Bothrops jararaca (jararaca) (taxid:8724)

Venom composition

Figure 1: Composition of toxin transcripts in newborn and adult cDNA libraries from B.jararaca venom glands (Zelanis et al., 2012). CRISP, PLA2 (phospholipase A2), L-amino-acid oxidase (flavin monoamine oxidase), C-type lectin (true venom lectin), SVMP (snake venom metalloproteinase), serine protease (peptidase S1), BPP-natriuretic peptide (bradykinin-potentiating peptide and natriuretic peptide, nerve-growth factor (NGF-beta), VEGF (vascular endothelium growth factor see PDGF/VEGF growth factor).

Ontogenic variations are quantitative as shown in Fig.1, but also qualitative when metalloproteinases are considered. Adult and newborn snakes have only a few metalloproteinase transcripts in common, the majority being specific for each transcriptome. In addition, the ratio of subfamilies of metalloproteinases is different, newborn snakes being rich in P-III subfamilies, and adult in P-I. Some other families (i.e. serine proteinases, bradykinin-potentiating peptides, C-type lectins and phospholipases A2) are common to both newborn and adult snakes whereas many families are identified as specific for the adult venom gland transcriptome (Zelanis et al., 2012).

Coagulant activity of newborn venom is higher than that of adult venom (Zelanis et al., 2010).

Clinical Effects, Treatment, Antivenoms See the Clinical Toxinology Resources Website.

Lethal dose Newborn venom
LD(50) is 3.33 mg/kg when intraperitoneally injected into mice.
LD(50) is 0.05 mg/kg when intramuscularly injected into chick.

Adult venom
LD(50) is 2.26 mg/kg when intraperitoneally injected into mice.
LD(50) is 1.36 mg/kg when intramuscularly injected into chick.
(Zelanis et al., 2010)

Venom protein entries in UniProtKB/Swiss-Prot

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58 entries grouped by species

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58 entries

Bothrops jararaca (Jararaca) (Bothrops jajaraca)

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BNP1_BOTJA Bradykinin-potentiating and C-type natriuretic peptides ... Bradykinin-potentiating peptide ...

BNP2_BOTJA Bradykinin-potentiating and C-type natriuretic peptides (Brain ... Bradykinin-potentiating peptide ...

BPP11_BOTJA Bradykinin-potentiating peptide 11 (BPP-11) Bradykinin-potentiating peptide ...

BPP7A_BOTJA Bradykinin-potentiating peptide 7a (BPP-7a) (Proline-rich ... Bradykinin-potentiating peptide ...

BPPAB_BOTJA Bradykinin-potentiating peptide 10b (BPP-10b) ... Bradykinin-potentiating peptide ...

BPPBD_BOTJA Bradykinin-potentiating peptide 11d (BPP-11d) Bradykinin-potentiating peptide ...

BPPBG_BOTJA Bradykinin-potentiating peptide 11g (BPP-11g) Bradykinin-potentiating peptide ...

BPPBH_BOTJA Bradykinin-potentiating peptide 11h (BPP-11h) Bradykinin-potentiating peptide ...

BPPBI_BOTJA Bradykinin-potentiating peptide 11i (BPP-11i) Bradykinin-potentiating peptide ...

BPPBJ_BOTJA Bradykinin-potentiating peptide 11j (BPP-11j) Bradykinin-potentiating peptide ...

BPPCA_BOTJA Bradykinin-potentiating peptide 12a (BPP-12a) Bradykinin-potentiating peptide ...

BPPCB_BOTJA Bradykinin-potentiating peptide 12b (BPP-12b) Bradykinin-potentiating peptide ...

BPPCC_BOTJA Bradykinin-potentiating peptide 12c (BPP-12c) [Cleaved into: ... Bradykinin-potentiating peptide ...

BPPCE_BOTJA Bradykinin-potentiating peptide 12e (BPP-12e) Bradykinin-potentiating peptide ...

BPPDB_BOTJA Bradykinin-potentiating peptide 13b (BPP-13b) Bradykinin-potentiating peptide ...

BPPDC_BOTJA Bradykinin-potentiating peptide 13c (BPP-13c) Bradykinin-potentiating peptide ...

BPPDD_BOTJA Bradykinin-potentiating peptide 13d (BPP-13d) Bradykinin-potentiating peptide ...

BPPEA_BOTJA Bradykinin-potentiating peptide 14a (BPP-14a) [Cleaved into: ... Bradykinin-potentiating peptide ...

LECJ3_BOTJA Jararafibrase-3 (EC 3.4.24.-) (Jararafibrase III) True venom lectin family

LEC_BOTJA C-type lectin BjL (CTL) (Galactoside-binding lectin BjL) True venom lectin family

OXLA_BOTJA L-amino-acid oxidase (BjarLAAO-I) (LAO) (EC 1.4.3.2) Flavin monoamine oxidase family, ...

PA2A_BOTJA Acidic phospholipase A2 (svPLA2) (EC 3.1.1.4) (BJ-PLA2) ... Phospholipase A2 family, Group ...

PA2_BOTJA Phospholipase A2 (svPLA2) (EC 3.1.1.4) (Phosphatidylcholine ... Phospholipase A2 family, Group ...

QPCT_BOTJA Glutaminyl-peptide cyclotransferase (EC 2.3.2.5) (Glutaminyl ... Glutaminyl-peptide ...

