Fibrinogenolytic toxin

Fibrinogenolytic toxins are proteases involved in degradation of fibrinogen leading to a decrease of plasma fibrinogen concentration and ultimately reduced blood coagulation, thus facilitating the spread of the toxic components throughout the prey's circulation.

See also UniProtKB-keyword.

Venom protein entries in UniProtKB/Swiss-Prot

(all links/actions below point to uniprot.org website)

107 entries grouped by species

reorder by family

1 entry

Agkistrodon bilineatus (Cantil) (Tropical moccasin)

1 entry

Agkistrodon contortrix laticinctus (Broad-banded copperhead) (Agkistrodon mokasen laticinctus)

2 entries

Agkistrodon piscivorus leucostoma (Western cottonmouth) (Acontias leucostoma)

VM1V1_AGKPL Snake venom metalloproteinase VMP1 (AplVMP-I) (AplVMP1) (SVMP) ... Venom metalloproteinase (M12B) ...

VM2V2_AGKPL Zinc metalloproteinase/disintegrin VMP-II (AplVMP2) [Cleaved ... Venom metalloproteinase (M12B) ...

1 entry

Bitis arietans (African puff adder)

1 entry

Borikenophis portoricensis (Puerto Rican racer) (Alsophis portoricensis)

1 entry

Bothrocophias andianus (Andean lancehead) (Bothrops andianus)

2 entries

Bothrops asper (Terciopelo)

"Bothrops asper" VenomZone page

VM1B1_BOTAS Snake venom metalloproteinase BaP1 (SVMP) (EC 3.4.24.-) ... Venom metalloproteinase (M12B) ...

pdb 1ND1; 2W12; 2W13; 2W14; 2W15

VM3BA_BOTAS Snake venom metalloproteinase basparin-A (SVMP) (EC 3.4.24.-) Venom metalloproteinase (M12B) ...

4 entries

Bothrops atrox (Barba amarilla) (Fer-de-lance)

VM1B1_BOTAT Snake venom metalloproteinase Batx-1 (SVMP) (EC 3.4.24.-) ... Venom metalloproteinase (M12B) ...

VM31_BOTAT Zinc metalloproteinase-disintegrin-like batroxstatin-1 (EC ... Venom metalloproteinase (M12B) ...

VM32_BOTAT Zinc metalloproteinase-disintegrin-like batroxstatin-2 (EC ... Venom metalloproteinase (M12B) ...

VM33_BOTAT Zinc metalloproteinase-disintegrin-like batroxstatin-3 (EC ... Venom metalloproteinase (M12B) ...

2 entries

Bothrops barnetti (Barnett's lancehead) (Trimeresurus barnetti)

VM1B1_BOTBA Zinc metalloproteinase barnettlysin-1 (EC 3.4.24.-) ... Venom metalloproteinase (M12B) ...

VSP_BOTBA Thrombin-like enzyme barnettobin (Bb-TLE) (SVTLE) (EC 3.4.21.-) ... Peptidase S1 family, Snake venom ...

4 entries

Bothrops jararaca (Jararaca) (Bothrops jajaraca)

VM1BJ_BOTJA Snake venom metalloproteinase bothrojaractivase (SVMP) (EC ... Venom metalloproteinase (M12B) ...

VM3JA_BOTJA Zinc metalloproteinase-disintegrin-like jararhagin (EC ... Venom metalloproteinase (M12B) ...

VSP14_BOTJA Snake venom serine protease HS114 (SVSP) (EC 3.4.21.-) (BjSP) ... Peptidase S1 family, Snake venom ...

VSP3_BOTJA Snake venom serine protease BPA (SVSP) (EC 3.4.21.-) (Bothrops ... Peptidase S1 family, Snake venom ...

1 entry

Bothrops jararacussu (Jararacussu)

2 entries

Bothrops leucurus (Whitetail lancehead)

VM1B_BOTLC Snake venom metalloproteinase BleucMP (SVMP) (EC 3.4.24.-) Venom metalloproteinase (M12B) ...

VM3LB_BOTLC Zinc metalloproteinase leucurolysin-B (Leuc-B) (EC 3.4.24.-) ... Venom metalloproteinase (M12B) ...

1 entry

Bothrops marajoensis (Marajo lancehead)

2 entries

Bothrops moojeni (Lance-headed viper) (Caissaca)

VM1BI_BOTMO Snake venom metalloproteinase BmooMPalpha-I (SVMP) (EC 3.4.24.-) Venom metalloproteinase (M12B) ...

pdb 3GBO

VM3_BOTMO Zinc metalloproteinase-disintegrin-like moojenin (EC 3.4.24.-) ... Venom metalloproteinase (M12B) ...

