G-protein coupled receptor impairing toxin (GPCR regulator)

Receptor G-protein coupled receptors (GPCRs) are membrane proteins constituted of seven transmembrane segments linked by three external and three internal loops. GPCRs constitute the largest family of membrane proteins. They transduce external stimuli into the cell and control almost all physiological processes in humans (Jacoby et al., 2006).

Venom protein entries in UniProtKB/Swiss-Prot

(all links/actions below point to uniprot.org website)

149 entries grouped by species

reorder by family

1 entry

Agkistrodon bilineatus (Cantil) (Tropical moccasin)

1 entry

Atractaspis bibronii (Bibron's mole viper) (Southern stiletto snake)

2 entries

Atractaspis engaddensis (Israeli burrowing asp) (Israeli mole viper)

SRTXD_ATREN Sarafotoxin-D (SRTX-D) (S6D) Endothelin/sarafotoxin family

SRTX_ATREN Sarafotoxin [Cleaved into: Sarafotoxin-A, Ser-isoform (SRTX-A) ... Endothelin/sarafotoxin family

pdb 1SRB; 6LRY

2 entries

Atractaspis irregularis (Variable burrowing asp) (Elaps irregularis)

SRTX1_ATRIR Sarafotoxin-i1 (SRTX-i1) (Sarafotoxin-i3) (SRTX-i3) Endothelin/sarafotoxin family

pdb 2LDE

SRTX2_ATRIR Sarafotoxin-i2 (SRTX-i2) Endothelin/sarafotoxin family

1 entry

Atractaspis microlepidota microlepidota

1 entry

Bothrops insularis (Golden lancehead) (Lachesis insularis)

3 entries

Bothrops jararaca (Jararaca) (Bothrops jajaraca)

BNP1_BOTJA Bradykinin-potentiating and C-type natriuretic peptides ... Bradykinin-potentiating peptide ...

BNP2_BOTJA Bradykinin-potentiating and C-type natriuretic peptides (Brain ... Bradykinin-potentiating peptide ...

BPP7A_BOTJA Bradykinin-potentiating peptide 7a (BPP-7a) (Proline-rich ... Bradykinin-potentiating peptide ...

5 entries

Bungarus multicinctus (Many-banded krait)

"Bungarus multicinctus" VenomZone page

3NO52_BUNMU Long neurotoxin homolog NTL2 Snake three-finger toxin family, ...

3NO56_BUNMU Long neurotoxin homolog TA-bm16 (Delta-protein) Snake three-finger toxin family, ...

3NO5I_BUNMU Gamma-bungarotoxin (Long neurotoxin homolog NTL2I) Snake three-finger toxin family, ...

pdb 1MR6

3NOHE_BUNMU Muscarinic toxin BM14 Snake three-finger toxin family, ...

3SO8_BUNMU Muscarinic toxin-like protein Snake three-finger toxin family, ...

2 entries

Buthus occitanus israelis (Common yellow scorpion) (Buthus israelis)

LV1A_BUTOS Lipolysis-activating peptide 1-alpha chain (BoiLVP1-alpha) ... Long (3 C-C) scorpion toxin ...

LV1B_BUTOS Lipolysis-activating peptide 1-beta chain (BoiLVP1-beta) ... Long (3 C-C) scorpion toxin ...

2 entries

Buthus occitanus tunetanus (Common European scorpion) (Buthus tunetanus)

LV1A_BUTOC Lipolysis-activating peptide 1-alpha chain (BotLVP1-alpha) ... Long (3 C-C) scorpion toxin ...

LV1B_BUTOC Lipolysis-activating peptide 1-beta chain (BotLVP1-beta) ... Long (3 C-C) scorpion toxin ...

1 entry

Conus arenatus (Sand-dusted cone)

1 entry

Conus betulinus (Beech cone)

1 entry

Conus consors (Singed cone)

4 entries

Conus geographus (Geography cone) (Nubecula geographus)

CESS_CONGE Conopressin-conophysin [Cleaved into: Conopressin-G (Con-G) ... Vasopressin/oxytocin family

CONG_CONGE Contulakin-G (CGX-1160) Conotoxin C superfamily

CSST1_CONGE Consomatin G1 (ConSST G1) (Somatostatin-related peptide) (SSRP) Conotoxin C superfamily, ...

