Cardiotoxin

Cardiotoxins are components that are specifically toxic to the heart. They cause heart electrophysiology dysfunction or/and muscle damage.

Also see UniProtKB-keyword.

Venom protein entries in UniProtKB/Swiss-Prot

(all links/actions below point to uniprot.org website)

137 entries grouped by species

reorder by family

2 entries

Anthopleura elegantissima (Green aggregating anemone) (Actinia elegantissima)

NA11_ANTEL Delta-actitoxin-Ael1b (Delta-AITX-Ael1b) (Toxin APE 1-1) Sea anemone sodium channel ...

NA13_ANTEL Delta-actitoxin-Ael1c (Delta-AITX-Ael1c) (Toxin APE 1-2) Sea anemone sodium channel ...

2 entries

Anthopleura fuscoviridis (Sea anemone)

NA11_ANTFU Delta-actitoxin-Afv1a (Delta-AITX-Afv1a) (Toxin AFT-I) (AFI) Sea anemone sodium channel ...

NA12_ANTFU Delta-actitoxin-Afv1b (Delta-AITX-Afv1b) (AFT-II) (AFII) Sea anemone sodium channel ...

4 entries

Anthopleura sp. (strain 'Zhanjiang') (Sea anemone)

NA116_ANTS7 Delta-actitoxin-Aspp1d (Delta-AITX-Aspp1d) (Toxin Hk16a) Sea anemone sodium channel ...

NA12A_ANTS7 Delta-actitoxin-Aspp1a (Delta-AITX-Aspp1a) (Toxin Hk2a) Sea anemone sodium channel ...

NA17A_ANTS7 Delta-actitoxin-Aspp1b (Delta-AITX-Aspp1b) (Toxin Hk7a) Sea anemone sodium channel ...

NA18A_ANTS7 Delta-actitoxin-Aspp1c (Delta-AITX-Aspp1c) (Toxin Hk8a) Sea anemone sodium channel ...

6 entries

Anthopleura xanthogrammica (Giant green sea anemone) (Actinia xanthogrammica)

NA12_ANTXA Delta-actitoxin-Axm1e (Delta-AITX-Axm1e) (PCR2-5) (Toxin PCR2) Sea anemone sodium channel ...

NA13_ANTXA Delta-actitoxin-Axm1d (Delta-AITX-Axm1d) (PCR2-1) (Toxin PCR3) Sea anemone sodium channel ...

NA14_ANTXA Delta-actitoxin-Axm1f (Delta-AITX-Axm1f) (PCR2-10) (Toxin PCR4) Sea anemone sodium channel ...

NA16_ANTXA Delta-actitoxin-Axm1h (Delta-AITX-Axm1h) (PCR3-7) (Toxin PCR6) Sea anemone sodium channel ...

NA1A_ANTXA Delta-actitoxin-Axm1a (Delta-AITX-Axm1a) (Anthopleurin-A) (AP-A) ... Sea anemone sodium channel ...

pdb 1AHL

NA1B_ANTXA Delta-actitoxin-Axm1b (Delta-AITX-Axm1b) (Anthopleurin-B) (AP-B) ... Sea anemone sodium channel ...

pdb 1APF

1 entry

Atractaspis bibronii (Bibron's mole viper) (Southern stiletto snake)

2 entries

Atractaspis engaddensis (Israeli burrowing asp) (Israeli mole viper)

SRTXD_ATREN Sarafotoxin-D (SRTX-D) (S6D) Endothelin/sarafotoxin family

SRTX_ATREN Sarafotoxin [Cleaved into: Sarafotoxin-A, Ser-isoform (SRTX-A) ... Endothelin/sarafotoxin family

pdb 1SRB; 6LRY

2 entries

Atractaspis irregularis (Variable burrowing asp) (Elaps irregularis)

SRTX1_ATRIR Sarafotoxin-i1 (SRTX-i1) (Sarafotoxin-i3) (SRTX-i3) Endothelin/sarafotoxin family

pdb 2LDE

SRTX2_ATRIR Sarafotoxin-i2 (SRTX-i2) Endothelin/sarafotoxin family

1 entry

Atractaspis microlepidota microlepidota

2 entries

Bunodosoma granuliferum (Red warty sea anemone)

NA12_BUNGR Delta-actitoxin-Bgr2a (Delta-AITX-Bgr2a) (Bg II) (BgII) ... Sea anemone sodium channel ...

