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Tityus obscurus
(Amazonian scorpion)
(taxid:1221240)
Venom composition
Figure 1: Composition of T.obscurus venom, studied at the transcriptomic level. This venom contains the following families (classified by activity): sodium channel toxin (NaTx), anionic peptide, anticoagulant peptide (negligible), antimicrobial peptide (AMP),
bradykinin potentiating-peptide (BPP)
, chitinase (negligible),
CRISP
, hyaluronidase, insulin-like growth factor, lipase,
metalloproreinase
,
phospholipase A2 (PA2)
, phospholipase C (negligible), potassium channel toxin (KTx), proteinase inhibitor, other proteinase, conserved venom component (
de Oliveira et al., 2018
). Families with an asterix (*) are those with peptides identified by proteomic analysis.
Clinical Effects, Treatment, Antivenoms
See the
Clinical Toxinology Resources Website
.
Lethal dose
LD(50) is 3.13 mg/kg by intraperitoneal injection into mice (
Santos da Silva et al., 2017
).
Taxonomy
UniProt taxonomy
Wikipedia
Order
:
Scorpiones
Family
:
Buthidae
Genus:
Tityus
Species
:
obscurus
Activity
see
UniProtKB browsing by keyword
Reference
Batista et al., 2004
de Oliveira et al., 2018
Venom protein entries in UniProtKB/Swiss-Prot
(all links/actions below point to
uniprot.org
website)
39 entries
grouped
by species
reorder by family
39 entries
Tityus obscurus (Amazonian scorpion) (Tityus cambridgei)
CYCTI_TITOB
Cyclotide trypsin inhibitor TopI1
Not in a family
6MRQ
KA131_TITOB
Potassium channel toxin alpha-KTx 13.1 (Toxin Tc1) (Toxin To1)
Short scorpion toxin
...
1JLZ
KA181_TITOB
Potassium channel toxin alpha-KTx 18.1 (Toxin Tc32) (Toxin To32)
Short scorpion toxin
...
2JP6
KAX44_TITOB
Potassium channel toxin alpha-KTx 4.4 (Toxin Tc30) (Toxin To30)
Short scorpion toxin
...
NDB32_TITOB
Antimicrobial peptide ToAP2
Non-disulfide-bridged peptide
...
NDB44_TITOB
Peptide ToAP4
Non-disulfide-bridged peptide
...
SC27_TITOB
Toxin To27 (Toxin Tc27)
Not in a family
SC29_TITOB
Toxin To29 (Toxin Tc29)
Not in a family
SC31_TITOB
Toxin To31 (Toxin Tc31)
Not in a family
SC33_TITOB
Toxin To33 (Toxin Tc33)
Not in a family
SC35_TITOB
Toxin To35 (Toxin Tc35)
Not in a family
SC37_TITOB
Toxin To37 (Toxin Tc37)
Not in a family
SC39_TITOB
Toxin To39 (Toxin Tc39)
Not in a family
SC40_TITOB
Toxin To40 (Toxin Tc40)
Not in a family
SC46_TITOB
Toxin To46 (Toxin Tc46)
Not in a family
SC56_TITOB
Toxin To56 (Toxin Tc56)
Not in a family
SC58_TITOB
Toxin To58 (Toxin Tc58)
Not in a family
SC61_TITOB
Toxin To61 (Toxin Tc61)
Not in a family
SC64_TITOB
Toxin To64 (Toxin Tc64)
Not in a family
SC83_TITOB
Toxin To83 (Toxin Tc83)
Not in a family
SCX10_TITOB
Toxin To10 (T-alpha* NaTx3.9)
Long (4 C-C) scorpion toxin
...
SCX11_TITOB
Toxin To11 (T NaTx14.9)
Long (4 C-C) scorpion toxin
...
SCX12_TITOB
Toxin To12 (T-beta* NaTx5.5)
Long (4 C-C) scorpion toxin
...
SCX13_TITOB
Sodium channel toxin To13 (T NaTx8.1)
Long (4 C-C) scorpion toxin
...
SCX14_TITOB
Toxin To14 (T-alpha* NaTx3.10) (Toxin Tc41) (Toxin To41)
Long (4 C-C) scorpion toxin
...
SCX15_TITOB
Toxin To15 (T-beta* NaTx1.4)
Long (4 C-C) scorpion toxin
...
SCX1_TITOB
Beta-mammal/insect toxin To1 (NaTx12.1) (Toxin Tc49b)
Long (4 C-C) scorpion toxin
...
SCX2_TITOB
Alpha-toxin To2 (Alpha-toxin Tc48a) (Alpha-toxin To48a)
...
Long (4 C-C) scorpion toxin
...
SCX3_TITOB
Toxin To3 (PT-alpha' NaTx14.2) (Toxin Tc48b/Tc49a) (Toxin
...
Long (4 C-C) scorpion toxin
...
SCX4_TITOB
Beta-toxin To4 (PT-beta* NaTx13.9) (Toxin Tc54)
Long (4 C-C) scorpion toxin
...
SCX5_TITOB
Toxin To5 (PT-Arthr*-beta* NaTx2.7) (Toxin Tc66) (Toxin To66)
Long (4 C-C) scorpion toxin
...
SCX6_TITOB
Toxin To6 (PT-alpha* NaTx7.5) (Toxin Tc43) (Toxin To43)
Long (4 C-C) scorpion toxin
...
SCX7_TITOB
Toxin To7 (PT-alpha* NaTx7.6) (Toxin Tc50) (Toxin To50)
Long (4 C-C) scorpion toxin
...
SCX8_TITOB
Toxin To8 (PT-beta* NaTx10.1)
Long (4 C-C) scorpion toxin
...
SCX9_TITOB
Toxin To9 (T-alpha* NaTx3.8)
Long (4 C-C) scorpion toxin
...
TOACP_TITOB
Peptide ToAcP
Not in a family
TOAP1_TITOB
Antimicrobial peptide ToAp1
Non-disulfide-bridged peptide
...
TOAP3_TITOB
Antimicrobial peptide ToAP3
Non-disulfide-bridged peptide
...
VMP_TITOB
Metalloproteinase (EC 3.4.24.-)
Venom metalloproteinase (M12B)
...