CSST2_CONGE Consomatin G2 (ConSST G2) (Somatostatin-related peptide) (SSRP) Conotoxin C superfamily, ...

1 entry

Conus grahami (Cone snail) (Africonus grahami)

1 entry

Conus lenavati (Cone snail)

1 entry

Conus litoglyphus (Lithograph cone)

2 entries

Conus litteratus (Lettered cone)

"Conus litteratus" VenomZone page

CON1_CONLT Contulakin-Lt1 Conotoxin C superfamily

CON2_CONLT Contulakin-Lt2 Conotoxin C superfamily

1 entry

Conus lividus (Livid cone)

1 entry

Conus magus (Magical cone)

1 entry

Conus maioensis (Sea snail) (Africonus maioensis)

2 entries

Conus mercator (Trader cone) (Varioconus mercator)

CSST1_CONMK Consomatin Mrc1 (ConSST Mrc1) (Somatostatin-related peptide) ... Conotoxin C superfamily, ...

CSST3_CONMK Consomatin Mrc3 (ConSST Mrc3) (Somatostatin-related peptide) ... Conotoxin C superfamily, ...

2 entries

Conus miliaris (Thousand-spot cone)

CONO1_CONML Conopressin-M1 (Con-M1) Vasopressin/oxytocin family

CONO2_CONML Conopressin-M2 Vasopressin/oxytocin family

3 entries

Conus monile (Necklace cone)

CESS1_CONMO Conopressin-conophysin, isoform 1 [Cleaved into: Conopressin-E; ... Vasopressin/oxytocin family

CESS2_CONMO Conopressin/conophysin, isoform 2 [Cleaved into: Conopressin-R; ... Vasopressin/oxytocin family

CESS3_CONMO Conopressin/conophysin, isoform 3 [Cleaved into: Conopressin-K; ... Vasopressin/oxytocin family

1 entry

Conus neocostatus (Cone snail) (Asprella neocostatus)

1 entry

Conus radiatus (Rayed cone)

1 entry

Conus raulsilvai (Sea snail) (Africonus raulsilvai)

1 entry

Conus regius (Crown cone)

2 entries

Conus rolani (Cone snail)

CSST1_CONRO Consomatin Ro1 (ConSST Ro1) (Somatostatin-related peptide) ... Conotoxin C superfamily, ...

CSST2_CONRO Consomatin Ro2 (ConSST Ro2) (Somatostatin-related peptide) ... Conotoxin C superfamily, ...

1 entry

Conus spurius (Alphabet cone)

1 entry

Conus striatus (Striated cone)

1 entry

Conus terebra (Sea snail) (Virgiconus terebra)

2 entries

Conus textile (Cloth-of-gold cone)

"Conus textile" VenomZone page

CONO_CONTE Conopressin-Tx Vasopressin/oxytocin family

CRFA2_CONTE Conorfamide-Tx2 (CNF-Tx2) (Cono-RFamide-Tx2) FARP (FMRFamide related peptide) ...

2 entries

Conus tulipa (Fish-hunting cone snail) (Tulip cone)

CA1A_CONTU Rho-conotoxin TIA (Rho-TIA) Conotoxin A superfamily

pdb 1IEN; 2LR9

CONOT_CONTU Conopressin-T (Con-T) Vasopressin/oxytocin family

1 entry

Conus victoriae (Queen Victoria cone)

1 entry

Conus villepinii (Villepin's cone)

1 entry

Crotalus atrox (Western diamondback rattlesnake)

1 entry

Crotalus durissus terrificus (South American rattlesnake)

1 entry

Crotalus viridis viridis (Prairie rattlesnake)

3 entries

Cyphononyx dorsalis (Spider wasp) (Cyphononyx fulvognathus)

BRK6_CYPDO Bradykinin-related peptide Cd-146 Bradykinin-related peptide ...