NA13_BUNGR Delta-actitoxin-Bgr2b (Delta-AITX-Bgr2b) (Bg III) (BgIII) ... Sea anemone sodium channel ...

2 entries

Chironex fleckeri (Australian box jellyfish)

JTX11_CHIFL Toxin CfTX-1 (Toxin 1) Jellyfish toxin family, Type I ...

JTX12_CHIFL Toxin CfTX-2 (Toxin 2) Jellyfish toxin family, Type I ...

1 entry

Conus villepinii (Villepin's cone)

1 entry

Daboia russelii (Russel's viper) (Vipera russelii)

1 entry

Deccanometrus bengalensis (Indian black scorpion) (Heterometrus bengalensis)

2 entries

Dendroaspis angusticeps (Eastern green mamba) (Naja angusticeps)

3SL2_DENAN Toxin C10S2C2 Snake three-finger toxin family, ...

VKTHC_DENAN Kunitz-type serine protease inhibitor homolog calcicludine (CAC) ... Venom Kunitz-type family

pdb 1BF0; 5YV7; 6KZF

1 entry

Dendroaspis jamesoni kaimosae (Eastern Jameson's mamba)

2 entries

Dendroaspis polylepis polylepis (Black mamba)

3SL2_DENPO Toxin FS-2 (FS2) Snake three-finger toxin family, ...

pdb 1TFS

3SLS_DENPO Calciseptin (Calciseptine) (CaS) (L-type calcium channel ... Snake three-finger toxin family, ...

pdb 8WE7; 8WE8

5 entries

Hemachatus haemachatus (Rinkhals) (Sepedon haemachatus)

3SB1_HEMHA Cytotoxin 1 (Hemolytic protein 12B) Snake three-finger toxin family, ...

3SB2_HEMHA Cytotoxin 2 (Toxin 12A) Snake three-finger toxin family, ...

3SB3_HEMHA Cytotoxin 3 (Toxin 11/11A) Snake three-finger toxin family, ...

3SBH_HEMHA Three-finger hemachatoxin Snake three-finger toxin family, ...

pdb 3VTS

3SOE_HEMHA Cytotoxin homolog (Toxin 9B/9BB) Snake three-finger toxin family, ...

1 entry

Hottentotta judaicus (Black scorpion) (Buthotus judaicus)

1 entry

Leiurus hebraeus (Hebrew deathstalker scorpion) (Leiurus quinquestriatus hebraeus)

1 entry

Mesobuthus martensii (Manchurian scorpion) (Buthus martensii)

SCM1_MESMA Alpha-like toxin BmK M1 (BmK-M1) (BmKM1) (BmK-I) (BmK I) (BmKI) ... Long (4 C-C) scorpion toxin ...

pdb 1DJT; 1SN1; 1T7A; 1T7B; 1T7E; 1ZU3; 1ZUT; 1ZVE; 1ZVG; 1ZYV; 1ZYW

10 entries

Naja annulifera (Banded Egyptian cobra) (Naja haje annulifera)

3SA1_NAJHA Cytotoxin 1 (Toxin V(II)1) Snake three-finger toxin family, ...

3SA2_NAJHA Cytotoxin 2 (Toxin V(II)2/V(II)2A) Snake three-finger toxin family, ...

3SA3_NAJHA Cytotoxin 3 (Toxin CM-8/CM-8A) Snake three-finger toxin family, ...

3SA4_NAJHA Cytotoxin 4 (Toxin CM-11) Snake three-finger toxin family, ...

3SA5_NAJHA Cytotoxin 5 (Toxin CM-6) Snake three-finger toxin family, ...

3SA6_NAJHA Cytotoxin 6 (Toxin CM-2H) Snake three-finger toxin family, ...

3SA7_NAJHA Cytotoxin 7 (Toxin CM-4B) Snake three-finger toxin family, ...

3SA8_NAJHA Cytotoxin 8 (Toxin CM-7) Snake three-finger toxin family, ...

3SA9_NAJHA Cytotoxin 9 (Toxin CM-2e) Snake three-finger toxin family, ...

3SAA_NAJHA Cytotoxin 10 (Toxin CM-4a) Snake three-finger toxin family, ...

