Proton-gated sodium channel impairing toxin ~ VenomZone

Channel Acid-sensing ion channels (ASICs) are voltage-insensitive, proton-gated cation channels activated by extracellular acidosis. In mammals, 4 genes encode at least 6 different subunits, the variants ASIC1a and ASIC1b, the variants ASIC2a and ASIC2b, and ASIC3 and ASIC4. Three identical or different subunits are required to form a functional channel (except for ASIC2b and ASIC4, which do not form proton-gated channels when expressed alone). Acid-sensing ion channel 1a (ASIC1a) and ASIC2 (both variants a and b) are widely expressed in neurons of the central nervous system, whereas almost all subunits (except ASIC4) are present in sensory neurons of the peripheral nervous system including nociceptors.

Toxin

	Channel	Toxins from different taxa that target channels. Click on to retrieve toxins of interest.
	Human	Snake	Scorpion	Cone snail	Spider	Cnidarian	Insect	Other	All
Subunit contained in homo- or heterotrimer:
ASIC1a			-				-	-
ASIC1b			-				-	-
ASIC2a			-			-	-	-
ASIC2b			-				-	-
ASIC3			-		-		-	-
ASIC4		-	-	-	-	-	-	-	-
all			-					-

Proton-gated sodium channel impairing toxin

Venom protein entries in UniProtKB/Swiss-Prot

Anthopleura cascaia (Sea anemone)

Anthopleura elegantissima (Green aggregating anemone) (Actinia elegantissima)

Conus cancellatus (Cancellate cone) (Conus austini)

Conus textile (Cloth-of-gold cone)

Dendroaspis angusticeps (Eastern green mamba) (Naja angusticeps)

Dendroaspis polylepis polylepis (Black mamba)

Hadronyche infensa (Fraser island funnel-web spider) (Atrax infensus)

Heteractis magnifica (Magnificent sea anemone) (Radianthus magnifica)

Heteroscodra maculata (Togo starburst tarantula) (Togo starburst baboon spider)

Micrurus tener tener (Texas coral snake)

Phymanthus crucifer (Red beaded anemone)

Psalmopoeus cambridgei (Trinidad chevron tarantula)

Radianthus crispa (Leathery sea anemone) (Heteractis crispa)

Sphex argentatus argentatus (Black digger wasp)

Urticina grebelnyi (Painted anemone)