BRKC_CYPDO Cyphokinin (Bradykinin-related peptide) [Cleaved into: ... Bradykinin-related peptide ...

BRKF_CYPDO Fulvonin (Bradykinin-related peptide) Bradykinin-related peptide ...

12 entries

Dendroaspis angusticeps (Eastern green mamba) (Naja angusticeps)

3SI12_DENAN Muscarinic m1-toxin2 Snake three-finger toxin family, ...

3SI13_DENAN Muscarinic m1-toxin3 Snake three-finger toxin family, ...

3SI14_DENAN Muscarinic m1-toxin4 Snake three-finger toxin family, ...

3SI1A_DENAN Toxin AdTx1 (Rho-elapitoxin-Da1a) (Rho-Da1a) (Rho-EPTX-Da1a) Snake three-finger toxin family, ...

pdb 4IYE; 5MG9

3SI1B_DENAN Rho-elapitoxin-Da1b (Rho-Da1b) (Rho-EPTX-Da1b) Snake three-finger toxin family, ...

3SIM1_DENAN Muscarinic toxin 1 (MT1) (MTx1) Snake three-finger toxin family, ...

pdb 3FEV; 3NEQ; 4DO8

3SIM2_DENAN Muscarinic toxin 2 (MT2) (MTx2) Snake three-finger toxin family, ...

pdb 1FF4

3SIM3_DENAN Muscarinic toxin 3 (MT3) Snake three-finger toxin family, ...

3SIM4_DENAN Muscarinic toxin 4 (MT4) Snake three-finger toxin family, ...

3SIM7_DENAN Muscarinic toxin 7 (MT-7) (MT7) (Muscarinic toxin 1) (m1-toxin) Snake three-finger toxin family, ...

pdb 2VLW; 3FEV; 3NEQ; 6WJC

3SUB_DENAN Muscarinic toxin 2 (m2-toxin) Snake three-finger toxin family, ...

MAMB1_DENAN Mambaquaretin-1 (MQ-1) (MQ1) (Upsilon-Da2a) Venom Kunitz-type family

pdb 5M4V

1 entry

Dendroaspis jamesoni kaimosae (Eastern Jameson's mamba)

7 entries

Dendroaspis polylepis polylepis (Black mamba)

3SI3_DENPO Adrenergic toxin rho-elapitoxin-Dp1b (rho-EPTX-Dp1b) (Muscarinic ... Snake three-finger toxin family, ...

3SIMA_DENPO Muscarinic toxin alpha (MT-alpha) Snake three-finger toxin family, ...

3SIMB_DENPO Adrenergic toxin rho-elapitoxin-Dp1a (rho-EPTX-Dp1a) (Muscarinic ... Snake three-finger toxin family, ...

3SX9_DENPO Dendroaspis polylepis MT9 (Three-finger toxin) (3FTx) Snake three-finger toxin family, ...

pdb 6R5M

MAMB3_DENPO Mambaquaretin-3 (MQ3) (Upsilon-Dp2a) Venom Kunitz-type family

MAMB7_DENPO Mambaquaretin-7 (MQ7) (Kunitz-type serine protease inhibitor ... Venom Kunitz-type family

MIT1_DENPO Toxin MIT1 (MIT 1) (Black mamba intestinal toxin 1) (Black mamba ... AVIT (prokineticin) family

pdb 1IMT

4 entries

Dendroaspis viridis (Western green mamba)

MAMB2_DENVI Mambaquaretin-2 (MQ2) (Upsilon-Dv2a) Venom Kunitz-type family

MAMB4_DENVI Mambaquaretin-4 (MQ4) (Upsilon-Dv2c) Venom Kunitz-type family

MAMB6_DENVI Mambaquaretin-6 (MQ6) (Upsilon-Dv2d) Venom Kunitz-type family

MAMB9_DENVI Mambaquaretin-9 (MQ9) (Upsilon-Dv2b) Venom Kunitz-type family

2 entries

Doratifera vulnerans (Mottled cup moth)

Z11_DORVU Z-limacoditoxin(1)-Dv1 (Z-LCTX(1)-Dv1) (Vulnericin) Limacoditoxin-1 (ACP-like) ...

