SVMPs) and PA2 (phospholipase A2).

Clinical Effects, Treatment, Antivenoms See the Clinical Toxinology Resources Website
and the WHO venomous snake database to access snake distribution and antivenom products.
Lethal dose LD(50) of A.contortrix is
9.17 mg/kg by intraperitoneal injection and
10.17 mg/kg by intravenous injection (Arce et al., 2003).

Venom protein entries in UniProtKB/Swiss-Prot

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7 entries grouped by species (browse by taxonomy, browse by keywords)

7 entries

Agkistrodon contortrix contortrix (Southern copperhead)

DIDA_AGKCO Disintegrin acostatin-alpha [Cleaved into: Disintegrin ... Disintegrin family, Dimeric ...
NGFV_AGKCO Venom nerve growth factor (v-NGF) (vNGF) (Fragment) NGF-beta family
VM1F_AGKCO Snake venom metalloproteinase fibrolase (SVMP) (EC ... Venom metalloproteinase (M12B) ...
VM2AB_AGKCO Zinc metalloproteinase/disintegrin [Cleaved into: Snake venom ... Venom metalloproteinase (M12B) ...
VM2CO_AGKCO Zinc metalloproteinase/disintegrin [Cleaved into: Snake venom ... Venom metalloproteinase (M12B) ...
VSP2_AGKCO Thrombin-like enzyme contortrixobin (SVTLE) (EC 3.4.21.-) ... Peptidase S1 family, Snake venom ...
VSPCA_AGKCO Protein C activator (EC 3.4.21.-) (ACC-C) (Snake venom serine ... Peptidase S1 family, Snake venom ...