Proton-gated sodium channel impairing toxin

Channel Acid-sensing ion channels (ASICs) are voltage-insensitive, proton-gated cation channels activated by extracellular acidosis. In mammals, 4 genes encode at least 6 different subunits, the variants ASIC1a and ASIC1b, the variants ASIC2a and ASIC2b, and ASIC3 and ASIC4. Three identical or different subunits are required to form a functional channel (except for ASIC2b and ASIC4, which do not form proton-gated channels when expressed alone). Acid-sensing ion channel 1a (ASIC1a) and ASIC2 (both variants a and b) are widely expressed in neurons of the central nervous system, whereas almost all subunits (except ASIC4) are present in sensory neurons of the peripheral nervous system including nociceptors.
Channel Toxins from different taxa that target channels.
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Human Snake Scorpion Cone
Spider Cnidarian Insect Other All
Subunit contained in homo- or heterotrimer:
ASIC1a - - - -
ASIC1b - - - -
ASIC2a - - - - -
ASIC2b - - - -
ASIC3 - - - - -
ASIC4 - - - - - - - -
all - - - -

Venom protein entries in UniProtKB/Swiss-Prot

21 entries grouped by species (browse by taxonomy, browse by keywords)

1 entry

Anthopleura elegantissima (Green aggregating anemone) (Actinia elegantissima)

BDS2_ANTEL Pi-actitoxin-Ael2b (Pi-AITX-Ael2b) (Toxin APETx2) Sea anemone type 3 (BDS) ...

2 entries

Conus cancellatus (Cancellate cone) (Conus austini)

CRF1_CONCF Conorfamide-As1 (Conorfamide-As1a) (CNF-As1a) ... FARP (FMRFamide related peptide) ...
CRF2_CONCF Conorfamide-As2 (Conorfamide-As2a) (CNF-As2a) ... FARP (FMRFamide related peptide) ...

1 entry

Conus textile (Cloth-of-gold cone)

"Conus textile" VenomZone page
COS_CONTE Conorfamide Tx1.3 (AIVGRPRFamide) (AIVGRPRFa) (Cono-RFamide ... NPY family

1 entry

Dendroaspis angusticeps (Eastern green mamba) (Naja angusticeps)

3SX3_DENAN Mambalgin-3 (Mamb-3) Snake three-finger toxin family, ...

2 entries

Dendroaspis polylepis polylepis (Black mamba)

3SX1_DENPO Mambalgin-1 (Mamb-1) (Pi-Dp1) Snake three-finger toxin family, ...
3SX2_DENPO Mambalgin-2 (Ma-2) (Mamb-2) (Pi-Dp2) Snake three-finger toxin family, ...

4 entries

Hadronyche infensa (Fraser island funnel-web spider) (Atrax infensus)

TP1A_HADIN Pi-hexatoxin-Hi1a (Pi-HXTXHi1a) Psalmotoxin-1 family, ...
TP1B_HADIN Pi-hexatoxin-Hi1b (Pi-HXTXHi1b) Psalmotoxin-1 family, ...
TP1C_HADIN Pi-hexatoxin-Hi1c (Pi-HXTXHi1c) Psalmotoxin-1 family, ...
TP1D_HADIN Pi-hexatoxin-Hi1d (Pi-HXTXHi1d) Psalmotoxin-1 family, ...

4 entries

Heteractis crispa (Leathery sea anemone) (Radianthus macrodactylus)

BDS5A_HETCR Pi-stichotoxin-Hcr5a (Pi-SHTX-Hcr5a) (Pi-AnmTX Hcr 1b-1) Sea anemone type 3 (BDS) ...
BDS5B_HETCR Pi-stichotoxin-Hcr5b (Pi-SHTX-Hcr5b) (Pi-AnmTX Hcr 1b-2) Sea anemone type 3 (BDS) ...
BDS5C_HETCR Pi-stichotoxin-Hcr5c (Pi-SHTX-Hcr5c) (Pi-AnmTX Hcr 1b-3) Sea anemone type 3 (BDS) ...
BDS5D_HETCR Pi-stichotoxin-Hcr5d (Pi-SHTX-Hcr5d) (Pi-AnmTX Hcr 1b-4) Sea anemone type 3 (BDS) ...

1 entry

Heteroscodra maculata (Togo starburst tarantula) (Togo starburst baboon spider)

TX3A_HETMC Pi-theraphotoxin-Hm3a (Pi-TRTX-Hm3a) Psalmotoxin-1 family

2 entries

Micrurus tener tener (Texas coral snake)

PA2HB_MICTN Basic phospholipase A2 homolog MitTx-beta (svPLA2 homolog) Phospholipase A2 family, Group I ...
VKTA_MICTN Kunitz-type neurotoxin MitTx-alpha Venom Kunitz-type family

1 entry

Phymanthus crucifer (Red beaded anemone)

TXPM1_PHYCF Pi-phymatoxin-Pcf1a (Pi-PMTX-Pcf1a) (Pi-PMTX-Pcr1a) (Toxin ... Not in a family

1 entry

Psalmopoeus cambridgei (Trinidad chevron tarantula)

TXP1_PSACA Psalmotoxin-1 (PcTx1) (Pi-theraphotoxin-Pc1a) (Pi-TRTX-Pc1a) Psalmotoxin-1 family

1 entry

Urticina grebelnyi (Painted anemone)

TX9A_URTGR Precursor protein UG [Cleaved into: U-actitoxin-Ugr1c ... Sea anemone structural class 9a ...