28 entries

Naja atra (Chinese cobra)

"Naja atra" VenomZone page

3SA1A_NAJAT Cytotoxin 1a (Cardiotoxin-1a) Snake three-finger toxin family, ...

3SA1B_NAJAT Cytotoxin 1b (Cardiotoxin-1b) Snake three-finger toxin family, ...

3SA1C_NAJAT Cytotoxin 1c (Cardiotoxin-1c) Snake three-finger toxin family, ...

3SA1D_NAJAT Cytotoxin 1d/1e (Cardiotoxin-1d/1e) Snake three-finger toxin family, ...

3SA1F_NAJAT Cytotoxin 1f (Cardiotoxin 1f) Snake three-finger toxin family, ...

3SA1_NAJAT Cytotoxin 1 (CX1) (Cardiotoxin 1) (CTX-1) (CTX1) (Cardiotoxin ... Snake three-finger toxin family, ...

pdb 2CDX

3SA2_NAJAT Cytotoxin 2 (Cardiotoxin 1A) (Cardiotoxin 2) (CTX-2) ... Snake three-finger toxin family, ...

pdb 1CRE; 1CRF; 4OM4

3SA3A_NAJAT Cytotoxin 3a (Cardiotoxin-31) (Ctx-31) (Cardiotoxin-3a) Snake three-finger toxin family, ...

3SA3B_NAJAT Cytotoxin 3b (Cardiotoxin 3b) Snake three-finger toxin family, ...

3SA3D_NAJAT Cytotoxin 3d (Cardiotoxin 3d) Snake three-finger toxin family, ...

3SA3_NAJAT Cytotoxin 3 (Cardiotoxin 3) (CTX-3) (CTX3) (Cardiotoxin A3) (CTX ... Snake three-finger toxin family, ...

pdb 1H0J; 1I02; 1XT3; 2BHI; 2CRS; 2CRT

3SA4N_NAJAT Cytotoxin 4N (Cardiotoxin-4N) (CTX-4N) Snake three-finger toxin family, ...

3SA4_NAJAT Cytotoxin 4 (CTX-4M) (CTX4) (Cardiotoxin A4) (CTX A4) ... Snake three-finger toxin family, ...

pdb 1KBS; 1KBT; 4OM5

3SA5_NAJAT Cytotoxin 5 (Cardiotoxin 5) (CTX5) Snake three-finger toxin family, ...

3SA6_NAJAT Cytotoxin 6 (Cardiotoxin-6) (CTX6) Snake three-finger toxin family, ...

3SA8A_NAJAT Cytotoxin 8 (Cardiotoxin-8) (CTX8) Snake three-finger toxin family, ...

3SA8B_NAJAT Cytotoxin 8 (Cardiotoxin VIII) (Cardiotoxin-8) (CTX8) Snake three-finger toxin family, ...

3SAA_NAJAT Cytotoxin 10 (Cardiotoxin-10) (CTX10) (Ctx-10) Snake three-finger toxin family, ...

3SADB_NAJAT Cytotoxin SP13b Snake three-finger toxin family, ...

3SAFA_NAJAT Cytotoxin SP15a Snake three-finger toxin family, ...

3SAFC_NAJAT Cytotoxin SP15c Snake three-finger toxin family, ...

3SAFD_NAJAT Cytotoxin SP15d Snake three-finger toxin family, ...

3SAG_NAJAT Cytotoxin najalgesin Snake three-finger toxin family, ...

3SAN_NAJAT Cytotoxin 6 (Cardiotoxin 6) (CTX6) (Cardiotoxin A6) (CTX A6) ... Snake three-finger toxin family, ...

pdb 1UG4

3SAPF_NAJAT Cytotoxin I-like P-15 (Cardiotoxin I-like P-15) Snake three-finger toxin family, ...

3SATF_NAJAT Cytotoxin I-like T-15 (Cardiotoxin I-like T-15) Snake three-finger toxin family, ...

3SAT_NAJAT Cytotoxin 5 (Cardiotoxin A4b) (CTX-A4b) (Cardiotoxin T) ... Snake three-finger toxin family, ...

pdb 1CHV

3SOF7_NAJAT Cytotoxin 7 (Cardiotoxin-7) (CTX7) (Ctx-7) (Cardiotoxin-like ... Snake three-finger toxin family, ...