Z14_DORVU Z-limacoditoxin(1)-Dv4 (Z-LCTX(1)-Dv4) (Vulnericin) Limacoditoxin-1 (ACP-like) ...

3 entries

Heloderma horridum horridum (Mexican beaded lizard)

EXE1_HELHO Exendin-1 (Helospectin-1) (VIP-like 1) [Cleaved into: Exendin-1b ... Glucagon family

EXE3_HELHO Exendin-3 (Glucagon-like 3) Glucagon family

HKS_HELHO Helokinestatin-1 (Helokinestatin) Not in a family

3 entries

Heloderma suspectum (Gila monster)

EXE1_HELSU Exendin-1 (Helospectin I) (Helospectin-1) (VIP-like 1) [Cleaved ... Glucagon family

EXE2_HELSU Exendin-2-long [Cleaved into: Exendin-2 (Helodermin) (VIP-like ... Glucagon family

EXE4_HELSU Exendin-4 (Exenatide) Glucagon family

pdb 1JRJ; 2MJ9; 2NAV; 2NAW; 3C59; 3C5T; 5NIQ; 5OTT; 6GDZ; 6GE2; 7LLL; 7MLL

3 entries

Heloderma suspectum cinctum (Banded Gila monster)

EXE2_HELSC Exendin-2-long [Cleaved into: Exendin-2 (Helodermin) (VIP-like ... Glucagon family

EXE4_HELSC Exendin-4 Glucagon family

VNHP_HELSC Natriuretic and helokinestatin peptides [Cleaved into: ... Natriuretic peptide family

1 entry

Heloderma suspectum suspectum (Reticulate Gila monster)

1 entry

Latrodectus geometricus (Brown widow spider)

1 entry

Latrodectus tredecimguttatus (Mediterranean black widow spider) (Latrodectus mactans tredecimguttatus)

6 entries

Lychas mucronatus (Chinese swimming scorpion)

LV1A1_LYCMC Lipolysis-activating peptide 1-alpha chain (LVP1-alpha) ... Long (3 C-C) scorpion toxin ...

LV1A2_LYCMC Lipolysis-activating peptide 1-alpha chain (LVP1-alpha) [Cleaved ... Long (3 C-C) scorpion toxin ...

LV1B1_LYCMC Lipolysis-activating peptide 1-beta chain (LVP1-beta) ... Long (3 C-C) scorpion toxin ...

LV1B2_LYCMC Lipolysis-activating peptide 1-beta chain (LVP1-beta) Long (3 C-C) scorpion toxin ...

LVPAH_LYCMC Lipolysis-activating peptide 1-alpha chain (LVP1-alpha) ... Long (3 C-C) scorpion toxin ...

LVPAY_LYCMC Lipolysis-activating peptide 1-alpha chain (LVP1-alpha) [Cleaved ... Long (3 C-C) scorpion toxin ...

1 entry

Lycosa erythrognatha (Wolf spider) (Scaptocosa raptoria)

1 entry

Megascolia flavifrons (Garden dagger wasp) (Solitary wasp)

1 entry

Meiacanthus atrodorsalis (Forktail blenny) (Petroscirtes atrodorsalis)

3 entries

Mesobuthus martensii (Manchurian scorpion) (Buthus martensii)

LV1A_MESMA Lipolysis-activating peptide 1-alpha chain (BmLVP1-alpha) ... Long (3 C-C) scorpion toxin ...

LV1B_MESMA HMG-CoA reductase inhibitor bumarsin (JCH2) ... Long (3 C-C) scorpion toxin ...

YA_MESMA BmK-YA precursor [Cleaved into: BmK-YA 1 (Enkephalin-like ... Not in a family

1 entry

Micrurus lemniscatus (South American coral snake)

3 entries

Naja atra (Chinese cobra)

"Naja atra" VenomZone page

3SO8_NAJAT Neurotoxin homolog NL1 Snake three-finger toxin family, ...

