A hypotensive agent is a molecule which causes hypotension by lowering blood pressure or causing a sudden drop in blood pressure.
Venom proteins from different families act as hypotensive agents, either by direct or indirect mechanisms. For example, natriuretic peptides modulate body fluid volume by provoking vasodilation, natriuresis and diuresis through binding to the membrane-bound receptors NPR1-NPR3, bradykinin-potentiating peptides potentiate the hypotensive cardiovascular response to bradykinin, while some serine proteases release bradykinin from kininogen.
See also UniProtKB-keyword
Hypotensive agent (Antihypertensive agents)
Venom protein entries in UniProtKB/Swiss-Prot
(all links/actions below point to uniprot.org website)178 entries grouped by species
1 entry
Agkistrodon piscivorus piscivorus (Eastern cottonmouth)
1 entry
Anemonia sulcata (Mediterranean snakelocks sea anemone)
14 entries
Anemonia viridis (Snakelocks anemone)
1 entry
Austrelaps superbus (Lowland copperhead snake) (Hoplocephalus superbus)
2 entries
Bitis rhinoceros (West African gaboon viper) (Vipera rhinoceros)
2 entries
Bothrops alternatus (Urutu) (Rhinocerophis alternatus)
1 entry
Bothrops atrox (Barba amarilla) (Fer-de-lance)
8 entries
Bothrops cotiara (Cotiara) (Rhinocerophis cotiara)
1 entry
Bothrops erythromelas (Caatinga lance head)
6 entries
Bothrops fonsecai (Fonseca's lancehead) (Rhinocerophis fonsecai)
3 entries
Bothrops insularis (Golden lancehead) (Lachesis insularis)
19 entries
Bothrops jararaca (Jararaca) (Bothrops jajaraca)
2 entries
Bothrops jararacussu (Jararacussu)
1 entry
Bothrops leucurus (Whitetail lancehead)
2 entries
Bothrops moojeni (Lance-headed viper) (Caissaca)
5 entries
Bothrops neuwiedi (Neuwied's lancehead)
1 entry
Bothrops pirajai (Piraja's lancehead)
1 entry
Bungarus flaviceps flaviceps (Red-headed krait)
1 entry
Bungarus multicinctus (Many-banded krait)
1 entry
Buthus occitanus (Common European scorpion)
1 entry
Caribicus warreni (Haitian giant galliwasp) (Celestus warreni)
1 entry
Cerastes cerastes (Horned desert viper)
1 entry
Chiropsoides quadrigatus (Box jellyfish) (Chiropsalmus quadrigatus)
1 entry
Craspedocephalus gramineus (Bamboo pit viper) (Trimeresurus gramineus)
3 entries
Crotalus adamanteus (Eastern diamondback rattlesnake)
2 entries
Crotalus atrox (Western diamondback rattlesnake)
1 entry
Crotalus durissus cascavella (Northeastern Brazilian rattlesnake)
1 entry
Crotalus durissus collilineatus (Brazilian rattlesnake)
1 entry
Crotalus durissus terrificus (South American rattlesnake)
2 entries
Crotalus oreganus abyssus (Grand Canyon rattlesnake) (Crotalus abyssus)
4 entries
Crotalus viridis viridis (Prairie rattlesnake)
2 entries
Cryptophis nigrescens (Eastern small-eyed snake) (Rhinoplocephalus nigrescens)
1 entry
Daboia palaestinae (Palestine viper) (Vipera palaestinae)
2 entries
Dendroaspis angusticeps (Eastern green mamba) (Naja angusticeps)
1 entry
Echis ocellatus (Ocellated saw-scaled viper)
2 entries
Gloydius blomhoffii (Mamushi) (Agkistrodon halys blomhoffi)
2 entries
Gloydius halys (Chinese water mocassin) (Agkistrodon halys)
2 entries
Heloderma horridum horridum (Mexican beaded lizard)
3 entries
Heloderma suspectum (Gila monster)
3 entries
Heloderma suspectum cinctum (Banded Gila monster)
4 entries
Hemachatus haemachatus (Rinkhals) (Sepedon haemachatus)
2 entries
Hoplocephalus stephensii (Stephens' banded snake)
1 entry
Hydrophis hardwickii (Hardwick's spine-bellied seasnake) (Lapemis hardwickii)
2 entries
Lachesis muta muta (Bushmaster)
3 entries
Lychas mucronatus (Chinese swimming scorpion)
1 entry
Lycosa erythrognatha (Wolf spider) (Scaptocosa raptoria)
1 entry
Macrovipera lebetina (Levantine viper) (Vipera lebetina)
1 entry
Meiacanthus atrodorsalis (Forktail blenny) (Petroscirtes atrodorsalis)
1 entry
Mesobuthus martensii (Manchurian scorpion) (Buthus martensii)
1 entry
Micrurus altirostris (Uruguayan coral snake) (Elaps altirostris)
1 entry
Micrurus corallinus (Brazilian coral snake)
1 entry
Micrurus fulvius (Eastern coral snake) (Coluber fulvius)
1 entry
Naja atra (Chinese cobra)
2 entries
Notechis scutatus scutatus (Mainland tiger snake) (Common tiger snake)
1 entry
Ophiophagus hannah (King cobra) (Naja hannah)
1 entry
Ornithorhynchus anatinus (Duckbill platypus)
5 entries
Oxyuranus microlepidotus (Inland taipan) (Diemenia microlepidota)
3 entries
Oxyuranus scutellatus canni (Papuan taipan)
3 entries
Oxyuranus scutellatus scutellatus (Australian taipan) (Coastal taipan)
1 entry
Parapolybia indica (Lesser paper wasp)
1 entry
Philodryas olfersii (Green snake)
1 entry
Polistes major (Neotropical social wasp)
1 entry
Protobothrops elegans (Elegant pitviper) (Trimeresurus elegans)
1 entry
Protobothrops flavoviridis (Habu) (Trimeresurus flavoviridis)
3 entries
Protobothrops mucrosquamatus (Taiwan habu) (Trimeresurus mucrosquamatus)
4 entries
Pseudechis australis (Mulga snake) (King brown snake)
2 entries
Pseudechis porphyriacus (Red-bellied black snake)
1 entry
Pseudocerastes persicus (Persian horned viper) (False horned viper)
1 entry
Pseudonaja textilis (Eastern brown snake)
1 entry
Rhabdophis tigrinus tigrinus (Tiger keelback snake)
1 entry
Sistrurus catenatus edwardsii (Desert massasauga) (Crotalophorus edwardsii)
1 entry
Tityus discrepans (Venezuelan scorpion)
1 entry
Tityus metuendus (Scorpion)
6 entries
Tityus serrulatus (Brazilian scorpion)
1 entry
Tropidechis carinatus (Australian rough-scaled snake)
1 entry
Varanus eremius (Rusty desert monitor)
2 entries
Varanus varius (Lace monitor lizard) (Lacerta varia)
1 entry
Vespa mandarinia (Asian giant hornet)
1 entry
Vespa xanthoptera (Japanese yellow hornet) (Vespa simillima xanthoptera)
1 entry
Vespula maculifrons (Eastern yellow jacket) (Wasp)
1 entry