1 entry

Naja haje haje (Egyptian cobra)

8 entries

Naja kaouthia (Monocled cobra) (Naja siamensis)

3NO2_NAJKA Tryptophan-containing weak neurotoxin (WTX) Snake three-finger toxin family, ...

pdb 2MJ0

3SA1_NAJKA Cytotoxin 1 (NK-CT1) Snake three-finger toxin family, ...

3SA2_NAJKA Cytotoxin 2 Snake three-finger toxin family, ...

3SA3_NAJKA Cytotoxin 3 (CX3) (Toxin CM-7) Snake three-finger toxin family, ...

pdb 6RC7

3SA4_NAJKA Cytotoxin 4 (Cytotoxin IV) (Siamextin) Snake three-finger toxin family, ...

3SA5_NAJKA Cytotoxin 5 (Cytotoxin II) Snake three-finger toxin family, ...

3SA7A_NAJKA Cytotoxin 2 (CX2) (Toxin CM-7A) Snake three-finger toxin family, ...

pdb 7O2K

3SA8_NAJKA Cytotoxin 1 (CTX1) (CX1) (Cardiotoxin F8) (Cardiotoxin-I) ... Snake three-finger toxin family, ...

1 entry

Naja melanoleuca (Forest cobra) (Black-lipped cobra)

5 entries

Naja mossambica (Mozambique spitting cobra)

"Naja mossambica" VenomZone page

3SA1_NAJMO Cytotoxin 1 (CTX M1) (Cardiotoxin IIB) (CTX-IIB) (Cytotoxin ... Snake three-finger toxin family, ...

pdb 2CCX

3SA2_NAJMO Cytotoxin 2 (CTX M2) (Cardiotoxin IIA) (CTX IIA) (Cytotoxin ... Snake three-finger toxin family, ...

3SA3_NAJMO Cytotoxin 3 (CTX M4) (Cytotoxin V(II)3) Snake three-finger toxin family, ...

3SA4_NAJMO Cytotoxin 4 (CTX M3) (Cardiotoxin VII4) (Cytotoxin V(II)4) Snake three-finger toxin family, ...

pdb 1CDT

3SA5_NAJMO Cytotoxin 5 (CTX M5) (CTX V) Snake three-finger toxin family, ...

10 entries

Naja naja (Indian cobra)

3SA1_NAJNA Cytotoxin 1 (Cobramine-A) (Cytotoxin I) (Cytotoxin XI) ... Snake three-finger toxin family, ...

3SA2A_NAJNA Cytotoxin 2a (CTX2a) (Cytotoxin 2) (CTX2) Snake three-finger toxin family, ...

3SA2_NAJNA Cytotoxin 2 (Cobramine-B) (Cytotoxin II) Snake three-finger toxin family, ...

3SA3A_NAJNA Cytotoxin 3a (CTX3a) Snake three-finger toxin family, ...

3SA3_NAJNA Cytotoxin 3 (Cytotoxin IIa) Snake three-finger toxin family, ...

3SA7_NAJNA Cytotoxin 7 (CTX7) Snake three-finger toxin family, ...

3SA8_NAJNA Cytotoxin 8 (CTX8) Snake three-finger toxin family, ...

3SA9_NAJNA Cytotoxin 9 (CTX9) Snake three-finger toxin family, ...

3SAA_NAJNA Cytotoxin 10 (CTX10) Snake three-finger toxin family, ...

3SAW_NAJNA Cytotoxin NN-32 Snake three-finger toxin family, ...

1 entry

Naja nigricollis (Black-necked spitting cobra)

3 entries

Naja nivea (Cape cobra) (Coluber niveus)

3SA1_NAJNI Cytotoxin 1 (Toxin V(II)1) Snake three-finger toxin family, ...

3SA2_NAJNI Cytotoxin 2 (Toxin V(II)2) Snake three-finger toxin family, ...

3SA3_NAJNI Cytotoxin 3 (Toxin V(II)3) Snake three-finger toxin family, ...