PA2A1_NAJAT Acidic phospholipase A2 1 (svPLA2) (EC 3.1.1.4) (Muscarinic ... Phospholipase A2 family, Group I ...

pdb 1POA; 1POB

VKT_NAJAT Kunitz-type serine protease inhibitor NACI (Naja atra ... Venom Kunitz-type family

pdb 2M99

3 entries

Naja kaouthia (Monocled cobra) (Naja siamensis)

3NO2_NAJKA Tryptophan-containing weak neurotoxin (WTX) Snake three-finger toxin family, ...

pdb 2MJ0

3SO8_NAJKA Muscarinic toxin-like protein 3 (MTLP-3) Snake three-finger toxin family, ...

3SUC1_NAJKA Muscarinic toxin-like protein 1 (MTLP-1) Snake three-finger toxin family, ...

1 entry

Naja melanoleuca (Forest cobra) (Black-lipped cobra)

1 entry

Naja naja (Indian cobra)

1 entry

Naja sputatrix (Malayan spitting cobra) (Naja naja sputatrix)

9 entries

Ophiophagus hannah (King cobra) (Naja hannah)

3SDC1_OPHHA Beta-cardiotoxin CTX21 Snake three-finger toxin family, ...

3SDC3_OPHHA Beta-cardiotoxin CTX23 Snake three-finger toxin family, ...

3SDC4_OPHHA Beta-cardiotoxin CTX14 Snake three-finger toxin family, ...

3SDC5_OPHHA Beta-cardiotoxin CTX15 (OH-84) Snake three-finger toxin family, ...

3SDC7_OPHHA Beta-cardiotoxin CTX27 (OH-27) Snake three-finger toxin family, ...

pdb 3PLC

3SDC9_OPHHA Beta-cardiotoxin CTX9 Snake three-finger toxin family, ...

3SI35_OPHHA Short neurotoxin OH-35 Snake three-finger toxin family, ...

3SIM6_OPHHA Muscarinic toxin MTX6 Snake three-finger toxin family, ...

3SIM8_OPHHA Muscarinic toxin 38 (MTX38) Snake three-finger toxin family, ...

1 entry

Parabuthus transvaalicus (South African fattail scorpion)

1 entry

Parapolybia indica (Lesser paper wasp)

1 entry

Poecilotheria regalis (Indian ornamental tree spider)

1 entry

Polistes major (Neotropical social wasp)

1 entry

Polybia occidentalis (Paper wasp)

1 entry

Protopolybia exigua (Neotropical social wasp)

1 entry

Scolopendra mutilans (Chinese red-headed centipede) (Scolopendra subspinipes mutilans)

1 entry

Synanceia verrucosa (Reef stonefish)

3 entries

Tityus serrulatus (Brazilian scorpion)

"Tityus serrulatus" VenomZone page

NDB31_TITSE Hypotensin toxin Ts31 (Anti-hypertensive peptide) ... Non-disulfide-bridged peptide ...

NDBH1_TITSE Hypotensin-1 (Anti-hypertensive peptide) (Hypotensin I) ... Non-disulfide-bridged peptide ...

NDBH2_TITSE Hypotensin-2 (Hypotensin II) (TsHpt-II) (Toxin Ts14 2) [Cleaved ... Non-disulfide-bridged peptide ...

3 entries

Varanus varius (Lace monitor lizard) (Lacerta varia)

CCT1_VARVA Cholecystoxin (Cholecystoxin-Vvar1) [Cleaved into: ... Gastrin/cholecystokinin family

VAR1_VARVA AVIToxin-VAR1 AVIT (prokineticin) family

VAR2_VARVA AVIToxin-VAR2 AVIT (prokineticin) family

1 entry

Vespa mandarinia (Asian giant hornet)

1 entry

Vespa xanthoptera (Japanese yellow hornet) (Vespa simillima xanthoptera)

1 entry

Vespula maculifrons (Eastern yellow jacket) (Wasp)

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