Loxosceles intermedia (Brown spider)

Venom composition image
Figure 1: Composition of L.intermedia venom, studied at the transcriptomic level (Gremski et al., 2010). The venom contains the following families: LiTx3-related, LiTx, peptidase M12A (astacin-like metalloprotease), SicTox (arthropod phospholipase D) , neurotoxin-Magi 3-like,serine protease, TCTP (translationally controlled tumor protein) , allergen, hyaluronidase (glycosyl hydrolase 56) and serine protease inhibitor.
Clinical Effects, Treatment, Antivenoms See the Clinical Toxinology Resources Website.
Lethal dose LD(50) is 0.48 mg/kg when injected into mice (Barbaro et al., 1996).
LD(50) is 0.34 mg/kg by subcutaneous injection into mice (Dias-Lopez et al., 2010).
LD(50) is 1.80 ± 0.30 μg/g when injected into lepidoperan Agrotis ipsilon larvae (de Castro et al., 2004).
LD(50) is 1.39 ± 0.34 μg/g when injected into lepidoperan Diatraea saccharalis larvae (de Castro et al., 2004).
LD(50) is 1.92 ± 0.71 μg/g when injected into lepidoperan Spodoptera cosmioides larvae (de Castro et al., 2004).
LD(50) is 1.90 ± 0.11 μg/g when injected into lepidoperan Spodoptera frugiperdalarvae larvae
(de Castro et al., 2004).
Species diet Ants have been found in the mouth of one specimen of this species (Zobel-Thropp et al., 2012).
Taxonomy

UniProt taxonomy
Wikipedia

Infraorder: Araneae


Suborder: Araneomorphae
Family: Sicariidae
Genus: Loxosceles
Species: intermedia
Activity Complement system impairing toxin
Dermonecrotic toxin
Hemostasis impairing toxin
  Hemorrhagic toxin
Neurotoxin
and also
G-protein coupled receptor impairing toxin
Ion channel impairing toxin
or see
UniProtKB browsing by keyword
Reference Transcriptomic
Gremski et al., 2010
Proteomic
Machado et al., 2005, dos Sandos et al., 2009

Venom protein entries in UniProtKB/Swiss-Prot

(all links/actions below point to uniprot.org website)

26 entries grouped by family

6 entries

Arthropod phospholipase D family, Class II subfamily

Select_allDeselect_all
A1IA3_LOXIN Dermonecrotic toxin LiSicTox-alphaIA2aiii (EC ... Loxosceles intermedia (Brown spider)
A1IB1_LOXIN Dermonecrotic toxin LiSicTox-alphaIA2bi (EC ... Loxosceles intermedia (Brown spider)
A1IB2_LOXIN Dermonecrotic toxin LiSicTox-alphaIA2bii (EC ... Loxosceles intermedia (Brown spider)
A1X1_LOXIN Dermonecrotic toxin LiSicTox-alphaI-1 (EC ... Loxosceles intermedia (Brown spider)
A22_LOXIN Dermonecrotic toxin LiSicTox-alphaII2 (EC ... Loxosceles intermedia (Brown spider)
B1H2_LOXIN Dermonecrotic toxin LiSicTox-betaIA1ii (EC ... Loxosceles intermedia (Brown spider)

8 entries

Arthropod phospholipase D family, Class II subfamily, Class IIa sub-subfamily

Select_allDeselect_all
A1HA_LOXIN Dermonecrotic toxin LiSicTox-alphaIA1a (EC ... Loxosceles intermedia (Brown spider)

pdb 3RLG; 3RLH

A1HB1_LOXIN Dermonecrotic toxin LiSicTox-alphaIA1bi (EC ... Loxosceles intermedia (Brown spider)
A1HB2_LOXIN Dermonecrotic toxin LiSicTox-alphaIA1bii (EC ... Loxosceles intermedia (Brown spider)

pdb 4RW3; 4RW5

A1IA1_LOXIN Dermonecrotic toxin LiSicTox-alphaIA2ai (EC ... Loxosceles intermedia (Brown spider)
A1IA2_LOXIN Dermonecrotic toxin LiSicTox-alphaIA2aii (EC ... Loxosceles intermedia (Brown spider)
A21_LOXIN Dermonecrotic toxin LiSicTox-alphaII1 (EC ... Loxosceles intermedia (Brown spider)
A4A1_LOXIN Dermonecrotic toxin LiSicTox-alphaIVA1 (EC ... Loxosceles intermedia (Brown spider)
A51_LOXIN Dermonecrotic toxin LiSicTox-alphaV1 (EC ... Loxosceles intermedia (Brown spider)

2 entries

Arthropod phospholipase D family, Class II subfamily, Class IIb sub-subfamily

Select_allDeselect_all
B1H1_LOXIN Dermonecrotic toxin LiSicTox-betaIA1i (EC ... Loxosceles intermedia (Brown spider)
B1Q_LOXIN Dermonecrotic toxin LiSicTox-betaID1 (EC ... Loxosceles intermedia (Brown spider)

1 entry

Glycosyl hydrolase 56 family

"Glycosyl hydrolase 56 family" VenomZone page
HYAL_LOXIN Hyaluronidase (EC 3.2.1.35) (Chondroitinase) ... Loxosceles intermedia (Brown spider)

3 entries

Neurotoxin 28 (Litx) family

Select_allDeselect_all
TX1_LOXIN U1-sicaritoxin-Li1a (U1-SCRTX-Li1a) (LiTx1) Loxosceles intermedia (Brown spider)
TX2_LOXIN U1-sicaritoxin-Li1b (U1-SCRTX-Li1b) (LiTx2) Loxosceles intermedia (Brown spider)
TX4_LOXIN U1-sicaritoxin-Li1c (U1-SCRTX-Li1c) (LiTx4) Loxosceles intermedia (Brown spider)

2 entries

Neurotoxin 39 family

Select_allDeselect_all
TX32_LOXIN U2-sicaritoxin-Li1b (U2-SCRTX-Li1b) Loxosceles intermedia (Brown spider)
TX3_LOXIN U2-sicaritoxin-Li1a (U2-SCRTX-Li1a) (LiTx3) ... Loxosceles intermedia (Brown spider)

3 entries

Not in a family

Select_allDeselect_all
VMPA2_LOXIN Astacin-like metalloprotease toxin 2 (EC ... Loxosceles intermedia (Brown spider)
VMPA3_LOXIN Astacin-like metalloprotease toxin 3 (EC ... Loxosceles intermedia (Brown spider)
VMPA_LOXIN Astacin-like metalloprotease toxin 1 (EC ... Loxosceles intermedia (Brown spider)

1 entry

TCTP family

"TCTP family" VenomZone page
TCTP_LOXIN Translationally-controlled tumor protein homolog ... Loxosceles intermedia (Brown spider)