3 entries

Naja oxiana (Central Asian cobra) (Oxus cobra)

3SA1_NAJOX Cytotoxin 1 (Cytotoxin I) (CTI) Snake three-finger toxin family, ...

pdb 1RL5; 1ZAD; 5NPN; 5NQ4; 5T8A

3SA2_NAJOX Cytotoxin 2 (Cytotoxin II) (CTII) Snake three-finger toxin family, ...

pdb 1CB9; 1CCQ; 1FFJ

3SA5_NAJOX Cytotoxin Vc-5 Snake three-finger toxin family, ...

1 entry

Naja pallida (Red spitting cobra)

1 entry

Naja sagittifera (Andaman cobra)

13 entries

Naja sputatrix (Malayan spitting cobra) (Naja naja sputatrix)

3SA0_NAJSP Cytotoxin (CTX) (Cardiotoxin) Snake three-finger toxin family, ...

3SA1_NAJSP Cytotoxin 1 (Cardiotoxin-1) (CTX-1) (Ctx1) Snake three-finger toxin family, ...

3SA2A_NAJSP Cytotoxin 2a (Cardiotoxin 2a) (CTX-2a) (Ctx2a) Snake three-finger toxin family, ...

3SA2B_NAJSP Cytotoxin 2b (Cardiotoxin-2b) (CTX-2b) (Ctx2b) Snake three-finger toxin family, ...

3SA2C_NAJSP Cytotoxin 2c (Cardiotoxin-2c) (CTX-2c) (Ctx2c) Snake three-finger toxin family, ...

3SA3_NAJSP Cytotoxin 3 (Cardiotoxin-3) (CTX-3) (Ctx3) Snake three-finger toxin family, ...

3SA4A_NAJSP Cytotoxin 4a (Cardiotoxin-4a) (CTX-4a) (Ctx4a) Snake three-finger toxin family, ...

3SA4B_NAJSP Cytotoxin 4b (Cardiotoxin-4b) (CTX-4b) (Ctx4b) Snake three-finger toxin family, ...

3SA5A_NAJSP Cytotoxin 5a (Cardiotoxin 5a) (CTX-5a) (Ctx5a) Snake three-finger toxin family, ...

3SA5B_NAJSP Cytotoxin 5b (Cardiotoxin 5b) (CTX-5b) (Ctx5b) Snake three-finger toxin family, ...

3SA6_NAJSP Cytotoxin 6 (Cardiotoxin-6) (CTX-6) (Ctx6) Snake three-finger toxin family, ...

3SA7_NAJSP Cytotoxin 7 (Cardiotoxin-7) (CTX-7) (Ctx7) Snake three-finger toxin family, ...

3SAC3_NAJSP Cytotoxin KJC3 Snake three-finger toxin family, ...

7 entries

Ophiophagus hannah (King cobra) (Naja hannah)

3SDC1_OPHHA Beta-cardiotoxin CTX21 Snake three-finger toxin family, ...

3SDC3_OPHHA Beta-cardiotoxin CTX23 Snake three-finger toxin family, ...

3SDC4_OPHHA Beta-cardiotoxin CTX14 Snake three-finger toxin family, ...

3SDC5_OPHHA Beta-cardiotoxin CTX15 (OH-84) Snake three-finger toxin family, ...

3SDC7_OPHHA Beta-cardiotoxin CTX27 (OH-27) Snake three-finger toxin family, ...

pdb 3PLC

3SDC9_OPHHA Beta-cardiotoxin CTX9 Snake three-finger toxin family, ...

PA2A1_OPHHA Acidic phospholipase A2 1 (svPLA2) (EC 3.1.1.4) (APLA2-1) (OHV ... Phospholipase A2 family, Group I ...

pdb 1GP7

1 entry

Parabuthus granulatus (Granulated thick-tailed scorpion)

3 entries

Phlogius sp. (Tarantula spider)

HM1A_PHLSP Mu-theraphotoxin-Phlo1a (Mu-TRTX-Phlo1a) Neurotoxin 10 (Hwtx-1) family, ...

HM1B_PHLSP Mu-theraphotoxin-Phlo1b (Mu-TRTX-Phlo1b) Neurotoxin 10 (Hwtx-1) family, ...

PM2A_PHLSP Mu-theraphotoxin-Phlo2a (Mu-TRTX-Phlo2a) Neurotoxin 30 (phrixotoxin) ...

1 entry

Tityus serrulatus (Brazilian scorpion)

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