4 entries

Bothrops pauloensis (Neuwied's lancehead) (Bothrops neuwiedi pauloensis)

VM11_BOTPA Snake venom metalloproteinase BpMP-1 (SVMP) (EC 3.4.24.-) ... Venom metalloproteinase (M12B) ...

VM1B1_BOTPA Snake venom metalloproteinase BnP1 (SVMP) (EC 3.4.24.-) Venom metalloproteinase (M12B) ...

VM1B2_BOTPA Snake venom metalloproteinase BnP2 (SVMP) (EC 3.4.24.-) Venom metalloproteinase (M12B) ...

VM1N_BOTPA Snake venom metalloproteinase neuwiedase (SVMP) (EC 3.4.24.-) Venom metalloproteinase (M12B) ...

1 entry

Bothrops pirajai (Piraja's lancehead)

1 entry

Bungarus fasciatus (Banded krait) (Pseudoboa fasciata)

1 entry

Bungarus multicinctus (Many-banded krait)

1 entry

Cerastes cerastes (Horned desert viper)

8 entries

Crotalus atrox (Western diamondback rattlesnake)

VM1AT_CROAT Snake venom metalloproteinase atroxase (SVMP) (EC 3.4.24.43) ... Venom metalloproteinase (M12B) ...

VM1CR_CROAT Snake venom metalloproteinase crotalin (SVMP) (EC 3.4.24.-) Venom metalloproteinase (M12B) ...

VM2A_CROAT Snake venom metalloproteinase CatroxMP-II (SVMP) (EC 3.4.24.-) ... Venom metalloproteinase (M12B) ...

VM3V1_CROAT Zinc metalloproteinase-disintegrin-like VAP1 (EC 3.4.24.-) ... Venom metalloproteinase (M12B) ...

pdb 2ERO; 2ERP; 2ERQ

VMXCA_CROAT Snake venom metalloproteinase catroxase (SVMP) (EC 3.4.21.-) Venom metalloproteinase (M12B) ...

VSP3_CROAT Alpha-fibrinogenase A3 (EC 3.4.21.-) (Snake venom serine ... Peptidase S1 family, Snake venom ...

VSPA1_CROAT Alpha-fibrinogenase A1 (EC 3.4.21.-) (Snake venom serine ... Peptidase S1 family, Snake venom ...

VSPA2_CROAT Alpha-fibrinogenase A2 (EC 3.4.21.-) (Snake venom serine ... Peptidase S1 family, Snake venom ...

2 entries

Crotalus durissus cascavella (Northeastern Brazilian rattlesnake)

VM31_CRODC Zinc metalloproteinase-disintegrin-like crotastatin (EC ... Venom metalloproteinase (M12B) ...

VSP_CRODC Thrombin-like enzyme F202 (SVTLE) (EC 3.4.21.-) ... Peptidase S1 family, Snake venom ...

2 entries

Crotalus durissus cumanensis (South American rattlesnake)

VSP1_CRODM Thrombin-like enzyme Cdc SI (SVTLE) (EC 3.4.21.-) ... Peptidase S1 family, Snake venom ...

VSP2_CRODM Thrombin-like enzyme Cdc SII (SVTLE) (EC 3.4.21.-) ... Peptidase S1 family, Snake venom ...

1 entry

Crotalus durissus terrificus (South American rattlesnake)

1 entry

Crotalus vegrandis (Uracoan rattlesnake) (Crotalus durissus vegrandis)

1 entry

Daboia russelii (Russel's viper) (Vipera russelii)

3 entries

Daboia siamensis (Eastern Russel's viper) (Daboia russelii siamensis)

VM3DM_DABSI Zinc metalloproteinase-disintegrin-like daborhagin-M (EC ... Venom metalloproteinase (M12B) ...

VSPAF_DABSI Alpha-fibrinogenase-like (RVAF) (EC 3.4.21.-) (Snake venom ... Peptidase S1 family, Snake venom ...

VSPB_DABSI Beta-fibrinogenase-like (RVBF) (EC 3.4.21.-) (Snake venom serine ... Peptidase S1 family, Snake venom ...

2 entries

Deinagkistrodon acutus (Hundred-pace snake) (Agkistrodon acutus)

VM3A2_DEIAC Zinc metalloproteinase recombinant fibrinogenase II (FIIa) (rF ... Venom metalloproteinase (M12B) ...

VSPP_DEIAC Snake venom serine protease Dav-PA (SVSP) (AaV-SP-I) (AaV-SP-II) ... Peptidase S1 family, Snake venom ...

pdb 1OP0; 1OP2

1 entry

Echis ocellatus (Ocellated saw-scaled viper)

2 entries

Gloydius blomhoffii (Mamushi) (Agkistrodon halys blomhoffi)

VSP1_GLOBL Thrombin-like enzyme halystase (SVTLE) (EC 3.4.21.-) (Snake ... Peptidase S1 family, Snake venom ...

