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Agkistrodon piscivorus piscivorus
(Eastern cottonmouth)
(taxid:8716)
Venom composition
Figure 1: Composition of A.p.piscivorus venom, studied at proteomic level (
Lomonte, et al., 2014
). This venom contains the following families: SVMP (
venom metalloproteinase
), serine protease (
peptidase S1
), peptides (include tripeptide SVMP inhibitors and bradykinin-potentiating and bradykinin-inhibitory peptides), LAAO (
L-amino-acid oxidase (flavin monoamine oxidase)
),
disintegrin
,
snaclec
(also known as C-type lectin-like),
CRISP
, PA2 (
phospholipase A2
).
Clinical Effects, Treatment, Antivenoms
See the
Clinical Toxinology Resources Website
.
Lethal dose
LD(50) of A.piscivorus is
6.24 mg/kg by intraperitoneal injection and
5.13 mg/kg by intravenous injection (
Arce et al., 2003
).
Taxonomy
UniProt taxonomy
The Reptile database
Wikipedia
Infraorder
:
Serpentes
Family
:
Viperidae
Genus:
Agkistrodon
Activity
Cell adhesion impairing toxin
Hemostasis impairing toxin
Hemorrhagic toxin
Platelet agg. inhibiting toxin
Myotoxin
or see
UniProtKB browsing by keyword
Reference
Lomonte, et al., 2014
Venom protein entries in UniProtKB/Swiss-Prot
(all links/actions below point to
uniprot.org
website)
10 entries
grouped
by species
reorder by family
10 entries
Agkistrodon piscivorus piscivorus (Eastern cottonmouth)
BPPF_AGKPI
Bradykinin-potentiating peptide F (AppF) (BPP-F)
Bradykinin-potentiating peptide
...
CRVP_AGKPI
Cysteine-rich venom protein piscivorin
CRISP family
DIDA_AGKPI
Disintegrin piscivostatin-alpha (PVS-alpha)
Disintegrin family, Dimeric
...
LECG_AGKPI
C-type lectin APL (CTL)
True venom lectin family
PA2B1_AGKPI
Basic phospholipase A2 APP-D49 (svPLA2) (EC 3.1.1.4) (App-dimer)
...
Phospholipase A2 family, Group
...
1VAP
PA2HB_AGKPI
Basic phospholipase A2 homolog AppP2 (svPLA2 homolog) (APP-K49)
Phospholipase A2 family, Group
...
1PPA
TXVE_AGKPI
Snake venom vascular endothelial growth factor toxin apiscin
...
PDGF/VEGF growth factor family,
...
VEGFA_AGKPI
Vascular endothelial growth factor A (VEGF-A)
PDGF/VEGF growth factor family
VM2PB_AGKPI
Zinc metalloproteinase/disintegrin [Cleaved into: Snake venom
...
Venom metalloproteinase (M12B)
...
VM2_AGKPI
Disintegrin applaggin (Applagin) (Platelet aggregation
...
Venom metalloproteinase (M12B)
...