SL1A_BOTJA Snaclec GPIB-binding protein subunit alpha (GPIb-BP subunit ... Snaclec family

SL1B_BOTJA Snaclec GPIB-binding protein subunit beta (GPIb-BP subunit beta) Snaclec family

SL9A_BOTJA Snaclec coagulation factor IX/factor X-binding protein subunit A ... Snaclec family

SL9B_BOTJA Snaclec coagulation factor IX/factor X-binding protein subunit B ... Snaclec family

SLAA_BOTJA Snaclec bothrojaracin subunit alpha (BJC subunit alpha) Snaclec family

SLAB_BOTJA Snaclec bothrojaracin subunit beta (BJC subunit beta) Snaclec family

SLEA_BOTJA Snaclec botrocetin subunit alpha (Platelet coagglutinin) Snaclec family

pdb 1FVU; 1IJK; 1U0N; 1U0O

SLEB_BOTJA Snaclec botrocetin subunit beta (Platelet coagglutinin) Snaclec family

pdb 1FVU; 1IJK; 1U0N; 1U0O

TXVE_BOTJA Snake venom vascular endothelial growth factor toxin (svVEGF) ... PDGF/VEGF growth factor family, ...

VM1BJ_BOTJA Snake venom metalloproteinase bothrojaractivase (SVMP) (EC ... Venom metalloproteinase (M12B) ...

VM2J2_BOTJA Zinc metalloproteinase/disintegrin [Cleaved into: Snake venom ... Venom metalloproteinase (M12B) ...

VM2JA_BOTJA Disintegrin jarastatin (JT) (Platelet aggregation activation ... Venom metalloproteinase (M12B) ...

VM2JC_BOTJA Zinc metalloproteinase/disintegrin [Cleaved into: Snake venom ... Venom metalloproteinase (M12B) ...

VM2JR_BOTJA Zinc metalloproteinase-disintegrin jararin (EC 3.4.24.-) (Snake ... Venom metalloproteinase (M12B) ...

VM3B1_BOTJA Zinc metalloproteinase-disintegrin-like bothrojarin-1 (EC ... Venom metalloproteinase (M12B) ...

VM3B2_BOTJA Zinc metalloproteinase-disintegrin-like bothrojarin-2 (EC ... Venom metalloproteinase (M12B) ...

VM3B3_BOTJA Zinc metalloproteinase-disintegrin-like bothrojarin-3 (EC ... Venom metalloproteinase (M12B) ...

VM3B4_BOTJA Zinc metalloproteinase-disintegrin-like bothrojarin-4 (EC ... Venom metalloproteinase (M12B) ...

VM3BP_BOTJA Zinc metalloproteinase-disintegrin-like bothropasin (EC ... Venom metalloproteinase (M12B) ...

VM3B_BOTJA Zinc metalloproteinase-disintegrin-like botrocetin (EC 3.4.24.-) ... Venom metalloproteinase (M12B) ...

VM3H3_BOTJA Zinc metalloproteinase-disintegrin-like HF3 (EC 3.4.24.-) (Snake ... Venom metalloproteinase (M12B) ...

VM3JA_BOTJA Zinc metalloproteinase-disintegrin-like jararhagin (EC ... Venom metalloproteinase (M12B) ...

VMXBN_BOTJA Snake venom metalloproteinase bothrolysin (SVMP) (EC 3.4.24.50) ... Venom metalloproteinase (M12B) ...

VMXJ4_BOTJA Snake venom metalloproteinase jararafibrase-4 (SVMP) (EC ... Venom metalloproteinase (M12B) ...

VSP12_BOTJA Snake venom serine protease HS112 (SVSP) (EC 3.4.21.-) Peptidase S1 family, Snake venom ...

VSP14_BOTJA Snake venom serine protease HS114 (SVSP) (EC 3.4.21.-) (BjSP) ... Peptidase S1 family, Snake venom ...

VSP1_BOTJA Platelet-aggregating proteinase PA-BJ (EC 3.4.21.-) (Snake venom ... Peptidase S1 family, Snake venom ...

VSP2_BOTJA Thrombin-like enzyme KN-BJ 2 (SVTLE) (EC 3.4.21.-) ... Peptidase S1 family, Snake venom ...

VSP3_BOTJA Snake venom serine protease BPA (SVSP) (EC 3.4.21.-) (Bothrops ... Peptidase S1 family, Snake venom ...

VSPA_BOTJA Thrombin-like enzyme bothrombin (SVTLE) (EC 3.4.21.74) (Factor ... Peptidase S1 family, Snake venom ...

VSPH_BOTJA Snake venom serine protease homolog HS120 (Venom serine ... Peptidase S1 family, Snake venom ...

VSPT1_BOTJA Thrombin-like enzyme TL-BJ 1 (SVTLE) (EC 3.4.21.-) ... Peptidase S1 family, Snake venom ...

VSPT2_BOTJA Thrombin-like enzyme TL-BJ 2 (SVTLE) (EC 3.4.21.-) ... Peptidase S1 family, Snake venom ...

VSPT3_BOTJA Thrombin-like enzyme TL-BJ 3 (SVTLE) (EC 3.4.21.-) ... Peptidase S1 family, Snake venom ...

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