VSPB_GLOBL Beta-fibrinogenase brevinase (EC 3.4.21.-) (Snake venom serine ... Peptidase S1 family, Snake venom ...

5 entries

Gloydius brevicauda (Korean slamosa snake) (Agkistrodon halys brevicaudus)

VM2MC_GLOBR Zinc metalloproteinase/disintegrin [Cleaved into: Snake venom ... Venom metalloproteinase (M12B) ...

VM2MD_GLOBR Zinc metalloproteinase/disintegrin [Cleaved into: Snake venom ... Venom metalloproteinase (M12B) ...

VM32A_GLOBR Zinc metalloproteinase-disintegrin-like brevilysin H2a (EC ... Venom metalloproteinase (M12B) ...

VM32B_GLOBR Zinc metalloproteinase-disintegrin-like brevilysin H2b (EC ... Venom metalloproteinase (M12B) ...

VM3H6_GLOBR Zinc metalloproteinase-disintegrin-like brevilysin H6 (Mt-a) (EC ... Venom metalloproteinase (M12B) ...

3 entries

Gloydius halys (Chinese water mocassin) (Agkistrodon halys)

VAE1_GLOHA Thrombin-like enzyme agkihpin-1 (TLE agkihpin-1) (EC 3.4.21.-) ... Peptidase S1 family, Snake venom ...

VAE2_GLOHA Thrombin-like enzyme agkihpin-2 (TLE agkihpin-2) (EC 3.4.21.-) ... Peptidase S1 family, Snake venom ...

VSPI_GLOHA Thrombin-like enzyme AhV_TL-I (SVTLE AhV_TL-I) (EC 3.4.21.-) Peptidase S1 family, Snake venom ...

pdb 4E7N

1 entry

Gloydius shedaoensis (Shedao island pit viper) (Agkistrodon shedaoensis)

1 entry

Hippasa partita (Funnel-web spider) (Hippasa deserticola)

1 entry

Hydrophis hardwickii (Hardwick's spine-bellied seasnake) (Lapemis hardwickii)

6 entries

Lachesis muta rhombeata (Bushmaster)

VM31_LACMR Zinc metalloproteinase-disintegrin-like lachestatin-1 (EC ... Venom metalloproteinase (M12B) ...

VM32_LACMR Zinc metalloproteinase-disintegrin-like lachestatin-2 (EC ... Venom metalloproteinase (M12B) ...

VSP2_LACMR Thrombin-like enzyme LmrSP-2 (SVTLE) (EC 3.4.21.-) (Snake venom ... Peptidase S1 family, Snake venom ...

VSP3_LACMR Thrombin-like enzyme LmrSP-3 (SVTLE) (EC 3.4.21.-) (Snake venom ... Peptidase S1 family, Snake venom ...

VSP4_LACMR Snake venom serine protease LmrSP-4 (SVSP) (EC 3.4.21.-) Peptidase S1 family, Snake venom ...

VSPF_LACMR Thrombin-like enzyme LMR-47 (SVTLE LM-47) (SVTLE LMR-47) (EC ... Peptidase S1 family, Snake venom ...

8 entries

Macrovipera lebetina (Levantine viper) (Vipera lebetina)

VM1F_MACLB Snake venom metalloproteinase fibrolase (SVMP) (EC 3.4.24.72) ... Venom metalloproteinase (M12B) ...

VM1L4_MACLB Snake venom metalloproteinase lebetase-4 (Le-4) (Le4) (EC ... Venom metalloproteinase (M12B) ...

VM2L2_MACLB Zinc metalloproteinase/disintegrin [Cleaved into: Snake venom ... Venom metalloproteinase (M12B) ...

VM3VA_MACLB Zinc metalloproteinase-disintegrin-like VLAIP-A (EC 3.4.24.-) ... Venom metalloproteinase (M12B) ...

VM3VB_MACLB Zinc metalloproteinase-disintegrin-like VLAIP-B (EC 3.4.24.-) ... Venom metalloproteinase (M12B) ...

VSPA_MACLB Alpha-fibrinogenase (VLAF) (EC 3.4.21.-) (Snake venom serine ... Peptidase S1 family, Snake venom ...

VSPBF_MACLB Beta-fibrinogenase (VLBF) (EC 3.4.21.-) (Snake venom serine ... Peptidase S1 family, Snake venom ...

VSPY_MACLB Chymotrypsin-like protease VLCTLP (EC 3.4.21.-) (Snake venom ... Peptidase S1 family, Snake venom ...

3 entries

Naja atra (Chinese cobra)

"Naja atra" VenomZone page

VM3AH_NAJAT Zinc metalloproteinase atrahagin (EC 3.4.24.-) (Snake venom ... Venom metalloproteinase (M12B) ...

VM3B_NAJAT Zinc metalloproteinase-disintegrin-like atrase-B (EC 3.4.24.-) ... Venom metalloproteinase (M12B) ...

VM3_NAJAT Zinc metalloproteinase-disintegrin-like NaMP (EC 3.4.24.-) ... Venom metalloproteinase (M12B) ...

2 entries

Ophiophagus hannah (King cobra) (Naja hannah)

VM3_OPHHA Zinc metalloproteinase-disintegrin-like ohanin (EC 3.4.24.-) ... Venom metalloproteinase (M12B) ...

VSP1_OPHHA Alpha- and beta-fibrinogenase OhS1 (EC 3.4.21.-) (Snake venom ... Peptidase S1 family, Snake venom ...

1 entry

Protobothrops flavoviridis (Habu) (Trimeresurus flavoviridis)

3 entries

Protobothrops jerdonii (Jerdon's pitviper) (Trimeresurus jerdonii)

VM2JT_PROJR Zinc metalloproteinase-disintegrin jerdonitin (EC 3.4.24.-) ... Venom metalloproteinase (M12B) ...

VSPJF_PROJR Beta-fibrinogenase jerdofibrase (EC 3.4.21.-) (Snake venom ... Peptidase S1 family, Snake venom ...

VSPJN_PROJR Snake venom serine protease jerdonase (SVSP) (EC 3.4.21.-) Peptidase S1 family, Snake venom ...

6 entries

Protobothrops mucrosquamatus (Taiwan habu) (Trimeresurus mucrosquamatus)

VM2T3_PROMU Zinc metalloproteinase/disintegrin [Cleaved into: Snake venom ... Venom metalloproteinase (M12B) ...

pdb 1KUF; 1KUG; 1KUI; 1KUK

VSP1_PROMU Beta-fibrinogenase mucrofibrase-1 (EC 3.4.21.-) (Snake venom ... Peptidase S1 family, Snake venom ...

VSP2_PROMU Beta-fibrinogenase mucrofibrase-2 (EC 3.4.21.-) (Snake venom ... Peptidase S1 family, Snake venom ...

VSP3_PROMU Beta-fibrinogenase mucrofibrase-3 (EC 3.4.21.-) (Snake venom ... Peptidase S1 family, Snake venom ...

VSP4_PROMU Beta-fibrinogenase mucrofibrase-4 (EC 3.4.21.-) (Snake venom ... Peptidase S1 family, Snake venom ...

VSP5_PROMU Beta-fibrinogenase mucrofibrase-5 (EC 3.4.21.-) (Snake venom ... Peptidase S1 family, Snake venom ...

3 entries

Trimeresurus albolabris (White-lipped pit viper) (Cryptelytrops albolabris)

VM3AL_TRIAB Zinc metalloproteinase-disintegrin-like alborhagin (EC 3.4.24.-) ... Venom metalloproteinase (M12B) ...

VSPAF_TRIAB Alpha-fibrinogenase albofibrase (EC 3.4.21.-) (Snake venom ... Peptidase S1 family, Snake venom ...

VSPC_TRIAB Thrombin-like enzyme chitribrisin (SVTLE chitribrisin) (EC ... Peptidase S1 family, Snake venom ...

3 entries

Trimeresurus stejnegeri (Chinese green tree viper) (Viridovipera stejnegeri)

VM3TM_TRIST Zinc metalloproteinase-disintegrin-like TSV-DM (EC 3.4.24.-) ... Venom metalloproteinase (M12B) ...

VSPS1_TRIST Alpha- and beta-fibrinogenase stejnefibrase-1 (EC 3.4.21.-) ... Peptidase S1 family, Snake venom ...

VSPS2_TRIST Beta-fibrinogenase stejnefibrase-2 (EC 3.4.21.-) (Snake venom ... Peptidase S1 family, Snake venom ...

5 entries

Vipera ammodytes ammodytes (Western sand viper)

"Vipera ammodytes ammodytes" VenomZone page

VM3A_VIPAA Zinc metalloproteinase-disintegrin-like ammodytagin (EC ... Venom metalloproteinase (M12B) ...

VM3_VIPAA Zinc metalloproteinase-disintegrin-like VaH1 (EC 3.4.24.-) ... Venom metalloproteinase (M12B) ...

VMF1_VIPAA Zinc metalloproteinase-disintegrin-like protein F1 (EC 3.4.24.-) ... Venom metalloproteinase (M12B) ...

VMH3_VIPAA Zinc metalloproteinase-disintegrin-like protein H3 (EC 3.4.24.-) ... Venom metalloproteinase (M12B) ...

VMH4A_VIPAA Zinc metalloproteinase-disintegrin-like protein H4 subunit A (EC ... Venom metalloproteinase (M12B) ...

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